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Research progress on classification, sources and functions of dietary polyphenols for prevention and treatment of chronic diseases

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Journal of Future Foods 2023年第4期3卷 289-305页

作者： Wei Li Haihong Chen Bing Xu Yi Wang Canyang Zhang Yong Cao Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China b Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China College of Food Science South China Agricultural UniversityGuangzhou 510642China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Dietary polyphenols are the most abundant antioxidants in daily diet and widely distributed in plants and plant-based foods,including vegetables,fruits,cereals,nuts,and beverages(e.g.,tea,coffee,red wine).Over the past decades,there has been rising scientific interest in their diverse benefits to human health,since dietary polyphenols display various bioactivities,such as antioxidant activity,anti-inflammatory activity,anticancer,anti-microbial activity,neuro-protective activity,among *** studies have demonstrated that diet with polyphenols is strongly related to decrease the risk of chronic *** this review,firstly,we systematically summarize classification and sources of dietary polyphenols,and focus on the current evidences defining their function and mechanism on improving chronic diseases,including diabetes,obesity,hypertension,***,future directions of dietary polyphenols are ***,despite the physiological effects of dietary polyphenols have been widely convinced in vitro and in vivo,human trials show inconsistent evidence with their beneficial effects in chronic diseases administration,so as to their unclear molecular *** clinical studies are needed to provide clear evidence on dietary polyphenols against chronic *** general,this paper provides comprehensive review of the sources and compositions of dietary polyphenols from plant materials,and presents an overview of the evidence on dietary polyphenols against chronic diseases,which may offer some constructive inspirations for further research on dietary polyphenols and industrial application in the food and medicine industry.

关键词： Dietary polyphenols Source Chronic diseases Diabetes Obesity Hypertension Hyperuricemia

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Essential oils and its antibacterial,antifungal and anti-oxidant activity applications:A review

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Food Bioscience 2022年第3期47卷 145-160页

作者： Tianyu Hou Siva Sankar Sana Huizhen Li Yun Xing Anima Nanda Vasudeva Reddy Netala Zhijun Zhang School of Chemical Engineering and Technology North University of ChinaTaiyuan030051China Jinzhong Institute of Industrial Technology and Innovation North University of ChinaJinzhong030600China Graduate School of Humanities Nagoya UniversityNagoya464-8601Japan Department of Biomedical Engineering Sathyabama Institute of Science and TechnologyChennaiTamilnaduIndia

Essential oils (EOs) seem to be more versatile and consist of a variety of volatile and organic biological active substances that are also employed as the better substitutes in the bacteria,fungal and various food *** researchers have done detailed research about the antibacterial property of essential oils and their respective *** several pioneering works in the past have explained the mode of action of some compounds,an extensive understanding of most of the substances and their molecular mechanisms is still *** particular,the bioactivity characteristics of EOs were evaluated by the main components found in *** components were commonly utilized in the applications of bactericidal,fungicidal,medicinal and antioxidant *** oils bioactivity can be contrasted with the behavior of pharmaceutical formulations which are produced ***,essential oils are showing promise organic extracts that require further analysis in the nutrition or pharmaceutical companies for potential applications as supplements,additives or *** of their diverse activities like antifungal and antibacterial characteristics,essential oils may be utilized as alternate additives to improve the grain and seed shelf *** review aims to provide a summary of existing information on the antibacterial and antifungal properties of EOs,their mechanism,and ingredients in identifying the areas of study that can promote the implementation in various bacterial and fungal properties.

关键词： Essential oils Terepnoids Antibacterial activity Antifungal activity Antioxidant activity

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Optimizing Trading Strategies in Quantitative Markets Using Multi-Agent Reinforcement Learning

Optimizing Trading Strategies in Quantitative Markets Using ...

