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Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial

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Food Science and Human Wellness 2023年第5期12卷 1917-1923页

作者： Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang Department of Cosmetic Science and Institute of Cosmetic Science Chia Nan University of Pharmacy and ScienceTainan 71710China Research&Design Center TCI CO.Ltd.Taipei 114722China Institute of Food Safety and Risk Management Department of Food ScienceTaiwan Ocean UniversityKeelung 202301China Graduate Institute of Biomedical Engineering Chung Hsing UniversityTaichung 202301China

Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract(HappyAngel^(■))was used to treat human hair follicle dermal papilla cells(HFDPCs)and the expression of reactive oxygen species(ROS), dihydrotestosterone(DHT), and hair-related genes(SRD5A1, SRD5A2, AR, and KROX20)were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract(HappyAngel^(■))can stimulate hair growth and inhibit the activation of hair loss genes.

关键词： Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells

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The Impact of Oxygen Concentration on Interactions between Breast Cancer Cells and the Vascular Network

The Impact of Oxygen Concentration on Interactions between B...

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IEEE International Conference on Nano/Molecular Medicine and engineering (NANOMED)

作者： Satoshi Aratake Kenichi Funamoto Graduate School of Biomedical Engineering Tohoku University Sendai Japan Institute of Fluid Science Tohoku University Sendai Japan

Cancer cells can metastasize from the primary tumor to other organs by invading blood vessels and lymphatic vessels. The hypoxic conditions generated in a tumor microenvironment influence the growth of the cancer. However, few studies have focused on the interaction between cancer cells and the vascular network under different oxygen concentrations, a shortcoming that this study sought to address. In the experiments described here, breast cancer cells and cells that form the vascular networks (vascular endothelial cells and fibroblasts) were co-cultured in different channels in a microfluidic device, while controlling the oxygen concentration. We observed that growth of the cancer cells was strongly affected by the interaction with the vascular network, such that the number of cells migrating toward the vascular network increased under hypoxic conditions compared to the atmospheric oxygen concentration. Additionally, angiogenesis from the vascular network was observed under hypoxia with little change in the growth of the cancer cells.

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Identifying Prognostic Markers of Non-small Cell Lung Carcinoma Using Bioinformatics

Identifying Prognostic Markers of Non-small Cell Lung Carcin...

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International Conference on Industrial Instrumentation and Control,ICI2C 2021

作者： Khan, Siladitya Chakraborty, Debamitra Department of Biomedical Engineering University of Rochester RochesterNY14627 United States Goergen Institute for Data Science University of Rochester RochesterNY14627 United States Materials Science Graduate Program University of Rochester RochesterNY14627 United States

ISBN: (纸本)9789811670107

We present a transcriptomics pipeline for performing the functional analysis of array expression profiling data of normal and adenocarcinoma lung tissue. Our aims are twofold, firstly to elucidate molecular processes that transform normal tissue, to a lung adenocarcinoma. Following this, we perform functional analysis to screen potential hub genes and demonstrate their value in cancer prognosis. Analysis was performed on a total of 500 differentially expressed genes (DEG), screened for their regulation and transcriptional modulation in a female population carrying non–small cell lung carcinoma (NSCLC). Key pathways like cytokine-cytokine receptors, ECM receptor interactions, and TNF signaling were identified suggesting a potential role in lung tumorigenesis. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Bioinformatics

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Long-Term Photobiomodulation of Cellular and Mitochondrial Activities in IMR-32 Cells Using an 810 nm Light-Emitting Diode

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IEEE Journal of Selected Topics in Quantum Electronics 2023年第4期29卷 1页

作者： Hsieh, Huai-Ching Lee, Yi-Ju Sung, Kung-Bin Wei, An-Chi National Taiwan University Department of Life Science Department of Electrical Engineering Taipei106319 Taiwan National Taiwan University Graduate Institute of Biomedical Electronics and Bioinformatics Taipei106319 Taiwan National Taiwan University Department of Electrical Engineering Graduate Institute of Biomedical Electronics Bioinformatics and Molecular Imaging Center Taipei106319 Taiwan National Taiwan University Department of Electrical Engineering Graduate Institute of Biomedical Electronics and Bioinformatics Taipei106319 Taiwan

In photobiomodulation (PBM), biological tissues are stimulated using low-energy light. Mitochondria are thought to be integral to the process, and PBM effects vary with light parameters. Biphasic curves are commonly used to describe the dose response of PBM but do not fit in some cases. Dose-dependent PBM effects, especially mitochondrial responses, must be understood to optimize clinical therapies. However, most previous studies have reported short-term mitochondrial activity changes, neglecting long-term effects or dose-dependent changes in whole transcriptomes. We studied the effects of 3-day PBM with an 810 nm circular LED beam on human neuroblastoma IMR-32 cells. Two light doses with opposite effects on mitochondrial DNA copy number were chosen to analyze total RNA, protein content and function of mitochondrial respiratory complexes, and mitochondrial morphology. Daily 15-minute 810 nm light treatment enhanced drug resistance to the mitochondrial inhibitors and uncoupling agent via two distinct mechanisms: 1.40 mW/cm2 light increased cell proliferation and the proportion of cells in the cell cycle S phase;1.95 mW/cm2 light enhanced oxidative phosphorylation at the RNA, protein, and functional levels and the proportion of network-like mitochondria. Our findings reveal the complexity of PBM dose responses and provide insights into light-cell interactions. © 1995-2012 IEEE.

