检索结果-内蒙古大学图书馆

arXiv 2018年

作者： Gadde, Manasa Sorace, Anna G. Wong, Enoch Syed, Anum Phillips, Caleb Rahal, Omar Yankeelov, Thomas E. Woodward, Wendy A. Rylander, Marissa Nichole Department of Biomedical Engineering Austin TX United States Departments of Diagnostic Medicine Austin TX United States Department of Oncology Austin TX United States Livestrong Cancer Institutes Austin TX United States Institute for Computational and Engineering Sciences Austin TX United States M. D. Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic HoustonTX United States Department of Experimental Radiation Oncology HoustonTX United States Department of Mechanical Engineering Austin TX United States

Background: Tumor stromal interactions have been shown to be the driving force behind the poor prognosis associated with aggressive breast tumors. These interactions, specifically between tumor and the surrounding extracellular matrix (ECM), and between tumor and vascular endothelial cells, promote tumor formation, angiogenesis, and metastasis to distant tissues. In this study, we develop an in vitro vascularized breast tumor platform that allows for investigation of tumor-stromal interactions in three aggressive breast tumor derived cell lines: MDA-IBC3, SUM149, and MDA-MB-231. Methods: The in vitro breast tumor platform consists of a cylindrical endothelial vessel, surrounded by a tumor cell-seeded collagen matrix allowing for direct interactions between endothelial and cancer cells. The platform recapitulates key characteristics of breast tumors, including increased vascular permeability, vessel sprouting, and ECM remodeling. Morphological and quantitative analysis reveals differential effects from each tumor cell type on endothelial coverage, permeability, expression of vascular endothelial growth factor (VEGF), and collagen remodeling. Results: The triple negative tumors, SUM149 and MDA-MB-321, resulted in a significantly (p Copyright © 2018, The Authors. All rights reserved.

关键词： Collagen

来源：评论

学校读者我要写书评

暂无评论

Magnetofluorescent nanocomposites integrating magnetic nanoparticles and near infrared quantum dots for tumor cell targeting 9th

Magnetofluorescent nanocomposites integrating magnetic nanop...

引用

9th Japanese-Mediterranean Workshop on Applied Electromagnetic engineering for Magnetic, Superconducting, Multifunctional and Nano Materials, 2015

作者： Zhu, Xiaoshan Department of Electrical and Biomedical Engineering University of Nevada Reno NV United States Biomedical Engineering Program University of Nevada Reno NV United States

ISBN: (纸本)9783035710267

In this work, we report the preparation of MFNCs integrating MnFe2O4 magnetic nanoparticles (MNPs), near infrared CuInS2/ZnS quantum dots (QDs) and poly(ethylene glycol)-bpoly(lactide-co-glycolide) (PEG-PLGA) in a tetrahydrofuran (THF)/water solvent system. It is found that the MFNCs possess high (Mn + Fe) recovery rates, and the optical properties and magnetic relaxivity of the MFNCs are tunable according to the MNP:QD mass ratios. Furthermore, the MFNCs present excellent capability for tumor cell targeting once they are conjugated with bioprobes specific to tumor cells. This study opens an avenue for the MFNCs to be employed in broad biological or biomedical applications. © 2016 Trans Tech Publications, Switzerland.

