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Cytochrome P450 Monooxygenase CYP716A141 is a Unique b-Amyrin C-16b Oxidase Involved in Triterpenoid Saponin Biosynthesis in Platycodon grandiflorus (vol 57, pg 874, 2017)

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PLANT AND CELL PHYSIOLOGY 2017年第6期58卷 1119-1119页

作者： Tamura, Keita Teranishi, Yuga Ueda, Shinya Suzuki, Hideyuki Kawano, Noriaki Yoshimatsu, Kayo Saito, Kazuki Kawahara, Nobuo Muranaka, Toshiya Seki, Hikaru Department of Biotechnology Graduate School of Engineering Osaka University Suita Japan. Department of Research & Development Kazusa DNA Research Institute Kisarazu Japan. Tsukuba Division Research Center for Medicinal Plant Resources National Institutes of Biomedical Innovation Health and Nutrition Tsukuba Japan. Graduate School of Pharmaceutical Sciences Chiba University Chiba Japan.

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Frontispiz: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate

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Angewandte Chemie 2019年第24期131卷

作者： Beomsue Kim Masahiro Fukuda Jung‐Yeol Lee Dongdong Su Srikanta Sanu Aymeric Silvin Audrey T. T. Khoo Taejoon Kwon Xiao Liu Weijie Chi Xiaogang Liu Sejong Choi Diana S. Y. Wan Sung‐Jin Park Jin‐Soo Kim Florent Ginhoux H. Shawn Je Young‐Tae Chang Singapore Bioimaging Consortium Agency for Science Technology and Research (A*STAR) Singapore 138667 Singapore Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore 169857 Singapore Department of Chemistry Pohang University of Science and Technology Pohang 37673 Korea Present address: New drug discovery center DGMIF Daegu 41061 Korea Singapore Immunology Network A*STAR Singapore 138648 Singapore Department of Biomedical Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Korea Center for Self-assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Korea Singapore University of Technology and Design Singapore 487372 Singapore Department of Chemistry Seoul National University Seoul 08826 Korea Center for Genome Engineering IBS Daejeon 34047 Korea

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Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate

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Angewandte Chemie 2019年第24期131卷

Microglia, the brain‐resident macrophage, are involved in brain development and contribute to the progression of neural disorders. Despite the importance of microglia, imaging of live microglia at a cellular resolution has been limited to transgenic mice. Efforts have therefore been dedicated to developing new methods for microglia detection and imaging. Using a thorough structure–activity relationships study, we developed CDr20, a high‐performance fluorogenic chemical probe that enables the visualization of microglia both in vitro and in vivo. Using a genome‐scale CRISPR‐Cas9 knockout screen, the UDP‐glucuronosyltransferase Ugt1a7c was identified as the target of CDr20. The glucuronidation of CDr20 by Ugt1a7c in microglia produces fluorescence.

关键词： Biologische Aktivität Fluoreszsonden Kontrastmittel Mikroglia Struktur-Aktivitäts-Bezieung

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Frontispiece: Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate

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Angewandte Chemie International Edition 2019年第24期58卷

作者： Dr. Beomsue Kim Dr. Masahiro Fukuda Dr. Jung-Yeol Lee Dr. Dongdong Su Dr. Srikanta Sanu Dr. Aymeric Silvin Audrey T. T. Khoo Prof. Taejoon Kwon Xiao Liu Dr. Weijie Chi Prof. Xiaogang Liu Sejong Choi Diana S. Y. Wan Dr. Sung-Jin Park Prof. Jin-Soo Kim Prof. Florent Ginhoux Prof. H. Shawn Je Prof. Young-Tae Chang Singapore Bioimaging Consortium Agency for Science Technology and Research (A*STAR) Singapore 138667 Singapore Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore 169857 Singapore Department of Chemistry Pohang University of Science and Technology Pohang 37673 Korea Present address: New drug discovery center DGMIF Daegu 41061 Korea Singapore Immunology Network A*STAR Singapore 138648 Singapore Department of Biomedical Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Korea Center for Self-assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Korea Singapore University of Technology and Design Singapore 487372 Singapore Department of Chemistry Seoul National University Seoul 08826 Korea Center for Genome Engineering IBS Daejeon 34047 Korea

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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Effect of various submucosal fluid cushions on optothermal interaction of porcine tissues with 808-NM near infrared laser 8

Effect of various submucosal fluid cushions on optothermal i...

