检索结果-内蒙古大学图书馆

International Congress on Image and Signal Processing, biomedical engineering and Informatics (CISP-BMEI)

作者： Jiao Liu Xiaoyu Song Feng Zhou Saidong Ma Zhengyang Liu Jiaxi Li Xinyu Chai Liming Li Tianruo Guo School of Biomedical Engineering Shanghai Jiao Tong University SJTU Shanghai China Graduate School of Biomedical Engineering The University of New South Wales UNSW Sydney Australia

A suprachoroidal retinal prosthesis is implanted between the choroid and the sclera, offering the advantages of low surgical complexity and high stability. However, the relatively longer distance between electrodes and the retina leads to higher retinal ganglion cells (RGC) excitation threshold and lower spatial resolution. To maximize the advantages of suprachoroidal stimulation (SS), it is of great significance to explore additional strategies to lower the threshold and improve the spatial resolution. Temporal interference (TI) was reported to induce localized neural excitation in deep regions, indicating a promising avenue for enhancing suprachoroidal retinal stimulation. This study combines the advancements of TI and SS, resulting in the novel approach of Temporal Interference-Suprachoroidal Stimulation (TI-SS). The effect of electrode position and size on the distribution of the maximum electric potential (EP max ) generated by TI-SS was investigated by finite element modelling. Higher EP max values corresponds to lower RGC excitation threshold. In addition, the EP max distribution induced by TI-SS and SS were compared. Our simulation suggests a decrease in EP max value when stimulating electrodes are moved from cornea to sclera under TI-SS. And the EP max distribution exhibits a notable transition from a bimodal distribution to a unimodal distribution as the return electrodes are moved to the posterior of the eyeball and get closer. The EP max values induced by TI-SS is generally higher than those induced by SS, indicating that RGC excitation threshold triggered by TI-SS is lower compared to SS. This study offers preliminary evidence demonstrating the enhanced performance of TI-SS in comparison to conventional SS approach.

关键词：

来源：评论

学校读者我要写书评

暂无评论

mRNA vaccines: Past, present, future

引用

Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 491-522页

作者： Mia Karam Georges Daoud Biomedical Engineering Program Maroun Semaan Faculty of Engineering and ArchitectureBeirut 11072020Lebanon Department of Biochemistry and Molecular Genetics Faculty of MedicineBeirut 11072020Lebanon Department of Anatomy Cell Biologyand Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 11072020Lebanon

mRNA vaccines have emerged as promising alternative platforms to conventional *** ease of production,low cost,safety profile and high potency render them ideal candidates for prevention and treatment of infectious diseases,especially in the midst of *** challenges that face in vitro transcribed RNA were partially amended by addition of tethered adjuvants or co-delivery of naked mRNA with an adjuvanttethered ***,it wasn’t until recently that the progress made in nanotechnology helped enhance mRNA stability and delivery by entrapment in novel delivery systems of which,lipid *** continuous advancement in the fields of nanotechnology and tissue engineering provided novel carriers for mRNA vaccines such as polymeric nanoparticles and *** studies have shown the advantages of adopting mRNA vaccines for viral diseases and cancer in animal and human ***-amplifying mRNA is considered today the next generation of mRNA vaccines and current studies reveal promising *** review provides a comprehensive overview of mRNA vaccines used in past and present studies,and discusses future directions and challenges in advancing this vaccine platform to widespread clinical use.

关键词： mRNA vaccine Virus Cancer Nanoparticles COVID-19

来源：评论

学校读者我要写书评

暂无评论

Quantifying White Matter Hyperintensities: Predicting Periventricular Fazekas Scores with Uncertainty Estimation 22

Quantifying White Matter Hyperintensities: Predicting Perive...

