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IEEE International Workshop on Medical Measurement and Applications (MEMEA)

作者： Leonardo Ormaza-Siguenza Leticia Silva Ana Cecilia Villa-Parra Teodiano Bastos-Filho Biomedical Engineering Research Group - GlIB Universidad Politecnica Salesiana Cuenca Ecuador Postgraduate Program in Electrical Engineering Universidade Federal do Espirito Santo Vitoria Brazil

ISBN: (数字)9798350307993

ISBN: (纸本)9798350308006

Ensuring the health and safety of workers in indus-trial environments is of utmost importance. In Brazil, Regula-tory Normatives (RNs) mandate Periodic Medical Examinations (PMEs), with the frequency of these examinations primarily determined by the level of risk to which workers are exposed. However, normally these examinations do not provide a real-time assessment of workers' health status. The aim of this study is to introduce the Integrated Portable Medical Assistant (IPMA), which is a multimodal equipment capable of automatically collecting biomedical data, such as oxygen saturation level, body temperature, and heart rate of users. This equipment aids in monitoring the health of industry workers through Machine Learning (ML) algorithms, and can store biomedical data for ongoing research and tracking the health condition of workers. Preliminary findings evaluating 14 workers and 2 doctors suggest promising results using this equipment in industries. In terms of equipment usability, the workers reported the IPMA to be highly user-friendly through evaluation conducted through the System Usability Scale (SUS) and the Post-Study System Usability Questionnaire (PSSUQ), which also provided average scores above 85 and 1.9, respectively. Overall, the IPMA shows promising potential for improving safety and well-being in industrial workplaces, and it may also contribute to reducing worker absenteeism due to some illness.

关键词： Industries Temperature distribution Machine learning algorithms Medical services Machine learning Real-time systems Sensors

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Slit-Wall Differentiation Method for Depth-of-Interaction Measurement for PET

Slit-Wall Differentiation Method for Depth-of-Interaction Me...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee H. Hemmati M. Yi S.I. Kwon University of California Davis Biomedical Engineering Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In positron emission tomography (PET), accurately measuring the Depth-of-Interaction (DOI) of 511 keV gamma ray interactions is essential for improving spatial resolution in small animal PET, especially at off-center detector positions. DOI resolution can be improved by modifying crystal structures, reflectors, or by using dual readout techniques. Most methods, except for the more electronics-intensive dual side readout, increase light sharing among pixels, thereby reducing photon availability per pixel. This study introduces a novel Slit-Wall Differentiation (SWD) method, designed to restrict light sharing to just four adjacent pixels, thus enhancing DOI accuracy. The SWD method involves placing strategic slits on the adjacent faces of each pixel, controlling light sharing depending on the DOI position. DOI information is calculated from the output patterns of Silicon Photomultiplier (SiPM) arrays. The effectiveness of the proposed method was validated through GATE simulations (vGATE 9.2) using a $3 \times 3$ Lutetium-Yttrium Oxyorthosilicate (LYSO) array with enhanced specular reflectors (ESRs). An LYSO array fabricated based on the proposed configuration was successfully prepared. For practical validation, an experimental setup using a 4 $\times 4$ NUV-HD-MT (Broadcom) SiPM array is also configured.

关键词： Temperature measurement Photomultipliers Semiconductor device measurement Semiconductor detectors Position measurement Silicon Positron emission tomography

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FPGA-Based Single-Input Time-to-Digital Converter with Rise Time Correction and Sub-2 ps Resolution for Precision Timing Applications

FPGA-Based Single-Input Time-to-Digital Converter with Rise ...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： D. Lee M. Yi S.I. Kwon Biomedical Engineering University of California Davis Davis California United States of America Seoul National University Interdisciplinary Program in Bioengineering College of Engineering Seoul Republic of Korea

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

In numerous fields, including physics, industry, and medical technology, the precise measurement of extremely short time intervals, such as those below 100 ps, is essential. This research introduces an innovative FPGA-based time-to-digital converter (TDC) implemented on the UltraScale+ platform (VCU118, Xilinx). The UltraScale+ platform improves upon timing resolution by incorporating a CARRY8 primitive cell as a delay element, an improvement over the CARRY4, which was widely used in previous platforms. Through the novel end-of-propagation (EOP) technique, the implemented TDC achieves an average bin size of 1.11 ps, demonstrating significant resource efficiency compared to other reported FPGA-based TDCs. This study details the design, implementation, and empirical validation of the TDC. Additionally, a unique feature of the proposed TDC is its ability to measure the input pulse width and apply rise time correction without requiring additional inputs. To demonstrate its practical applicability, the developed TDC was connected to the output of an ultrafast Cherenkov-Radiator-Integrated (CRI)-MCP-PMT after evaluating its electrical performance. The preliminary coincidence timing resolution of a pair of CRI-MCP-PMTs shows improvements from 107 ps to 73 ps (FWHM) with the proposed rise time correction. These advancements highlight the potential of the TDC not only for next-generation medical applications but also for its transformative impact in applications demanding ultra-precise timing.