关键词： Nanocomposites

来源：评论

学校读者我要写书评

暂无评论

Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

引用

NPJ Regenerative medicine 2023年第1期8卷 47页

作者： Wencheng Zhang Xicheng Wang Giacomo Lanzoni Eliane Wauthier Sean Simpson Jennifer Ashley Ezzell Amanda Allen Carolyn Suitt Jonah Krolik Alexander Jhirad Juan Dominguez-Bendala Vincenzo Cardinale Domenico Alvaro Diletta Overi Eugenio Gaudio Praveen Sethupathy Guido Carpino Christopher Adin Jorge A Piedrahita Kyle Mathews Zhiying He Lola McAdams Reid Department of Cell Biology and Physiology University of North Carolina (UNC) School of Medicine Chapel Hill NC 27599 USA. Institute for Regenerative Medicine Shanghai East Hospital School of Life Sciences and Technology Tongji University School of Medicine 200123 Shanghai China. Shanghai Engineering Research Center of Stem Cells Translational Medicine 200335 Shanghai China. Shanghai Institute of Stem Cell Research and Clinical Translation 200120 Shanghai China. Diabetes Research Institute Leonard Miller School of Medicine 1450 N.W. 10th Avenue Miami FL 33136 USA. Department of Molecular Biomedical Sciences North Carolina State University (NCSU) College of Veterinary Medicine Raleigh NC 27606 USA. Comparative Medicine Institute NCSU Raleigh NC 27606 USA. Center for Gastrointestinal Biology and Disease (CGIBD) UNC School of Medicine Chapel Hill NC 27599 USA. Department of Medico-Surgical Sciences and Biotechnologies Sapienza University Rome Latina 04100 Italy. Department of Translational and Precision Medicine Sapienza University Rome 00185 Italy. Department of Anatomical Histological Forensic Medicine and Orthopedics Sciences Sapienza University Rome 00161 Italy. Department of Biomedical Sciences Cornell University College of Veterinary Medicine Ithaca NY 14853 USA. pr46@cornell.edu. Department of Anatomical Histological Forensic Medicine and Orthopedics Sciences Sapienza University Rome 00161 Italy. guido.carpino@uniroma1.it. Department of Clinical Sciences Soft Tissue and Oncologic Surgery Service College of Veterinary Medicine NCSU Raleigh NC 27606 USA. adinc@ufl.edu. Department of Small Animal Clinical Sciences University of Florida College of Veterinary Medicine Gainesville FL 32608 USA. adinc@ufl.edu. Department of Molecular Biomedical Sciences North Carolina State University (NCSU) College of Veterinary Medicine Raleigh NC 27606 USA. japiedra@ncsu.edu. Comparative Medicine Institute NCSU Raleigh NC 27606 USA. japiedra@ncsu

来源：评论

学校读者我要写书评

暂无评论

直流电动力学湍流的尺度律及其级串过程

直流电动力学湍流的尺度律及其级串过程

引用

第十届全国流体力学学术会议

作者：赵伟王归仁西北大学光子学与光子技术研究所 University of South Carolina Department of Mechanical Engineering and Biomedical Program

在之前的研究中,我们对交流(AC)电动力学(electrokinetic)湍流的尺度律及其能量和标量的级串过程进行了详细的描述。鉴于交流电动力学与直流(DC)电动力学在电体积力(electric volume force)产生机理上面的不同,交流电动力学湍流的尺度... 详细信息

在之前的研究中,我们对交流(AC)电动力学(electrokinetic)湍流的尺度律及其能量和标量的级串过程进行了详细的描述。鉴于交流电动力学与直流(DC)电动力学在电体积力(electric volume force)产生机理上面的不同,交流电动力学湍流的尺度律无法直接推广到直流的情况。因此,在本研究中,我们对直流电动力学湍流的尺度律及其能量和标量级串过程进行了补充研究,以完备对电动力学湍流发生发展机制的理论框架。研究发现,直流电动力流动中的电体积力要大于交流电动力流动中的电体积力,但这两种电动力湍流的级串过程和标度指数都是相同的。进一步研究发现,电惯性(electroinertial effect)和电粘性(electroviscous effect)效应所起作用的尺度范围是不同的,前者的尺度范围与Ra成正比,而后者的尺度范围与Ra成正比,这里Ra是电瑞利数(electric Rayleigh number)。这充分解释了,为什么在低电瑞利数下,混沌电动力流动是由于电粘性效应产生的,而在高点电瑞利数下,电动力湍流是由于电惯性效应产生的。鉴于直流电动力学湍流可以广泛存在于中间尺度的大气现象(地球上1-10m尺度范围内),对该流动的研究会充实我们对自然现象的理解。同时,直流电动力学湍流对于EHD推进器和微纳混合器/反应器的开发也有重要意义。

