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Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

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Mechanobiology in Medicine 2025年第1期3卷 57-67页

作者： Alexander M.Regner Maximilien DeLeon Kalin D.Gibbons Sean Howard Derek Q.Nesbitt Seyedeh F.Darghiasi Anamaria G.Zavala Trevor J.Lujan Clare K.Fitzpatrick Mary C.Farach-Carson Danielle Wu Gunes Uzer Mechanical and Biomedical Engineering Department Boise State UniversityUSA Department of Diagnostic and Biomedical Sciences UTHealth Houston School of DentistryUSA Department of Bioengineering Rice UniversityUSA Department of Biosciences Rice UniversityUSA Biomedical Engineering Program Boise State UniversityUSA

Aged individuals and astronauts experience bone loss despite rigorous physical *** mechanoresponse is in-part regulated by mesenchymal stem cells(MSCs)that respond to mechanical *** delivery of low intensity vibration(LIV)recovers MSC proliferation in senescence and simulated microgravity models,indicating that age-related reductions in mechanical signal delivery within bone marrow may contribute to declining bone *** answer this question,we developed a 3D bone marrow analog that controls trabecular geometry,marrow mechanics and external *** finite element(FE)models were developed to quantify strain environment within hydrogels during *** marrow analogs with gyroid-based trabeculae of scaffold volume fractions(SV/TV)corresponding to adult(25%)and aged(13%)mice were printed using polylactic acid(PLA).MSCs encapsulated in migration-permissive hydrogels within printed trabeculae showed robust cell populations on both PLA surface and hydrogel within a *** 14 days of LIV treatment(1 g,100 Hz,1 h/day),cell proliferation,type-I collagen(Collagen-I)and filamentous actin(F-actin)were quantified for the cells in the hydrogel *** LIV increased all measured outcomes,FE models predicted higher von Mises strains for the 13%SV/TV groups(0.2%)when compared to the 25%SV/TV group(0.1%).While LIV increased collagen-I volume 34%more in 13%SV/TV groups when compared to 25%SV/TV groups,collagen-I and F-actin measures remained lower in the 13%SV/TV groups when compared to 25%SV/TV counterparts,indicating that both LIV-induced strains and scaffold volume fraction(*** scaffold surface)affect cell behavior in the hydrogel ***,bone marrow analogs offer a robust and repeatable platform to study bone mechanobiology.

关键词： Mechanical signals Low-intensity vibration Mesenchymal stem cells 3D printing Mechanical modeling Tissue modeling

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Ethanol Detection Using a Swelling POF Alcohol Sensor with a Protective Polymer Layer 28

Ethanol Detection Using a Swelling POF Alcohol Sensor with a...

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28th International Conference on Optical Fiber Sensors, OFS 2023

作者： Amano, Tatsuki Suzuki, Yutaka Morisawa, Masayuki Graduate Faculty of Interdisciplinary Research University of Yamanashi 4-3-11 Takeda Kofu400-8510 Japan Department of Biomedical Engineering Faculty of Science and Technology Toyo University 2100 Kujirai Kawagoe350-8585 Japan

ISBN: (纸本)9781957171302

We have developed a plastic optical fiber (POF) sensor using novolac resin, which swells in alcohol, as the cladding material. In this study, we added a polystyrene layer between the POF core and cladding. This layer was designed to prevent alcohol adsorption into the polymethyl methacrylate core. Consequently, we developed a POF sensor capable of selective and repetitive ethanol detection. © Optica Publishing Group 2023, © 2023 The Author(s)

关键词： Ethanol

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Swallowing Parameters in Neck Ultrasound Video for Quantitative Evaluation of Jelly Beverages 13

Swallowing Parameters in Neck Ultrasound Video for Quantitat...

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13th IEEE Global Conference on Consumer Electronic, GCCE 2024

作者： Muramatsu, Hideaki Suzuki, Yutaka Kubo, Takao Morisawa, Masayuki The University of Electro-Communications Graduate School of Informatics and Engineering 1-5-1 Chofugaoka Chofu Japan Toyo University Department of Biomedical Engineering 48-1 Oka Asaka Saitama Japan Research Institute Morinaga & Co. Ltd. 2-1-1 Shimosueyoshi Tsurumi-ku Kanagawa Yokohama Japan University of Yamanashi Faculty of Engineering 4-3-11 Takeda Yamanashi Kofu Japan