关键词： Industries Semiconductor device measurement Microwave integrated circuits Image resolution Semiconductor detectors Pulse measurements Medical services

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Classification of Human Blastocyst Quality Using Wavelets and Transfer Learning

Classification of Human Blastocyst Quality Using Wavelets an...

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International Conference on Computer, Communication and Computational Sciences, IC4S 2019

作者： Irmawati Basari Gunawan, Dadang Department of Electrical Engineering Universitas Indonesia Depok Indonesia Biomedical Engineering Program Department of Electrical Engineering Universitas Indonesia Depok Indonesia

ISBN: (纸本)9789811544088

Embryo culture and transfer are the procedure of maturation and transmission of the embryo into the uterus. This procedure is one of a stage in the series of in vitro fertilization processes, better known as IVF. The selection of good quality embryos to be implanted presents a problem because of the blastocyst image. Blastocyst image is a very intricate texture to be visually determined, which is good or poor quality. This research aims to implement the pre-trained Inception-v3 network to predict blastocyst quality with add image pre-processing using wavelets. Using only 249 of human blastocyst microscope images, we developed an accurate classifier that can classify blastocyst quality with a transfer learning. The experiment with twenty epochs, the accuracy of training for only raw blastocyst images is 95%, and the best training accuracy uses a pre-processing image with Daubechies 6-tap of 99.29%. Our model was then tested on the 14 of blastocyst images and classified the images of two kinds of grade with the best accuracy of around 64.29%. © 2021, Springer Nature Singapore Pte Ltd.

关键词： Textures

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A Computational Simulation Framework for Unraveling Idiopathic Atrial Fibrillation Mechanisms

SSRN

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SSRN 2025年

作者： Lian, Xin Li, Haiying Chen, Yanhong Yu, Shiqi He, Linsheng Wu, Jian Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Shenzhen518055 China The University of Hong Kong Shenzhen Hospital Shenzhen518053 China Department of Biomedical Engineering

Background and Objective: Idiopathic atrial fibrillation (IAF) is characterized by spontaneous onset in the absence of apparent structural heart abnormalities, posing challenges in delineating the individual contributions of potential risk factors. To address it, we developed a computational simulation framework aimed at uncovering novel mechanistic insights into the initiation and maintenance of ***: Using a 3D virtual human atrial model, we simulated atrial electrical activity under diverse electrophysiological conditions. Three key factors were investigated in this study: atrial tissue conductivity (ATC), atrial effective refractory period (AERP), and sinus cycle length (SCL), with each systematically explored within its physiological range. Specific parameters linked to the onset of IAF were identified and rigorously analyzed for their impacts on the complexity, stability and spatial disorder of atrial electrical ***: When the AERP shortened to 94 ms and the ATC was at ATC1 or ATC2 level, even rapid sinus stimulation at 2.5 Hz failed to trigger IAF. Conversely, when the AERP remained at 94 ms and the ATC decreased further, even slow sinus stimulation at 1Hz could trigger IAF. Furthermore, when the AERP was ≥141ms, neither slow conduction nor high-frequency stimulation could trigger IAF. Compared to the initial value, both slow conduction and high frequency stimulation increased the number of spiral waves, with increase rates of 63% and 129%. High-frequency stimulation also enhanced the stability of spiral waves (48% increase in lifespan), while slow conduction exacerbated the spatial disorder of electrical activity (27% reduction in OI). Additionally, the interatrial septum is identified as a primary source of disorganized electrical ***: The onset of IAF typically requires both a short AERP and low ATC, while appropriate high-frequency stimulation and slow conduction facilitate the maintenance of IAF. © 2025, The Authors. A

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β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model

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Bioactive Materials 2024年第9期39卷 273-286页

作者： Anna Laura Nelson Chiara Mancino Xueqin Gao Joshua AChoe Laura Chubb Katherine Williams Molly Czachor Ralph Marcucio Francesca Taraballi John P.Cooke Johnny Huard Chelsea Bahney Nicole Ehrhart Steadman Philippon Research Institute(SPRI) Center for Regenerative and Personalized MedicineVailCOUSA Houston Methodist Research Institute Center for Musculoskeletal RegenerationHouston TXUSA University of Wisconsin-Madison Department of Orthopedics and RehabilitationDepartment of Biomedical EngineeringMedical Scientist Training ProgramMadisonWIUSA Colorado State University School of Biomedical EngineeringFort Collins COUSA Colorado State University Department of Clinical SciencesFort Collins COUSA Colorado State University Department of MicrobiologyImmunologyand PathologyFort CollinsCOUSA Houston Methodist Research Institute Center for RNA TherapeuticsDepartment of Cardiovascular SciencesHoustonTXUSA University of Californi1 San Francisco(UCSF)Orthopaedic Trauma InstituteSan FranciscoCAUSA

Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture *** this study,we aimed to develop an osteoanabolic therapy which activates the Wnt/β-catenin pathway,a molecular driver of endochondral *** hypothesize that using an mRNAbased therapeutic encodingβ-catenin could promote cartilage to bone transformation formation by activating the canonical Wnt signaling pathway in *** optimize a delivery platform built on recent advancements in liposomal technologies,two FDA-approved ionizable phospholipids,DLin-MC3-DMA(MC3)and SM-102,were used to fabricate unique ionizable lipid nanoparticle(LNP)formulations and then tested for transfection efficacy both in vitro and in a murine tibia fracture *** firefly luciferase mRNA as a reporter gene to track and quantify transfection,SM-102 LNPs showed enhanced transfection efficacy in vitro and prolonged transfection,minimal fracture interference and no localized inflammatory response in vivo over MC3 *** generatedβ-cateninGOF mRNA encapsulated in SM-102 LNPs(SM-102-β-cateninGOF mRNA)showed bioactivity in vitro through upregulation of downstream canonical Wnt genes,axin2 and *** testing SM-102-β-cateninGOF mRNA therapeutic in a murine tibia fracture model,histomorphometric analysis showed increased bone and decreased cartilage composition with the 45μg concentration at 2 weeks post-fracture.μCT testing confirmed that SM-102-β-cateninGOF mRNA promoted bone formation in vivo,revealing significantly more bone volume over total volume in the 45μg ***,we generated a novel mRNA-based therapeutic encoding aβ-catenin mRNA and optimized an SM-102-based LNP to maximize transfection efficacy with a localized delivery.

关键词： Gene therapy Fracture healing Lipid nanoparticles mRNA Canonical Wnt

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TiO2 Hole Transport Layer Incorporated in a Thermally Evaporated Sb2Se3 Photoelectrode Exhibiting Low Onset Potential for Photoelectrochemical Applications

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Energy and Fuels 2024年第17期38卷 16936-16948页

作者： Xavier, Thatheyus Peter Piraviperumal, Malar Kuo, Chih-Yu Govindasamy, Mani Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur603203 India Department of Chemical Engineering & Biotechnology National Taipei University of Technology Taipei City10608 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India Taipei10608 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Developing cost-effective photoelectrodes with a low band gap in the NIR-visible regions remains a challenge to achieve effective hydrogen production. We report the details of superstrate-configured photocathodes, consisting of antimony selenide (Sb2Se3) light absorbing layers with titanium dioxide (TiO2) as a hole transport layer, exhibiting the capability for hydrogen evolution with broad range light absorption enabled by the low band gap value of ∼1.2 eV of Sb2Se3. Strong anisotropy is a significant characteristic property of Sb2Se3, allowing superior electrical transportation along the [hkl] crystallographic orientation, which is obtained via close space evaporation of presynthesized bulk material at a growth temperature of 250 °C, over the solution-processed TiO2 film on a fluorine-doped tin oxide (FTO) substrate. The superstrate-configured FTO/TiO2/Sb2Se3 photocathode exhibited a photocurrent density of 100 μA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. To further improve photocurrent density, Pt as a cocatalyst was deposited over Sb2Se3 that led to enhanced photocurrent to 3 mA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. Despite the relatively lower photocurrent observed, which resulted due to a large conduction band offset (ΔECB = 0.99 eV) of the TiO2/Sb2Se3 interface in a superstrate configuration, a significantly lower onset potential of −0.1 V vs RHE was observed. The results are encouraging due to the low band gap of Sb2Se3, photocorrosion stability, and straightforward fabrication, which is expected to assist for significant outcomes. © 2024 American Chemical Society.

关键词： Titanium dioxide

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NREM3 sleep disrupts the brain-periphery hemodynamic coupling 14

NREM3 sleep disrupts the brain-periphery hemodynamic couplin...

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Optics in Health Care and biomedical Optics XIV 2024

作者： Nair, Vidhya Vijayakrishnan Kish, Brianna R. Oshima, Hideyuki Wen, Qiuting Tong, Yunjie Schwichtenberg, A.J. Weldon School of Biomedical Engineering Purdue University West LafayetteIN United States Graduate School of Engineering and Science Shibaura Institute of Technology Japan Department of Radiology and Imaging Sciences Indiana University School of Medicine IndianapolisIN United States Department of Human Development and Family Science College of Health and Human Sciences Purdue University West LafayetteIN United States

ISBN: (纸本)9781510682122

This study investigates the coupling strength between low-frequency peripheral and cerebral hemodynamics among young, healthy volunteers, with concurrent acquisition of peripheral NIRS, brain fMRI, and EEG across wake and NREM sleep. The results document a strong positive coupling between low-frequency peripheral and cerebral hemodynamics during all stages except deep sleep (NREM3). Collectively, our results demonstrate that systemic physiology remains a dominant source of variability in brain hemodynamics both during resting wakefulness and light NREM sleep. However, deep NREM3 sleep may be an exception to this phenomenon implicative of its noteworthy role in optimal restoration of cerebral vasomotion. © 2024 SPIE.

