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Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

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Bioactive Materials 2023年第6期24卷 497-506页

作者： Jaehoon Kim Hyeji Um Na Hee Kim Dokyoung Kim Department of Biomedical Science Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Kyung Hee UniversitySeoul02447Republic of Korea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoul02447Republic of Korea Center for Converging Humanities Kyung Hee UniversitySeoul02447Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul02447Republic of Korea UC San Diego Materials Research Science and Engineering Center 9500 Gilman Drive La JollaCA92093USA

There has been a lot of basic and clinical research on Alzheimer’s disease(AD)over the last 100 years,but its mechanisms and treatments have not been fully *** some controversies,the amyloid-beta hypothesis is one of the most widely accepted causes of *** this study,we disclose a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles(pSiNPs)as a therapeutic nano-platform to overcome *** hypothesized that the negatively charged sulfonic acid functional group could disaggregate plaques and construct a chemical *** a result of the in vitro assay of amyloid plaques and library screening,we confirmed that 6-amino-2-naphthalenesulfonic acid(ANA)showed the highest efficacy for plaque disaggregation as a hit *** confirm the targeted delivery of ANA to the AD brain,a nano-platform was created using porous silicon nanoparticles(pSiNPs)with ANA loaded into the pore of pSiNPs and biotin-polyethylene glycol(PEG)surface *** resulting nano-formulation,named Biotin-CaCl2-ANA-pSiNPs(BCAP),delivered a large amount of ANA to the AD brain and ameliorated memory impairment of the AD mouse model through the disaggregation of amyloid plaques in the *** study presents a new bioactive small molecule for amyloid plaque disaggregation and its promising therapeutic nano-platform for AD brain-targeted delivery.

关键词： Alzheimer’s disease Plaques disaggregation Nanotherapeutics Brain-targeted drug delivery Porous silicon nanoparticles

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Intraoperative Detection of Surgical Gauze Using Deep Convolutional Neural Network

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Annals of biomedical engineering 2023年第2期51卷 352-362页

作者： Lai, Shuo-Lun Chen, Chi-Sheng Lin, Been-Ren Chang, Ruey-Feng Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University No.1 Sec.4 Roosevelt Road Taipei10617 Taiwan Division of Colorectal Surgery Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

During laparoscopic surgery, surgical gauze is usually inserted into the body cavity to help achieve hemostasis. Retention of surgical gauze in the body cavity may necessitate reoperation and increase surgical risk. Using deep learning technology, this study aimed to propose a neural network model for gauze detection from the surgical video to record the presence of the gauze. The model was trained by the training group using YOLO (You Only Look Once)v5x6, then applied to the testing group. Positive predicted value (PPV), sensitivity, and mean average precision (mAP) were calculated. Furthermore, a timeline of gauze presence in the video was drawn by the model as well as human annotation to evaluate the accuracy. After the model was well-trained, the PPV, sensitivity, and mAP in the testing group were 0.920, 0.828, and 0.881, respectively. The inference time was 11.3 ms per image. The average accuracy of the model adding a marking and filtering process was 0.899. In conclusion, surgical gauze can be successfully detected using deep learning in the surgical video. Our model provided a fast detection of surgical gauze, allowing further real-time gauze tracing in laparoscopic surgery that may help surgeons recall the location of the missing gauze. © 2022, The Author(s) under exclusive licence to biomedical engineering Society.

关键词： Neural network models

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Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

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Materials Today Bio 2023年 23卷 100876页

作者： Jheng, Pei-Ru Chiang, Chia-Che Kang, Jiunn-Horng Fan, Yu-Jui Wu, Kevin C.-W. Chen, Yan-Ting Liang, Jia-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Chuang, Er-Yuan Graduate Institute of Nanomedicine and Medical Engineering Graduate Institute of Biomedical Materials and Tissue Engineering Institute of Biomedical Optomechatronics International Ph.D. Program in Biomedical Engineering School of Biomedical Engineering College of Biomedical Engineering Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan Department of Chemical Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Department of Plasma Physics and Technology Faculty of Science Masaryk University Brno Czech Republic Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy. © 2023 The Authors

关键词： Infrared devices

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Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flexible Bioelectrodes for Neural Sensing

Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flex...

