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IEEE Asia-Pacific Conference on Geoscience, Electronics and Remote Sensing Technology (AGERS)

作者： Vi Bauty Riska Utami Heroe Wijanto Miftadi Sudjai Graduate Program of Regulation and Management of Telecommunication School of Electrical Engineering Telkom University Bandung Indonesia The University Center of Excellence for Intelligent Sensing-IoT School of Electrical Engineering Telkom University Bandung Indonesia Center of Excellence in Biomedical and Healthcare Technology School of Electrical Engineering Telkom University Bandung Indonesia

ISBN: (数字)9798331543105

ISBN: (纸本)9798331543112

Current satellite technology has developed rapidly from traditional satellites to High Throughput Satellite (HTS) because it offers the advantages of multibeam antennas and reuse frequencies. Nevertheless, intersystem interference exists. This study discusses Co-Channel Interference (CCI) in the 4-reuse color scheme on an 8-beam GSO HTS with Ku-band frequencies in Indonesia. The analysis was conducted by analyzing the link budget and capacity before and after interference on the user communication side, forward downlink, and return uplink. The results of the link budget before CCI, Carrier to Noise ratio or C/N on Beam 1 to 8 ranging from 23.34 dB to 23.50 dB. And C/N on the return uplink is 18.74 dB to 19.07 dB. Then after interference, the Carrier to Noise plus Interference Ratio or C/(N+I) on the forward downlink produces 11.96 dB to 12.15 dB. While the return uplink produces C/(N+I) of 13.91 to 14.05 dB for Beam 1 to Beam 8. Because CCI decreases signal quality, the total capacity decreases where the forward downlink before interference produces 8.99 Gbps to 4.74 Gbps. The return uplink capacity of 7.09 Gbps due to interference becomes 5.27 Gbps. The purpose of further research recommendations is to analyze CCI on other reuse color schemes with a more significant number of beams and analyze appropriate mitigation techniques.

关键词： High-temperature superconductors Satellite antennas Satellites Image color analysis Prevention and mitigation Downlink Throughput Ku-band Uplink Interchannel interference

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Biological Tissue Analysis by Mid-infrared Photoacoustic Spectroscopy Using Piezoelectric Transducer

Biological Tissue Analysis by Mid-infrared Photoacoustic Spe...

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Pacific Rim Conference on Lasers and Electro-Optics (CLEO/Pacific Rim)

作者： Ryota Sasaki Saiko Kino Yuji Matsuura Graduate School of Biomedical Engineering Tohoku University Sendai Miyagi Japan

A piezoelectric photoacoustic spectroscopy system detecting ultrasound induced by irradiation of mid-infrared laser light is developed. A photoacoustic spectrum of human skin was obtained and an investigation to impro...

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Polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: a novel approach to ovarian cancer therapy

RSC Pharmaceutics

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RSC Pharmaceutics 2025年第3期2卷 553-569页

作者： Wagner, Angela M. Lanier, Olivia L. Savk, Ani Peppas, Nicholas A. McKetta Department of Chemical Engineering The University of Texas at Austin Austin TX United States Institute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Austin TX United States Department of Biomedical Engineering The University of Texas at Austin Austin TX United States Department of Chemical and Biological Engineering University of New Mexico Albuquerque NM United States Department of Biomedical Engineering University of New Mexico Albuquerque NM United States Cancer Therapeutics Program University of New Mexico Comprehensive Cancer Center Albuquerque NM United States Department of Surgery and Perioperative Care Dell Medical School University of Texas at Austin Austin TX United States Department of Pediatrics Dell Medical School University of Texas at Austin Austin TX United States Division of Molecular Pharmaceutics and Drug Delivery College of Pharmacy The University of Texas at Austin Austin TX United States

Ovarian cancer is one of the leading causes of cancer-related deaths in women, with limited progress in treatments despite decades of research. Common treatment protocols rely on surgical removal of tumors and chemotherapy drugs, such as paclitaxel and carboplatin, which are capable of reaching cancer cells throughout the body. However, the effectiveness of these drugs is often limited due to toxic reactions in patients, nonspecific drug distribution affecting healthy cells, and the development of treatment resistance. In this study, we introduce a polybasic nanogel system composed of poly(diethylaminoethyl methacrylate-co-cyclohexyl methacrylate)-g-poly(ethylene glycol) designed for the targeted co-delivery of paclitaxel and carboplatin directly to ovarian cancer cells. These nanogel systems can respond to the cellular microenvironment to achieve controlled, on-demand drug release, reducing off-target effects and enhancing therapeutic uptake. Additionally, we investigated nanoparticle degradation and controlled drug release as a function of various crosslinkers, including tetraethylene glycol dimethacrylate, bis(2-methacryloyl)oxyethyl disulfide, poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)dimethacrylate, and polycaprolactone dimethacrylate. Our results, using OVCAR-3 human ovarian cancer cells, demonstrated that this dual-delivery system outperformed free drugs in inducing cancer cell death, representing a promising advance in the field of nanoparticle-based therapies for ovarian cancer. By loading two chemotherapeutic agents into a single, environmentally responsive particle, this approach shows the potential to overcome common resistance mechanisms and achieve more effective tumor suppression. In summary, by delivering chemotherapy more precisely, it may be possible to enhance therapeutic outcomes while minimizing toxicity and nonspecific drug distribution, ultimately improving patient quality of life. © 2025 RSC.