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Hengxi Zhang Zhendong Shi Yuanquan Hu Wenbo Ding Ercan E. Kuruoğlu Xiao-Ping Zhang Shenzhen International Graduate School Tsinghua University Shenzhen China Department of Electrical Computer and Biomedical Engineering Ryerson University Toronto Canada

Quantitative markets are characterized by swift dynamics and abundant uncertainties, making the pursuit of profit-driven stock trading actions inherently challenging. Within this context, Reinforcement Learning (RL) — which operates on a reward-centric mechanism for optimal control — has surfaced as a potentially effective solution to the intricate financial decision-making conundrums presented. This paper delves into the fusion of two established financial trading strategies, namely the constant proportion portfolio insurance (CPPI) and the time-invariant portfolio protection (TIPP), with the multi-agent deep deterministic policy gradient (MADDPG) framework. As a result, we introduce two novel multi-agent RL (MARL) methods: CPPI-MADDPG and TIPP-MADDPG, tailored for probing strategic trading within quantitative markets. To validate these innovations, we implemented them on a diverse selection of 100 real-market shares. Our empirical findings reveal that the CPPI-MADDPG and TIPP-MADDPG strategies consistently outpace their traditional counterparts, affirming their efficacy in the realm of quantitative trading.

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Thermal dose Analysis for High Intensity Focused Ultrasound Applications in Continuous and Pulsed Mode 19

Thermal dose Analysis for High Intensity Focused Ultrasound ...

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19th Global Medical engineering Physics Exchanges/Pan American Health Care Exchanges, GMEPE/PAHCE 2025

作者： Taka, E.N. Sosa, M. Pereira, W.C.A. Cortela, G. Federal University of Rio de Janeiro Biomedical Engineering Program Rio de Janeiro Brazil University of the Republic Ultrasound Laboratory Montevideo Uruguay

ISBN: (纸本)9798331596965

Thermal ablation is a method used to cause tumor cell death by heating the tissue, and one way to achieve this is to use the heating properties of ultrasound with High Intensity Focused Ultrasound (HIFU). Thermal ablation with HIFU has been shown to be a noninvasive and effective approach to tumor treatment. There are different approaches to the application of HIFU, two of which are continuous and pulsed. To characterize these two modalities, a comparative analysis of the thermal dose (TD) achieved by continuous and pulsed HIFU is performed, keeping all the other parameters constant. The thermal dose is calculated from the temperatures measured using thermocouples inserted in ex vivo skeletal muscle tissue (SMT) samples, exposed to both modalities. A single element HIFU transducer with a f = 1.1 MHz (Sonic Concepts H-104 Transducer Series, O64 mm, WA, USA) is used to generate the ultrasound pulses. The continuous mode used consists of a single pulse of 20 s of duration;whereas the pulsed mode consists of two pulses of 10 s of duration separated by 5 s of dead time, during which there is no sonification. Both are excited with an input of 350 mV, resulting in an output power of 31 ± 1 W, this way the same amount of energy is deposited in the sample by both modalities. The TD model CEM43 was used to analyze the response of the sample to the continuous and pulsed HIFU, which is one of the most widely accepted for thermal dosimetry. The results show that the use of continuous HIFU achieves slightly higher temperatures than pulsed HIFU, but the difference becomes more notable in the calculated TD, being the dose of continuous HIFU several times the dose of pulsed HIFU. © 2025 IEEE.

关键词： Ultrasonic testing

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Phase Aberration Correction with Adaptive Coherence-Weighted Point Spread Function Restoration Filtering Technique

Phase Aberration Correction with Adaptive Coherence-Weighted...

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2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Shen, Wei-Hsiang Lin, Yu-An Li, Pai-Chi Li, Meng-Lin National Tsing Hua University Department of Electrical Engineering Hsinchu Taiwan National Taiwan University Insitute of Biomedical Electronics and Bioinformatics Institue of Medical Device and Imaging Graduate School of Advanced Technology Department of Electrical Engineering Taipei Taiwan National Tsing Hua University Institute of Photonics Technologies Brain Research Center Department of Electrical Engineering Hsinchu Taiwan

ISBN: (纸本)9798350346459

Phase aberration is an inherent side effect of ultrasound imaging due to the speed of sound inhomogeneity nature of human tissues, resulting in focusing error and reduced image contrast. This work introduces a phase aberration correction technique by leveraging a point spread function (PSF) restoration filter. A convolutional neural network (CNN) is used to estimate phase-aberrated PSFs and design the restoration filter. In addition, we incorporate coherence index weighting, derived from the restoration filtering, to further suppress sidelobe energy. Evaluation using Field II-simulated phantoms showed clearer cyst borders and reduced sidelobe energy leakage after PSF restoration and filter-derived coherence weighting, leading to improvement in image contrast and quality. © 2023 IEEE.

