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Initial performance evaluation of a 3D gel dosimeter based on modified tetrazolium compounds

Journal of Physics: Conference Series 2019年第1期1305卷

作者： Rubin Hazarika Kalin I Penev Kibret Mequanint Kevin Jordan London Regional Cancer Program London Health Sciences Centre London ON N6A 4L6 Canada Modus Medical Devices Inc. 1570 N Routledge Park London ON N6H 5L6 Canada Department of Chemical and Biochemical Engineering The University of Western Ontario London ON N5A 5B9 Canada Biomedical Engineering Program The University of Western Ontario London ON N5A 5B9 Canada Dept of Medical Biophysics The University of Western Ontario London ON N6A 5B9 Canada

Tetrazolium-based 3D gellan gum gel dosimeters have been reported previously and tested at several sites. They show no image diffusion and excellent stability; however, the dose sensitivity of the current commercial product, ClearView™, is relatively low for routine clinical applications. Here we report initial testing of a second generation product with increased sensitivity and retained non-diffusive properties. This formulation has a 25% increase in sensitivity relative to ClearView™. However, the sample has a higher initial attenuation and the background attenuation increases faster than ClearView™. The composition was tested in a 1-liter sealed container using a 2x2 cm, 6MV, x-ray beam, and show agreement between Monte Carlo simulation and measurements.

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Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF

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Nature 2024年第8012期629卷 E12页

作者： Sandi Radko-Juettner Hong Yue Jacquelyn A Myers Raymond D Carter Alexis N Robertson Priya Mittal Zhexin Zhu Baranda S Hansen Katherine A Donovan Moritz Hunkeler Wojciech Rosikiewicz Zhiping Wu Meghan G McReynolds Shourya S Roy Burman Anna M Schmoker Nada Mageed Scott A Brown Robert J Mobley Janet F Partridge Elizabeth A Stewart Shondra M Pruett-Miller Behnam Nabet Junmin Peng Nathanael S Gray Eric S Fischer Charles W M Roberts Division of Molecular Oncology Department of Oncology St Jude Children's Research Hospital Memphis TN USA. St Jude Graduate School of Biomedical Sciences St Jude Children's Research Hospital Memphis TN USA. Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA. Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA. Department of Cell and Molecular Biology St Jude Children's Research Hospital Memphis TN USA. The Center for Advanced Genome Engineering St Jude Children's Research Hospital Memphis TN USA. Center for Applied Bioinformatics St Jude Children's Research Hospital Memphis TN USA. Department of Structural Biology St Jude Children's Research Hospital Memphis TN USA. Department of Immunology St Jude Children's Research Hospital Memphis TN USA. Department of Developmental Neurobiology St Jude Children's Research Hospital Memphis TN USA. Department of Oncology St Jude Children's Research Hospital Memphis TN USA. Cancer Center St Jude Children's Research Hospital Memphis TN USA. Human Biology Division Fred Hutchinson Cancer Center Seattle WA USA. Department of Chemical and Systems Biology ChEM-H Stanford Cancer Institute Stanford Medicine Stanford CA USA. Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA. eric_fischer@dfci.harvard.edu. Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA. eric_fischer@dfci.harvard.edu. Division of Molecular Oncology Department of Oncology St Jude Children's Research Hospital Memphis TN USA. charles.roberts@***. Cancer Center St Jude Children's Research Hospital Memphis TN USA. charles.roberts@***.

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Multistatic microwave holography: Initial results on anthropomorphic phantoms 10

Multistatic microwave holography: Initial results on anthrop...

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10th European Conference on Antennas and Propagation, EuCAP 2016

作者： Tapia, Daniel Flores Nepote, Mario Solis Herrera, Diego Rodriguez Lei, Fu Yonsheng, Gui Benyon, Valerie Can-Min, Hu Pistorius, Stephen Latif, Saeed Department of Physics and Astronomy Biomedical Engineering Program Department of Electrical and Computer Engineering University of Manitoba WinnipegManitoba Canada Department of Electrical and Computer Engineering University of South Alabama MobileAlabama United States

ISBN: (纸本)9788890701863

Ultra Wide Band Radar is a novel technology used for breast cancer detection. This imaging modality uses ultra wide band waveforms to form a reflectivity map of the breast region in which tumors can potentially been clearly distinguished. In this study, the authors assess the use of a novel Breast UWBR reconstruction approach, microwave holography, on anthropomorphic phantoms. These phantoms mimic both the shape and dielectric properties of human breast. The images formed using microwave holography are consistent with the location of the synthetic breast structures and show signal to clutter level above 3dB. © 2016 European Association of Antennas and Propagation.

