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International Conference on Applied System Innovation (ICASI)

作者： Nisar Ahmad Yao-Tien Chen International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan

ISBN: (数字)9798350394924

ISBN: (纸本)9798350394931

Medical image segmentation plays a crucial role in identifying and analyzing anatomical structures in medical images. This requires an accurate medical segmentation tool to delineate and quantitatively analyze the target regions, diagnose any abnormality, and assist in treatment planning. Deep learning approaches have emerged as a promising solution for automating medical segmentation. However, challenges arise when dealing with the complex shapes and spatial variations of some target regions, especially in 3D MRI scans. To deal with such transformations, specific techniques are required to properly analyze and preprocess the dataset and perform image filtering to provide better features for improved prediction performance of deep learning architectures. This study focuses on improving brain tumor segmentation in multimodal 3D MRI images. We observed significant improvements in multimodal brain tumor segmentation results (accuracy, IoU, and mIoU) using an optimized 3D Gabor filter, which helps extract meaningful features. Multichannel input images were preprocessed to remove noise and select an appropriate resolution to reduce computational complexity. An improvement in mean Intersection over Union (mIoU) from 0.714 to 0.804 and accuracy from 0.982 to 0.991 were achieved, which shows a major improvement. This work contributes to the field of medical image segmentation by offering an improved and efficient approach for brain tumor analysis in 3D MRI scans, potentially aiding in diagnosis and treatment planning.

关键词： Deep learning Image segmentation Solid modeling Three-dimensional displays Magnetic resonance imaging Feature extraction Planning

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Facile synthesis of cobalt, nickel and manganese-based metal organic framework derived layered double hydroxides on Ni foam as effective binder-free electrodes of energy storage devices

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Journal of Energy Storage 2024年 78卷

作者： Kuo, Tsung-Rong Huang, Jing-Mei You, Xiang-Yu Subbiramaniyan, Kubendhiran Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Metal organic framework (MOF) derivatives have attracted intensive attention as the active material of energy storage devices. Layered double hydroxide (LDH) with large surface area, high redox capability and good cycling stability is regard as one of efficient active materials. Developing MOF-derived LDH with multiple metals can possibly achieve excellent surface properties, high electrical conductivity and abundant redox reactions. However, synthesizing MOF-derived LDH is time-consuming and requires high temperature environments. In this work, a simple and time-effective precipitation and etching process is proposed to synthesize MOF-derived LDH on nickel foam (NF) as binder-free electrodes of energy storage devices. The cobalt, nickel and manganese are utilized to design MOF-derived LDH with different metal species and numbers. The trimetallic MOF-derived LDH based on Co, Ni and Mn presents a high specific capacitance (CF) of 1113.7 F/g at 20 mV/s, due to abundant electroactive sites and multiple redox states for carrying out large numbers of redox reactions. The energy storage device composed of the trimetallic MOF-derived LDH and carbon on NF as electrodes presents the maximum energy density of 61.5 Wh/kg at the power density of 750 W/kg, and the CF retention of 92.5% and Coulombic efficiency of 95% after 10,000 charge/discharge cycles. © 2023 Elsevier Ltd

关键词： Electrodes

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Effects of pilates exercises on radiographic lumbo-pelvic alignment and range of motion in non-specific low back pain patients

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Journal of Bodywork and Movement Therapies 2024年 38卷 339-345页

作者： Huang, Ching Hsieh, Yueh-Ling Chou, Li-Wei Wang, Jaw-Lin Chien, Andy Department of Physical Therapy Taoyuan General Hospital Ministry of Health and Welfare Taoyuan Taiwan Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University Taichung Taiwan Department of Physical Medicine and Rehabilitation China Medical University Hospital Taichung Taiwan Department of Physical Medicine and Rehabilitation Asia University Hospital Asia University Taichung Taiwan Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan

