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International Conference on Knowledge and Smart Technology

作者： Pargorn Puttapirat Montri Phothisonothai Suchada Tantisatirapong Biomedical Engineering Program Faculty of Engineering Srinakharinwirot University International College King Mongkut's Institute of Technology Ladkrabang

ISBN: (纸本)9781467381406

This paper investigates automated segmentation of malaria parasites in images of Giemsa-stained thin blood film specimens. The Giemsa staining exhibits not only on the malaria parasites, but also platelets and artifacts. We aim to extract erythrocytes both normal and infected cells from other particles and separate overlapping cells. Our approach is compared with manual cell counting and existing program named CELLCOUNTER. Our processing framework provides 97% accuracy, which yields predominant detection more accurate than the CELLCOUNTER. The results also indicate high correlation between our proposed method and the manual cell counting.

关键词： Erythrocytes segmentation Giemsa stained thin blood film Malaria parasites Decorrelation Multichannel Image Enhancement

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Development of a cost-effective ecg monitor for cardiac arrhythmia detection using heart rate variability

Development of a cost-effective ecg monitor for cardiac arrh...

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biomedical engineering International Conference (BMEiCON)

作者： Apiwat Lek-uthai Pakpum Somboon Arporn Teeramongkonrasmee Dept. of Electrical Engineering Chulalongkorn University Bangkok Thailand Biomedical Engineering Program Chulalongkorn University Bangkok Thailand

ISBN: (纸本)9781509039418

Ischemic Heart Disease (IHD) and stroke are statistically the leading causes of death world-wide. Both diseases deal with various types of cardiac arrhythmias, e.g. premature ventricular contractions (PVCs), ventricular and supra-ventricular tachycardia, atrial fibrillation. For monitoring and detecting such an irregular heart rhythm accurately, we are now developing a very cost-effective ECG monitor, which is implemented in 8-bit MCU with an efficient QRS detector using steep-slope algorithm and arrhythmia detection algorithm using a simple heart rate variability (HRV) parameter. This work shows the results of evaluating the real-time steep-slope algorithm using MIT-BIH Arrhythmia Database. The performance of this algorithm has 99.72% of sensitivity and 99.19% of positive predictivity. We then show the preliminary results of arrhythmia detection using various types of normal and abnormal ECGs from an ECG simulator. The result is, 18 of 20 ECG test signals were correctly detected.

关键词： Electrocardiography Detectors Heart rate variability Real-time systems Monitoring Databases biomedical monitoring

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Estimation and identification of low attenuation areas (LAA) in lung obtained from ct imaging data

Transactions of Japanese Society for Medical and Biological ...

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Transactions of Japanese Society for Medical and Biological engineering 2016年第PROC期54卷 1-2页

作者： Akiyama, Masaki Kimura, Kazuyuki Okamoto, Kurefu Ueno, Kenji Kitama, Masataka Sugawara, Toshitsugu Division of Biomedical Engineering Graduate School of Hokkaido University of Science Japan Medical Corporation Seishinkai Okamoto Hospital Japan

The low attenuation areas (LAA) in lung are understood one of the important factor for promoting Chronic Obstructive Pulmonary Disease (COPD). Mortality of COPD has been increasing, and World Health Organization (WHO) expects it to become the third leading cause of death in the world by 2030, up from its current tenth place. In this present report, we studied the estimating procedure for confirm the primary changes of LAA using Computed tomography (CT) images. Under -950 HU CT areas were scored in CT image, and estimated using Goddard's method. No relationships were confirmed in age and smoking history. The data might be indicated that the other factors of promoting LAA have been existed. © 2016, Japan Soc. of Med. Electronics and Biol. engineering. All rights reserved.

关键词： Computerized tomography

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A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

A DEP-based lab-on-a-chip system for the detection of multid...

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2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016

作者： Yalçın, Y. Demircan Özkayar, G. Özgür, E. Gündüz, U. Külah, H. Department of Electrical and Electronics Engineering METU Ankara Turkey Graduate School of Natural and Applied Sciences/ Biomedical Engineering METU Ankara Turkey Mikro Biyosistemler Inc. Ankara Turkey METU-MEMS Research and Application Center Ankara Turkey Department of Biology METU Ankara Turkey

ISBN: (纸本)9781940470023

This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells. © 2016 TRF

关键词： Mixtures

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Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control

Cerebral cortex communications

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Cerebral cortex communications 2020年第1期1卷 tgaa078页