引用

22nd IEEE International Symposium on biomedical Imaging, ISBI 2025

作者： Schmid, Susanne Shamaei, Amirmohammed Souza, Roberto Frayne, Richard Biomedical Engineering Graduate Program University of Calgary Canada University of Calgary Canada University of Calgary Canada University of Calgary Canada Hotchkiss Brain Institute University of Calgary Canada Seaman Family Mr Research Centre Foothills Medical Centre CalgaryAB Canada

ISBN: (纸本)9798331520526

White matter hyperintensities (WMH) are crucial markers in brain magnetic resonance (MR) images, often quantified using the Fazekas score. This study presents a deep learning model to predict Fazekas scores in the periventricular region from T1-weighted and FLAIR images. Our model achieved a Matthew correlation coefficient of 0.68 and F1 scores of 0.69, 0.88, 0.86, and 1.0 for Fazekas scores from 0 to 3, respectively, surpassing previous methods. We introduce a novel integration of t-distributed stochastic neighbor embedding (t-SNE) with uncertainty analysis using Monte Carlo dropout, offering insights into the model's decision-making. Results show effective class distinction, with increased uncertainty at class transitions indicating ambiguity, and confident misclassified cases suggesting overlapping features or label noise. These findings highlight that simple, well-tuned models, coupled with interpretability techniques, can provide robust predictions of WMH severity. © 2025 IEEE.

关键词： Monte Carlo methods

来源：评论

学校读者我要写书评

暂无评论

SuperCL: Superpixel Guided Contrastive Learning for Medical Image Segmentation Pre-training

arXiv

引用

arXiv 2025年

作者： Zeng, Shuang Zhu, Lei Zhang, Xinliang He, Hangzhou Lu, Yanye Institute of Medical Technology Peking University Health Science Center Peking University Beijing100191 China Department of Biomedical Engineering Peking University Beijing100871 China National Biomedical Imaging Center Peking University Beijing100871 China Institute of Biomedical Engineering Shenzhen Bay Laboratory Shenzhen5181071 China Institute of Biomedical Engineering Peking University Shenzhen Graduate School Shenzhen518055 China

Medical image segmentation is a critical yet challenging task, primarily due to the difficulty of obtaining extensive datasets of high-quality, expert-annotated images. Contrastive learning presents a potential but still problematic solution to this issue. Because most existing methods focus on extracting instance-level or pixel-to-pixel representation, which ignores the characteristics between intra-image similar pixel groups. Moreover, when considering contrastive pairs generation, most SOTA methods mainly rely on manually setting thresholds, which requires a large number of gradient experiments and lacks efficiency and generalization. To address these issues, we propose a novel contrastive learning approach named SuperCL for medical image segmentation pre-training. Specifically, our SuperCL exploits the structural prior and pixel correlation of images by introducing two novel contrastive pairs generation strategies: Intra-image Local Contrastive Pairs (ILCP) Generation and Inter-image Global Contrastive Pairs (IGCP) Generation. Considering superpixel cluster aligns well with the concept of contrastive pairs generation, we utilize the superpixel map to generate pseudo masks for both ILCP and IGCP to guide supervised contrastive learning. Moreover, we also propose two modules named Average SuperPixel Feature Map Generation (ASP) and Connected Components Label Generation (CCL) to better exploit the prior structural information for IGCP. Finally, experiments on 8 medical image datasets indicate our SuperCL outperforms existing 12 methods. i.e. Our SuperCL achieves a superior performance with more precise predictions from visualization figures and 3.15%, 5.44%, 7.89% DSC higher than the previous best results on MMWHS, CHAOS, Spleen with 10% annotations. Our code will be released after acceptance. © 2025, CC BY-NC-SA.

关键词： Image segmentation

来源：评论

学校读者我要写书评

暂无评论

Occupational Exposure of Therapeutic Staff in Deep Transcranial Magnetic Stimulation 35

Occupational Exposure of Therapeutic Staff in Deep Transcran...

引用

35th General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2023

作者： Lu, Mai Ueno, Shoogo Lanzhou Jiaotong University Key Lab. of Opto-Electronic Technology and Intelligent Control of Ministry of Education Lanzhou China The University of Tokyo Graduate School of Medicine Department of Biomedical Engineering Tokyo Japan

ISBN: (纸本)9789463968096

This study presented dosimetry analysis for therapeutic staff exposed to magnetic pulses from double cone and Halo-circular assembly (HCA) coils during deep transcranial magnetic stimulation (dTMS) applications. The magnetic field and the induced electric field in realistic human body model exposure to dTMS coils have been obtained by employing the impedance method. The exposure level by both double cone and HCA coils were assessed according to the limits defined by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines. The HCA coil generates higher exposure to therapeutic staff compared to that of double cone coil. © 2023 International Union of Radio Science.

关键词： Electric fields

来源：评论

学校读者我要写书评

暂无评论

A Motor Point Tracking Stimulation Device for surface FES on Biceps Brachii

A Motor Point Tracking Stimulation Device for surface FES on...