关键词： Optical transfer function

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Distributed Strain Sensing with Simple System Based on Slope-Assisted BOTDA Using Both Gain and Loss Spectra

Distributed Strain Sensing with Simple System Based on Slope...

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Optical Sensors, Sensors 2022

作者： Nonogaki, Hayato Saito, Daiki Hoshino, Kazuki Tanaka, Yosuke Zan, Mohd Saiful Dzulkefly Department of Biomedical Engineering Graduate School of Engineering Tokyo University of Agriculture and Technology 2-24-16 Naka-choKoganei Tokyo Japan Department of Electrical Electronic and Systems Engineering Faculty of Engineering and Built Environment Universiti Kebangsaan Malaysia UKM Selangor Bangi43600 Malaysia

We demonstrate real time distributed strain sensing by slope-assisted Brillouin optical time domain analysis using both loss and gain spectra, where the system is simplified by using deep intensity modulation and serr... 详细信息

ISBN: (纸本)9781557528209

关键词： Time domain analysis

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Thermal dose Analysis for High Intensity Focused Ultrasound Applications in Continuous and Pulsed Mode

Thermal dose Analysis for High Intensity Focused Ultrasound ...

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Pan American Health Care Exchanges, PAHCE

作者： E. N. Taka M. Sosa W. C. A. Pereira G. Cortela Biomedical Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Ultrasound Laboratory University of the Republic Montevideo Uruguay

ISBN: (数字)9798331596965

ISBN: (纸本)9798331596972

Thermal ablation is a method used to cause tumor cell death by heating the tissue, and one way to achieve this is to use the heating properties of ultrasound with High Intensity Focused Ultrasound (HIFU). Thermal ablation with HIFU has been shown to be a noninvasive and effective approach to tumor treatment. There are different approaches to the application of HIFU, two of which are continuous and pulsed. To characterize these two modalities, a comparative analysis of the thermal dose (TD) achieved by continuous and pulsed HIFU is performed, keeping all the other parameters constant. The thermal dose is calculated from the temperatures measured using thermocouples inserted in ex vivo skeletal muscle tissue (SMT) samples, exposed to both modalities. A single element HIFU transducer with a f = 1.1 MHz (Sonic Concepts H-104 Transducer Series, Ø64 mm, WA, USA) is used to generate the ultrasound pulses. The continuous mode used consists of a single pulse of 20 s of duration; whereas the pulsed mode consists of two pulses of 10 s of duration separated by 5 s of dead time, during which there is no sonification. Both are excited with an input of 350 mV, resulting in an output power of 31 ± 1 W, this way the same amount of energy is deposited in the sample by both modalities. The TD model CEM43 was used to analyze the response of the sample to the continuous and pulsed HIFU, which is one of the most widely accepted for thermal dosimetry. The results show that the use of continuous HIFU achieves slightly higher temperatures than pulsed HIFU, but the difference becomes more notable in the calculated TD, being the dose of continuous HIFU several times the dose of pulsed HIFU.

关键词： Temperature measurement Heating systems Temperature distribution Ultrasonic imaging Transducers Ultrasonic variables measurement Thermocouples Thermal analysis Monitoring Tumors

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Space Division Multiplexing Optical Coherence Tomography for Wide-field Angiographic Imaging of the Human Retina

Space Division Multiplexing Optical Coherence Tomography for...