作者： Yufen Chen Amy A Herrold Zoran Martinovich Sumra Bari Nicole L Vike Anne J Blood Alexa E Walter Jaroslaw Harezlak Peter H Seidenberg Manish Bhomia Barbara Knollmann-Ritschel Khrystyna Stetsiv James L Reilly Eric A Nauman Thomas M Talavage Linda Papa Semyon Slobounov Hans C Breiter Center for Translational Imaging Department of Radiology Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. Edward Hines Jr. VA Hospital Research Service Hines IL 60141 USA. Mental Health Services and Policy Program Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine Chicago IL 60611 USA. Warren Wright Adolescent Center Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. Mood and Motor Control Laboratory Departments of Neurology and Psychiatry Massachusetts General Hospital and Harvard Medical School Boston MA 02129 USA. Department of Kinesiology Pennsylvania State University University Park PA 16802 USA. Department of Epidemiology and Biostatistics Indiana University Bloomington IN 47405 USA. Departments of Orthopaedics & Rehabilitation and Family & Community Medicine Penn State College of Medicine Hershey PA 17033 USA. Department of Pathology Uniformed Services University of the Health Sciences Bethesda MD USA. Weldon School of Biomedical Engineering Purdue University West Lafayette IN 47907 USA. School of Electrical and Computer Engineering Purdue University West Lafayette IN 47907 USA. Department of Emergency Medicine Orlando Regional Medical Center Orlando FL USA.

Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of "imaging omics." Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel's test < 0.05) between abnormal miRNA levels and compromised Balance scores. Given the involvement of these miRNAs in inflammation and immune function and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model in these athletes with 11 years of average football exposure. rCBF, a systems biology measure, was necessary for miRNA to affect behavior.

关键词： football athletes head acceleration events microRNAs postural control regional cerebral blood flow

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Direct measurements of fluid slip using laser induced fluorescence photobleaching anemometer (LIFPA)

Direct measurements of fluid slip using laser induced fluore...

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2016年大连国际微纳流体和微流控芯片大会(2016 International Conference of Microfluidics, Nanofluidics and Lab-On-A-Chip

作者： Feng Shen Bin Zhou Guiren Wang Department of Mechanical Engineering & Biomedical Engineering Program University of South Carolina Columbia SC 29208 USA Department of Mechanical Engineering & Biomedical Engineering Program University of South Carolina Columbia SC 29208 USA College of Civil Engineering and Architecture Weifang University Weifang 261061 China Department of Mechanical Engineering & Biomedical Engineering Program University of South Carolina Columbia SC 29208 USA College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Beijing 100124 China

Fluid slip has been reported by a large number of studies using different techniques[1].However, the obtained slip lengths for Newtonian liquids vary from a few nanometers to about 1 μm, and there is little agreement...

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Determination of thermodynamic parameters for enolization reaction of malonic and metylmalonic acids by using quartz crystal microbalance

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Analytical Chemistry Research 2016年 8卷 9-15页

作者： Yoshimoto, Minoru Matsunaga, Taishi Tanaka, Mutsuo Kurosawa, Shigeru Department of Information Science and Biomedical Engineering Graduate School of Science and Engineering Kagoshima University 1-21-40 Korimoto Kagoshima 890-0065 Japan Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Central 6 1-1-1 Higashi Tsukuba Ibaraki 305-8566 Japan

We investigated the process of a bromination reaction of malonic acid and methylmalonic acid in the Belousov-Zhabotinsky reaction by using a quartz crystal microbalance (QCM). The process involves an enolization reaction as a rate-determining step. We found that, in the step, the variation of Br₂ concentration induced an exactly quantitative shift of a resonant frequency of the QCM, based on the change of the surface mass on the QCM and the solution viscosity and density. This new finding enabled us to estimate the reaction rate constants and the thermodynamic parameters of the enolization reaction due to a QCM measurement. The values measured by the QCM were in good agreement with those measured by a UV-spectrophotometer. As a result, we succeeded to develop a new measurement method of a nonlinear chemical reaction. © 2016 The Authors.

关键词： Belousov-Zhabotinsky reaction Enolization QCM Thermodynamics

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A full-color computer generated holography for panoramic reconstruction 54

A full-color computer generated holography for panoramic rec...