关键词： Microwave holography

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Quantifying spasticity in individual muscles using shear wave elastography

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Radiology Case Reports 2017年第2期12卷 348-352页

作者： Eby, Sarah F. Zhao, Heng Song, Pengfei Vareberg, Barbara J. Kinnick, Randall R. Greenleaf, James F. An, Kai-Nan Brown, Allen W. Chen, Shigao Mayo Medical School Mayo Graduate School Medical Scientist Training Program College of Medicine Mayo Clinic 200 First St. SW Rochester 55905 MN United States Biomechanics Laboratory Division of Orthopedic Research Mayo Clinic 200 First St. SW Rochester 55905 MN United States Department of Biomedical Engineering College of Medicine Mayo Clinic Rochester MN United States Department of Radiology Mayo Clinic Rochester MN United States Department of Physical Medicine and Rehabilitation Mayo Clinic Rochester MN United States

Spasticity is common following stroke;however, high subject variability and unreliable measurement techniques limit research and treatment advances. Our objective was to investigate the use of shear wave elastography (SWE) to characterize the spastic reflex in the biceps brachii during passive elbow extension in an individual with spasticity. The patient was a 42-year-old right-hand-dominant male with history of right middle cerebral artery-distribution ischemic infarction causing spastic left hemiparesis. We compared Fugl-Meyer scores (numerical evaluation of motor function, sensation, motion, and pain), Modified Ashworth scores (most commonly used clinical assessment of spasticity), and SWE measures of bilateral biceps brachii during passive elbow extension. We detected a catch that featured markedly increased stiffness of the brachialis muscle during several trials of the contralateral limb, especially at higher extension velocities. SWE was able to detect velocity-related increases in stiffness with extension of the contralateral limb, likely indicative of the spastic reflex. This study offers optimism that SWE can provide a rapid, real-time, quantitative technique that is readily accessible to clinicians for evaluating spasticity. © 2017 The Authors

关键词： Muscle spasticity Skeletal muscle Stroke Ultrasound Upper extremity

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Correction to: Material Mapping of QCT-Derived Scapular Models: A Comparison with Micro-CT Loaded Specimens Using Digital Volume Correlation

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Annals of biomedical engineering 2019年第11期47卷 2342页

作者： Nikolas K Knowles Jonathan Kusins Mohammadreza Faieghi Melissa Ryan Enrico Dall'Ara Louis M Ferreira School of Biomedical Engineering The University of Western Ontario London ON Canada. nknowle@uwo.ca. Roth|McFarlane Hand and Upper Limb Centre St. Josephs Health Care London ON Canada. nknowle@uwo.ca. Collaborative Training Program in MSK Health Research and Bone and Joint Institute The University of Western Ontario London ON Canada. nknowle@uwo.ca. Roth|McFarlane Hand and Upper Limb Centre Surgical Mechatronics Laboratory St. Josephs Health Care 268 Grosvenor St. London ON Canada. nknowle@uwo.ca. Department of Mechanical and Materials Engineering The University of Western Ontario London ON Canada. Roth|McFarlane Hand and Upper Limb Centre St. Josephs Health Care London ON Canada. Collaborative Training Program in MSK Health Research and Bone and Joint Institute The University of Western Ontario London ON Canada. School of Biomedical Engineering The University of Western Ontario London ON Canada. Department of Oncology and Metabolism and INSIGNEO Institute for In Silico Medicine University of Sheffield Sheffield UK.

The article Material Mapping of QCT-Derived Scapular Models: A Comparison with Micro-CT Loaded Specimens Using Digital Volume Correlation, written by Knowles et al, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 11 July 2019 without open access. With the author(s)' decision to opt for Open Choice the copyright of the article changed on [August 30] to © The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://***/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population

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Science advances 2025年第23期11卷 eadt0539页