引用

IEEE biomedical Circuits and Systems (BIOCAS)

作者： Shin Ebihara Yue Liu Masao Sugi Hiroshi Yokoi Jiang Yinlai Graduate School of Informatics and Engineering the University of Electro- Communications Tokyo Japan Center for Neuroscience and Biomedical Engineering the University of Electro-Communications Tokyo Japan

ISBN: (数字)9798350354959

ISBN: (纸本)9798350354966

Functional electrical stimulation (FES) is one of the early rehabilitation methods to restore motor function in patients suffered from central nervous system disorder. To improve the stimulation efficiency of FES, studies have been conducted on methods to stimulate the motor point (MP). Since the position of the MP on the skin changes with changes in muscle geometry during dynamic rehabilitation, this study proposes a MP tracking stimulation (MPTS) device to reduce muscle fatigue by accurately stimulating the MP by controlling electrode positions using a linear actuator. To deliver stimulation to the biceps brachii, the device follows and stimulates the MP by moving the stimulating electrode in accordance with the elbow joint angle measured by a rotary encoder. As an evaluation of this device, we compared the MPTS device with a conventional method of simultaneous 3-channel stimulation (SS). A muscle fatigue protocol was used to compare the effect of the two methods on muscle fatigue. The results showed that the rate of change in maximum voluntary contraction force (MVC) before and after the experiment was significantly smaller using MPTS than SS. MPTS has been indicated to be an effective method for reducing muscle fatigue associated with FES.

关键词： Electrodes Actuators Protocols Position control Muscles Fatigue Motors Iron Skin Elbow

来源：评论

学校读者我要写书评

暂无评论

Mechanical properties and corrosion resistance of powder metallurgical Mg-Zn-Ca/Fe bulk metal glass composites for biomedical application

引用

Journal of Materials Science & Technology 2022年第8期103卷 73-83页

作者： Kun Li Luxin Liang Peng Du Zeyun Cai Tao Xiang Hiroyasu Kanetaka Hong Wu Guoqiang Xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Graduate School of Biomedical Engineering Tohoku UniversitySendai980-8579Japan Graduate School of Dentistry Tohoku UniversitySendai 980-8575Japan State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Magnesium(Mg)alloys can be regarded as the most promising biodegradable implant materials for orthopedic and stent applications due to their good biocompatibility and low Young’s modulus which is near to that of natural ***,its applicability is hindered because it exhibits a high corrosion rate in the physiological *** this work,we fabricated Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass composites via spark plasma sintering(SPS).We studied the influence of different contents of Fe on the properties of the *** results indicated that Fe was uniformly distributed on the surface of Mg_(66)Zn_(30)Ca_(4) metallic glass(MG)as a second phase,which led to an improvement in the corrosion resistance and mechanical *** standard potential of Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass(BMG)composites increased as compared to Mg_(66)Zn_(30)Ca_(4),while their mechanical strength improved from 355 MPa to 616 ***,cytotoxicity was investigated via the CCK-8 assay and calcein-AM staining,which revealed that the extraction mediums diluted 6 times(EM×6)of the Mg_(66)Zn_(30)Ca_(4) and Mg_(66)Zn_(30)Ca_(4)/Fe did not cause cell toxicity on day 3 and 5,while the EM×6 of the Mg_(66)Zn_(30)Ca_(4) showed cytotoxicity on day 1,3 and ***,Mg_(66)Zn_(30)Ca_(4)/Fe BMG composites exhibit significant potential for fabricating implants with good mechanical strength and corrosion resistance.

关键词： Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass composites Spark plasma sintering Corrosion behaviour Mechanical strength

来源：评论

学校读者我要写书评

暂无评论

A Pulsed Electrochemistry Readout IC with Slew-rate Booting Technique and Phase-domain ΔΣ ADC for Si-Nanowire Electrical Double-layer Capacitance Measurement

A Pulsed Electrochemistry Readout IC with Slew-rate Booting ...

