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SSRN 2024年

作者： Lee, So-Hyeon Lee, Junsang Kim, Younghoon Kim, Ju-Young Ulsan44919 Korea Republic of Weldon School of Biomedical Engineering Purdue University West LafayetteIN47907 United States Graduate School of Semiconductor Materials and Devices Engineering UNIST Ulsan44919 Korea Republic of

Using instrumented indentation testing, we explore the measurement of surface residual stress in H-section steel beams produced through the quenching and self-tempering (QST) process. We establish a significant correlation between the plastic pile-up behavior observed during indentation and the magnitude of surface residual stress. We thoroughly clarify the distribution of plastic pile-up and residual stress, linking their variations to non-uniform phase transformation and changes in mechanical properties resulting from the QST process. Moreover, we employ an indentation curve analysis to evaluate surface residual stress, obviating the need for direct measurements of pile-up height. These findings facilitate the measurement of non-uniform surface residual stress in H-section beams, crucial for ensuring structural integrity, yet challenging to measure in situ. © 2024, The Authors. All rights reserved.

关键词： Residual stresses

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Fusion of Resonant Tunneling Diodes and Terahertz Silicon Photonics for Interconnects

Fusion of Resonant Tunneling Diodes and Terahertz Silicon Ph...

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IEEE Photonics Conference (IPC)

作者： Nguyen H. Ngo Yuta Inose Yosuke Nishida Ratmalgre Koala Yuji Matsuura Shuichi Murakami Yoshiharu Yamada Hidemasa Yamane Tadao Nagatsuma Masayuki Fujita Graduate School of Engineering Science Osaka University Toyonaka Japan ROHM Co. Ltd. Kyoto Japan Graduate School of Biomedical Engineering Tohoku University Sendai Japan Osaka Research Institute of Industrial Science and Technology Osaka Japan

ISBN: (数字)9798350361957

ISBN: (纸本)9798350361964

We propose terahertz interconnects with resonant tunneling diodes (RTDs) achieving 100-Gbit/s on-off keying modulation by circuit simulation. High-definition video transmission is demonstrated as a proof-of-concept for a hybrid link composed of silicon dielectric waveguides, fiber, and wireless, showcasing the potential for terahertz silicon photonics devices.

关键词： Couplings Wireless communication Wireless sensor networks Transmitting antennas Integrated circuit interconnections Terahertz radiation Silicon photonics Optical fiber devices Dielectrics Resonant tunneling devices

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Radiomic Analysis of Molecular Magnetic Resonance Imaging of Aortic Atherosclerosis in Rabbits

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Current medical science 2025年 2025 Jun 13页

作者： Hwunjae Lee YUHS-KRIBB Medical Convergence Research Institute Yonsei University College of Medicine Seoul 03722 Republic of Korea. hwunjaelee@yonsei.ac.kr. Graduate Program of Biomedical Engineering Yonsei University College of Medicine Seoul 03722 Republic of Korea. hwunjaelee@yonsei.ac.kr.

OBJECTIVE:Atherosclerosis involves not only the narrowing of blood vessels and plaque accumulation but also changes in plaque composition and stability, all of which are critical for disease progression. Conventional imaging techniques such as magnetic resonance angiography (MRA) and digital subtraction angiography (DSA) primarily assess luminal narrowing and plaque size, but have limited capability in identifying plaque instability and inflammation within the vascular muscle wall. This study aimed to develop and evaluate a novel imaging approach using ligand-modified nanomagnetic contrast (lmNMC) nanoprobes in combination with molecular magnetic resonance imaging (mMRI) to visualize and quantify vascular inflammation and plaque characteristics in a rabbit model of atherosclerosis. METHODS:A rabbit model of atherosclerosis was established and underwent mMRI before and after administration of lmNMC nanoprobes. Radiomic features were extracted from segmented images using discrete wavelet transform (DWT) to assess spatial frequency changes and gray-level co-occurrence matrix (GLCM) analysis to evaluate textural properties. Further radiomic analysis was performed using neural network-based regression and clustering, including the application of self-organizing maps (SOMs) to validate the consistency of radiomic pattern between training and testing data. RESULTS:Radiomic analysis revealed significant changes in spatial frequency between pre- and post-contrast images in both the horizontal and vertical directions. GLCM analysis showed an increase in contrast from 0.08463 to 0.1021 and a slight decrease in homogeneity from 0.9593 to 0.9540. Energy values declined from 0.2256 to 0.2019, while correlation increased marginally from 0.9659 to 0.9708. Neural network regression demonstrated strong convergence between target and output coordinates. Additionally, SOM clustering revealed consistent weight locations and neighbor distances across datasets, supporting the reliability

关键词： Atherosclerosis Discrete wavelet transform Magnetic nanoprobe Magnetic resonance imaging Radiomic feature

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Surface Residual Stress in H-Section Steel Beams Processed by Quenching and Self-Tempering Using Instrumented Indentation Testing