关键词： Sleep research

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Evaluation of fluoride concentration in toothpastes with antimicrobial molecules commercialized in Brazil

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Research on biomedical engineering 2021年第1期37卷 9-14页

作者： Medeiros, Maria da Conceição de Araújo Valadas, Lídia Audrey Rocha Lotif, Mara Assef Leitão Bottenberg, Peter Marciano, Fernanda Roberta Biomedical Engineering Postgraduate Program Brazil University São Paulo Brazil Development and Technological Innovation in Medicines Postgraduate Program Federal University of Ceara Fortaleza Brazil Brussels Belgium

Purpose: This study aimed to analyze the fluoride concentrations in different dentifrices with antimicrobial and natural molecules marketed in Brazil. Thus, 12 dentifrices were selected to be analyzed for the concentration of total fluoride (TF), total soluble fluoride (TSF) and ionizable fluoride (IF). Methods: Two tubes of each brand were purchased at different locations. The samples were analyzed in duplicates using an ion-specific electrode and the concentrations were determined in μg F/g. Results: The TF of all calcium carbonate dentifrices showed averages below 1500 ppm F. Regarding TSF, only one toothpaste had an average above 1000 ppm F−, while the IF values were almost 500 ppm F. In the analysis of fluoride in dentifrices which present silica as abrasive, the TF presented averages below 1500 ppm F, while the TSF all presented averages close to 1000 ppm F−, and the IF values varied from close to 500 ppm to more than 1000 ppm F. In dentifrices whose formulation contained calcium carbonate associated with silica or other formulations such as sodium bicarbonate, the TF, TSF, and IF values were all above 1000 ppm F. Conclusion: The evaluated dentifrices generally showed TF concentrations lower than those declared on the packaging;however, the TSF content remained close to 1000 ppm F. It can be concluded that the analyzed dentifrices with antimicrobial molecules showed values close to those suggested regarding anti-caries effect. © 2020, Sociedade Brasileira de Engenharia Biomedica.

关键词： Calcium carbonate

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Novel compounds of Djulis (Chenopodium formosanum Koidz) increases collagen, antioxidants, inhibits adipogenesis

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Natural Product Research 2024年第16期38卷 2763-2772页

作者： Lin, Yuan-You Lin, Yung-Kai Lin, Yung-Hsiang Chiang, Chi-Fu Research & Design Center TCI CO. Ltd Taipei Taiwan Institute of Food Safety and Risk Management National Taiwan Ocean University Keelung Taiwan Department of Food Science National Taiwan Ocean University Keelung Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung Taiwan

Djulis (Chenopodium formosanum Koidz), is rich in nutrients and contains various bioactive components such as polyphenols and alkaloids. The new compound has a broad application prospect, including food additives, health products, drugs, etc. The purpose of this study was to find out new compounds from Djulis. It was found that 24 compounds including 7 phenols, 11 flavonoids, 4 plant alkaloids, 2 sterols. Among those, TCI-CF-22-S (Methyl 3,6-dihydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-23-S (Methyl 6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-24-S (Kaempferol-3-O-b-D-apifuranosyl-(1→2)-a-L-arabinopyranoside) were isolated from djulis sources for the first time, and the structures of compounds were assigned by 1D, 2D NMR spectroscopy. TCI-CF-01(Caffeic acid), TCI-CF-02 (20-Hydroxyecdysone), TCI-CF-03 (Japonicone), TCI-CF-04 (3,4-Dihydroxyphenylacetiate), TCI-CF-05 (Quercetin-3-O-rutinoside-7-O-rhamnopyranoside), TCI-CF-06 (Guanosine), TCI-CF-07(Adenine), TCI-CF-08 (Coumaric acid) increased collagen production, and TCI-CF-03 (Japonicone), TCI-CF-04 (3,4-Dihydroxyphenylacetiate), TCI-CF-06 (Guanosine), TCI-CF-17 (Rutin), TCI-CF-20 (Protocatechuic acid) decreased advanced glycation end products (AGEs). In addition, TCI-CF-22-S (Methyl 6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-23-S (Methyl 3,6-dihydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate) inhibited the formation of fatty oil droplets. Djulis has 24 compounds that may have various applications, including increasing collagen production and reducing advanced glycation end products and fatty oil droplets. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Antioxidants chenolactam chenopodium formosanum collagen djulis

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