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Cell-Based Microfluidic Device Utilizing Cell Sheet Technology

Cyborg and Bionic Systems 2022年第1期2022卷 35-42页

作者： Katsuhisa Sakaguchi Kei Akimoto Masanori Takaira Ryu-ichiro Tanaka Tatsuya Shimizu Shinjiro Umezu Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advaneed Science and Enginring TWInsWaseda University2-2 Wakamatsu-ChoShinju-KuTokyo 162-8480Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University 1-104 Totsuka-ChoShinju-KuTokyo 169-8555Japan Insttute of Advanced BiomedicalEngineering and Seience TWIns Tokyo Women's Medical University8-1 Kawada-ChoShinju-KuTokyo 162-8666Japan

The developmentof microelectromechanical systems hasresulted in the rapid development of polydimethylpolysiloxane(PDMS)microfluidic devices for drug screening *** cell functions,such as the response of endothelial cells to fluids,have beenelucdated using microuidic ***,organon-achip systems that includeorgans that are importantfor biologicalcirculation,such as the heart,liver,pancreas,kidneys,and brain,have been *** organs realize the biologicalcirculation system in a manner that cannot be reproduced by artificial organs;however,the flow channels between the organsare often artifically created by *** this study,we developeda microfluidic device consisting only of cels,by combiningcell sheet technology with microtitanium *** were placed between stacked fibroblast cellsheets,and the celisheets adhered to each other,afer which the microwires were removed leaving a luminal structure with a size approximatelyequal to the arteriolar *** lumen structure was constructed using wires with diameters of 50,100,150,and 200μm,which were approximations of the arteriole *** using a perfusion device,we successfully perfused theluminal structure created inside the *** results revealed that a aulture solution can be supplied toa cellsheet witha very high cell *** biofabrication technology proposed in this study can contribute to the development of organ-on-a-chip systems.

关键词： organs fluid diameters

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A Simulation Study on Model Reference Adaptive Trajectory Controller for Back Stretchable McKibben Pneumatic Artificial Muscles

A Simulation Study on Model Reference Adaptive Trajectory Co...

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Rehabilitation engineering and Assistive Technology (i-CREATe), International Convention on

作者： Zhongchao Zhou Shuai Mao Wenwei Yu Liang He Institute of Biomedical Engineering (IBME) University of Oxford Oxford UK Graduate School of Science and Engineering Chiba University Chiba Japan Center for Frontier Medical Engineering Chiba University Chiba Japan

ISBN: (数字)9798350355154

ISBN: (纸本)9798350355161

McKibben Pneumatic Artificial Muscles (PAMs) have been widely used in wearable and assistive robots due to their high compliance, and safety for human-robot interaction. While replacing one side of a PAM with pre-tensioned springs in an antagonistic configuration helps mitigate nonlinearity, it sacrifices the system's bidirectional actuation and faces challenges due to the typically unknown or fatigue-prone spring constants, making static controllers unsuitable for PAMs-spring driven antagonistic structure. To overcome these limitations, we propose a novel antagonistic structure that integrates both sides with PAMs enhanced by a back stretchable component (BSC), featuring a spring with a self-locking mechanism. This configuration enables effective bidirectional movement by locking and pulling the opposite BSC upon the actuation of one side. To manage the variability or unkown of the spring constant effectively, we introduce a Model Reference Adaptive Trajectory (MRAT) controller specifically designed for the PAMs-BSC driven system. The MRAT controller dynamically aligns the system's control response with a predefined reference model, ensuring adaptive control even with variable spring constants. In simulation experiments, systems with different spring constants were controlled for position tracking and compared with a conventional Sliding Mode Controller. The results indicated that the proposed MRAT controller ensures robustness and predictability of response despite the unknown or variable spring constants, which making MRAT controller more suitable for human-robot interaction scenarios.

关键词： Artificial muscles Adaptation models Human-robot interaction Control systems Assistive robots Robustness Trajectory Safety Springs Faces

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Using CT image-based biomarkers to improve the prediction of hypothyroidism after nasopharyngeal radiotherapy: a preliminary result 23

Using CT image-based biomarkers to improve the prediction of...