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Cardiac Fibroblast-Mediated ECM Remodeling Regulates Maturation in an in vitro Cardiac Bundle Developmental Model

SSRN

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SSRN 2024年

作者： Jang, Yongjun Kang, Myeongjin Kang, Yong Guk Lee, Dongtak Jung, Hyo Gi Yoon, Dae Sung Kim, Jongseong Park, Yongdoo Department of Biomedical Sciences College of Medicine Korea University Seoul Korea Republic of School of Biomedical Engineering Korea University Seoul Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul Korea Republic of

Cardiac fibroblasts play an important role in heart homeostasis, regeneration, and disease by producing extracellular matrix (ECM) proteins and remodeling enzymes. Under normal conditions, fibroblasts exist in a quiescent state and maintain homeostasis, such as tissue structure and ECM turnover. However, if they become activated upon stimuli, such as injury, aging, or mechanical stress, which can lead to disease through excessive cell proliferation and ECM production. In addition to studying fibroblasts in disease progression, their role in cardiac maturation during development and whether the mechanism of cytokine and ECM production is similar to that observed during disease progression is unclear. In this study, we examined the functional and structural maturation of cardiac tissue by modulating fibroblast activity using an in vitro model of cardiac bundle formation. In this model, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and human cardiac fibroblasts (CFBs) were co-cultured in a fibrin gel and their morphology, beating characteristics, beating force, and mRNA expression profiles were analyzed. The results indicated that the cardiac bundle model matured structurally and functionally through tissue contraction and collagen deposition by fibroblasts, whereas inhibition of these ECM remodeling reduced maturation. In particular, the expression of second harmonic generation (SHG) and COL1A revealed that while activated fibroblasts induce structural maturation through sustained collagen deposition, excessive collagen accumulation can reduce functional maturation. Our data suggest that collagen type I expression by cardiac fibroblasts is essential for myocardial tissue maintenance and development through ECM remodeling. Furthermore, the regulation of collagen deposition by fibroblast activity is a crucial factor that influences cardiac development and disease progression. © 2024, The Authors. All rights reserved.

关键词： Stem cells

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Towards a single-use, low-cost endoscope for gastroenterological diagnostics

Towards a single-use, low-cost endoscope for gastroenterolog...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Alysja Woods Chi Cong Nguyen Muhammad Saif Ul Islam Nigel H Lovell Thanh Nho Do David Tsai Graduate School of Biomedical Engineering UNSW Sydney Australia Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Australia School of Electrical Engineering & Telecommunications UNSW Sydney Australia

Early diagnosis and treatment of diseases in the gastrointestinal (GI) tract including colorectal cancers (CRC) via natural orifices have led to a significant increase in patient survival rates. Most screening procedures utilize image-guided techniques via a conventional endoscope. The cost of conventional endoscopes is substantial, ranging in the tens of thousands of USD or more. This presents significant burden for developing countries, which are disproportionally affected by gastroenterological diseases. Conventional endoscopes also require sterilization between use. This increases the chance of cross-infection between patients. To address these problems, this paper introduces a soft endoscope with a disposable insertion tube that can be articulated. This prototype device is hydraulically actuated, capable of a 10 mm bend radius and 180-degree bend angle. The camera system provides 110 degrees field-of-view. The component parts of this disposable endoscope costs less than 200 *** relevance—Our low-cost, single-use endoscope eliminates the sterilization step required by conventional systems, thereby reducing the risks of infection and lowering the operating costs. There is also significant scope for our device to be used beyond the human GI track, such as screening for lung or bladder cancers. Given the compact footprint, the minimal cost of the disposable parts, the proposed platform can widen cancer screening programs with quantifiable economic benefit for many patients, particularly those in developing countries.

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A Reliable Kinematic Measurement of Upper Limb Exoskeleton for VR Therapy with Visual-inertial Sensors

A Reliable Kinematic Measurement of Upper Limb Exoskeleton f...

