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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Qiao, Laicong Guo, Tianruo Xue, Ruier Sang, Rui Yang, Danting Deng, Fei Unsw Graduate School of Biomedical Engineering Tyree Institute of Health Engineering Sydney Australia Ningbo University School of Medicine China

ISBN: (纸本)9798350371499

Cytokines, essential regulatory proteins orchestrating various physiological processes and immune responses, play a pivotal role in assessing health status. Conventional cytokine detection methods, such as enzyme-linked immunosorbent assays, are reliable but time-consuming. Electrochemical aptamer-based sensors offer rapid response and higher selectivity, but fall short of achieving non-invasive detection. This study addresses these limitations by introducing a novel approach to improve cytokine detection performance. We employ a one-step electrodeposition method to synthesize and coat structured gold nanoparticles (Au NPs) onto a working electrode, optimizing surface morphology by manipulating applied voltage, deposition time, and reactant concentrations. The resulting nanostructured Au NPs exhibit diverse and previously unreported morphologies. Leveraging these advancements, we design a wearable device integrating the Au NPs-based sensor with structure-switch aptamers on a microfluidic chip. This wearable sensor shows a limit of detection of 0.3 pg/mL and a larger linear range of 0.3-100 pg/mL. This innovation allows for the non-invasive and continuous detection of cytokines, marking a significant step towards the development of wearable electrochemical biosensors for health *** Relevance - This research provides a novel wearable sensor for non-invasive continuous monitoring of cytokine IFN-γ from human sweat. This innovation holds immense clinical relevance, offering real-time insights into early disease responses and the onset of non-communicable health conditions. The advancement of wearable electrochemical biosensors, exhibiting enhanced performance, addresses a crucial need in clinical practice. This development offers a versatile and efficient tool for patient-friendly health monitoring, marking a significant step forward in the field. © 2024 IEEE.

关键词： Clinical research

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Heartbeat Classification Using MLP and Random Forest Techniques 9th

Heartbeat Classification Using MLP and Random Forest Techni...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Ortiz, Carlos A. L. Nadal, Jurandir Biomedical Engineering Program University Federal of Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494031

This work aims at presenting a method for heartbeat classification based on multi-layer perceptron (MLP) and random forest (RF) techniques applied to the first difference of ECG signals. From the MIT-BIH Arrhythmia Database, each annotated P-QRS segment was extracted, low-pass filtered, and the first-order difference was used as input for the neural networks. The MLP and Random Forest were used to obtain a model for classifying the heartbeats. The results were compared with other algorithms existing in the literature, and the model developed produced good results and noticed improvements when using the first difference. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： Low pass filters

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Variable Length Multi-Objective Whale Optimization for Trust Aware Data Gathering in Wireless Sensor Network

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IEEE Access 2025年 13卷 32100-32121页

作者： Saad, Mohammed Ayad Jaafar, Rosmina Chellappan, Kalaivani Faculty of Engineering and Built Environment Department of Electrical Electronics and System Engineering Selangor Bangi43600 Malaysia Al-Kitab University Department of Medical Instrumentations Technique Engineering Kirkuk36001 Iraq Universitas Airlangga Biomedical Engineering Study Program Faculty of Science and Technology Surabaya60115 Indonesia

Efficient data collection in wireless sensor networks (WSNs) is crucial. While traditional approaches rely on stationary data sinks, the use of mobile sinks, like unmanned aerial vehicles (UAVs), has shown promise in enhancing data-gathering capabilities. However, existing methods often overlook the importance of trust, leaving the network susceptible to malicious or faulty nodes. To address this issue, we propose a novel trust-aware data-gathering algorithm, Variable Length Multi-Objective Whale Optimization Data Gathering (VLMOWO-DG). Our algorithm simultaneously optimizes energy consumption, delay, and trust while employing mobile sinks to collect data from sensor nodes. By considering trust as a key performance metric, we improve data reliability and security. The VLMOWO-DG algorithm introduces flexibility through variable-length solution representation and application-oriented operators, allowing for efficient exploration of the solution space. Simulation results demonstrate that our proposed algorithm significantly outperforms established benchmarks, NSGA-II and NSGA-III, in terms of domination and hypervolume. This leads to a remarkable improvement of 200% in data gathering performance. © 2015 The Authors.

