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Frontiers in Education (FIE) Conference

作者： Davide Piovesan Anne Schmitz Kurt E. Hersch Biomedical Engineering Program Gannon University Erie PA Entrepreneurship Program Gannon University Erie PA

ISBN: (纸本)9781509017911

The integration of entrepreneurial aspects in biomedical engineering undergraduate programs is still at its infancy. It is difficult to integrate business specific classes in engineering program due to curriculum constraints and often student do not have any exposure to entrepreneurship. We present the result of two case studies which leveraged an alternative approach. An inter-universities business plan regional competition was utilized to establish and integrated collaboration between the biomedical and entrepreneurship program at Gannon University. The activity focused on a series of seminars in different classes where students were exposed the creation of a marketing plan, pricing model, organizational design and go-to-market strategies, which are common aspects of a business plan. The active interaction between engineering and Business fostered innovation that resulted in a positive outcome in the “Shark-Tank” style competition.

关键词： Bones Antibiotics Collaboration Nails Entrepreneurship Technological innovation

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Preparation and photoluminescence properties of green-emittingLiYb1-xTbx(MoO4)2(x = 0. 01-1) phosphors

Preparation and photoluminescence properties of green-emitti...

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China Functional Material Technology and Industry Forum, CFMTIF 2015

作者： Qiao, Xue-Bin Seo, Hyo-Jin Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronic Engineering Jiangsu Normal University Xuzhou221116 China Department of Physics and Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan608-737 Korea Republic of

ISBN: (纸本)9783038357551

Tb3+-doped LiYb1-xTbx(MoO4)2 (x = 0. 01-1) solid solutions were prepared by solid state reaction. Structural of the solid solution series was carried out by X-ray powder diffraction. By increasing the Tb3+concentration, the XRD results reveal that LiYb1-xTbx(MoO4)2 adopt a tetragonal structure with space group of I4(No. 82) and transfer to tetragonal structurewith space group of P41/a(No. 88)systemically. The emission and excitation spectra were employed to characterize the synthesized phosphors. Theexcitation spectra showed that LiYb1-xTbx(MoO4)2 can be efficiently excited by the lights of 250-500 nm, which well match with the emission wavelength of near-UV and blue LEDs chips. The phosphor showed bright green luminescence peaking at around 545 nm under the excitation at 266 nm and 490 nm. The Luminescence intensities are investigated under different Tb3+ concentrations. The luminescence decay and the color coordinates were also discussed in order to further investigate the potential applications. © 2016 Trans Tech Publications, Switzerland.

关键词： Luminescence

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How I Got into Microwaves-By Chance ...

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IEEE MICROWAVE MAGAZINE 2016年第9期17卷 130-130页

作者： Gardiol, Fred Biomedical Engineering Program and the Department of Electrical and Computer Engineering (ECE) Western University Informatics Center Federal University of Pernambuco - UFPE Recife Brazil

Reports on the author's experiences and education in the field of microwave engineering.

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EXTH-36. BIFUNCTIONAL RNA NANOPARTICLES INDUCE ANTITUMOR IMMUNE RESPONSES AND ALLOW MRI-BASED DETECTION OF DENDRITIC CELL MIGRATION AS A BIOMARKER OF ANTITUMOR IMMUNE RESPONSE

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Neuro-Oncology 2018年第SUPPL_6期20卷 vi92–vi93页

作者： Grippin, Adam Wummer, Brandon Sayour, Elias Monsalve, Adam Fillingim, Matthew Dyson, Kyle Wildes, Tyler Dobson, Jon Mitchell, Duane Preston A. Wells Jr. Center for Brain Tumor Therapy UF Brain Tumor Immunotherapy Program Department of Neurosurgery McKnight Brain Institute University of Florida Gainesville FL USA J. Crayton Pruitt Family Department of Biomedical Engineering Herbert Wertheim College of Engineering University of Florida Gainesville FL USA University of Florida Gainesville FL USA