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2024 Frontiers in Optics, FiO 2024

作者： Adkins, Aaron J. Hao, Senyue Ren, Chao Song, Andrew Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States

We have constructed a parallelized 4-channel multi-beam optical coherence tomography system capable of achieving high speed and wide field of view angiographic imaging of the retina. © Optica Publishing Group 202... 详细信息

关键词： Optical coherence tomography

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Evaluating Crosslinking Efficiency and Cytocompatibility of Three Commonly Used Photoinitiators Across Different Cell-Compatible Hydrogel Platforms

SSRN

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SSRN 2025年

作者： Gavish Moscovitz, Aya Simaan Yameen, Haneen Bar-Am, Orit Seliktar, Dror The Faculty of Biomedical Engineering Technion-Israel Institute of Technology Haifa Israel The Interdisciplinary Program in Biotechnology Technion–Israel Institute of Technology Haifa Israel

biomedical hydrogels that undergo a rapid liquid-to-solid phase transition often use a photopolymerization strategy to crosslink the polymer network. In applications such as 3D bioprinting or tissue engineering that involve cell-laden hydrogels, or where in-vivo polymerization is desired (i.e., in-situ), cytotoxicity of the hydrogel crosslinking reaction becomes an important issue. There are only a few cytocompatible photoinitiators (PIs) that are commonly used for crosslinking biomedical hydrogels, including Irgacure2959 (I2959), lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) and EosinY (EY). These PIs are illuminated at 365nm, 405nm and 525nm, respectively. The photopolymerization conditions, including PI concentration and illumination intensity may affect both the cytotoxicity of the reaction and the crosslinking of the hydrogel. Herein we tested these three PIs to optimize the maximum crosslinking efficiency while minimizing cell death associated with the photochemical reaction. Testing was performed on three different types of cell-compatible hydrogels used for cell encapsulation and 3D cell growth, including a synthetic material (poly(ethylene glycol)-diacrylate, PEG-DA), a semi-synthetic material (PEG-fibrinogen, PF) and a modified biological material (methacrylated fibrinogen, FibMA). Strain-rate controlled rheology was used to characterize the crosslinking reaction efficiency, both in terms of maximum shear storage modulus, G’, and crosslinking kinetics. Viability was examined on human dermal fibroblasts in 3D culture within photopolymerized PF hydrogels crosslinked using each of the PIs. The results showed that PI concentration and the illumination intensity had significant impact on the crosslinking efficiency, with each material system demonstrating different responses to the PI parameters. Optimal photo-crosslinking conditions, considering both crosslinking efficiency and cell viability were not the same for the modified protein hydrogels, as co

关键词： Cell death

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An interdisciplinary approach to high school curriculum development: Swarming Powered by Neuroscience 12

An interdisciplinary approach to high school curriculum deve...

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12th IEEE Integrated STEM Education Conference, ISEC 2022

作者： Buckley, Elise Monaco, Joseph D. Schultz, Kevin M. Chalmers, Robert W. Hadzic, Armin Zhang, Kechen Hwang, Grace M. Carr, M. Dwight United States Department of Biomedical Engineering School of Medicine JHU United States Jhuapl United States Computer Vision Researcher Formerly Jhuapl United States Biomedical Engineering School of Medicine Jhu United States Jhuapl Johns Hopkins University Kavli Neuroscience Discovery Institute United States Program Manager Stem Program Management Office Jhuapl United States

ISBN: (纸本)9781665484299

This article discusses how to create an interactive virtual training program at the intersection of neuroscience, robotics, and computer science for high school students with equity of access. A four-day microseminar, titled Swarming Powered by Neuroscience (SPN), was conducted virtually through a combination of presentations and interactive computer game simulations. The SPN microseminar was delivered by subject matter experts in neuroscience, mathematics, multi-agent swarm robotics, and education. The objective of this research was to determine if taking an interdisciplinary approach to high school education would enhance the students learning experiences in fields such as neuroscience, robotics, or computer science. This study found an improvement in student engagement for neuroscience by 16.6%, while interest in robotics and computer science improved respectively by 2.7% and 1.8%. The majority of students (64%) strongly agreed that they enjoyed learning from an interdisciplinary team of experts and 70% strongly agreed that the microseminar emphasized the need to have instruction teams with diverse disciplinary backgrounds. The curriculum materials, developed for the SPN microseminar, can be used by high school teachers to further evaluate interdisciplinary instructions across life and physical sciences and computer science. © 2022 IEEE.

关键词： Curricula

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