关键词： Data collection

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Heartbeat Classification Based on PCA and CNN 9th

Heartbeat Classification Based on PCA and CNN

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Ramalho, Tatiane C. Ortiz, Carlos A. L. Abrantes, Leonardo A. A. Nadal, Jurandir Biomedical Engineering Program University Federal of Rio de Janeiro Rio de Janeiro Brazil

ISBN: (纸本)9783031494031

This work presents a method for automatic heartbeat classification based on principal component analysis and a convolutional neural network on ECG signals. We developed a database holding the first ten principal components and the relative RR intervals of P-QRS complexes from the MIT-BIH Arrhythmia Database patients. The convolutional neural network was used to obtain a model for classifying heartbeats based on this database. This model was tested and compared to other algorithms existing in the literature, and the results evidenced the relative advantages of the method. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： Principal component analysis

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Recent development in multizonal scaffolds for osteochondral regeneration

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Bioactive Materials 2023年第7期25卷 122-159页

作者： Le Yu Sacha Cavelier Brett Hannon Mei Wei Department of Chemical and Biomolecular Engineering Ohio UniversityAthensOH45701USA Biomedical Engineering Program Ohio UniversityAthensOH45701USA Department of Mechanical Engineering Ohio UniversityAthensOH45701USA

Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral *** contrast to the current surgical approaches which yield only short-term relief of symptoms,tissue engineering strategy has been shown more promising outcomes in treating OC defects since its emergence in the *** particular,the use of multizonal scaffolds(MZSs)that mimic the gradient transitions,from cartilage surface to the subchondral bone with either continuous or discontinuous compositions,structures,and properties of natural OC tissue,has been gaining momentum in recent *** the latest developments in the field,this review offers a comprehensive summary of recent advances,current hurdles,and future perspectives of OC repair,particularly the use of MZSs including bilayered,trilayered,multilayered,and gradient scaffolds,by bringing together onerous demands of architecture designs,material selections,manufacturing techniques as well as the choices of growth factors and cells,each of which possesses its unique challenges and opportunities.

关键词： Multizonal scaffolds Osteochondral regeneration Fabrication Cells Growth factors

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In-vitro analysis of neo-sinus flow dynamics after transcatheter aortic valve replacement using particle image velocimetry technique

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Journal of Biorheology 2023年第2期37卷 162-169页

作者： Xu, Xuetong Hattori, Kaoru Ai, Ryusuke Iwasaki, Kiyotaka Department of Integrative Bioscience and Biomedical Engineering Graduate School and Advanced Science of Engineering Waseda University Tokyo1628480 Japan Waseda Research Institute for Science and Engineering Waseda University Tokyo1698555 Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University Tokyo1628480 Japan Cooperative Major in Advanced Biomedical Sciences Joint Graduate School of Tokyo Women’s Medical University and Waseda University Waseda University Tokyo1628480 Japan

Particle imaging velocimetry (PIV) is an effective methodology for investigating flow in the neo-sinus after transcatheter aortic valve replacement. However, understanding fluid dynamics in the lower part of the neo-sinus has been challenging due to limited optical access. In this study, we developed a novel PIV technique to extensively visualize the neo-sinus and to assess the potential risk of transcatheter heart valve (THV) leaflet thrombosis with the intra-annular valve. This technique involved shooting in the sinus and neo-sinus via the ventral wall of the aortic silicone model to visualize a larger region of the neo-sinus, including the lower portions (overlooking-view shooting). In the neo-sinus, stagnated flow was observed throughout the entire region in middle and late diastole. By contrast, in the native sinus, low-velocity vortical flow that inflows into the coronary artery was developed exclusively in the upper region. The present results suggest that the lower portion of the native sinus, as well as the neo-sinus, may be at high risk for leaflet thrombosis. The novel PIV technique holds promise for revealing influences of fluid dynamics on THV leaflet thrombosis with various stent flame designs. © 2023, Japanese Society of Biorheology. All rights reserved.

