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International Conference on Applied System Innovation (ICASI)

作者： Nisar Ahmad Yao-Tien Chen International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan

ISBN: (数字)9798350394924

ISBN: (纸本)9798350394931

Medical image segmentation plays a crucial role in identifying and analyzing anatomical structures in medical images. This requires an accurate medical segmentation tool to delineate and quantitatively analyze the target regions, diagnose any abnormality, and assist in treatment planning. Deep learning approaches have emerged as a promising solution for automating medical segmentation. However, challenges arise when dealing with the complex shapes and spatial variations of some target regions, especially in 3D MRI scans. To deal with such transformations, specific techniques are required to properly analyze and preprocess the dataset and perform image filtering to provide better features for improved prediction performance of deep learning architectures. This study focuses on improving brain tumor segmentation in multimodal 3D MRI images. We observed significant improvements in multimodal brain tumor segmentation results (accuracy, IoU, and mIoU) using an optimized 3D Gabor filter, which helps extract meaningful features. Multichannel input images were preprocessed to remove noise and select an appropriate resolution to reduce computational complexity. An improvement in mean Intersection over Union (mIoU) from 0.714 to 0.804 and accuracy from 0.982 to 0.991 were achieved, which shows a major improvement. This work contributes to the field of medical image segmentation by offering an improved and efficient approach for brain tumor analysis in 3D MRI scans, potentially aiding in diagnosis and treatment planning.

关键词： Deep learning Image segmentation Solid modeling Three-dimensional displays Magnetic resonance imaging Feature extraction Planning

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INTERNAL SKELETON MANIPULATION OF ENDOSKELETAL DROPLETS USING ACOUSTIC WAVES 25

INTERNAL SKELETON MANIPULATION OF ENDOSKELETAL DROPLETS USIN...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Shakya, Gazendra Yang, Tao Gao, Yu Fajrial, Apresio K. Borden, Mark A. Ding, Xiaoyun Department of Mechanical Engineering University of Colorado BoulderCO United States Biomedical Engineering Program University of Colorado BoulderCO United States

ISBN: (纸本)9781733419031

In this work, we report the microfluidic generation of anisotropic endoskeletal droplets and the manipulation of their internal structure using standing surface acoustic waves. Interestingly, the acoustic field drove attraction and aggregation of the liquid spheres and simultaneous rotation and repulsion of the solid disks inside them. This fascinating clustering behavior results in unique colloidal architectures. Additionally, it also allows for reversible manipulation of the solid disk between parallel and perpendicular orientations by varying the acoustic driving frequency. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Drops

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Development of non-contact body fluid volume measurement monitor with microwave

Transactions of Japanese Society for Medical and Biological ...

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Transactions of Japanese Society for Medical and Biological engineering 2020年第1期58卷 47-53页

作者： Kanamaru, Tomoya Ito, Yusei Akimoto, Toshinari Terada, Nobuyuki Graduate School of Science and Engineering Toyo University Japan Department of Biomedical Engineering College of Science and Engineering Toyo University Japan Faculty of Advanced Engineering Nippon Institute of Technology Japan Research Center for Biomedical Engineering Toyo University Japan

We developed a non-contact device that measures the volume of body fluids using microwave transmission. This device detects the phase difference between the radio waves that pass through the measurement target and the radio waves that do not pass through. When the radio waves pass through the water, the phase of the radio waves is delayed. The change in water volume cause phase differences, and our proposed device measures the relative temporal change of congestion without restraint. Deep vein thrombosis is caused by hypercoagulability, stagnation of blood flow, and vascular endothelial dysfunction. Remaining in a seated position for prolonged periods of time may cause deep vein thrombosis due to the stagnation of blood flow and may result in death. This device measures the volume of body fluids in the lower limbs. If venous congestion can be detected, we believe that the device will be developed as a new preventive measure for deep vein thrombosis. In this study, a subjectʼs lower leg was compressed with a cuff at a pressure of 60 mmHg for 5 min to induce venous congestion. We simultaneously measured the changes in phase difference and the changes in the outer diameter of the calf by our proposed device and a strain gauge. The results showed a strong correlation between the change in the phase difference and the change in the outer diameter of the calf. These findings suggest that the proposed device is able to measure the volume of body fluids without contact. Future work may explore the application of the device for measuring fluids in the lower body of individuals who sit for prolonged periods of time, including in e-sports. © 2020, Japan Soc. of Med. Electronics and Biol. engineering. All rights reserved.