BACKGROUND Cancer vaccines are a promising approach to personalized cancer immunotherapy, but the lack of meaningful biomarkers of patient response to treatment limits their development. We recently reported in a randomized and blinded pilot clinical trial that RNA-pulsed dendritic cells (DCs) combined with tetanus-diphtheria (Td) booster vaccine prolong progression-free and overall survival in patients with glioblastoma (Mitchell et al, Nature 2015). Furthermore, we demonstrated that DC migration to lymph nodes assessed by SPECT/CT imaging strongly correlates with clinical outcomes. While this finding may provide a novel imaging biomarker for response to DC vaccines, the complexity and regulatory requirements of nuclear medicine-based imaging of radiolabeled cells limits widespread utilization of this technique. We have therefore developed bi-functional RNA-loaded magnetic nanoparticles to load DCs with RNA-encoded antigens, enhance DC migration to lymph nodes, and track migration in vivo using an MRI-based imaging modality. METHODS Immune-stimulatorycationic liposomes with iron oxide nanoparticle cores were complexed with mRNA. The resulting iron oxide-loaded RNA-NPs (IO-RNA-NPs) were used to transfect DCs ex vivo in the presence of a magnetic field. IO-RNA-NP-loaded DCs were then injected intradermally into tumor-bearing C57Bl6 mice and tracked noninvasively with T2-weighted 11T MRI. RESULTS The presence of iron oxide in RNA-NPs did not significantly alter particle characteristics. Additionally, inclusion of iron oxide within RNA-NPs enabled magnetically enhanced transfection through application of external magnetic fields. Compared to RNA electroporation, IO-RNA-NP loading enhanced production of inflammatory cytokines and DC migration to lymph nodes. IO-RNA-NPs also produced a reduction in T2-weighted MRI intensity and an increase in MRI-detected lymph node size that correlated directly with the number of iron oxide loaded DCs in treated lymph nodes, inhibition

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CMUT arrays incorporating anodically bondable LTCC for small diameter ultrasonic endoscope

CMUT arrays incorporating anodically bondable LTCC for small...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Fikret Yildiz Tadao Matsunaga Yoichi Haga Graduate School of Engineering Sendai Japan Graduate School of Engineering Tohoku University Micro System Integration Center (uSIC) Tohoku University Graduate School of Biomedical Engineering Tohoku University

ISBN: (纸本)9781509019489

This paper reports fabrication of CMUT (Capacitive Micromachined Ultrasonic Transducer) based forward looking ultrasonic endoscope using custom designed LTCC (Low Temperature Co-fired Ceramic). Bottom electrodes and cavities are separately patterned on LTCC and SOI wafers, respectively. LTCC wafer is used as bottom substrate (prime wafer) for anodic bonding and ring array and linear array CMUTs transducers are fabricated. To drive transducer arrays electrical connections between transducer arrays and IC (Integrated Circuits) are achieved by LTCC side via accomplished hexagonal shape dicing of CMUT after fabrication. Design, fabrication process and first fabrication results are presented. The advantages of CMUT packaging using LTCC side via compared to previously announced CMUT probe packaging such as TSV (Through Silicon Via) scheme are discussed.

关键词： Bonding Packaging Substrates Electrodes Transducers Silicon

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Preparation and characterization of anionized and cationized gelatin derivatives and their microspheres for drug delivery system

Preparation and characterization of anionized and cationized...

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biomedical engineering International Conference (BMEiCON)

作者： Papawee Likitdecharoj Juthamas Ratanavaraporn Biomedical engineering Program Chulalongkorn University Bangkok Thailand Chulalongkorn University Bangkok TH

ISBN: (纸本)9781509039418

Gelatin is a protein derived from collagen by an acid treatment (type A gelatin, GA) or an alkaline treatment (type B gelatin, GB). In this study, GA and GB were chemically modified by introducing functional groups on their structures to obtain cationized (GE) and anioized gelatin derivatives (GS), respectively. Conjugation of ethylenediamine resulted in the higher positive charge and free amino group content of GE. Various gelatin derivatives GA, GB, GE and GS were fabricated into microspheres using water in oil emulsion and dehydrothermal crosslinking techniques. All gelatin microspheres had a round shape with average size around 40-50 μm in the dry state. In the swollen state, sizes of GA, GB, and GS microspheres were increased to 73-89 μm while that of GE microspheres was up to 150 μm. The highly hydrophilicity of strong positive charged GE may be attributed to its high swelling ability (swelling ratio ~ 3.1) and solubility after immersed in water at 37°C for 24 h although it had high crosslinking degree. On the other hand, GA, GB, and GS had swelling ratio only 1.7-1.9 and less water-solubilized. These gelatin microspheres having different properties will be introduced as carrier for delivery of drug in which the release rate of drug can be controlled. This drug delivery system will be applied for the localized treatment of disease like osteoarthritis with minimal invasion.

