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Novel compounds of Djulis (Chenopodium formosanum Koidz) increases collagen, antioxidants, inhibits adipogenesis

Natural Product Research 2024年第16期38卷 2763-2772页

作者： Lin, Yuan-You Lin, Yung-Kai Lin, Yung-Hsiang Chiang, Chi-Fu Research & Design Center TCI CO. Ltd Taipei Taiwan Institute of Food Safety and Risk Management National Taiwan Ocean University Keelung Taiwan Department of Food Science National Taiwan Ocean University Keelung Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung Taiwan

Djulis (Chenopodium formosanum Koidz), is rich in nutrients and contains various bioactive components such as polyphenols and alkaloids. The new compound has a broad application prospect, including food additives, health products, drugs, etc. The purpose of this study was to find out new compounds from Djulis. It was found that 24 compounds including 7 phenols, 11 flavonoids, 4 plant alkaloids, 2 sterols. Among those, TCI-CF-22-S (Methyl 3,6-dihydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-23-S (Methyl 6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-24-S (Kaempferol-3-O-b-D-apifuranosyl-(1→2)-a-L-arabinopyranoside) were isolated from djulis sources for the first time, and the structures of compounds were assigned by 1D, 2D NMR spectroscopy. TCI-CF-01(Caffeic acid), TCI-CF-02 (20-Hydroxyecdysone), TCI-CF-03 (Japonicone), TCI-CF-04 (3,4-Dihydroxyphenylacetiate), TCI-CF-05 (Quercetin-3-O-rutinoside-7-O-rhamnopyranoside), TCI-CF-06 (Guanosine), TCI-CF-07(Adenine), TCI-CF-08 (Coumaric acid) increased collagen production, and TCI-CF-03 (Japonicone), TCI-CF-04 (3,4-Dihydroxyphenylacetiate), TCI-CF-06 (Guanosine), TCI-CF-17 (Rutin), TCI-CF-20 (Protocatechuic acid) decreased advanced glycation end products (AGEs). In addition, TCI-CF-22-S (Methyl 6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate), TCI-CF-23-S (Methyl 3,6-dihydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate) inhibited the formation of fatty oil droplets. Djulis has 24 compounds that may have various applications, including increasing collagen production and reducing advanced glycation end products and fatty oil droplets. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Antioxidants chenolactam chenopodium formosanum collagen djulis

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NREM3 sleep disrupts the brain-periphery hemodynamic coupling 14

NREM3 sleep disrupts the brain-periphery hemodynamic couplin...

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Optics in Health Care and biomedical Optics XIV 2024

作者： Nair, Vidhya Vijayakrishnan Kish, Brianna R. Oshima, Hideyuki Wen, Qiuting Tong, Yunjie Schwichtenberg, A.J. Weldon School of Biomedical Engineering Purdue University West LafayetteIN United States Graduate School of Engineering and Science Shibaura Institute of Technology Japan Department of Radiology and Imaging Sciences Indiana University School of Medicine IndianapolisIN United States Department of Human Development and Family Science College of Health and Human Sciences Purdue University West LafayetteIN United States

ISBN: (纸本)9781510682122

This study investigates the coupling strength between low-frequency peripheral and cerebral hemodynamics among young, healthy volunteers, with concurrent acquisition of peripheral NIRS, brain fMRI, and EEG across wake and NREM sleep. The results document a strong positive coupling between low-frequency peripheral and cerebral hemodynamics during all stages except deep sleep (NREM3). Collectively, our results demonstrate that systemic physiology remains a dominant source of variability in brain hemodynamics both during resting wakefulness and light NREM sleep. However, deep NREM3 sleep may be an exception to this phenomenon implicative of its noteworthy role in optimal restoration of cerebral vasomotion. © 2024 SPIE.

关键词： Sleep research

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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3D bioprinted chondrogenic gelatin methacrylate-poly(ethylene glycol)diacrylate composite scaffolds for intervertebral disc restoration

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International Journal of Extreme Manufacturing 2025年第1期7卷 610-621页

作者： Maria D Astudillo Potes Maryam Tilton Indranath Mitra Xifeng Liu Babak Dashtdar Emily T Camilleri Benjamin D Elder Lichun Lu Mayo Clinic Alix School of Medicine RochesterMNUnited States of America Mayo Clinic Graduate School of Biomedical Sciences RochesterMNUnited States of America Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUnited States of America Department of Orthopedic Surgery Mayo ClinicRochesterMNUnited States of America Department of Neurological Surgery Mayo ClinicRochesterMNUnited States of America Walker Department of Mechanical Engineering The University of Texas at AustinAustinTXUnited States of America