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SSRN 2024年

关键词： Residual stresses

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A Comprehensive Study on How Different Mineralization Processes Affect Native Structure of Wetspun Collagen Fibers and Mineral Quality by Using S(Ftir)

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SSRN 2024年

作者： Hacıosmanoğlu, Selçuk Kaan Belet, Abdulbaki Kamel, Gihan Kazanci, Murat Nanoscience and Nanoengineering Program Graduate School Istanbul Medeniyet University Istanbul34700 Turkey Biomedical Engineering Department School of Engineering and Natural Sciences Istanbul Medeniyet University Istanbul34700 Turkey Allan19252 Jordan Department of Physics Faculty of Sciences Helwan University Cairo Egypt

The collagen fibers could easily be produced via wet-spinning and mineralized by employing different mineralization methods. Herein, three different methods are used to obtain mineralized collagen fibers those are the Polymer-Induced Liquid-Precursor (P.I.L.P.), In-situ and Hydroxyapatite Mineral Addition (H.A.M.A.). Synchrotron Fourier-Transform Infrared Microspectroscopy is a powerful tool that sheds light on the molecular structure of collagen fibers. In this paper we discussed three different mineralization methods and detail their effects on the structure of collagen. One of the discussed highlights is that the applied mineralization methods caused distinct spectral shifts for the protein bands’ positions. It is demonstrated that among the suggested mineralization methods, In-situ and PILP have less, and H.A.M.A. has more effect on the native structure of collagen bundles and PILP gives the higher ratio of Ca/PO4. © 2024, The Authors. All rights reserved.

关键词： Collagen

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Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection

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Research 2022年第3期2022卷 91-104页

作者： Xiaohui Mou Hongbo Zhang Hua Qiu Wentai Zhang Ying Wang Kaiqin Xiong Nan Huang Hélder A.Santos Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong 523059China Guangdong Provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong 510080China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku Biosciences CenterUniversity of Turku andÅbo Akademi University20520 TurkuFinland State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438China Department of Biomedical Engineering and W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen/University of GroningenAnt.Deusinglaan 19713 AV GroningenNetherlands Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014 HelsinkiFinland

Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices,leading to significant mortality in *** address this issue,here,we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide,with bio-orthogonal click chemistry,to tailor the surface functionalities of tubing and *** by mussel adhesive foot protein,a bioclickable peptide mimic(DOPA)4-azidebased structure is designed and grafted on an aminated tubing robustly based on catechol-amine ***,the dibenzylcyclooctyne(DBCO)modified nitric oxide generating species of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions and the DBCO-modified antimicrobial peptide(DBCO-AMP)are clicked onto the grafted surfaces via bio-orthogonal *** combination of the robustly grafted AMP and Cu-DOTA endows the modified tubing with durable antimicrobial properties and ability in long-term catalytically generating NO from endogenous snitrosothiols to resist adhesion/activation of platelets,thus preventing the formation of ***,this biomimetic surface engineering technology provides a promising solution for multicomponent surface functionalization and the surface bioengineering of biomedical devices with enhanced clinical performance.

关键词： DOTA generating Engine

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Mental Stress Analysis using the Power Spectrum of fNIRS Signals

Mental Stress Analysis using the Power Spectrum of fNIRS Sig...

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2022 International Conference on Electrical and Computing Technologies and Applications, ICECTA 2022

作者： Katmah, Rateb Al-Shargie, Fares Tariq, Usman Babiloni, Fabio Al-Mughairbi, Fadwa Al-Nashash, Hasan American University of Sharjah Biomedical Engineering Graduate Program Sharjah United Arab Emirates American University of Sharjah Department of Electrical Engineering Sharjah United Arab Emirates University of Sapienza Rome Department of Molecular Medicine Rome Italy United Arab Emirates University College of Medicines and Health Sciences Al-Ain United Arab Emirates

ISBN: (数字)9781665456005

ISBN: (纸本)9781665456005

Mental stress is one of the major health problems in modern societies. Detecting mental stress at its early stage and developing a method of stress mitigation is very important for safety, health and quality of life. In this study, we employed a modified Stroop Color Word Task (SCWT) with time constrains and negative feedback about the performance, together with Binaural Beats Stimulation (BBs), to induce three varied levels of mental stress. Level one was based on SCWT alone and level two was based on SCWT+time-pressure and level three was by utilizing SCWT+time-pressure+BBs. We then quantified the level of stress using a NASA TLX questionnaire and functional near-infrared spectroscopy (fNIRS). The fNIRS signals were then analyzed using the Welch power spectrum density (PSD) to investigate the discrepancy in brain activity across the three levels of mental stress. We found that the mean PSD value in the frequency range of 0.2 to 0.5 Hz has significantly changed between the three stress levels. These findings indicate that the fNIRS power spectrum analysis method could be used as a robust marker for mental stress. © 2022 IEEE.