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Advances in Science and engineering Technology International Conferences (ASET)

作者： Kashif Rast Baz Khan Amani Al-Othman Hasan Al-Nashash Mohammad Al-Sayah Biomedical Engineering Graduate Program American University of Sharjah Sharjah UAE Department of Chemical and Biological Engineering American University of Sharjah Sharjah UAE Department of Electrical Engineering American University of Sharjah Sharjah UAE Chemistry and Environmental Sciences American University of Sharjah Sharjah UAE

Research applications of neural sensing and muscle stimulation have been advanced by the development of bioelectrodes that are biocompatible, flexible and long lasting. The existing metallic made bioelectrodes exhibit extremely high electrochemical resistances that would interfere with the neural-electrode bridge and suffer from mechanical and immunological mismatch. Novel, flexible, implantable bioelectrodes based on MXenes (Ti 3 C 2 ) and Polydimethylsiloxane (PDMS) composite are proposed. Mxenes possess the advantage of having metallic ultra-conductive transition metals consisting of large groups of carbides, nitrides, or carbonitrides, while PDMS has inherent biostability, flexibility and biocompatibility. In the current research, PDMS has been used as the supporting matrix for conductive fillers such as PMMA, PEDOT, and Mxenes. A series of characterization techniques were performed such as Electrochemical Impedance Spectroscopy (EIS), Cyclic Voltammetry (CV) and mechanical testing. The average results of triplicate samples exhibited samples' bulk impedance of 0.913 kΩ, an impedance of 1.612 MΩ, at 1 kHz frequency and a conductivity of 1.41x10 -4 S/cm, charge storage capacity of 0.056 mC/cm 2 and Young's modulus of 3.81 MPa.

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Design of Wireless Electromyography (EMG) Monitoring System for Muscle Activity Detection on Parkinson Disease

Design of Wireless Electromyography (EMG) Monitoring System ...

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2020 International Conference on Smart Technology and Applications, ICoSTA 2020

作者： Fadhlannisa, Nisrina Firyal Basari, Basari Universitas Indonesia Biomedical Engineering Course Program West Java Indonesia Universitas Indonesia Biomedical Engineering Course Program Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Indonesia

ISBN: (纸本)9781728130835

Parkinson's disease attacking 1 percent of the elder population in this world, with one of the main symptoms of this disease being resting tremor. Until now, Parkinson's disease information acquisition can only be done through patients' visits to clinics or hospitals, whereas the aspects of the disease are also shown during in-between those visits. In this research, we develop an Electromyography (EMG) based remote-monitoring systemin order for patients are able to be checked more frequently and the results are in always-renewed information. This monitoring system utilizes NodeMCU as the compiler component and ESP8266 WiFi module and web server. The data acquired from an arm of a tested person will always be read in real-time and can be displayed on web-based platform. From the data acquired, they are processed in detail for pattern characteristics analysis. We have successfully carried out the experimental test by displaying on the web server-based monitoring system. © 2020 IEEE.

关键词： Neurodegenerative diseases

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Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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Food Science and Human Wellness 2024年第4期13卷 1886-1905页

作者： Wei Li Haihong Chen Hongliang Chen Ziyin Li Wei Hu Qinxuan Zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

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Dental Imaging Using a Higher Signal-to-Noise Ratio Optical Coherence Tomography System

Dental Imaging Using a Higher Signal-to-Noise Ratio Optical ...