Degenerative spine pathologies,including intervertebral disc(IVD)degeneration,present a significant healthcare challenge due to their association with chronic pain and *** study explores an innovative approach to IVD regeneration utilizing 3D bioprinting technology,specifically visible light-based digital light processing,to fabricate tissue scaffolds that closely mimic the native architecture of the *** a hybrid bioink composed of gelatin methacrylate(GelMA)and poly(ethylene glycol)diacrylate(PEGDA)at a 10%concentration,we achieved enhanced printing fidelity and mechanical properties suitable for load-bearing applications such as the *** rat bone marrow-derived mesenchymal stem cell spheroids with chondrogenic media before incorporating them into the GelMA-PEGDA scaffold further promoted the regenerative capabilities of this *** findings demonstrate that this bioprinted scaffold not only supports cell viability and integration but also contributes to the restoration of disc height in a rat caudal disc model without inducing adverse inflammatory *** study underscores the potential of combining advanced bioprinting techniques and cell preconditioning strategies to develop effective treatments for IVD degeneration and other musculoskeletal disorders,highlighting the need for further research into the dynamic interplay between cellular migration and the hydrogel matrix.

关键词： intervertebral disc regeneration 3D bioprinting gelatin-based hydrogels mesenchymal stem cell spheroids tissue engineering

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A Missing Key to Understand the Electrical Resonance and the Mechanical Property of Neurons: a Channel-Membrane Interaction Mechanism

arXiv

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arXiv 2023年

作者： Yu, Shoujun Guo, Tianruo Yue, Wenji Tsai, David Tai, Yanlong Song, Bing Wang, Hao China Graduate School of Biomedical Engineering University of New South Wales SydneyNSW2052 Australia

The recent study of the interaction between the fatty acyl tails of lipids and the K+ channel establishes the connection between flexoelectricity and the ion channel's dynamics, named Channel-Membrane Interaction ...

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Undulating Seal Whiskers Evolved Optimal Wavelength-to-Diameter Ratio for Efficient Reduction in Vortex-Induced Vibrations (Adv. Sci. 2/2024)

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ADVANCED SCIENCE 2024年第2期11卷 e2304304页

作者： Kamat, Amar M. Zheng, Xingwen Bos, Julian Cao, Ming Triantafyllou, Michael S. Kottapalli, Ajay Giri Prakash Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Discrete Technology and Production Automation Group Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA USA MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA

Seals are well-known for their remarkable hydrodynamic trail-following capabilities made possible by undulating flow-sensing whiskers that enable the seals to detect fish swimming as far as 180 m away. In this work, the form-function relationship in the undulating whiskers of two different phocid seal species, viz. harbor and gray seals, is studied. The geometry and material properties of excised harbor and grey seal whiskers are systematically characterized using blue light 3D scanning, optical and scanning electron microscopy, and nanoindentation. The effect of the undulating geometry on the whiskers’ vibration in uniform water flow is studied using both experimental (piezoelectric MEMS and 3D-printed piezoresistive sensors developed in-house) and numerical (finite element method) techniques. The results indicate that the dimensionless ratio of undulation wavelength to mean whisker diameter (λ/Dm) in phocid seals may have evolved to be in the optimal range of 4.4–4.6, enabling an order-of-magnitude reduction in vortex-induced vibrations (compared to a similarly-shaped circular cylinder) and, consequently, an enhanced flow sensing capability with minimal self-induced noise. The results highlight the importance of the dimensionless λ/Dm ratio in the biomimetic design of seal whisker-inspired vibration-resistant structures, such as marine risers and wake detection sensors for submarines.

关键词： 3D printing biological fluid dynamics biomimetics microelectromechanical systems (MEMS) seal whiskers vortex-induced vibrations

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Emerging natural hemp seed proteins and their functions for nutraceutical applications

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Food Science and Human Wellness 2023年第4期12卷 929-941页

作者： Haihong Chen Bing Xu Yi Wang Wei Li Dong He Yan Zhang Xizhen Zhang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Chemical Engineering and Energy Technology Engineering Research Center of Health Food Design&Nutrition RegulationKey Laboratory of Healthy Food Development and Nutrition Regulation of China National Light IndustryDongguan University of TechnologyDongguan 523808China Hebei Food Inspection and Research Institute Shijiazhuang 050091China College of life Science and Technology Guangxi UniversityNanning 530004China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

With changing dietary habits and increasing awareness of the nutraceutical role of dietary foods,the demand for natural plant proteins and interest in non-traditional protein sources in the food industry are *** hemp,belonging to the plant family Cannabaceae,is cultivated for its fibre and edible *** to its nutritional value,it has also been used in the food industry and *** particular,hemp seed proteins have drawn considerable attention in both scientific and industrial fields because of their excellent nutraceutical values,superior digestibility,low allergenicity and diverse techno-functional *** this review,we provide a summary of the current research progress on the extraction and purification processes,physiochemical properties,nutraceutical functions,and applications of hemp seed *** in the application of advanced technologies for hemp seed bioactive peptide mining are also *** review provides up-to-date insights into the nutraceutical values,health benefits,and future applications of this emerging plant source protein.