关键词：直流电动力流动湍流特征尺度级串电惯性与电粘性

来源：评论

学校读者我要写书评

暂无评论

交流电渗流在近壁面处的混沌行为及其频率依赖性

交流电渗流在近壁面处的混沌行为及其频率依赖性

引用

第十届全国流体力学学术会议

作者：赵伟王凯歌白晋涛王归仁西北大学光子学与光子技术研究所 University of South Carolina Department of Mechanical Engineering and Biomedical Program

由于壁面粘性的影响,一般认为电渗流在电场力驱动下,其电双层(electric double layer)附近的速度响应为线性的,满足线性化的Navier-Stokes方程。然而,我们近期的基于激光诱发荧光漂白速度计(Laser Induced Fluorescence Photobleaching ... 详细信息

由于壁面粘性的影响,一般认为电渗流在电场力驱动下,其电双层(electric double layer)附近的速度响应为线性的,满足线性化的Navier-Stokes方程。然而,我们近期的基于激光诱发荧光漂白速度计(Laser Induced Fluorescence Photobleaching Anemometer)的研究发现,当交流电渗流(AC EOF)的电场强度足够大时,电双层附近的电渗流速度波动呈现随机性,电渗流表现出混沌流动(chaotic flow)特征。进一步的研究发现,电渗流从周期性流动向混沌流动的转捩过程与施加的外电场的频率具有直接的关系。不同的外电场频率下,混沌流动的产生机理并不完全相同。而传统意义上的电动力流动的转捩过程(受电瑞利数控制),例如电动力流动不稳定性,一般仅仅与外电场的强度相关(Posner et al,PNAS,2012)。该研究成果显示,或者电双层附近的流体粘性远远小于其表观粘性,或者电双层自身的形成过程并非我们所熟知的那么迅速。该研究对于理解重要的壁面滑移现象和电双层形成过程具有极为重要的意义,对于研究转捩过程在微纳米尺度下的内在(intrinsic)机制也有重要的帮助。

关键词：交流电渗流混沌流动频率依赖性 LIFPA 电双层

来源：评论

学校读者我要写书评

暂无评论

Peptide Brush Polymers for Efficient Delivery of a Gene Editing Protein to Stem Cells

引用

Angewandte Chemie 2019年第44期131卷

作者： Angela P. Blum David A. Nelles Francisco J. Hidalgo Mollie A. Touve Deborah S. Sim Assael A. Madrigal Gene W. Yeo Nathan C. Gianneschi Department of Chemistry and Biochemistry University of California San Diego La Jolla CA USA Departments of Chemistry Hamilton College Clinton NY USA Department of Cellular and Molecular Medicine Stem Cell Program Institute of Genomic Medicine University of California San Diego La Jolla CA USA Departments of Chemistry Materials Science & Engineering Biomedical Engineering International Institute for Nanotechnology Northwestern University Evanston IL USA Molecular Engineering Laboratory A*STAR Singapore Singapore

The scarcity of effective means to deliver functional proteins to living cells is a central problem in biotechnology and medicine. Herein, we report the efficient delivery of an active DNA‐modifying enzyme to human stem cells through high‐density cell penetrating peptide brush polymers. Cre recombinase is mixed with a fluorophore‐tagged polymer carrier and then applied directly to induced pluripotent stem cells or HEK293T cells. This results in efficient delivery of Cre protein as measured by activation of a genomically integrated Cre‐mediated recombination reporter. We observed that brush polymer formulations utilizing cell penetrating peptides promoted Cre delivery but oligopeptides alone or oligopeptides displayed on nanoparticles did not. Overall, we report the efficient delivery of a genome‐modifying enzyme to stem cells that may be generalizable to other, difficult‐to‐transduce cell types.

关键词： Enzymtransport Proteintransport Stammzellen Zellaufnahme Zellpenetrierende Peptide

来源：评论

学校读者我要写书评

暂无评论

The Quantification of Corrosion Damage for Pre-stressed Conditions: A Model Using Stainless Steel

引用

Journal of Bio- and Tribo-Corrosion 2016年第1期2卷 1-10页

作者： Munir, Selin Walsh, William R. The Surgical and Orthopaedic Research Laboratories Prince of Wales Hospital UNSW Sydney Australia The Graduate School of Biomedical Engineering UNSW Sydney Australia