关键词： Volume measurement

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Facile synthesis of cobalt, nickel and manganese-based metal organic framework derived layered double hydroxides on Ni foam as effective binder-free electrodes of energy storage devices

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Journal of Energy Storage 2024年 78卷

作者： Kuo, Tsung-Rong Huang, Jing-Mei You, Xiang-Yu Subbiramaniyan, Kubendhiran Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Metal organic framework (MOF) derivatives have attracted intensive attention as the active material of energy storage devices. Layered double hydroxide (LDH) with large surface area, high redox capability and good cycling stability is regard as one of efficient active materials. Developing MOF-derived LDH with multiple metals can possibly achieve excellent surface properties, high electrical conductivity and abundant redox reactions. However, synthesizing MOF-derived LDH is time-consuming and requires high temperature environments. In this work, a simple and time-effective precipitation and etching process is proposed to synthesize MOF-derived LDH on nickel foam (NF) as binder-free electrodes of energy storage devices. The cobalt, nickel and manganese are utilized to design MOF-derived LDH with different metal species and numbers. The trimetallic MOF-derived LDH based on Co, Ni and Mn presents a high specific capacitance (CF) of 1113.7 F/g at 20 mV/s, due to abundant electroactive sites and multiple redox states for carrying out large numbers of redox reactions. The energy storage device composed of the trimetallic MOF-derived LDH and carbon on NF as electrodes presents the maximum energy density of 61.5 Wh/kg at the power density of 750 W/kg, and the CF retention of 92.5% and Coulombic efficiency of 95% after 10,000 charge/discharge cycles. © 2023 Elsevier Ltd

关键词： Electrodes

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Effects of pilates exercises on radiographic lumbo-pelvic alignment and range of motion in non-specific low back pain patients

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Journal of Bodywork and Movement Therapies 2024年 38卷 339-345页

作者： Huang, Ching Hsieh, Yueh-Ling Chou, Li-Wei Wang, Jaw-Lin Chien, Andy Department of Physical Therapy Taoyuan General Hospital Ministry of Health and Welfare Taoyuan Taiwan Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University Taichung Taiwan Department of Physical Medicine and Rehabilitation China Medical University Hospital Taichung Taiwan Department of Physical Medicine and Rehabilitation Asia University Hospital Asia University Taichung Taiwan Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan

Objectives: To determine the effects of Pilates exercises on lumbo-pelvic alignment in non-specific low back pain (NSLBP) patients. Methods: Twenty-two patients (Male:7;Female:15) with NSLBP aged 20–65 years were recruited and classified based on a modified O'Sullivan's classification system into flexion pattern (FP) or active extension pattern (EP) groups. Oswestry Disability index (ODI), Roland-Morris Disability Questionnaire (RMDQ) as well as radiographic lumbar global range of motion (ROM) and lumbo-pelvic alignment were measured Pre- and immediately post-intervention and at 6- and 12-month. The intervention included supervised six-weeks Pilates program with 60 min per session and up to two sessions per week. Results: Lumbar lordosis, sacral slope and sacral inclination were found to be significantly different between the FP and EP groups based on the O'Sullivan's classification system. However, despite the significant changes in RMDQ (p = 0.001), no significant changes were found for any of the alignment parameters (p > 0.05) post intervention for both groups. For lumbar global ROM, a statistically significant change was observed for the EP group (p = 0.028) but not for the FP group (p = 0.249). No significant correlations were identified between any of the self-reported outcomes, radiographic alignment and ROM parameters. Conclusions: Patients self-perceived long-term functional improvements based on responding to questionnaires after Pilates exercises were not reflected in significant changes in lumbo-pelvic alignment or lumbar ROM. This may be due to the current cohort demonstrating within normal ranges due to the lesser severity of their condition, but further research is needed for clarification. © 2024 Elsevier Ltd

关键词： Low back pain O'Sullivan's classification Pilates Radiography

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Prediction of Therapy Response in Patients with NSCLC based on CT Images 2022

Prediction of Therapy Response in Patients with NSCLC based ...