关键词： Proteins

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Relationship between short-term ozone exposure, cause-specific mortality, and high-risk populations: A nationwide, time-stratified, case-crossover study

Relationship between short-term ozone exposure, cause-specif...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Cinoo Kang Yejin Kim Jieun Oh Hyewon Yun Juyeon Yang Chaerin Park Sooyoung Kim Seoyeong Ahn Ayoung Kim Dohoon Kwon Jinah Park Ejin Kim Ho Kim Whanhee Lee Department of Public Health Sciences Graduate School of Public Health Seoul National University Seoul South Korea Graduate School of Data Science Pusan National University Busan South Korea School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan South Korea Department of Information Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan South Korea Institute of Health and Environment Graduate School of Public Health Seoul National University Seoul South Korea Research and Management Center for Health Risk of Particulate Matter Seoul Republic of Korea

Ground-level ozone is formed by chemical reactions between nitrogen oxides (NOx) and volatile organic compounds (VOC) under sunlight, primarily from industrial and vehicular emissions.

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Ground-level ozone is formed by chemical reactions between nitrogen oxides (NOx) and volatile organic compounds (VOC) under sunlight, primarily from industrial and vehicular emissions.

关键词： Volatile organic compounds Mortality Cardiac arrest biomedical measurement Aging Chemical reactions Air quality Nitrogen Bioinformatics

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Behavior of breast cancer cells under oxygen concentration gradients in a microfluidic device

Behavior of breast cancer cells under oxygen concentration g...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Satoshi Aratake Naoto Kawahara Kenichi Funamoto Graduate School of Biomedical Engineering Tohoku University Sendai Japan Institute of Fluid Science Tohoku University Sendai Japan

The tumor microenvironment (TME) is known as a chronic hypoxic environment, with spatiotemporal variation in oxygen concentration depending on the distance from blood vessels and the blood supply. In our previous studies, cancer cell behavior was observed under hypoxic conditions with spatial variation of oxygen concentration (oxygen concentration gradients); however, that under oxygen concentration gradients at low oxygen levels found in the TME has not been studied. In this study, we investigated the behavior of breast cancer cells at various oxygen concentration gradients, generated using a microfluidic device with oxygen concentration controllability. The results showed that cell distribution was altered in response to oxygen concentration, and tended to increase in a specific region at around 5% O 2 . Evaluation of changes in cell numbers due to proliferation, migration, and cell death indicated that proliferation strongly affected cell distribution.

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A CNN-based demultiplexing method for an interleaved signal multiplexing readout with a TOF-DOI brain PET detector

A CNN-based demultiplexing method for an interleaved signal ...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： M. Niu X. Jiang S. Huang Z. Chen Y. Zhao Y. Yang W. Huang H. Yang X. Zhang Z. Deng Z. Gu Shenzhen Bay Laboratory Institute of Biomedical Engineering Shenzhen China Nanchang University Nanchang China Peking University Shenzhen Graduate School Shenzhen China

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

A prototype PET system for human brain-dedicated PET imaging (named N-PET) is being developed at Shenzhen Bay Laboratory, which uses multi-resolution TOF-DOI detectors. High resolution PET imaging systems require a significantly large number of readout channels, which increase the system complexity, power consumption, heat production, and cost. In this study, we investigate an interleaved signal multiplexing readout that utilizes the characteristic light-sharing pattern of depth-encoding N-PET detector modules. In this study, we proposed a demultiplexing method using a CNN model, which was trained by 16 channel synthetic multiplexed signals and 64-channel ground-truth data. The CNN model used in this work was a typical U-net model. We reduced the number of layers in the network and decreased the number of kernels in each convolutional layer for shrinking the paths. The CNN input is a $4 \times 4$ matrix representing the integrated charges of the 16 -channel outputs from the multiplexing circuit. The output is an $8 \times 8$ matrix representing the original 64 -channel demultiplexed data. By using the CNN predicted 64-channel data, all crystals could be clearly resolved in the flood images. Energy spectrum of the detector obtained by the sum of the multiplexed 16-channel data and the sum of the CNN predicted 64-channel data were similar. The average DOI resolution obtained by measured and CNN predicted data were 4.1 and 3.9 mm. In the future, timing resolution using this signal multiplexing circuit will be studied. The proposed demultiplexing method provides an alternative approach for the development of N-PET system, potentially bringing benefits in terms of commercial viability, power efficiency, and cost-effectiveness.