关键词： Drugs Drug delivery Oils Proteins Shape Chemicals Morphology

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Smart wheelchair based on eye tracking

Smart wheelchair based on eye tracking

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biomedical engineering International Conference (BMEiCON)

作者： Nutthanan Wanluk Sarinporn Visitsattapongse Aniwat Juhong C. Pintavirooj Biomedical Engineering Program King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9781509039418

This project is a smart wheelchair based on eye tracking which is designed for people with locomotor disabilities. The add-on controlled module can be used with any electrical wheelchair. The smart wheel chair consists of four modules including imaging processing module, wheelchair-controlled module, SMS manager module and appliance-controlled module. The image processing module comprises of a webcam installed on the eyeglass and C++ customized image processing software. The captured image which is transmitted to raspberry Pi microcontroller will be processed using OpenCV to derive the 2D direction of eye ball. The coordinate of eyeball movement is then wirelessly transmitted to wheelchair-controlled module to control the movement of wheel chair. The wheelchair-controlled module is two dimensional rotating stages that installed to the joystick of the electrical wheelchair to replace the manual control of the wheelchair. The motion of eyeball is also used as the cursor control on the raspberry Pi screen to control the operation of some equipped appliance and send message to smart phone.

关键词： Wheelchairs Gaze tracking Webcams biomedical engineering Image processing Wheels

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Highly sensitive pressure sensor with silicon-on-nothing (SON) MOSFET for sensor integrated heterogeneous system

Highly sensitive pressure sensor with silicon-on-nothing (SO...

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IEEE Silicon Nanoelectronics Workshop (SNW)

作者： Hisashi Kino Takafumi Fukushima Tetsu Tanaka Frontier Research Institute for Interdisciplinary Sciences (FRIS) Tohoku University Japan Department of Mechanical Systems Engineering Tohoku University Japan Department of Biomedical Engineering Graduate School of Biomedical Engineering Tohoku University Japan

ISBN: (纸本)9781509007271

MOSFETs have the potential to be-come a highly sensitive pressure sensor compared with conventional piezoresistive device such as doped Si. In this study, we have proposed a novel pressure sensor composed of silicon-on-nothing (SON) MOSET. It was clearly indicated that the SON-MOSFET had high gauge factor of 230 which was more than twice as high as conventional values. These results expedite developments and realization of sensor integrated heterogeneous system.

关键词： Stress MOSFET Finite element analysis MOSFET circuits Substrates

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Stress and office-syndrome detection using EEG, HRV and hand movement

Stress and office-syndrome detection using EEG, HRV and hand...

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biomedical engineering International Conference (BMEiCON)

作者： Parkbhum Reanaree Polachet Tananchana Worapong Narongwongwathana Chuchart Pintavirooj Biomedical Engineering Program King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9781509039418

Stress and Office syndrome are a serious problem that affects a large number of people and tend to develop health problems that can interfere with work and quality of life. In fact, the Institute reports that up to 90 percent clinical studies have shown that stress and office syndrome are a major cause of cardiovascular disease, depression, suicide and substance abuse. Treatment's cost are more than ten million baht each year in healthcare expenses. According to these problems we designed to use wearable technology which can be tracked and managed to helping them reduce their problems. Low-cost single dry-sensor EEG Neurosky headset and intelligent watch made by Arduino was used in this project. The EEG signal, hear rate variation and hand movement are analyzed to indicate stress level and the Office syndrome can be detected by intelligent watch. The goals of this research is to detect stress and Office syndrome and reduce chance to be the diseases.

关键词： Stress Heart rate Electroencephalography Stress measurement Biochemistry Feature extraction Accelerometers

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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