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7th International Conference on Medical and Health Informatics, ICMHI 2023

作者： Ritlumlert, Napat Wongwattananard, Siriporn Prayongrat, Anussara Kitpanit, Sarin Kannarunimit, Danita Chakkabat, Chakkapong Lertbutsayanukul, Chawalit Sriswasdi, Sira Rakvongthai, Yothin Department of Radiology Chulalongkorn University Biomedical Imaging Group Department of Radiology Faculty of Medicine Chulalongkorn University Bangkok Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Department of Radiology Division of Radiation Oncology King Chulalongkorn Memorial Hospital Bangkok Thailand Research Affairs Faculty of Medicine Chulalongkorn University Bangkok Thailand Center for Artificial Intelligence in Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand

ISBN: (纸本)9798400700712

Hypothyroidism after treatment is the late-effect complication of head and neck radiotherapy. Early detection can greatly reduce hypothyroidism. The objective of this study is to enhance the prediction of hypothyroidism from radiation treatment in nasopharyngeal cancer by using CT image-based biomarkers. We collected data from 220 patients with nasopharyngeal carcinoma who underwent CT before radiation therapy. Manual thyroid segmentation was performed on CT images. To create a prediction model using logistic regression with regularization, image characteristics were quantified and extracted into three groups: the shape-based group, the first-order statistics group, and the texture-based group. Combined with the clinical data, the combined model received the best results in terms of the area under the receiver operating characteristics curve (AUC) of 0.73 ± 0.07, precision of 0.65 ± 0.08, recall rate of 0.62 ± 0.12, F1-score of 0.63 ± 0.08, and accuracy of 0.65 ± 0.07. The TSH level and seven texture features - glrlm short run emphasis, glrlm run entropy, glrlm gray level non-uniformity normalized, glszm big area low gray level emphasis, gldm dependence non-uniformity, ngtdm coarseness, and ngtdm complexity - were the key predictors from the combined model. In conclusion, the pretreatment thyroid image contains useful information which showed potential for improving the prediction of hypothyroidism after nasopharyngeal radiotherapy. © 2023 ACM.

关键词： Radiotherapy

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Development of Trans-nail PPG Controller Using Fingertip Blood Volume Changes to Enable Highly Accurate Motion Prediction

Development of Trans-nail PPG Controller Using Fingertip Blo...

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IEEE biomedical Circuits and Systems (BIOCAS)

作者： Kohei Nakamura Bang Du Keishun Sugishita Ryo Hasegawa Hisashi Kino Takafumi Fukushima Koji Kiyoyama Tetsu Tanaka Department of Mechanical Systems Engineering Graduate School of Engineering Tohoku University Sendai Japan Graduate School of Biomedical Engineering Tohoku University Sendai Japan Graduate School of Engineering Nagasaki Institute of Applied Science Nagasaki Japan

The widespread adoption of Virtual Reality (VR)/Augmented Reality (AR) has increased the demand for versatile controllers for VR/AR. Most conventional controllers for VR/AR have issues with a lack of immersive sensation, comfort, and stability. This study proposes a trans-nail PPG (photoplethysmography) controller using fingertip blood volume changes to enable accurate motion prediction. This controller utilizes the fact that the mainly DC component of the PPG signal varies with the state and movement of the hand and fingers. Based on reservoir computing, this controller also learns the PPG signals under various conditions and predicts the state and movement of the hand and fingers. Since this controller is attached to the fingernail, it does not compromise immersion, comfort, or stability. Three PPG sensor circuits in the trans-nail PPG sensor were designed, prototyped, and assembled with an LED on a nail-sized PCB. The output signals of the PPG sensor for various motions such as thumb raising and lowering, wrist raising and lowering, and wrist twisting were used for the learning and predictions of reservoir computing. As a result, the motion predictions with accuracies of over 90% were achieved successfully.