作者： Ting-Yuan Liu Hsing-Fang Lu Yu-Chia Chen Chi-Chou Liao Ying-Ju Lin Jai-Sing Yang Wen-Ling Liao Wei-De Lin Shih-Yin Chen Yu-Chuen Huang Wei-Yong Lin Yu-Huei Liu Kai-Cheng Hsu Shih-Sheng Chang Hong-Da Chen Yu-Pao Chou Jan-Gowth Chang Chung-Hsing Wang Chwen-Tzuei Chang Chung-Ming Huang Kai-Jieh Yeo Tzu-Yuan Wang Chin-Chung Yeh Jiunn-Horng Chen Chi-Ping Huang Hsueh-Chou Lai Rong-Hsing Chen Hui-Ju Lin Po-Yuan Wu Jiu-Yao Wang Chin-Chi Kuo Der-Yang Cho Chang-Hai Tsai Fuu-Jen Tsai Million-person precision medicine initiative Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. Master Program for Digital Health Innovation China Medical University Taichung 406040 Taiwan. Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung 40402 Taiwan. School of Post Baccalaureate Chinese Medicine China Medical University Taichung 404333 Taiwan. Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung 406040 Taiwan. Center for Personalized Medicine Department of Medical Research China Medical University Hospital Taichung 406040 Taiwan. School of Chinese Medicine China Medical University Taichung 406040 Taiwan. Drug Development Center China Medical University Taichung 406040 Taiwan. Artificial Intelligence Center China Medical University Hospital Taichung 40402 Taiwan. Department of Neurology China Medical University Hospital Taichung 40402 Taiwan. Department of Medicine China Medical University Taichung 406040 Taiwan. Department of Laboratory Medicine China Medical University Hospital Taichung 40402 Taiwan. Department of Bioinformatics and Medical Engineering Asia University Taichung 41300 Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. Division of Genetics and Metabolism Children's Hospital of China Medical University Taichung 404447 Taiwan. Intelligent Diabetes Metabolism and Exercise Center Department of Internal Medicine China Medical University Hospital Taichung 40402 Taiwan. Division of Immunology and Rheumatology Department of Internal Medicine China Medical University Hospital Taichung 40402 Taiwan. Division of Endocrine and Metabolism China Medical University Hospital Taichung 40402 Taiwan. Department of Urology China Medical University Hospital Taichung 40402 Taiwan. Cen

We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice supports early risk prediction and personalized prevention. To further expand translational value, we also conducted pharmacogenomic analysis and human leukocyte antigen typing. HiGenome offers a large-scale genetic and clinical dataset from the Taiwanese Han population, supporting population-specific analyses and precision medicine development in East Asia. The hospital-based design enables continuous follow-up and longitudinal data expansion.

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Front Cover, Volume 43, Issue 10

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Human Mutation 2022年第10期43卷

作者： Sheng-Jia Lin Barbara Vona Hillary M. Porter Mahmoud Izadi Kevin Huang Yves Lacassie Jill A. Rosenfeld Saadullah Khan Cassidy Petree Tayyiba A. Ali Nazif Muhammad Sher A. Khan Noor Muhammad Pengfei Liu Marie-Louise Haymon Franz Rüschendorf Il-Keun Kong Linda Schnapp Natasha Shur Lynn Chorich Lawrence Layman Thomas Haaf Ehsan Pourkarimi Hyung-Goo Kim Gaurav K. Varshney Genes & Human Disease Research Program Oklahoma Medical Research Foundation Oklahoma City Oklahoma USA Institute of Human Genetics Julius Maximilians University Würzburg Würzburg Germany Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen Göttingen Germany Institute of Human Genetics University Medical Center Göttingen Göttingen Germany Gaurav K. Varshney Genes & Human Disease Research Program Oklahoma Medical Research Foundation Oklahoma City OK 73104 USA. Children's National Hospital Rare Disease Institute Washington District of Columbia USA Division of Genomics and Translational Medicine College of Health and Life Sciences Hamad Bin Khalifa University Doha Qatar Department of Pediatrics Louisiana State University Health Sciences Center Head Division of Clinical Genetics and Dept. of Genetics Children's Hospital 1986-2016 New Orleans Los Angeles USA Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas USA Baylor Genetics Laboratories Houston Texas USA Department of Biotechnology and Genetic Engineering Kohat University of Science & Technology Kohat Khyber Pakhtunkhwa Pakistan Children Hospital New Orleans Louisiana Pediatric Radiology Tulane Associate Professor of Radiology New Orleans Los Angeles USA Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany Department of Animal Sciences Division of Applied Life Science (BK21 Four) Gyeongsang National University Jinju South Korea Section of Reproductive Endocrinology Infertility & Genetics Department of Obstetrics and Gynecology Department of Neuroscience and Regenerative Medicine Medical College of Georgia Augusta University Augusta USA Neurological Disorders Research Center Qatar Biomedical Research Institute Hamad Bin Khalifa University Doha Qatar

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Modelling and control of a 2-link mobile manipulator with virtual prototyping 13

Modelling and control of a 2-link mobile manipulator with vi...

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13th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2016

作者： Meng, Zehui Liang, Xinquan Andersen, Hans Ang, Marcelo H. NUS Graduate School of Integrative Science and Engineering National University of Singapore Singapore Singapore Department of Mechanical Engineering National University of Singapore Singapore Singapore Department of Biomedical Engineering National University of Singapore Singapore Singapore

ISBN: (纸本)9781509008216

Mobile manipulators are nowadays popular in various fields, including military missions, civil defense, rescue, and social services. Along with the wide use of such robots, the associated control problems require more and more attention to the nonlinearity and uncertainties of the dynamic models. In this paper, targeting the challenges of trajectory control for applications in which the robots have to overcome complex terrain conditions, we present a rapid virtual prototyping using Matlab-Simulink with embedded design and implementation of two control strategies - feedforward nonlinear control and adaptive control for controlling the end-effector of a two-link robot arm with/without well-known models. Simulation results show the efficacy of the feedforward nonlinear controller and adaptive controller developed. Comparisons of the performances are made to provide an analytical evaluation as well as a general reference for selecting controllers in different cases. © 2016 IEEE.