Objectives: To determine the effects of Pilates exercises on lumbo-pelvic alignment in non-specific low back pain (NSLBP) patients. Methods: Twenty-two patients (Male:7;Female:15) with NSLBP aged 20–65 years were recruited and classified based on a modified O'Sullivan's classification system into flexion pattern (FP) or active extension pattern (EP) groups. Oswestry Disability index (ODI), Roland-Morris Disability Questionnaire (RMDQ) as well as radiographic lumbar global range of motion (ROM) and lumbo-pelvic alignment were measured Pre- and immediately post-intervention and at 6- and 12-month. The intervention included supervised six-weeks Pilates program with 60 min per session and up to two sessions per week. Results: Lumbar lordosis, sacral slope and sacral inclination were found to be significantly different between the FP and EP groups based on the O'Sullivan's classification system. However, despite the significant changes in RMDQ (p = 0.001), no significant changes were found for any of the alignment parameters (p > 0.05) post intervention for both groups. For lumbar global ROM, a statistically significant change was observed for the EP group (p = 0.028) but not for the FP group (p = 0.249). No significant correlations were identified between any of the self-reported outcomes, radiographic alignment and ROM parameters. Conclusions: Patients self-perceived long-term functional improvements based on responding to questionnaires after Pilates exercises were not reflected in significant changes in lumbo-pelvic alignment or lumbar ROM. This may be due to the current cohort demonstrating within normal ranges due to the lesser severity of their condition, but further research is needed for clarification. © 2024 Elsevier Ltd

关键词： Low back pain O'Sullivan's classification Pilates Radiography

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Prediction of Therapy Response in Patients with NSCLC based on CT Images 2022

Prediction of Therapy Response in Patients with NSCLC based ...

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4th International Conference on Intelligent Medicine and Image Processing, IMIP 2022

作者： Zhang, Xianru Liu, Lixin Chen, W.E.I. Yang, Fengchang Qiao, X.U. Chen, Yen-Wei Department of Biomedical Engineering School of Control Science and Engineering Shandong University China School and Hospital of Stomatology Shandong University China Department of Radiology Shandong Cancer Hospital and Institute Cheeloo College of Medicine Shandong University China Graduate School of Information Science and Engineering Ritsumeikan University Japan

ISBN: (纸本)9781450396202

Lung cancer has the highest mortality rate, and patients with non-small cell lung cancer (NSCLC) account for 75% to 80% of these cases. Treatment response varies greatly among patients. Therefore, there is significant clinical value in predicting the therapy efficacy for patients. In this paper, we investigated the therapy efficacy prediction model based on CT images, including traditional radiomics methods and deep learning models in 2D and 3D. The model based on ResNet18 showed predictive performance and outperformed the conventional radiomics models in prediction. © 2022 ACM.

关键词： Forecasting

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A Ripple-Based Constant On-Time Controlled DC-DC Buck Converter with Inductor Current Sensing Technique

A Ripple-Based Constant On-Time Controlled DC-DC Buck Conver...

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IEEE International Symposium on Circuits and Systems (ISCAS)

作者： Sheng-Jen Cheng Chieh-Ju Tsai Sheng-Yu Wang Wei-Yi Liu Chung-Ping Chen Graduate Institute of Electronics Engineering National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan

This letter implements a ripple-based constant on-time (RBCOT) buck converter with a fast transient response fabricated in the TSMC $0.18 \mu \mathrm{m}$ CMOS process. The steady-state measurement shows that this chip can regulate output voltage from 0.9V to 1.8V while the input voltage is set at 3.3V and the output load current varies from 0.1A to 1A. The load transient response shows that when the output voltage is 0.9V, the undershoot voltage is 78m V and the overshoot voltage is 126m V. The settling time is $2.8\mu \mathrm{s}$ for a step-up load and $2.5\mu \mathrm{s}$ for a step-down load. The chip area is 0.922 mm2, The maximum efficiency is 92.32%. This work improves the traditional inductor current ramp compensation technique. Here, we utilize an accurate transconductance amplifier to amplify the inductor current, increasing system stability and efficiency. By adopting negative inductor current feedback to improve the transient response. Through the V 2 controlled dual loop structures to eliminate the output dc voltage offset issues.

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Design of a surgical instrument to locally excise liver tissue 4

Design of a surgical instrument to locally excise liver tiss...