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The Role of Aldehyde-Functionalized Crosslinkers on the Property of Chitosan Hydrogels (vol 22, 2100477, 2022)

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MACROMOLECULAR BIOSCIENCE 2022年第10期22卷 e2200366页

作者： Yeh, Ying-Yu Tsai, Yu-Ting Wu, Chun-Yu Tu, Ling-Hsien Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei 10617 Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 10607 Taiwan Department of Chemistry National Taiwan Normal University Taipei 11677 Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei 10607 Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei 11490 Taiwan

Chitosan has been utilized as a popular biopolymer to fabricate hydrogels for biomedical applications. However, chitosan hydrogels are generally too brittle to mimic the deformability of the extracellular matrix in many tissues and organs. In particular, the role of the varied crosslinkers in determining the elasticity of chitosan hydrogels is lack of discussion. Here, three aldehyde-functionalized crosslinkers (i.e., aldehyde-modified poly(xylitol sebacate)- co -poly(ethylene glycol) (APP), glutaraldehyde (GA), and polydextran aldehyde (PDA)) are used to react with quaternized chitosan (QCS) through imine bonds to form hydrogels. The microstructures, mechanical performances, and cytocompatibility of the three hydrogels are systematically investigated. The APP/QCS hydrogels presented the best compressive and stretch properties among the three hydrogels. The mechanical property and antibacterial activity of APP/QCS hydrogels can be further modulated using varied QCS amounts, where more QCS contributed higher stiffness and stretchability as well as better bacterial inhibition to the APP/QCS hydrogels. Taken together, it is demonstrated that the inherent elastomeric characteristic of APP crosslinker provides the desirable elasticity and stretchability to QCS hydrogels compared to the other aldehyde-functionalized crosslinkers of GA and PDA. This strategy of using multivalent elastomeric crosslinkers to fabricate deformable chitosan hydrogels can expand the use of chitosan hydrogels in tissue engineering applications.

关键词： antibacterial property chitosan elasticity hydrogels stretchability

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Selective intrafascicular stimulation of myelinated and unmyelinated nerve fibers through a longitudinal electrode: A computational study

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Computers in Biology and Medicine 2024年 176卷 108556-108556页

作者： Wang, Xintong Zhang, Yapeng Guo, Tianruo Wu, Shuhui Zhong, Junwen Cheng, Chengkung Sui, Xiaohong School of Biomedical Engineering Shanghai Jiao Tong University Shanghai200240 China Graduate School of Biomedical Engineering The University of New South Wales SydneyNSW2052 Australia Department of Electromechanical Engineering University of Macau Macau SAR 999078 China Med-X Research Institute Shanghai Jiao Tong University Engineering Research Center of Digital Medicine Ministry of Education Shanghai China

Carbon nanotube (CNT) fiber electrodes have demonstrated exceptional spatial selectivity and sustained reliability in the context of intrafascicular electrical stimulation, as evidenced through rigorous animal experimentation. A significant presence of unmyelinated C fibers, known to induce uncomfortable somatosensory experiences, exists within peripheral nerves. This presence poses a considerable challenge to the excitation of myelinated Aβ fibers, which are crucial for tactile sensation. To achieve nuanced tactile sensory feedback utilizing CNT fiber electrodes, the selective stimulation of Aβ sensory afferents emerges as a critical factor. In confronting this challenge, the present investigation sought to refine and apply a rat sciatic-nerve model leveraging the capabilities of the COMSOL-NEURON framework. This approach enables a systematic evaluation of the influence exerted by stimulation parameters and electrode geometry on the activation dynamics of both myelinated Aβ and unmyelinated C fibers. The findings advocate for the utilization of current pulses featuring a pulse width of 600 μs, alongside the deployment of CNT fibers characterized by a diminutive diameter of 10 μm, with an exclusively exposed cross-sectional area, to facilitate reduced activation current thresholds. Comparative analysis under monopolar and bipolar electrical stimulation conditions revealed proximate activation thresholds, albeit with bipolar stimulation exhibiting superior fiber selectivity relative to its monopolar counterpart. Concerning pulse waveform characteristics, the adoption of an anodic-first biphasic stimulation modality is favored, taking into account the dual criteria of activation threshold and fiber selectivity optimization. Consequently, this investigation furnishes an efficacious stimulation paradigm for the selective activation of touch-related nerve fibers, alongside provisioning a comprehensive theoretical foundation for the realization of natural tactile feedback