关键词： Manipulators

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Apoptotic effects on cultured cells of atmospheric-pressure plasma produced using various gases

Apoptotic effects on cultured cells of atmospheric-pressure ...

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作者： Tominami, Kanako Kanetaka, Hiroyasu Kudo, Tada-Aki Sasaki, Shota Kaneko, Toshiro Graduate School of Biomedical Engineering Tohoku University Sendai980-8575 Japan Graduate School of Dentistry Tohoku University Sendai980-8575 Japan Department of Electronic Engineering Tohoku University Sendai980-8579 Japan

This study investigated the effects of low-temperature atmospheric-pressure plasma on various cells such as rat fibroblastic Rat-1 cell line, rat neuroblastoma-like PC12 cell line, and rat macrophage-like NR8383 cell line. The plasma was irradiated directly to a culture medium containing plated cells for 0-20 s. The applied voltage, excitation frequency, and argon or helium gas flow were, respectively, 3-6 kV, 10 kHz, and 3 L/min. Cell viability and apoptotic activity were evaluated using annexin-V/propidium iodide staining. Results showed that the low-temperature atmospheric-pressure plasma irradiation promoted cell death in a discharge-voltage-dependent and irradiation-time-dependent manner. Furthermore, different effects are produced depending on the cell type. Moreover, entirely different mechanisms might be responsible for the induction of apoptosis in cells by helium and argon plasma. © 2016 The Japan Society of Applied Physics.

关键词： Rats

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Brain perfusion mediates the relationship between miRNA levels and postural control

arXiv

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arXiv 2019年

作者： Chen, Yufen Herrold, Amy A. Martinovich, Zoran Blood, Anne J. Vike, Nicole Walter, Alexa E. Harezlak, Jaroslaw Seidenberg, Peter H. Bhomia, Manish Knollmann-Ritschel, Barbara Reilly, James L. Nauman, Eric A. Talavage, Thomas M. Papa, Linda Slobounov, Semyon Breiter, Hans C. Center for Translational Imaging Department of Radiology Feinberg School of Medicine Northwestern University ChicagoIL60611 United States Edward Hines Jr. VA Hospital Research Service HinesIL60141 United States Warren Wright Adolescent Center Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University ChicagoIL60611 United States Mental Health Services and Policy Program Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine ChicagoIL60611 United States Mood and Motor Control Laboratory Departments of Neurology and Psychiatry Massachusetts General Hospital Harvard Medical School BostonMA02129 United States Laboratory of Neuroimaging and Genetics Department of Psychiatry Massachusetts General Hospital Harvard Medical School BostonMA02129 United States Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School BostonMA02129 United States School of Electrical and Computer Engineering Purdue University West LafayetteIN47907 United States Weldon School of Biomedical Engineering Purdue University West LafayetteIN47907 United States Department of Kinesiology Pennsylvania State University University ParkPA16802 United States Department of Epidemiology and Biostatistics Indiana University BloomingtonIN47405 United States Departments of Orthopaedics & Rehabilitation and Family & Community Medicine Penn State College of Medicine HersheyPA17033 Department of Pathology Uniformed Services University of the Health Sciences BethesdaMD United States Department of Basic Medical Sciences Purdue University West LafayetteIN47907 United States Department of Emergency Medicine Orlando Regional Medical Center OrlandoFL United States

Transcriptomics, regional cerebral blood flow (rCBF), and a spatial motor virtual reality task were integrated using mediation analysis in a novel demonstration of "imaging omics". Data collected in NCAA Division I football athletes cleared for play before in-season training showed significant relationships in a) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, (b) elevated putamen rCBF to compromised balance scores, and (c) compromised balance scores to elevated miRNA levels. rCBF acted as a mediator variable (minimum 70% mediation, significant Sobel's test) between abnormal miRNA levels and compromised balance scores. Given the involvement of these miRNAs in inflammation and immune function, and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model of repetitive head acceleration events (HAEs). rCBF, a systems biology measure, was necessary for miRNA to affect behavior. These results suggest miRNA as a potential diagnostic biomarker for repetitive HAEs. Copyright © 2019, The Authors. All rights reserved.

关键词： Sports

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