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IEEE/ASME (AIM) International Conference on Advanced Intelligent Mechatronics

作者： Thomas M. Kwok Tong Li Haoyong Yu Integrative Sciences and Engineering Programme NUS Graduate School National University of Singapore Singapore Dept. of Biomedical Engineering National University of Singapore Singapore

Virtual reality (VR) is a powerful technology that provides a structured and safe environment for ADL training, allowing patients to have a similar experience as real-world training. However, a limited robot sensing system is proven reliable for such training. The effectiveness of current robot sensors was limited due to inherent technical problems, such as the installation challenges of encoders and IMU’s drifting, acceleration, and magnetic issues. Thus, we propose a novel and reliable sensing system consisting of absolute rotary encoders and visual-inertial sensors for the upper-limb exoskeleton in VR therapy. Our sensing system has demonstrated angle measurement for various robot joint types, including hinge, ball, and revolute joints along the limb’s longitudinal axis. Its sensing feedback can construct virtual arms that interact with virtual objects in the VR environment. In our experiments, with Vicon as the ground truth, our visual-inertial sensors achieved root-mean-square errors smaller than 2.3491° and a strong correlation (r ≥ 0. 9640, p < 0. 001). Additionally, the experiment result of seven healthy subjects indicated that subjects had similar muscle activations, joint ROM, and joint trajectories in the VR task with our sensing system, compared with the real-world task. Thus, our proposed sensing system can potentially be used in the upper-limb exoskeleton for VR therapy.

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Multiplexed Implantable 'Barcode' Platform for Continuous Oxygen and Glucose Monitoring

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IEEE Sensors Journal 2024年

作者： Chen, Zheyuan Falohun, Tokunbo Kameoka, Jun Mcshane, Michael J. Texas A&M University Department of Biomedical Engineering College StationTX77843 United States Texas A&M University Department of Electrical and Computer Engineering College StationTX77843 United States Waseda University Graduate School of Information Production and Systems Fukuoka808-0135 Japan Texas A&M University Department of Biomedical Engineering Department of Materials Science and Engineering College StationTX77843 United States

Multianalyte biosensors have been of interest in various applications, especially in healthcare areas that target a broad range of biomarkers related to various pathological diseases. However, successful examples of such sensors generally utilize electrochemical transducers, a fact which limits their use as implants due to the presence of interferents in vivo, the difficulty of transdermal signal transduction, and the difficulty of miniaturizing the electronics into an integrated biocompatible form factor suitable for implantation. In this study, we demonstrate an attractive alternative for multiplexed sensing platform based on oxidoreductase enzymes coupled with optically distinct oxygen-sensitive metalloporphyrin phosphors which are immobilized within nanofilm-coated alginate microparticles;these are embedded in discrete compartments of a single miniature biocompatible hydrogel to achieve a 'barcode' sensor device. Continuous multiplex oxygen and glucose monitoring were demonstrated through the measurement of phosphorescence lifetime changes of the metalloporphyrin phosphors when exposed to different environmental conditions. The phosphorescence lifetime exhibited a negative correlation with increases in oxygen concentration for all compartments. In contrast, the oxygen-responsive assays maintained a constant phosphorescence lifetime and the glucose-responsive assays showed increased phosphorescence lifetime when the glucose concentration increased from 0 to 400 mg/dL. This observation confirmed the desired behavior without any apparent crosstalk between the adjacent oxygen- and glucose-responsive compartments. Furthermore, the sensors demonstrated high stability during repeated glucose challenges over 10 cycles. These findings suggest that the hydrogel barcode optical sensing platform has potential for use in various situations requiring multiplexed chemical analysis such as in continuous medical monitoring. © 2001-2012 IEEE.

关键词： Phosphorescence

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Light Gradient Boosting Machine-Based Fatality Prediction of Single-Vehicle Motorcycle Crashes

Light Gradient Boosting Machine-Based Fatality Prediction of...