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4th International Conference on Intelligent Medicine and Image Processing, IMIP 2022

作者： Zhang, Xianru Liu, Lixin Chen, W.E.I. Yang, Fengchang Qiao, X.U. Chen, Yen-Wei Department of Biomedical Engineering School of Control Science and Engineering Shandong University China School and Hospital of Stomatology Shandong University China Department of Radiology Shandong Cancer Hospital and Institute Cheeloo College of Medicine Shandong University China Graduate School of Information Science and Engineering Ritsumeikan University Japan

ISBN: (纸本)9781450396202

Lung cancer has the highest mortality rate, and patients with non-small cell lung cancer (NSCLC) account for 75% to 80% of these cases. Treatment response varies greatly among patients. Therefore, there is significant clinical value in predicting the therapy efficacy for patients. In this paper, we investigated the therapy efficacy prediction model based on CT images, including traditional radiomics methods and deep learning models in 2D and 3D. The model based on ResNet18 showed predictive performance and outperformed the conventional radiomics models in prediction. © 2022 ACM.

关键词： Forecasting

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A Ripple-Based Constant On-Time Controlled DC-DC Buck Converter with Inductor Current Sensing Technique

A Ripple-Based Constant On-Time Controlled DC-DC Buck Conver...

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IEEE International Symposium on Circuits and Systems (ISCAS)

作者： Sheng-Jen Cheng Chieh-Ju Tsai Sheng-Yu Wang Wei-Yi Liu Chung-Ping Chen Graduate Institute of Electronics Engineering National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan

This letter implements a ripple-based constant on-time (RBCOT) buck converter with a fast transient response fabricated in the TSMC $0.18 \mu \mathrm{m}$ CMOS process. The steady-state measurement shows that this chip can regulate output voltage from 0.9V to 1.8V while the input voltage is set at 3.3V and the output load current varies from 0.1A to 1A. The load transient response shows that when the output voltage is 0.9V, the undershoot voltage is 78m V and the overshoot voltage is 126m V. The settling time is $2.8\mu \mathrm{s}$ for a step-up load and $2.5\mu \mathrm{s}$ for a step-down load. The chip area is 0.922 mm2, The maximum efficiency is 92.32%. This work improves the traditional inductor current ramp compensation technique. Here, we utilize an accurate transconductance amplifier to amplify the inductor current, increasing system stability and efficiency. By adopting negative inductor current feedback to improve the transient response. Through the V 2 controlled dual loop structures to eliminate the output dc voltage offset issues.

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Design of a surgical instrument to locally excise liver tissue 4

Design of a surgical instrument to locally excise liver tiss...

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4th IEEE Global Conference on Life Sciences and Technologies, LifeTech 2022

作者： Higashi, Takuya Aihara, Hiroki Funahashi, Misa Hidaka, Masaaki Kosaka, Taiichiro Eguchi, Susumu Endo, Chiaki Tsuchiya, Jun Moromugi, Shunji Chuo Univercity Graduate School of Science and Engineering Tokyo Japan Chuo Univercity Department of Electrical Electronic and Comunication Engineering Tokyo Japan Nagasaki University Garaduate School of Biomedical Sciences Nagasaki Japan Takashima Sangyo Co. Nagano Japan

ISBN: (纸本)9781665419048

The authors proposed a new surgical instrument that can cut a target region of the liver from the surface into a cylindrical shape and remove a tumor with less loss of liver tissue. The instrument has a unique mechanism that drives the four blades three-dimensionally, alternating between cutting and coagulation. In order to confirm the effectiveness of the proposed mechanism, a desktop experimental prototype was manufactured. Through an experiment on a pig liver using a prototype, it was shown that the target portion can be excised into a cylindrical shape as expected by the proposed mechanism. © 2022 IEEE.