关键词： Electrodes

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Effect of exposure to a light-emitting diode (LED) on the physicochemical characteristics of natural latex biomembranes used to treat diabetic ulcers

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Research on biomedical engineering 2022年第3期38卷 901-911页

作者： Santana, Thamis Fernandes Oliveira, Rebeca Hannah de Melo dos Santos, Ludmila Evangelista Lima, Eunice Paloma Nascimento Faria, Sylvia de Sousa Fonseca, Marcos Augusto Moutinho da Silva, Jaqueline Rodrigues Tatmatsu-Rocha, José Carlos Gomes, Marília Miranda Forte Fleury Rosa, Mário Fabrício Fleury Rosa, Suélia de Siqueira Rodrigues Carneiro, Marcella Lemos Brettas Postgraduate Program in Biomedical Engineering University of Brasilia Federal District Brasilia Brazil Postgraduate Program in Materials Science and Engineering Federal University of Campina Grande Paraiba Campina Grande Brazil Department of Electrical Engineering University of Brasilia Federal District Brasilia Brazil Postgraduate Program in Biology Animal University of Brasilia Federal District Brasilia Brazil Medicine Faculty Physical Therapy Department Federal University of Ceara Ceara Fortaleza Brazil Postgraduate Technology and Health Program University of Brasília Federal District Brasília Brazil

Purpose: Natural latex biomembrane has shown high therapeutic potential for the treatment of diabetic ulcers when associated with phototherapy. In this study, physical and chemical alterations in the latex biomembranes were evaluated after exposure to light-emitting diode (LED) irradiation and after contact with NaCl solution. Methods: There were three experimental groups: natural latex biomembranes (1) in natura;(2) after 35 min of LED light irradiation;and (3) after immersion in NaCl 0.9 g% solution. The samples were analyzed by tensile strength test, thermogravimetry, contact angle wettability, and Fourier-transform infrared spectroscopy. Results: The biomembranes that were submitted to contact with NaCl aqueous solution or exposure to LED did not undergo impairment of mechanical resistance. The thermogravimetry analysis indicated that increasing temperature led to mass loss in all samples, referring to their decomposition temperatures. In the wettability test, biomembranes exposed to LED showed a significant reduction in the contact angle between 0 and 10 min, indicating an increase in hydrophilicity, suggesting water storage capacity. The Fourier-transform infrared spectrometry assay showed that there was a more significant reduction in vibration intensity after immersion in NaCl solution compared to untreated biomembranes. An increase in the intensity of the entire spectrum of biomembranes exposed to LED was observed in comparison with the other samples, which may be related to photodegradation caused by LED light irradiation. Conclusion: The biomembranes underwent significant changes in its chemical structure after being subjected to different types of exposure and maintained its elasticity and tensile strength properties, in addition to showing good water retention capacity after exposure to LED. Thus, it maintains many of its properties for application as a tissue-regenerating biomaterial, even when subjected to LED irradiation and a humid environment. © 20

关键词： Tissue regeneration

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First Results on Graph Similarity Search in Resting-State Functional Connectivity Networks Using Spectral and Graph Edit Distances

First Results on Graph Similarity Search in Resting-State Fu...

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18th International Joint Conference on biomedical engineering Systems and Technologies, BIOSTEC 2025

作者： Carvalho, M.A.G. Frayne, R. School of Technology University of Campinas Brazil Radiology and Clinical Neurosciences Hotchkiss Brain Institute Univ. of Calgary Canada Seaman Family MR Research Centre Foothills Medical Centre Calgary Canada Biomedical Engineering Graduate Program University of Calgary Canada Calgary Image Processing and Analysis Centre Foothills Medical Centre Calgary Canada