关键词： Power spectrum

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Development of an Ankle Assistive Robot with Instantly Gait-Adaptive Method

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Journal of Robotics and Mechatronics 2023年第3期35卷 669-683页

作者： Xu, Ming-Yang Hua, Yi-Fan Li, Yun-Fan Zhuang, Jyun-Rong Osawa, Keisuke Nakagawa, Kei Lee, Hee-Hyol Yuge, Louis Tanaka, Eiichiro Graduate School of Information Production and Systems Waseda University 2-7 Hibikino Wakamatsu-ku Fukuoka Kitakyushu808-0135 Japan Department of Mechanical Engineering National Chung Hsing University No.145 Xingda Rd. South District Taichung City402202 Taiwan Graduate School of Biomedical and Health Sciences Hiroshima University 1-2-3 Kasumi Minami-ku Hiroshima734-8551 Japan

As the population ages, the number of elderly people suffering from systemic diseases such as stroke in-creases. To address this problem, various wearable walking assistive robots have been developed to promote physical exercise for stroke prevention. Wearable assistive robots have shown the ability to improve human mobility. However, most of these robots are heavy, bulky, and impractical. In this study, we developed a compact ankle assistive robot for elderly users to promote walking exercise. By informing the user of correct motion and timing, the robot can guide the user to achieve a healthy gait by only assisting their ankle joint. The robot provides faster-than-ankle motion to allow the user to feel supported while walk-ing. Users can adjust the robot’s assistance parameters through a graphical user interface (GUI) according to their needs. Furthermore, we proposed a gait-adaptive method for ankle assistive robots to adapt to the user’s changing gait. Hence, the robot can auto-matically adjust the parameters to provide more ac-curate walking assistance. Finally, the results of an evaluation experiment demonstrated the feasibility of human gait adaptation. The proposed methods have the advantages of low cost and easy implementation. © Fuji Technology Press Ltd.

关键词： Human robot interaction

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Use of Nonlinear Analysis Methods for Evaluating IMU Data of Bilateral Jump Landing Tasks 5

Use of Nonlinear Analysis Methods for Evaluating IMU Data of...

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5th IEEE Eurasia Conference on biomedical engineering, Healthcare and Sustainability, ECBIOS 2023

作者： Hejda, Jan Sugiarto, Tommy Volf, Petr Lin, Yi-Jia Kutilek, Patrik Hsu, Wei-Chun Sokol, Marek Wu, Jia-Lin Leova, Lydie Jiang, Yah-Shiun Deng, Yong-Jie Czech Technical University in Prague Faculty of Biomedical Engineering Department of Health Care and Population Protection Kladno Czech Republic Industrial Technology Research Institute Electronic and Optoelectronic System Research Laboratory Hsinchu County310 Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Division of Sports Medicine Taipei Medical University Hospital Department of Orthopedics Taipei110 Taiwan School of Medicine Taipei Medical University Department of Orthopedic Taipei110 Taiwan

ISBN: (纸本)9798350320978

The use of nonlinear analysis methods provides new information when evaluating linear acceleration and angular velocity from a system with Inertial Measurement Unit (IMU) recording. This information is used as additional input to improve the estimation of the angular displacements in a neural network model. The measurements were performed on 24 participants (18 males and 6 females of an average age of $22.6\pm \ 2.6$ years old, average height of $172.6\pm 10.3$ cm, and an average weight of $72.2\pm 16.02\ \text{kg})$ during bilateral jump landing tasks. In order to assess the differences between IMU estimated angle and the gold standard, data obtained from Qualysis optical Mocap (Qualisys AB, Göteborg, Sweden) and Delsys inertial measurement systems (Delsys Inc., Boston, MA, USA) were used for measurements during bilateral jump landing tasks. A total of 8 IMU sensors were placed on the sternum, L5, bilateral thighs, shanks, and foot. The thigh and shank sensors were placed on the middle of each thigh and shank along the anterior-posterior axis (middle thigh and middle shank) while the foot sensors were placed on the dorsal surface of the foot. Thirty retroreflective markers were placed on the pelvis and bilateral thigh, shanks, and foot to form a 7-linkage lower extremity model. Static calibration on each of the participants was performed during standing with anatomical position to define the neutral joint angle at bilateral hip, knee, and ankle. For quantification purposes, the Hurst exponent, Lyapunov exponent, approximate entropy, and multiscale sample entropy were used. The results suggest that when evaluating the placement of IMU on the shank and thigh to determine the knee angle, the Hurst exponent is capable of best distinguishing individual axes based on linear acceleration and angular velocity. © 2023 IEEE.

关键词： Angular velocity

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Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

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Food Science and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.Noel Baojun Xu William C.Cho Institute of Biomedical and Genetic Engineering(IBGE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetrics and Gynecology Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of *** researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling *** this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

关键词： Cancer Nutrigenomics Signaling Apoptosis Allium sativum

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