Stainless steel is used extensively within orthopaedics as part of varying surgical procedures such as trochanteric osteotomy, sternum closure, patella tendon repair and reconstruction, patellofemoral ligament reconstruction and internal fracture fixation. This study examines the changes in corrosion behaviour after applying plastic and elastic stresses. Furthermore it analyses how a tensile and a compressive load can affect the corrosion susceptibility of a material. Stainless steel test specimens were divided into three groups of seven to determine how corrosion susceptibility will change when a material is pre-stressed. Potentiodynamic testing was performed to investigate the pitting behaviour of ss304 after being exposed to pre-stressed conditions. All images graded exhibited both area and pit corrosion scores, which significantly differed between the 3 groups (p © 2016, Springer International Publishing Switzerland.

关键词： Pitting

来源：评论

学校读者我要写书评

暂无评论

Consistency of Surface Electromyography Assessment at Lower Limb Selected Muscles During Vertical Countermovement

Consistency of Surface Electromyography Assessment at Lower ...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Carlos Rodrigues Miguel Correia Joao M. C. S. Abrantes Jurandir Nadal Marco A. Benedetti Rodrigues Centre for Biomedical Engineering Research INESC TEC Porto Portugal INESC TEC FEUP Department of Electrical and Computer Engineering University of Porto Porto Portugal MovLab ULHT PEB UFRJ PPGEE UFPE Graduate Program in Electrical Engineering Federal University of Pernambuco Recife Brazil

Given the difficulty of invasive methods to assess muscle action during natural human movement, surface electromyography (sEMG) has been increasingly used to capture muscle activity in relation to kinesiological analysis of specific tasks. Isolated isometric, concentric and eccentric forms of muscle action have been receiving the most attention for research purposes. Nevertheless natural muscle action frequently involves the use of a preceding eccentric muscle action as a form of potentiation of immediate muscle concentric action, in what is designated as muscle stretch-shortening cycle (SSC). The most frequently applied protocols for the evaluation of SSC on vertical jumps are by virtue of their reproducibility and control of experimental conditions, squat jump (SJ) without countermovement (CM), countermovement jump (CMJ) with long CM and drop jump (DJ) with short CM. The methods used to extract information and relationship of the captured signals also present a high diversity, with the question about the consistency of the methods and obtained results. The objective of this study is to evaluate the consistency of the analysis and results by applying different EMGs signal analysis techniques related to strategic muscle groups of the lower limbs at different countermovement evaluated in vertical jumps. Raw sEMG signals of 5 lower limb muscles of 6 subjects during SJ, CMJ and DJ were rectified, filtered and obtained their envelope, and then correlated (CR) for detection of synergistic, agonist and antagonist activity, applied principal component analysis (PCA) for the detection of uncorrelated components explaining maximum variability and normalized cross-correlation (CCRN) for detection of maximum correlations and time lag. CR of EMG envelopes presented higher coactivities (CoA) in DJ relative to SJ and these CoA superior to CMJ with greater synergy in DJ relative to SJ and CMJ that present several loop cycles corresponding to time lag of activity. CCRN of the EMG e

关键词： Muscles Correlation Electromyography Principal component analysis Eigenvalues and eigenfunctions Electronic mail Radio frequency

来源：评论

学校读者我要写书评

暂无评论

Cognitive priority model for advanced telemedical support in Limited Bandwidth Applications

Cognitive priority model for advanced telemedical support in...

引用

IEEE Canadian Conference on Electrical and Computer engineering

作者： Thomas E. Doyle David. M. Musson Taralyn Schwering McMaster eHealth Graduate Program Electrical and Computer Engineering School of Biomedical Engineering McMaster University Hamilton Ontario Canada Undergraduate Medical Education Northern Ontario School of Medicine Thunder Bay Ontario Canada Electrical and Computer Engineering McMaster University Hamilton Ontario Canada