关键词： Surgical equipment

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Diopside-based bioactive glass-ceramic nanoparticles for osteoimmunomodulation

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Ceramics International 2025年

作者： Latt, Sun Sotoudehbagha, Pedram Cardenas, Valeria Larraza, Andres Razavi, Mehdi Cluster Department of Medicine University of Central Florida College of Medicine OrlandoFL32827 United States Burnett School of Biomedical Sciences University of Central Florida College of Medicine OrlandoFL32827 United States Department of Materials Science and Engineering University of Central Florida OrlandoFL32816 United States Biomedical Engineering Program Department of Mechanical and Aerospace Engineering University of Central Florida OrlandoFL32816 United States

The objective of this study was to develop and characterize an osteoimmunomodulatory diopside-based glass-ceramic nanoparticle synthesized using a sol-gel synthesis method. Hydroxyapatite nanoparticles were utilized as a gold standard control. X-ray diffraction, transmission electron microscopy, scanning electron microscopy equipped with energy dispersive spectroscopy, dynamic light scattering, and zeta-potential analysis were performed to characterize the crystalline phase, morphology, microstructure, composition, hydrodynamic size distribution, and surface charge, respectively. Weight loss, pH, and ion release were measured after immersion of glass-ceramic nanoparticles in simulated body fluid to evaluate the nanoparticle's biodegradation, showing ranges of Ca2+, Mg2+, and Si4+ ion release previously found to be osteogenic and angiogenic. Cytocompatibility with human bone-marrow-derived mesenchymal stem cells and murine RAW264.7 macrophages was studied using metabolic activity (MTT) and live/dead fluorescent assays, demonstrating dose-dependent cytotoxicity in RAW264.7 cells and excellent biocompatibility with mesenchymal stem cells. The effect of the nanoparticles on M1/M2 macrophage polarization potential was evaluated through ELISA and phase-contrast image analysis. Our glass-ceramic nanoparticle promoted greater M2-associated anti-inflammatory IL-1ra cytokine release than M1-associated pro-inflammatory TNF-α release compared to hydroxyapatite nanoparticles, though significant morphological changes were not observed. These results indicate that our glass-ceramic nanoparticle is a promising osteoimmunomodulatory biomaterial for bone regenerative applications. © 2025 Elsevier Ltd and Techna Group S.r.l.

关键词： Stem cells

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New Perspectives on Non-invasive Blood Pressure Measurement

New Perspectives on Non-invasive Blood Pressure Measurement

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Ahmadreza Argha Branko G. Celler Andy Yong Imants Rubenis Mark Butlin Alberto Avolio Graduate School of Biomedical Engineering The Tyree Institute of Health Engineering (IHealthE) and the Ageing Future Institute UNSW Sydney Biomedical Systems Research Laboratory School of Electrical Engineering and Telecommunication UNSW Sydney Concord Repatriation Hospital Cardiology University of Sydney Faculty of Medicine Sydney Department of Biomedical Sciences Faculty of Medicine Health and Human Sciences Macquarie University Sydney

Noninvasive blood pressure (NIBP) devices are calibrated against validated auscultation sphygmomanometers using Korotkoff sounds. This study aimed to investigate the timing of Korotkoff sounds in relation to pulse appearance in the brachial artery and values of intra-arterial blood pressure. Experiments were carried out on 15 participants, (14 males, 64.3 ± 10.4 years; one female, 86 yo), undergoing coronary angiography. A conventional occluding cuff, with a microphone for Korotkoff sounds, was placed on the upper arm (on the brachial artery). Intra-arterial blood pressure (IABP) was measured below the cuff with a fluid-filled catheter inserted via the radial artery and an external transducer. Finger photoplethysmography was used to measure brachial pulse wave velocity (PWV). Korotkoff sounds were processed electronically and custom algorithms identified the cuff pressure (CP) at which the first and last Korotkoff sounds were heard. PWV and max slope of the IABP pressure pulse were recorded to estimate arterial stiffness. The brachial artery closed at a CP of 132.0 ± 17.1 mmHg. Systolic and diastolic blood pressure (SBP and DBP) were 147.6 ± 14.3 and 72.7 ± 10.1 mmHg; mean pressure (MP, 100.1 ± 10.4 mmHg) was similar to MP derived from the peak of the oscillogram (98.5 ± 13.6 mmHg). Difference between IABP and CP recorded at first and last occurrence of Korotkoff sounds were, SBP: 19.0 ± 8.3 (range 2-29) mmHg, DBP: 4.0 ± 4.3 (range 2-12) mmHg. SBP derived from the onset of Korotkoff sounds can underestimate IABP by up to 19 mmHg. Since Korotkoff sounds are the recommended method mandated by the universal standard for the validation of blood pressure measuring devices, these errors are propagated through to all NIBP measurement devices irrespective of whether they use auscultatory or oscillometric methods.

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