引用

Symposium on VLSI Technology

作者： Po- Hsun Chu Cheng- Tse Tsai Yu-Siang Chou Nitish Kumar Shu-Ping Lin Yu-Te Liao Institute of Electrical and Computer Engineering National Yang Ming Chiao Tung University Graduate Institute of Biomedical Engineering National Chung Hsing University

ISBN: (数字)9798350361469

ISBN: (纸本)9798350361476

This paper presents a pulse-driven method for detecting Cardiac Troponin I using an electrical double-layer (EDL) capacitance sensing readout circuit and an on-chip pattern generator. The pattern generator is equipped with a slew rate-boosting driver circuit capable of handling EDL capacitance ranging up to 100 nF with a slew rate greater than 6.6 V /us while consuming only 13.5 µW. Additionally, the design achieves a dynamic range (DR) of 77.4 dB by implementing an oscillator-based readout circuit and a limit of detection (LoD) of 200 fg/mL in an undiluted PBS solution with a total power consumption of 120 µW.

关键词： Power demand Very large scale integration Electrochemistry Dynamic range Capacitance Generators Distance measurement

来源：评论

学校读者我要写书评

暂无评论

Use of Endoluminal and Transabdominal Ultrasound Biomicroscopy to Measure Colon Wall Thickness in Healthy and Tumor-Bearing Mice

Use of Endoluminal and Transabdominal Ultrasound Biomicrosco...

引用

Ultrasonics Symposium (LAUS), IEEE UFFC Latin America

作者： Juliana Oliveira da Silva Fernandes Rodrigo Pereira de Oliveira João Carlos Machado Biomedical Engineering Program/COPPE Federal University of Rio de Janeiro Rio de Janeiro Brazil Biomedical Engineering Program/COPPE and Post-Graduation Program in Surgical Sciences/Department of Surgery/School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil

ISBN: (数字)9798350349085

ISBN: (纸本)9798350349092

Colorectal cancer (CRC) ranks among the most prevalent tumors, particularly affecting men and women, with mouse models and imaging technologies like colonoscopy, endoluminal (eUBM), and transabdominal (tUBM) ultrasound biomicroscopy playing pivotal roles in exploring new treatment avenues. The evaluation of colon wall thickness (Wt), a significant marker of tumor presence, is feasible through eUBM or tUBM, contrasting with colonoscopy's limitations. This study scrutinizes the consistency of Wt measurements obtained via eUBM and tUBM in mice, with or without colon tumors induced by azoxymethane (AOM) and dextran sulfate sodium salt (DSS). UBM images were captured using both eUBM and tUBM instruments, with subsequent Wt measurements performed using ImageJ software. Comparison between Wt obtained from eUBM and tUBM images used the One-Way ANOVA, for normal distributed data, or the Kruskal-Wallis test otherwise. Local Ethics Committee for Animal Use in Research approved the work (protocol 014/20). In general, the results indicate a substantial median Wt disparity between control and tumor groups measured by both techniques (p<0.05). Notably, discrepancies in Wt findings between the two methods were observed in the control group (p<0.05), despite the excellent resolution of the images in delineating colon layers.

关键词： Ultrasonic imaging Ultrasonic variables measurement Colonoscopy Mice Colon Software measurement Spatial resolution

来源：评论

学校读者我要写书评

暂无评论

Computational Modeling of the Pendulum Test to Simulate Spasticity in the Elbow Joint 9th

Computational Modeling of the Pendulum Test to Simulate Spas...

引用

9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Pasqualin, B.R. Silva, V.A. Orselli, M.I.V. Manffra, E.F. Pontifícia Universidade Católica do Paraná Biomedical Engineering Curitiba Brazil Pontifícia Universidade Católica do Paraná Postgraduate Program in Health Technology Curitiba Brazil Instituto Vita São Paulo Brazil

ISBN: (纸本)9783031494062

Computational models have been developed to help understand phenomena such as spasticity. In this study, we aim to develop a computational model using the Matlab-OpenSim interface to simulate the passive pendulum test in the elbow joint and evaluate whether the input of a neural excitation pattern with spasticity in the model would be sufficient to reproduce an altered kinematic pattern during an elbow pendulum test. We built a model with two segments that represent the humerus and radius bones, added two actuators to represent the biceps and triceps muscles, and the excitation values were obtained from the electromyography signal available in the literature. For the first simulation we used the electromyography (EMG) signal from a non-spastic person and for the last simulation was used the excitation values from a person with mild spasticity. Our results showed that it is possible to reproduce the pendulum test at the elbow joint, but modifications in the model are necessary to better reproduce the movement. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： MATLAB

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：