Telemedicine offers the ability to provide real-time medical support, education, and care to remote and austere locations under limited bandwidth restrictions. These types of communication channels can easily be overwhelmed and delays or interruptions make communication difficult, if not impossible. These interruptions destroy the temporal orientation of communication resulting in significant cognitive loading. The objective of this research was to lower cognitive load and minimize digital communication bandwidth by developing a priority model from perceptual quality and content focus of telemedical video. H.264/AVC encoding was used to encode two types of medical context with varying bitrates, frame rates, and frame sizes. Telemedical video contexts were room awareness, and medical procedure. Objective quality and subjective quality tests were performed using Structural Similarity (SSIM) and perceptual feedback, respectively. The objective of this research is to develop context specific telemedicine communication models for the highest perceptual quality for available bandwidth for the purpose of increased temporal orientation and decreased cognitive load. Our research presents a method to select the best encoding parameters (maximum bitrate, frame rate and frame size) for the medical context to minimize bandwidth and maintain diagnostic and education quality.

关键词： biomedical Telemetry Telemedicine Telematics Medical Information Systems Medical Services Temporal Orientation Cognitive Load

来源：评论

学校读者我要写书评

暂无评论

THU0067 THREE-MONTH RADIOLOGICAL CHANGES IN WRIST JOINT MEASURED BY MRI AND HR-PQCT CAN PREDICT 12-MONTH CHANGES IN EROSION AND FUNCTIONAL OUTCOMES AFTER MTX AND ANTI-TNF TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A MULTI-MODALITY IMAGING STUDY

引用

Annals of the Rheumatic Diseases 2019年 78卷 302-302页

作者： Kenji Mamoto Tomohiro Shimizu Matthew Tanaka Valentina Pedoia Andrew Burghardt Ursula Heilmeier Thomas Link Jonathan Graf John Imboden LI Xiaojuan Cleveland Clinic Biomedical Engineering Program of Advanced Musculoskeletal Imaging (PAMI) Cleveland United States of America Yodogawa Christian Hospital Orthopaedic Surgery Osaka Japan Hokkaido University Medical School Orthopaedic Surgery Sapporo Japan University of California San Francisco Radiology and Biomedical Imaging Musculoskeletal Quantitative Imaging Research San Francisco United States of America University of California San Francisco Medicine Division of Rheumatology San Francisco United States of America

Background Magnetic resonance imaging (MRI) provides noninvasive methods to quantify joint inflammation and early cartilage degeneration in monitoring rheumatoid arthritis (RA) progression 1 . High-resolution peripheral quantitative computed tomography (HR-pQCT) provides reliable evaluation of bone erosion volumes 2 . Objectives To investigate if changes in MR measures from baseline to 3-month (3M) can predict changes in erosion volumes, clinical and functional assessment from baseline to 12-month (12M) in RA patients receiving methotrexate (MTX) and anti-tumor necrosis factor alpha (Anti-TNFα) therapy using MRI and HR-pQCT. Methods Seventeen RA patients with MTX treatment were recruited into either a low disease activity score (DAS) group (n=9, DAS28≤3.2) or high DAS group (n=8, DAS28>3.2). The low DAS group received MTX treatment only, while the high DAS group received additional Anti-TNFα treatment to MTX immediately after baseline visit (BL). Volumes of synovitis (SYN), bone marrow edema-like lesions (BMEL) and cartilage T1ρ values in wrist joint by MRI, bone erosion volumes in wrist joint by HR-pQCT, DAS28-CRP, Health Assessment Questionnaire (HAQ), and Michigan Hand Outcome Questionnaire (MHQ) were assessed at BL, 3M and 12M in all patients. Longitudinal changes were evaluated using paired t-test. Linear regression models were used to evaluate whether changes in imaging measure changes from BL to 3M predict changes in erosion volumes and patient outcomes (DAS28-CRP, HAQ, MHQ) from BL to 12M, after adjusting for age, gender, disease duration and therapy (Anti-TNFα added or not). Results Anti-TNFα therapy in the high DAS group resulted in significant decreases of SYN, BMEL at 3M and DAS28-CRP, HAQ and MHQ at 3M and 12M from BL ( Table. 1 ). The low DAS group in contrast, displayed significant increases in SYN and DAS-CRP at 3M and bone erosion volume at 3M and 12M from BL despite low disease activity ( Table. 1 ). Changes in SYN, not BMEL, T1ρ or bone erosion, f

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：