ISBN: (纸本)9798350355079

This research introduces an innovative method for evaluating jelly beverages using neck ultrasound videos. The expanding market for jelly beverages is increasing the demand for products tailored to consumers' preferences, moods, and swallowing capabilities. Traditionally, sensory analysis, which depends on subjective sensory perceptions, has been used to evaluate these beverages. To address this limitation, we propose a method using neck ultrasound videos, which displays promise for the quantitative assessment of swallowing function and food evaluation. This is achieved by observing the movement of the bolus and the esophageal wall tissue during swallowing. We identified three swallowing parameters in neck ultrasound videos and developed a combined evaluation method that enables a quantitative and multifaceted evaluation of jelly beverages. The findings indicate significant correlations between swallowing parameters and sensory evaluation terms. The developed approach offers manufacturers a tool to objectively evaluate and improve jelly beverage formulations to cater to consumers with varying swallowing capabilities. © 2024 IEEE.

关键词： Sensory analysis

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Review Integration of smartphone technology and artificial intelligence for advanced ophthalmic care:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 120-127页

作者： Kai Jin Yingyu Li Hongkang Wu Yih Chung Tham Victor Koh Yitian Zhao Ryo Kawasaki Andrzej Grzybowski Juan Ye Eye Center The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouChina Centre for Innovation and Precision Eye Health National University of SingaporeSingapore Department of Ophthalmology National University of SingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Ophthalmology and Visual Science Academic Clinical Program Duke-NUS Medical SchoolSingapore Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Ningbo Eye Hospital NingboChina Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Division of Public Health Department of Social MedicineGraduate School of MedicineOsaka UniversityOsakaJapan Artificial Intelligence Center for Medical Research and Application Osaka University HospitalOsakaJapan Institute for Research in Ophthalmology Foundation for Ophthalmology DevelopmentPoznanPoland

Background:The convergence of smartphone technology and artificial intelligence(AI)has revolutionized the landscape of ophthalmic care,offering unprecedented opportunities for diagnosis,monitoring,and management of ocular ***,there is a lack of systematic studies on discussing the integration of smart-phone and AI in this *** text:This review includes 52 studies,and explores the integration of smartphones and AI in ophthalmology,delineating its collective impact on screening methodologies,disease detection,telemedicine initiatives,and patient *** collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases,glaucoma,cataract,visual impairment in children and ocular surface ***,the utilization of smartphone-based imaging modalities,coupled with AI algorithms,is able to provide timely,efficient and cost-effective screening for ocular *** modality can also facilitate patient self-monitoring,remote patient monitoring and enhancing accessibility to eye care services,particularly in underserved *** involving data pri-vacy,algorithm validation,regulatory frameworks and issues of trust are still need to be ***,evaluation on real-world implementation is imperative as well,and real-world prospective studies are currently ***:Smartphone ocular imaging merged with AI enables earlier,precise diagnoses,personalized treat-ments,and enhanced service accessibility in eye *** is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations,promising a potential revolution in care access and global eye health equity.

关键词： Artificial intelligence Smartphone imaging Ophthalmology Telemedicine Ocular disease management

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MecLung—A Respiratory System Mechanical Simulator 9th

MecLung—A Respiratory System Mechanical Simulator

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Motta-Ribeiro, G.C. Pino, A.V. Castro Pinto, F.A.N. dos Santos, T.P. Mattos, G.M. Vale, M.J.O. Giannella-Neto, A. Fundação Coordenação de Projetos Pesquisas e Estudos Tecnológicos—COPPETEC Rio de Janeiro Brazil Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Mechanical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil ECCO Engenharia Clínica Consultoria Ltda Rio de Janeiro Brazil

ISBN: (纸本)9783031494062

MecLung is a mechanical simulator. It consists of a metal cylinder provided with a tight piston controlled by a motor and programmed to simulate resistances and compliances of the human respiratory system. Additionally, the simulator presents spontaneous activity resembling respiratory muscular drive. Resistances and compliances in the range of 5 to 50 hPa/l/s and 10 to 50 ml/hPa, respectively, covering the clauses of the ABNT ISO 80601-2-12 to test the performance of mechanical ventilators for adults, were tested. The airways pressure, flow rate and volume waveforms are available for the user through digital data at 200 Hz sampling frequency. The motion equation applied to the data recovers the mechanical impedances with an accuracy of 2% for pressure and volume-controlled mechanical ventilation. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Ventilation

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Impact of Cryopreservation on Elastomuscular Artery Mechanics