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IEEE International Conference on Communication, Networks and Satellite (ComNetSat)

作者： Dodi Zulherman Jia Yang Kosuke Shimizu Yasunari Yokota Graduate School of Engineering Gifu University Gifu Japan Dept. of Biomedical Engineering Telkom University Purwokerto Indonesia Toyota Transportation Research Institute (formerly) Aichi Japan Faculty of Engineering Gifu University Gifu Japan

ISBN: (数字)9798350368086

ISBN: (纸本)9798350368093

In this study, we utilized the light gradient boosting machine (LightGBM) model for prediction analysis of single-vehicle motorcycle crash fatality in Japan. We develop the model using Japan’s traffic crash data from 2019 to 2022. Since the single-vehicle motorcycle crash dataset has an imbalanced distribution property between fatal and non-fatal accidents, it has difficulty predicting fatal cases due to predicting bias on non-fatal cases. To address this issue, we observed the effect of resampling techniques such as Synthetic Minority Oversampling Technique (SMOTE), Edited Nearest Neighbors (ENN), and SMOTE-ENN on the LightGBM prediction results. Furthermore, our LightGBM using Shapley additive explanations (SHAP) identified the most influential features in predicting single-vehicle motorcycle crash fatalities. The experiment based on evaluation metrics shows that combining LightGBM and resampling techniques significantly improved the model performance based on evaluation metrics such as accuracy, AUC, ROC curve and G-mean. This confirms the effectiveness of this approach in reducing the impact of the imbalanced dataset and improving single-vehicle motorcycle crash fatality predictions. Moreover, based on the SHAP value analysis, crash type, road alignment, collision manner, terrain, and motorcyclist age significantly affect the fatality of single-vehicle motorcycle crashes.

关键词： Measurement Analytical models Accuracy Satellites Roads Motorcycles Predictive models Boosting Data models Accidents

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Off-Stoichiometry Thiol-Ene (OSTE) Hollow Microneedle Array for Liquid Collection and Delivery

Off-Stoichiometry Thiol-Ene (OSTE) Hollow Microneedle Array ...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Yeqian Liu Haonan Li Zitao Feng Zejingqiu Chen Muyang Zhang Jie Zhou Qinghao He Huiru Zhang Tao Jiang Weijin Guo Department of Biomedical Engineering Shantou University Shantou China Department of Electronic Engineering Shantou University Shantou China Department of Biology Shantou University Shantou China Guangdong Foshan Lianchuang Graduate School of Engineering Foshan China

ISBN: (数字)9798350359831

ISBN: (纸本)9798350359848

As an emerging microtechnology, microneedles have been widely used for liquid sampling and drug delivery. Here, we fabricate a hollow microneedle array by diffraction lithography of OSTE, which can easily control the features of microneedles, including height, diameter, and pitch distance. Furthermore, we integrate the microneedle array with a soft PDMS microfluidic chip, which can generate negative pressure for liquid collection from the skin, as well as positive pressure for liquid delivery into the skin by finger pressure. In addition, we have tested the performance of the integrated chip in terms of repeatability and capacity. We believe this work can provide design guidelines for hollow microneedle chips used for sample collection from skin and drug delivery through skin.

关键词： Fabrication Liquids Nanoelectromechanical systems Fingers Point of care Lithography Skin

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Design a Multifunctional Software for the Analysis of Biomechanical Stability of Bipedal Stance

SSRN

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SSRN 2024年

作者： Al-Ghali, Basma A. Jaber, Hussain A. Al-Saffar, Mais O. Çankaya, Ilyas Department of Biomedical Engineering College of Engineering Al-Nahrain University Baghdad Iraq Electrical and Electronics Engineering Department Graduate School of Natural Science Ankara Yıldırım Beyazıt University Ankara Turkey

Understanding the mechanisms of postural control is quite important for the evaluation of balance and stability, especially within both clinical and research environments. Center of pressure (CoP) signal is the commonly used for the assessment of postural stability. As the CoP signal is non-stationary, its analysis and interpretation are often challenging for clinicians and researches as well. This article describes a novel design of a computer-based application used for the analysis of CoP during standing stability tests. The application combines both traditional and advanced analytical techniques to evaluate postural control. The software was developed using python (ver 3.7.6), and the graphical user interface was built using tkinter library. The proposed software is designed to provide powerful tools for pre-processing, analyzing and visualizing CoP data in an easy to use and platform independent computer application. The software provides flexibility in importing data for different file formats (as a coordinate trace in anterio-posterior and mediolateral direction), different sampling frequencies, and various options of data filtering using low-pass Butterworth filter. Analysis methods incorporates standard measures including the mean and standard deviation of CoP displacements, ranges, and velocities, length of sway path, and the area of 95 % confidence ellipse. Furthermore, other advanced measures including approximate entropy (ApEn), wavelet transform of spectra, and DFA. The results are visualized numerically and graphically (CoP path, confidence ellipse area, and DFA) using matplotlib library. In addition, the user can export the statistical results as a text format. Converted to a standalone executable file using PyInstaller, this software offers a portable solution for CoP analysis over various computing environments. By combining traditional measures with nonlinear analytical techniques, this tool provides researchers and clinicians with a comprehensive

关键词： Butterworth filters

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