关键词： Hemp seed protein Extraction Purification Physicochemical properties Nutraceutical functions Food industry

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Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking

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Food Science and Human Wellness 2025年第2期14卷 450-468页

作者： Junyu Liu Zhengyang Song Haihong Chen Wen Zeng Guirong Han Wei Li Bing Xu Yuan Lu Canyang Zhang Zhenglian Xue Bin Lü Chong Zhang Song Yang Yi Wang Xinhui Xing MOE Key Laboratory for Industrial Biocatalysis Centre for Synthetic and Systems BiologyDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518055China Anhui University of Technology Maanshan 243002China Yunnan Shujian Tea Co. Ltd.Kunming 650000China Shandong Province Key Laboratory of Applied Mycology Qingdao International Center on Microbes Utilizing BiogasSchool of Life SciencesQingdao Agricultural UniversityQingdao 266109China

Pu-erh tea,a traditional Chinese beverage,performs an anti-obesity function,but the correlation between its components and efficacy remains ***,we screened two Pu-erh teas with significant anti-obesity efficacies from 11 *** vitro experiments revealed that lipid accumulation in L02 cells and lipid synthesis in 3T3-L1 cells were significantly better inhibited by Tea-B than *** in vivo experiments using model mice revealed that the differences in chemical components generated two pathways in the anti-obesity efficacy and mechanism of Pu-erh ***-A changes the histomorphology of brown adipose tissue(BAT)and increases the abundance of Coriobacteriaceae_UCG_002 and cyclic AMP in guts through high chemical contents of cyclopentasiloxane,decamethyl,tridecane and 1,2,3-trimethoxybenzene,eventually increasing BAT activation and fat browning gene expression;the high content of hexadecane and 1,2-dimethoxybenzene in Tea-B reduces white adipose tissue(WAT)accumulation and the process of fatty liver,increases the abundance of Odoribacter and sphinganine 1-phosphate,inhibits the expression of lipid synthesis and transport *** mechanistic findings on the association of the representative bioactive components in Pu-erh teas with the anti-obesity phenotypes,gut microbes,gut metabolite structure and anti-obesity pathways,which were obtained for the first time,provide foundations for developing functional Pu-erh tea.

关键词： Anti-obesity Bioactive components Lipid metabolism Multiomics analysis Pu-erh tea

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Simultaneous imaging of shallow and deep tissues based on multi-line scanning

Simultaneous imaging of shallow and deep tissues based on mu...

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Photonics in Dermatology and Plastic Surgery 2024

作者： Yoneyama, Naoshi Nakazawa, Sota Iyanagi, Kanta Tanihata, Yusuke Mori, Ryotaro Machida, Manabu Kennedy, Gordon T. Durkin, Anthony J. Kagawa, Keiichiro Graduate School of Integrated Science and Technology Shizuoka University Hamamatsu432-8011 Japan Faculty of Engineering Shizuoka University Hamamatsu432-8011 Japan Faculty of Engineering Kindai University Hiroshima739-2116 Japan Beckman Laser Institute University of California Irvine United States Biomedical Engineering Department University of California Irvine United States Research Institute of Electronics Shizuoka University Hamamatsu432-8011 Japan

ISBN: (纸本)9781510668911

We report a quantitative tissue imagining method that combines spatial frequency domain imaging (SFDI) and near-infrared spectroscopy (NIRS) by using an illumination of multiple scanned lines. SFDI is suitable for measuring superficial and shallow tissues (-1 and the NIRS processing for the line pitches of 0.625-10mm. The images by SFDI for higher spatial frequencies depicted the shallower blood vessels. In those by NIRS, the contrast of the deeper blood vessels was enhanced for the larger line pitches. © 2024 SPIE.

关键词： Tissue

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Resolving p53 to Create Clinically-Relevant Mutation Models

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1087-1090页

作者： Solares, Maria J. Jonaid, G.M. Kelly, Deborah F. Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Department of Biomedical Engineering Pennsylvania State University University Park PA United States Center for Structural Oncology Pennsylvania State University University Park PA United States Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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