关键词： Velocity measurement

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Smartphone-Integrated Reverse Lens Hemocount Microscope for Red Blood Cell Imaging

Smartphone-Integrated Reverse Lens Hemocount Microscope for ...

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2023 International Conference on Electrical engineering and Informatics, ICEEI 2023

作者： Izzrufi, Mochammad Izzrul Zakaria, Hasballah Bandung Institute of Technology Biomedical Engineering Study Program Bandung Indonesia

ISBN: (纸本)9798350381290

Anemia, a prevalent global medical condition affecting approximately 33% of the world's population in 2015 and 32% of Indonesian adolescents in 2018, is characterized by a reduction in red blood cell count or hemoglobin levels, resulting in diminished oxygen-carrying capacity within the bloodstream. The conventional method for detecting anemia involves Complete Blood Count (CBC), which demands specialized hematology analyzers and substantial time. In response to these constraints, the Hemocount, a portable microscope utilizing the reverse lens technique, was developed to capture high-quality images of red blood cells. This innovative approach requires blood sample standardization for optimal Hemocount performance. The technique involves inverting the mobile camera lens, aligning the sensor focus with the sample, while a preparation table and light source illuminate from below. Experiments with various lens, table, and light source configurations identified the optimal setup as employing the front camera lens from an iPhone 5s, a transparent table, and a cool white light source, yielding a digital image resolution of 42.19 nm/px. This resolution allows for blood cell detection within the size range of 165.92 px to 189.62 px. For optimal results when using Hemocount, a recommended blood concentration of 50% minimizes standard deviation, while concentrations of 30% maximize the correlation coefficient R, and 25% yield clear images by preventing red blood cell enlargement due to osmosis. © 2023 IEEE.

关键词： Light sources

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Comparative Analysis of Photoplethysmogram (PPG) Waveform Characteristics Across Various Body Sites Under Normal and Apneic Conditions 46

Comparative Analysis of Photoplethysmogram (PPG) Waveform Ch...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Rahme, Joe Saleh, Sahera Al-Sadek, Tamara Amatoury, Jason Khraiche, Massoud American University of Beirut Biomedical Engineering Program Beirut Lebanon American University of Beirut Department of Electrical Engineering Beirut Lebanon

ISBN: (纸本)9798350371499

Detecting sleep apnea through wearable devices poses challenges due to the condition's variability across populations and the inconsistencies in measurements attributed to current wearable technologies. This study aims at comparing photoplethysmogram (PPG) waveform characteristics in healthy subjects, including the change in amplitude, width, and time to peak (Tp) of the signal. PPG signals were recorded at six different body sites (wrist upper, wrist lower, ring finger, thumb, neck, and head) under both simulated normal and apneic conditions. A key objective of this work was to identify optimal LED intensities for detecting these waveform features at each site, providing valuable insights for future development of PPG hardware by pinpointing the most effective intensities. Additionally, the research aims for a better understanding of the variation of the PPG waveform between different body sites. © 2024 IEEE.

关键词： Photoplethysmography

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Adjustable polymer dispersed liquid crystal grating

Adjustable polymer dispersed liquid crystal grating

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

作者： Huang, Hsuan-Han Li, Yu-Jen Huang, Chiu-Chang Kuan, Chieh-Hsiung Graduate Institute of Electronics Engineering Department of Electrical Engineering National Taiwan University Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics Department of Electrical Engineering National Taiwan University Taiwan

The double-period grating structure is integrated in a polymer dispersed liquid crystal (PDLC) device and guides the arrangement of PDLC droplets. The grating period is changed by electronic control. CLEO 2024 © ... 详细信息

ISBN: (纸本)9781957171395

关键词： Electrooptical effects

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Adjustable polymer dispersed liquid crystal grating

Adjustable polymer dispersed liquid crystal grating

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CLEO: Science and Innovations in CLEO 2024, CLEO: S and I 2024 - Part of Conference on Lasers and Electro-Optics

关键词： Liquid crystals

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