The application of graph theory in the modeling and analysis of brain networks has generated both new op portunities as well as new challenges in neuroscience. Resting state functional connectivity (RSFC) networks studied with graphs is an important field of investigation because of the potential benefits in understanding function in healthy individuals and identifying evidence of brain diseases and injury in patients. This work is unique because it applies information retrieval techniques to create ranked lists from RSFC graph theory derived networks. In our analysis, we used a sample of whole-brain resting-state functional magnetic reso nance imaging (rs-fMRI) data obtained from Young (n = 10, age: 20.1±2.1) and Old (n = 10, 65.6±0.4) sex-balanced groups drawn from a healthy, i.e., neurotypical, cohort. We estimated two well-known distance metrics (graph edit distance and graph spectral distance) and by using information-retrieval graph ranking methods achieved precision measures at the top-5 positions of ranked lists of up to 80%. © 2025 by SCITEPRESS– Science and Technology Publications, Lda.

关键词： Graph neural networks

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Fluorescent Carbon Dots Illuminate Hydrogen Peroxide Detection: A Promising Approach

Fluorescent Carbon Dots Illuminate Hydrogen Peroxide Detecti...

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BioCAS Workshop, IEEE Colombian

作者： Jessica D. Sánchez Fonseca Nicolas J. Bonilla Fajardo Natalia Vargas Perdomo Oscar Julian Perdomo Charry Álvaro D. Orjuela-Cañón Emma Martín Rodriguez Diana C. Rodriguez Burbano Biomedical Engineering Program School of Medicine and Health Sciences Universidad del Rosario Bogotá Colombia Biomedical Engineering Program Colombian School of Engineering Universidad del Rosario Bogotá Colombia Department of Applied Physics Universidad Autónoma de Madrid Madrid Spain

Hydrogen peroxide ($H_{2}O_{2}$) is an oxidant widely used in industrial and biomedical applications that requires a sensitive and selective quantification method. Despite being one of the most used methods for detecting this oxidant, enzyme-based reactions still exhibit low-cost efficiency and pose high environmental hazards. Optical biosensors have emerged as an attractive alternative, offering potential advantages such as rapid response time and ease of operation. Carbon dots (CDs) are a type of carbon-based nanoparticles that are particularly appealing for this purpose because of their low-cost synthesis procedures and favorable chemical and optical properties. In this study, fluorescent CDs were synthesized via a microwave-assisted method using urea, L-histidine, and citric acid as precursors. The optical properties of the CDs were characterized using UV-Vis and fluorescence spectroscopy. The CDs exhibited a fluorescence sensing range between 1 mM to 50 mM, with a limit detection (LOD) for $H_{2}O_{2}$ of 0.1 mM. The selectivity of the CDs was tested in the presence of various interferents, and the results confirmed their potential for further applications, particularly in metabolite quantification and biological processes. Overall, the low-cost synthesis procedure and favorable properties of the CDs make them a promising candidate for $H_{2}O_{2}$ detection and other biosensing applications.

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Pilot Study of Distinct Graphs Models in Analysis of Brain Aging in Resting-State Functional Connectivity Networks

Pilot Study of Distinct Graphs Models in Analysis of Brain A...

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18th International Joint Conference on biomedical engineering Systems and Technologies, BIOSTEC 2025

Graphs have been used successfully to represent and analyze brain networks for many decades. Such structural and functional studies are important for revealing interactions between distinct areas of the brain that, for ex ample, are associated with the performance of a specific task or the onset of a cognitive disorder like dementia. In this pilot study, resting-state functional magnetic resonance imaging data were acquired in a sex-balanced sample of 10 young (20.1±2.1 years) and 10 old (65.6±0.4 years), presumed healthy, adults. We examined the effects of age on whole-brain resting-state functional connectivity (RSFC) networks. We examined two main graph modeling approaches to analyze RSFC networks. These approaches employ different strategies or graph models for thresholding over the complete network or examining changes in graph density. We com puted and compared one graph metric, the modularity, that was derived from the RSFC network graph models. Considering the need for a model that must preserve the network’s connectivity, strategies that use spanning trees as seeds to gradually increase the graph’s density seem more appropriate to represent brain networks. © 2025 by SCITEPRESS– Science and Technology Publications, Lda.

关键词： Magnetic resonance imaging

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