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8th Asian Conference on Refrigeration and Air-Conditioning, ACRA 2016

作者： Kim, Sunwook Kim, Jung Kyung Department of Integrative Biomedical Science and Engineering Graduate School Kookmin University 77 Jeongneung-ro Seongbuk-gu Seoul02707 Korea Republic of School of Mechanical Systems Engineering Kookmin University 77 Jeongneung-ro Seongbuk-gu Seoul02707 Korea Republic of

A high-power laser with 808-nm near infrared wavelength can be used for the removal of lesions in the procedure of digestive endoscopic submucosal dissection (ESD). In our previous study, we demonstrated that the perforation depth increased linearly with laser output power and irradiation time in both fillet and stomach tissue samples. Despite the structural and compositional distinction between two tissue types, there was no significant difference in perforation depth. We proposed that a properly designed submucosal fluid cushion (SFC), which is used for lifting the mucosal layer in ESD, could enhance the lasertissue interaction by absorbing 808-nm light selectively and minimize complications at the non-lesional deep tissue. Here, we further investigated the effect of SFC on the degree of perforation at the mucosal layer of the porcine stomach tissue and the temperature profile across the depth of the tissue sample with a given laser output energy. Materials, such as physiological saline, hypertonic saline, hyaluronic acid, glycerol, glucose, fibrinogen mixture, and hydroxypropyl methylcellulose mixed with various concentrations of methyl blue solution were used as SFC. We concluded that selective absorption of the laser energy at the mucosal layer was achieved by optimizing both optical and thermal properties of the SFC.

关键词： Tissue

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Structural analysis of BRCA1 reveals modification hotspot

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Science Advances 2017年第9期3卷 e1701386页

作者： Liang, Yanping Dearnaley, William J. Cameron Varano, A. Winton, Carly E. Gilmore, Brian L. Alden, Nick A. Sheng, Zhi Kelly, Deborah F. Virginia Tech Carilion Research Institute Virginia Tech RoanokeVA24016 United States Translational Biology Medicine and Health Graduate Program Virginia Tech BlacksburgVA24061 United States School of Biomedical Engineering and Science Virginia Tech BlacksburgVA24061 United States Virginia Tech Carilion School of Medicine Virginia Tech RoanokeVA24016 United States Department of Biological Sciences Virginia Tech BlacksburgVA24061 United States

Cancer cells afflicted with mutations in the breast cancer susceptibility protein (BRCA1) often suffer from increased DNA damage and genomic instability. The precise manner in which physical changes to BRCA1 influence its role in DNA maintenance remains unclear. We used single-particle electron microscopy to study the three-dimensional properties of BRCA1 naturally produced in breast cancer cells. Structural studies revealed new information for full-length BRCA1, engaging its nuclear binding partner, the BRCA1-associated RING domain protein (BARD1). Equally important, we identified a region in mutated BRCA1 that was highly susceptible to ubiquitination. We refer to this site as a modification "hotspot." Ubiquitin adducts in the hotspot region proved to be biochemically reversible. Collectively, we show how key changes to BRCA1 affect its structure-function relationship, and present new insights to potentially modulate mutated BRCA1 in human cancer cells. Copyright © 2017 The Authors, some rights reserved;exclusive licensee American Association for the Advancement of Science.

关键词： Cancer cells

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Simulation of motor current waveforms in monitoring aortic valve state during ventricular assist device support

Simulation of motor current waveforms in monitoring aortic v...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Khalid A. Alonazi Nigel H. Lovell Socrates Dokos Graduate School of Biomedical Engineering University of New South Wales Sydney NSW Australia

ISBN: (纸本)9781457702198

Monitoring of aortic valve (AV) opening and closure during left ventricular assist device (LVAD) heart pump support is crucial in preventing AV abnormalities and remodeling caused by anomalous resirculation. In this study, simulations of LVAD motor current waveforms were undertaken to investigate AV response to rotary blood pump assistance, as well as to detect AV open and close status under heart failure conditions. A two-dimensional fluid-structure interaction finite-element model is presented to predict AV state during LVAD outflow. The data will be useful in the development of a pump speed controller for optimal management of pump outflow.

关键词： Mathematical model Valves Blood Solid modeling Heart Impellers biomedical monitoring

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PO-438 Hyperthermia as neoadjuvant treatment for pancreatic tumours in murine models

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ESMO Open 2018年 3卷 A403-A403页

作者： Krzykawska-Serda, M. Ware, M.J. Lapin, N. Agha, M. Ho, J. Law, J. Newton, J. Nguyen, L. Curley, S. Corr, S. Faculty of Biochemistry- Biophysics and Biotechnology- Jagiellonian University Biophysics Krakow Poland Baylor Collage of Medicine Surgery Houston USA Baylor College of Medicine Interdepartmental program in Translational Biology and Molecular Medicine Houston USA Swansea University School of Medicine Swansea UK University of Houston Biomedical Engineering Houston USA Rice University Mechanical Engineering and Materials Science Houston USA

ABSTRACTIntroductionPancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. The hallmarks of this malignancy, such as it’s deprived vasculature, dense tumour stroma and hypoxic tumour microenvironment are some of the reasons for very poor chemotherapy and radiotherapy treatment efficacy. In these regards, a new combinatory treatment regimen was proposed: 1 non-invasive radiofrequency (RF) hyperthermia treatment to increase tumour perfusion, enhance cancer cell death and immune system stimulus; 2 chemotherapy regiment with Gemzar and Abraxane. Material and methodsOrthotropic and subcutaneous models of PDAC were induce by injection of PANC-1, AsPc-1 and Pan_O2 cancer cells into Balb/c nude or C57BL/6J mice. Tumour growth was monitored via ultrasound VEVO2100. Tumour perfusion after hyperthermia was monitored via intravital confocal microscopy and ultrasound microbubble contrast imaging. The tumour active vasculature was investigated using Doppler imaging. The chemotherapy with Gemzar and Abraxane was administered in combination with RF hyperthermia. A portable-RF system was used to produce local hyperthermia in the tumour tissue. The device is powered by 200 W and emits 13.56 MHz electric fields. The entire treatment scheme was repeated a total of 6 times at 72 hour time intervals (Q3D × 6 protocol) resulting in 16 days of treatment. The variety of histochemistry staining was performed post mortem to show the influence of treatment on the tumour vasculature and the degree of perfusion and necrosis. Results and discussionsWe showed that RF hyperthermia treatment as a neoadjuvant therapy can be promising for PDAC treatment. However, the effect is still unpredictable and depends on pre-existing tumour physiology before therapy. We established the most effective RF hyperthermia procedure to increase drug perfusion into tumour tissue (41°C for 20–30 min). We studied a variety of chemotherapy dosages to adjust clinical protocols into mouse mode

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Education for the future

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Science 2018年第6396期360卷 1409-1412页

作者： Cheung, Man Kit Schwendimann, Beat A. Ward, Adrian Pietrzak, Barbara Mollaoglu, Gurkan Duong, Michael Tran Allareddy, Veerasathpurush Ulltveit-Moe, Nils Dutton-Regester, Ken Zhang, Jian Scult, Matthew A. Singh, Poonam C. Yan, Hong Young Naz, Saima Isaacson, Kyle Dennis, Allison F. Beardsley, Felicia Rounds Al-Humaidan, Eyad Ibrahim Lo, Cody Jones, Tyler Sood, Prashant Nieuwenhuis, Rense Ali, Basant A. Yu, Kun-Hsing Arthur, Patrick Kobina Kumar, Brijesh Buschke, Falko Chen, Alexander Cingl, Lubomír O’Mullane, Anthony Peter Coetzee, Vinet Zaidi, Syed Shan-e-Ali Konstantinides, Nikos School of Life Sciences Chinese University of Hong Kong Shatin New Territories Hong Kong Graduate School of Education University of California Berkeley Berkeley 94720 CA United States University of Queensland St. Lucia 4072 QLD Australia Department of Hydrobiology Faculty of Biology Biological and Chemical Research Centre University of Warsaw Warsaw 02-089 Poland Department of Oncological Sciences University of Utah School of Medicine Salt Lake City 84112 UT United States Perelman School of Medicine University of Pennsylvania Philadelphia 19104 PA United States University of Illinois College of Dentistry Chicago 60612 IL United States Department of Information and Communication Technology University of Agder 4879 Grimstad Norway Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane 4006 QLD Australia School of Safety and Environmental Engineering Hunan Institute of Technology Hengyang Hunan 421002 China Lahore 54000 Punjab Pakistan Department of Psychology and Neuroscience Duke University Durham 27708 NC United States National Museum of Marine Biology and Aquarium Chercheng Pingtung County 94450 Taiwan Division of Plant Microbe Interactions CSIR–National Botanical Research Institute Lucknow 226001 Uttar Pradesh India Program in Cell Molecular Developmental Biology and Biophysics (CMDB) Johns Hopkins University Baltimore 21218 MD United States Stem Cell and Tissue Re-Engineering Program King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia Department of Sociology and Anthropology University of La Verne La Verne 91750 CA United States Department of Bioengineering University of Utah Salt Lake City 84112 UT United States MRC Centre for Medical Mycology University of Aberdeen Aberdeen AB25 2ZD United Kingdom Faculty of Medicine University of British Columbia Vancouver V6T 1Z2 BC Canada School of Engineering Brown University Providence 02912 RI United States

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