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4th IEEE Global Conference on Life Sciences and Technologies, LifeTech 2022

作者： Higashi, Takuya Aihara, Hiroki Funahashi, Misa Hidaka, Masaaki Kosaka, Taiichiro Eguchi, Susumu Endo, Chiaki Tsuchiya, Jun Moromugi, Shunji Chuo Univercity Graduate School of Science and Engineering Tokyo Japan Chuo Univercity Department of Electrical Electronic and Comunication Engineering Tokyo Japan Nagasaki University Garaduate School of Biomedical Sciences Nagasaki Japan Takashima Sangyo Co. Nagano Japan

ISBN: (纸本)9781665419048

The authors proposed a new surgical instrument that can cut a target region of the liver from the surface into a cylindrical shape and remove a tumor with less loss of liver tissue. The instrument has a unique mechanism that drives the four blades three-dimensionally, alternating between cutting and coagulation. In order to confirm the effectiveness of the proposed mechanism, a desktop experimental prototype was manufactured. Through an experiment on a pig liver using a prototype, it was shown that the target portion can be excised into a cylindrical shape as expected by the proposed mechanism. © 2022 IEEE.

关键词： Surgical equipment

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From biomimicry to bioelectronics:Smart materials for cardiac tissue engineering

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Nano Research 2020年第5期13卷 1253-1267页

作者： Olurotimi A.Bolonduro Breanna M.Duffy Akshita A.Rao Lauren D.Black Brian P.Timko Department of Biomedical Engineering Tufts UniversityMedfordMassachusetts 02155USA Department of Cell Molecular&Developmental BiologySchool of Graduate Biomedical SciencesTufts UniversityMassachusetts 02111USA

Effective strategies in cardiac tissue engineering require matrices that recapitulate the mechanical,topographic and electrical cues present in the native extracellular *** this review,we discuss recent efforts in materials science and nanotechnology to achieve functional three-dimensional(3D)scaffolds that modulate and monitor cardiac tissue *** consider key design considerations,including choice of biopolymer matrix,cell sources,and delivery methods for eventual *** then discuss how solid-state nanomaterials may be integrated within these systems to provide unique electrical and nanotopographic cues that improve electromechanical *** describe how these approaches may be extended to complex,spatially heterogeneous constructs using 3D bioprinting ***,we describe how scaffold materials may be augmented with bioelectronic components to achieve hybrid myocardium that monitors or controls electrophysiological ***,these approaches provide a framework for achieving cardiac tissues with tunable,rationally-designed *** discuss future prospects and remaining challenges for clinical translation.

关键词： cardiac tissue engineering extracellular matrix nanomaterial bioelectronics cyborg

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New Perspectives on Non-invasive Blood Pressure Measurement

New Perspectives on Non-invasive Blood Pressure Measurement

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Ahmadreza Argha Branko G. Celler Andy Yong Imants Rubenis Mark Butlin Alberto Avolio Graduate School of Biomedical Engineering The Tyree Institute of Health Engineering (IHealthE) and the Ageing Future Institute UNSW Sydney Biomedical Systems Research Laboratory School of Electrical Engineering and Telecommunication UNSW Sydney Concord Repatriation Hospital Cardiology University of Sydney Faculty of Medicine Sydney Department of Biomedical Sciences Faculty of Medicine Health and Human Sciences Macquarie University Sydney

Noninvasive blood pressure (NIBP) devices are calibrated against validated auscultation sphygmomanometers using Korotkoff sounds. This study aimed to investigate the timing of Korotkoff sounds in relation to pulse appearance in the brachial artery and values of intra-arterial blood pressure. Experiments were carried out on 15 participants, (14 males, 64.3 ± 10.4 years; one female, 86 yo), undergoing coronary angiography. A conventional occluding cuff, with a microphone for Korotkoff sounds, was placed on the upper arm (on the brachial artery). Intra-arterial blood pressure (IABP) was measured below the cuff with a fluid-filled catheter inserted via the radial artery and an external transducer. Finger photoplethysmography was used to measure brachial pulse wave velocity (PWV). Korotkoff sounds were processed electronically and custom algorithms identified the cuff pressure (CP) at which the first and last Korotkoff sounds were heard. PWV and max slope of the IABP pressure pulse were recorded to estimate arterial stiffness. The brachial artery closed at a CP of 132.0 ± 17.1 mmHg. Systolic and diastolic blood pressure (SBP and DBP) were 147.6 ± 14.3 and 72.7 ± 10.1 mmHg; mean pressure (MP, 100.1 ± 10.4 mmHg) was similar to MP derived from the peak of the oscillogram (98.5 ± 13.6 mmHg). Difference between IABP and CP recorded at first and last occurrence of Korotkoff sounds were, SBP: 19.0 ± 8.3 (range 2-29) mmHg, DBP: 4.0 ± 4.3 (range 2-12) mmHg. SBP derived from the onset of Korotkoff sounds can underestimate IABP by up to 19 mmHg. Since Korotkoff sounds are the recommended method mandated by the universal standard for the validation of blood pressure measuring devices, these errors are propagated through to all NIBP measurement devices irrespective of whether they use auscultatory or oscillometric methods.