SSRN

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SSRN 2024年

作者： Kostelnik, Colton J. Crouse, Kiersten J. Goldsmith, Jackson D. Eberth, John F. Aerospace Engineering and Engineering Mechanics The University of Texas at Austin AustinTX United States Biomedical Engineering Program University of South Carolina ColumbiaSC United States Mechanical Engineering Department University of South Carolina ColumbiaSC United States Biomedical Engineering Science and Health Systems Drexel University PhiladelphiaPA United States

Low temperatures slow or halt undesired biological and chemical processes, protecting cells, tissues, and organs during storage. Cryopreservation techniques, including controlled media exchange and regulated freezing conditions, aim to mitigate the physical consequences of freezing. Dimethyl sulfoxide (DMSO), for example, is a penetrating cryoprotecting agent (CPA) that minimizes ice crystal growth by replacing intracellular water, while polyvinyl alcohol (PVA) is a nonpenetrating CPA that prevents recrystallization during thawing. Since proteins and ground substance dominate the passive properties of soft biological tissues, we studied how different freezing rates, storage temperatures, storage durations, and presence of cryoprotecting agents (5% [v/v] DMSO + 1 mg/mL PVA) impact the histomechanical properties of the internal thoracic artery (ITA), a clinically relevant blood vessel with both elastic and muscular characteristics. Remarkably, biaxial mechanical analyses failed to reveal significant differences among the ten groups tested, suggesting that mechanical properties are virtually independent of cryopreservation technique. Scanning electron microscopy revealed minor CPA-independent delamination in rapidly frozen samples, while cryoprotected ITAs had better post-thaw viability than their unprotected counterparts using methyl thiazole-tetrazolium (MTT) metabolic assays, especially when frozen at a controlled rate. These results can be used to inform ongoing and future studies in vascular engineering and analysis. © 2024, The Authors. All rights reserved.

关键词： Dimethyl sulfoxide

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Classification of Epileptic EEG Signals Using Time-Frequency Analysis and Deep Learning

Classification of Epileptic EEG Signals Using Time-Frequency...

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Medical Technologies National Conference (TIPTEKNO)

作者： Mosab A. A. Yousif Mahmut Ozturk Department of Biomedical Engineering Institute of Graduate Studies Istanbul University – Cerrahpasa Istanbul Türkiye Department of Electrical and Electronics Engineering Engineering Faculty Istanbul University – Cerrahpasa Istanbul Türkiye

ISBN: (数字)9798331529819

ISBN: (纸本)9798331529826

Diagnosing and tracing of neurological disorders using Electrencephalography (EEG) signals is a promising and popular approach. For analyzing the EEG signals, time-frequency (TF) analysis is effective and useful method because of the stochastic behavior of the signals. Wavelet Transform (WT) was used broadly for analyzing the EEG signals and successful results were reported for various neurological disorders. As a new and promising TF method, concentration of frequency and time (ConceFT) was preferred to use in this study. This new TF method improves the TF resolution obtained using WT. ConceFT combines the multitaper technique and the synchrosqueezing transform (SST). This approach increases the TF resolution and the accuracy of the energy representation. In this paper, an algorithm designed for distinguishing the stages of epileptic seizure using ConceFT was presented. TF images of EEG signals were produced using ConceFT and these images were fed into SqueezeNet. The aim of this approach is to show the success of ConceFT in analyzing the non-stationary signals. Classifications of epileptic EEG signals were performed according to different scenarios. Classification accuracies were obtained between 91,18% and 100%, which showed the promising performance of ConceFT.

关键词： Neurological diseases Wavelet transforms Training Time-frequency analysis Accuracy Image resolution Energy resolution Wavelet analysis Electroencephalography Signal resolution

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The Design and Optimisation of W-Angular Plate on Quadrilateral Surface

The Design and Optimisation of W-Angular Plate on Quadrilate...

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Communication engineering and Emerging Technologies (ICoCET), IEEE International Conference on

作者： Riya Letchumi Rajan Nashrul Fazli Bin Mohd Nasir Normahira Binti Mamat Sahran Bin Yahaya Eugene Tan Lim Chee Chin Cheng Ee Meng Che Wan Sharifah Robiah Mohd Rafiq Bin Abdul Kadir Biomedical Electronic Engineering Program Faculty of Electronic Engineering and Technology Universiti Malaysia Perlis Perlis Malaysia Department of Orthopaedics Universiti Sains Malaysia Kubang Kerian Malaysia Leonix Sdn. Bhd. Batu Maung Malaysia Biomedical Engineering Department Faculty of Engineering Universiti Malaya Kuala Lumpur Malaysia