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54th Annual SID Symposium, Seminar, and Exhibition 2016, Display Week 2016

作者： Wu, Pei-Jung Chuang, Chih-Hao Chen, Chien-Yu Chang, Hsuan-Ting Chang, Tsung-Jan Institute of Imaging and Biomedical Photonics National Chiao Tung University Tainan Taiwan Graduate School of Electronic and Optoelectronic Engineering National Yunlin University of Science & Technology Taiwan Graduate Institute of Color and Illumination Technology National Taiwan University of Science and Technology Taiwan Department of Electrical Engineering National Yunlin University of Science and Technology Yunlin Taiwan

In this study, a full-color computer generated holography system is constructed for providing viewers with panoramic scene. For obtaining high image quality, the color mix proportion and correction of color difference... 详细信息

ISBN: (纸本)9781510832909

关键词： Color

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Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing

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Nature biotechnology 2020年第4期38卷 504页

作者： Christian Lieven Moritz E Beber Brett G Olivier Frank T Bergmann Meric Ataman Parizad Babaei Jennifer A Bartell Lars M Blank Siddharth Chauhan Kevin Correia Christian Diener Andreas Dräger Birgitta E Ebert Janaka N Edirisinghe José P Faria Adam M Feist Georgios Fengos Ronan M T Fleming Beatriz García-Jiménez Vassily Hatzimanikatis Wout van Helvoirt Christopher S Henry Henning Hermjakob Markus J Herrgård Ali Kaafarani Hyun Uk Kim Zachary King Steffen Klamt Edda Klipp Jasper J Koehorst Matthias König Meiyappan Lakshmanan Dong-Yup Lee Sang Yup Lee Sunjae Lee Nathan E Lewis Filipe Liu Hongwu Ma Daniel Machado Radhakrishnan Mahadevan Paulo Maia Adil Mardinoglu Gregory L Medlock Jonathan M Monk Jens Nielsen Lars Keld Nielsen Juan Nogales Intawat Nookaew Bernhard O Palsson Jason A Papin Kiran R Patil Mark Poolman Nathan D Price Osbaldo Resendis-Antonio Anne Richelle Isabel Rocha Benjamín J Sánchez Peter J Schaap Rahuman S Malik Sheriff Saeed Shoaie Nikolaus Sonnenschein Bas Teusink Paulo Vilaça Jon Olav Vik Judith A H Wodke Joana C Xavier Qianqian Yuan Maksim Zakhartsev Cheng Zhang Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark Lyngby Denmark. Systems Biology Lab Amsterdam Institute of Molecular and Life Sciences (AIMMS) Vrije Universiteit Amsterdam Amsterdam the Netherlands. BioQUANT/COS Heidelberg University Heidelberg Germany. Ecole Polytechnique Fédérale de Lausanne Laboratory of Computational Systems Biotechnology Lausanne Switzerland. iAMB-Institute of Applied Microbiology ABBt-Aachen Biology and Biotechnology RWTH Aachen University Aachen Germany. Department of Bioengineering University of California La Jolla CA USA. Department of Chemical Engineering and Applied Chemistry University of Toronto Toronto Ontario Canada. Human Systems Biology Laboratory Instituto Nacional de Medicina Genomica & Coordinación de la Investigación Científica-Red de Apoyo a la Investigación UNAM Mexico City Mexico. Institute for Systems Biology Seattle WA USA. Computational Systems Biology of Infection and Antimicrobial-Resistant Pathogens Institute for Biomedical Informatics (IBMI) Tübingen Germany. Department of Computer Science University of Tübingen Tübingen Germany. German Center for Infection Research (DZIF) partner site Tübingen Tübingen Germany. Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland Australia. Argonne National Laboratory Lemont IL USA. Analytical Biosciences Division of Systems Biomedicine and Pharmacology Leiden Academic Centre for Drug Research Leiden University Leiden the Netherlands. Department of Systems Biology Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas (CNB-CSIC) Madrid Spain. Centro de Biotecnología y Genómica de Plantas (CBGP UPM-INIA) Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Madrid Spain. Department of Animal and Aquacultural Sciences Faculty of Biosciences Norwegian University of Life Sciences Oslo Norway

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Adaptive Soft Robots: Soft Ultrathin Electronics Innervated Adaptive Fully Soft Robots (Adv. Mater. 13/2018)

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Advanced Materials 2018年第13期30卷

作者： Chengjun Wang Kyoseung Sim Jin Chen Hojin Kim Zhoulyu Rao Yuhang Li Weiqiu Chen Jizhou Song Rafael Verduzco Cunjiang Yu Department of Mechanical Engineering University of Houston Houston TX 77204 USA Department of Engineering Mechanics and Soft Matter Research Center Zhejiang University Hangzhou 310027 China Materials Science and Engineering Program University of Houston Houston TX 77204 USA Institute of Solid Mechanics Beihang University Beijing 100191 China Department of Chemical and Biomolecular Engineering Rice University Houston TX 77005 USA Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University Hangzhou 310027 China Department of Materials Sciences and Nano Engineering Rice University Houston TX 77005 USA Department of Electrical and Computer Engineering Department of Biomedical Engineering University of Houston Houston TX 77204 USA

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