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Impact of Environmental Carbon Dioxide Exposures on Sleep Latency Among Healthy Volunteers: A Randomized Order, Paired Crossover Study, Evidence from the Multiple Sleep Latency Test

SSRN

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SSRN 2024年

作者： Inada, Hitoshi Jin, Ruinian Momma, Haruki Ma, Dongmei Yuan, Keqing Nagatomi, Ryoichi Division of Biomedical Engineering for Health & Welfare Tohoku University Graduate School of Biomedical Engineering Miyagi Sendai980-8575 Japan Department of Medicine and Science in Sports and Exercise Tohoku University Graduate School of Medicine Miyagi Sendai980-8575 Japan Department of Biochemistry & Cellular Biology National Center of Neurology and Psychiatry Kodaira Tokyo187-8502 Japan

Background Daytime sleepiness affects work efficiency, occupational safety, and public health. Although previous studies have reported an association between environmental carbon dioxide (eCO2) and daytime sleepiness, it has been challenging to draw a firm conclusion due to the lack of standardized sampling and profiling protocols. Objective We examined the effect of eCO2 exposure on an objective measure of daytime sleepiness using a multiple sleep latency test (MSLT) in an environmentally controlled airtight chamber. Methods Eleven-volunteers were recruited and completed a 4-nap MSLT protocol in a soundproofed and temperature- and humidity-controlled room, and calculated the mean sleep latencies of four naps. On separate days, the participants underwent the MSLT under two conditions: the CO2 condition (4,851 ± 229 ppm) and the Control condition (1,102 ± 204 ppm), blinded to the group. Participants were required to perform a test unit such as the Stanford Sleepiness Scale (SSS) questionnaire, a 5-min Psychomotor Vigilance Test (PVT), and a 5-min Stroop test after each nap. We applied the mixed model with both factors between and within the subject to analyze primary outcomes. Results A significant reduction in sleep onset latency and higher SSS scores in the CO2 condition compared to the Control condition. No statistically significant effect on cognitive performance was observed after the CO2 exposure. Conclusion We reported here the final conclusion of eCO2 effect on daytime sleepiness based on the MSLT. Our results provide the first conclusive evidence that exposure to low levels of CO2 induces daytime sleepiness. © 2024, The Authors. All rights reserved.

关键词： Carbon dioxide

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Construction of Triboelectric Series and Chirality Detection of Amino Acids Using Triboelectric Nanogenerator

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Advanced Science 2024年第4期11卷 e2307266页

作者： Pal, Arnab Ganguly, Anindita Wei, Po-Han Barman, Snigdha Roy Chang, Chia-Chih Lin, Zong-Hong International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University 1001 University Road Hsinchu30010 Taiwan

Triboelectrification necessitates a frictional interaction between two materials, and their contact electrification is characteristically based on the polarity variance in the triboelectric series. Utilizing this fundamental advantage of the triboelectric phenomenon, different materials can be identified according to their contact electrification capability. Herein, an in-depth analysis of the amino acids present in the stratum corneum of human skin is performed and these are quantified regarding triboelectric polarization. The principal focus of this study lies in analyzing and identifying the amino acids present in copious amounts in the stratum corneum to explain their positive behavior during the contact electrification process. Thus, an augmented triboelectric series of amino acids with quantified triboelectric charging polarity by scrutinizing the transfer charge, work function, and atomic percentage is presented. Furthermore, the chirality of aspartic acid as it is most susceptible to racemization with clear consequences on the human skin is detected. The study is expected to accelerate research exploiting triboelectrification and provide valuable information on the surface properties and biological activities of these important biomolecules. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

关键词： Amino acids

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