ISBN: (数字)9798331504144

ISBN: (纸本)9798331504151

This study focuses on the design, optimization, and biomechanical evaluation of a W-angular hip plate intended for the quadrilateral surface of the human pelvis. The W angular configuration is chosen for its potential to enhance stability and load distribution across the complex pelvic anatomy. The primary objective is to investigate and refine the screw insertion technique that maximizes the plate's stability on the quadrilateral surface. This involves evaluating various parameters such as screw placement angles and depths to achieve optimal fixation. Mechanical behavior of the W-angular hip plate is comprehensively assessed under diverse loading conditions simulating activities essential to daily living, including walking, standing, and sitting. The evaluation encompasses the analysis of stress distribution, strain patterns, and deformation characteristics within the implant structure. Both male and female anatomical variations are considered to ensure a thorough assessment of performance across different patient demographics. The outcomes of this study aim to deepen the understanding of how the W-angular hip plate interacts with the pelvic bone and surrounding tissues under realistic conditions.

关键词： Legged locomotion Pelvic bones Loading Fasteners Stability analysis Pelvis Hip Stress Optimization Strain

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Brain Functional Network Topology and Seed-based Connectivity Alterations in Idiopathic Generalized Epilepsy Patients: An fMRI Study 23

Brain Functional Network Topology and Seed-based Connectivit...

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7th International Conference on Medical and Health Informatics, ICMHI 2023

作者： Hsu, Yun-Chi Lim, Siew-Na Chao, Yi-Ping Graduate Institute of Biomedical Engineering Chang Gung University Taiwan Department of Neurology Chang Gung Memorial Hospital Linkou Taiwan Department of Computer Science and Information Engineering Chang Gung University Taiwan Department of Otolaryngology-Head and Neck Surgery Chang Gung Memorial Hospital Linkou Taiwan

ISBN: (纸本)9798400700712

Unlike localized epilepsy, idiopathic generalized epilepsy (IGE) usually affects a wider range of parts of the brain making it less specific. Therefore, it becomes meaningful to investigate alterations among brain connectivity of IGE patients. Since structural brain abnormalities in patients with IGE may be uncertain, the aim of this study will be identifying functional alterations in IGE patients through resting state functional magnetic resonance imaging (rs-fMRI). Our rs-fMRI study of IGE patients and healthy controls were performed based on graph theoretical and seed-based connectivity aspects. Significant between-group differences were found in several regions which corresponds to previous studies and might provide further evidence indicating alterations in IGE patients. Moreover, the findings revealed in our further analyses of seed-based functional connectivity results considering subtypes of IGE accentuates the difference between classifications of IGE patients. Accordingly, findings in our study indicate more specific regions related to the underlying pathophysiological abnormalities of IGE and may also contribute to providing additional explanations for the classification of IGE subtypes. © 2023 Association for Computing Machinery. All rights reserved.

关键词： Graph theory

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Light-Weight Vision Language Model Guided Gesture Recognition Based on Electromyography

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IEEE Sensors Journal 2025年第12期25卷 22677-22685页

作者： Dere, Mustapha Deji Cheong, Saehyung Jo, Ji-Hun Ku, Giwon Lee, Boreom Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering Gwangju61005 Korea Republic of Gwangju Institute of Science and Technology AI Graduate School Gwangju61005 Korea Republic of

Neuromuscular dysfunction poses a critical health challenge, affecting both patients and caregivers. Current active rehabilitation devices relying on electromyography (EMG) face significant hurdles due to high data acquisition demands, inaccurate decoders, and model degradation from sensor distribution shifts across participants. We address these limitations with a vision language model (VLM) that pseudo-labels motor-intent predictions, enhancing decoding accuracy and reliability under sensor distribution shift across participants. Our proposed pipeline integrates visual information with EMG decoding by employing a parallel processing framework: vision data is processed through the VLM to determine user intent, object and grasp type, which in turn provides pseudo-labels for the EMG decoder’s output. The pseudo-label is then utilized to infer motor-intent, enabling precise external control of assistive devices. In our experimental analysis, our proposed pipeline demonstrated superior performance compared to an EMG-only decoder, achieving 100% decoding accuracy across four upper limb gestures in four participants despite sensor distribution shift across them. Our approach underscores the potential of integrating visual understanding with neural signal analysis to enhance the reliability and effectiveness of active rehabilitation devices, ultimately improving patient outcomes by providing more accurate and consistent assistive technologies. © 2001-2012 IEEE.

关键词： Assistive technology

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