关键词： Demultiplexing Semiconductor device measurement Image resolution Semiconductor detectors Energy resolution Prototypes Production

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Development and Clinical Evaluation of a Five-Fingered Myoelectric Prosthetic Hand with Pattern Recognition 4

Development and Clinical Evaluation of a Five-Fingered Myoel...

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4th IEEE Global Conference on Life Sciences and Technologies, LifeTech 2022

作者： Kuroda, Yuki Tsujimoto, Tatsuki Shimada, Takayoshi Yabuki, Yoshiko Bai, Dianchun Yamanoi, Yusuke Jiang, Yinlai Zhu, Jinying Yokoi, Hiroshi The University of Electro-Communications Graduate School of Informatics and Engineering Tokyo Japan Shenyang University of Technology School of Electrical Engineering Shenyang China The University of Electro-Communications Center for Neuroscience and Biomedical Engineering Tokyo Japan Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing China

ISBN: (纸本)9781665419048

This study reports the development of a five-fingered myoelectric prosthetic hand with a pattern recognition function. This hand is lightweight (330 gw) and has a mechanism by which the fingers absorb external force, preventing damage and making it safe to use. In addition, it includes electromyography sensors for robust measurements and a recognition stabilization filter to deal with the computational performance limitation of the controller. We applied this prosthetic hand to subjects and evaluated its discrimination and task performance. © 2022 IEEE.

关键词： Palmprint recognition

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Development of a Computational Model For ECT Stimulation Titration

Development of a Computational Model For ECT Stimulation Tit...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Joanne Flood Socrates Dokos Colleen Loo Graduate School of Biomedical Engineering University of New South Wales Sydney Australia The Black Dog Institute University of New South Wales Sydney Australia

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Electroconvulsive Therapy (ECT) is an effective treatment for treatment-resistant depression and other neurological illnesses. Nevertheless, the precise mechanism by which the dosage and stimulation configuration of ECT induce seizures in the brain remains unknown. Our objective is to create a computational model for ECT titration dosing and determine the relationship between seizure threshold, stimulus dosage, and individual head structure. We use a first-order differential equation combined with realistic head structures from magnetic resonance images of 7 participants. The ECT electric potential distribution was simulated for each head model using the COMSOL 6.1 finite element software. Reasonable predictions were achieved using a simple first-order RC electric circuit, successfully forecasting the seizure threshold for 5 out of 7 participants. Nevertheless, it is notable that one participant was titrated for a much longer period, potentially triggering an additional inhibitory mechanism not accounted for. The inclusion of non-linear dynamics further enhances predictions. The study revealed a time constant of approximately 0.5–3 seconds, indicating a non-ionic membrane component underlying seizure initiation. More probable mechanisms might be a transient rise in the permeability of the blood-brain barrier or the buildup of neurotransmitters. In conclusion, seizure threshold during ECT titration can be predicted using a finite element head model coupled with first-order dynamics.

关键词： Electric potential Head Computational modeling Brain modeling Magnetic heads Mathematical models Biomembranes Software Finite element analysis Transient analysis

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Evaluation of a new type of semi-monolithic DOI detector with different surface treatments

Evaluation of a new type of semi-monolithic DOI detector wit...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Y. Zhao M. Niu W. Huang X. Zhao H. Yang Z. Zhang Q. Ren W. He Z. Gu Shenzhen Bay Laboratory Institute of Biomedical Engineering Shenzhen China Shenzhen Graduate School Peking University Shenzhen China

A new type of semi-monolithic detector design, comprised of rows of pixelated crystals coupled to monolithic slabs using optical adhesive, is proposed. The semi-monolithic detector presents several advantages, including high precision in three-dimensional event localization, high detection efficiency, and simplified calibration. Moreover, this design has simple manufacturing process and low *** identify the optimal surface treatments for achieving high-quality flood images and high DOI resolution, the performance of five semi-monolithic detectors with different surface treatments were evaluated. Each prototype detector consists of two layers, and each layer consists of a 1 × 16 array of 1.53 × 1.03 × 0 mm3 LYSO crystals (1.61 mm pitch) and a monolithic slab of 5.84 × 0.5 × 0 mm3. The detectors were fabricated with either polished or unpolished crystal surfaces, and using different inter-crystal reflectors and optical adhesive of different refractive indexes (RI). Preliminary experimental studies in this work show that when the two optical coupling surfaces of the detector are unpolished and high-refractive optical adhesive is used, accurate two-dimensional position resolution and high DOI resolution can be obtained. The crystals in the prototype detectors can be clearly resolved except for the edge area. The optimal average DOI resolution and energy resolution are 6 mm and 11.5% FWHM, *** conclusion, the experimental results demonstrated the potential of the prototype semi-monolithic DOI detector for high spatial resolution PET imaging.

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