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Electrical, Computer and Energy Technologies (ICECET), International Conference on

作者： Akeem. A. Azeez Biniyam Mezgebo Rodrigo França Sherif S. Sherif Biomedical Engineering Graduate Program University of Manitoba Winnipeg Canada Dept. of Electrical andComputer Engineering University of Manitoba Winnipeg Canada Dept. of Restorative Dentistry University of Manitoba Winnipeg Canada Dept. of Electrical and Computer Engineering University of Manitoba Winnipeg Canada

This paper presents an optical coherence tomography (OCT) system in conjunction with a novel image reconstruction technique employed for in vitro imaging of human teeth. The primary goal is to enhance the signal-to-noise ratio (SNR) in the obtained images. The study entails a comparative analysis between the conventional Fast Fourier Transform (FFT) OCT image reconstruction method and a newly introduced scaled nonuniform discrete Fourier transform (NDFT) approach. The findings reveal that the NDFT method consistently delivers superior results in terms of peak signal-to-noise ratio (PSNR) and overall image quality, even when dealing with redundant and nonuniform frequency domain samples. In light of these results, this paper concludes that integrating NDFT into OCT procedures has the potential to significantly enhance the quality of image reconstructions, thereby fostering its broader application in the field of dental imaging.

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High Performance Fully Inkjet-Printed Organic Electrochemical Transistor (Oect) Based Sensor

SSRN

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SSRN 2022年

作者： Alchamaa, Walid Khraiche, Massoud Neural Engineering and Nanobiosensors Group Biomedical Engineering Program Maroun Semaan Faculty of Engineering and Architecture American University of Beirut Lebanon

High throughput, high sensitivity, and scalability point-of-care biosensors have the potential to significantly improve diagnosis and disease monitoring. Organic electrochemical transistors (OECTs) are a powerful platform for point-of-care biosensing given their sensitivity and performance. Unfortunately, these metrics are seldom achieved with novel and cost effective fabrication. In this work, we built high performance OECTs using state-of-the-art inkjet printing technology, a scalable, highly reproducible, and low-cost fabrication process. The design utilizes unique high conductivity PEDOT:PSS formulations driving higher ion-to-electron conversion, optimized cross-sectional area to channel length (W d=L) and volumetric capacitance. The design included high ratio of channel cross-sectional area to length (1857 µm) reaching a maximum corresponding transconductance value of 15.2 mS, an order of magnitude improvement on published work. The design was also tested with BSA proteins and showed a limit of detection on the order of 1pM of BSA. This work shows the potential of inkjet printing for fabricating low-cost, high-performance OECT-based point-of-care biosensors. © 2022, The Authors. All rights reserved.

关键词： Biosensors

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A Ph-Responsive Polycaprolactone-Copper Peroxide Composite Coating Fabricated Via Suspension Flame Spraying for Antimicrobial Applications

SSRN

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SSRN 2023年

作者： Cui, Tingting Zhou, Daofeng Zhang, Yu Song, Meiqi Dan, Yanxin Zhang, Botao Li, Hua Cixi Biomedical Research Institute Wenzhou Medical University Wenzhou325035 China Zhejiang Engineering Research Center for Biomedical Materials Zhejiang-Japan Joint Laboratory for Antibacterial and Antifouling Technology Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo315201 China Department of Applied Chemistry Graduate School of Engineering The University of Tokyo Bunkyo-ku Tokyo113-8656 Japan

In this study, a pH-responsive polycaprolactone (PCL)-copper peroxide (CuO2) composite antibacterial coating was developed by suspension flame spraying. The successful synthesis of CuO2 nanoparticles and fabrication of the PCL-CuO2 composite coatings were confirmed by microstructural and chemical analysis. The composite coatings were structurally homogeneous with the chemical properties of PCL well maintained. Acidic environment was found to effectively accelerate the dissociation of CuO2, allowing simultaneous release of Cu2+ and H2O2. Antimicrobial tests clearly revealed enhanced antibacterial properties of the PCL-CuO2 composite coating against both Escherichia coli and Staphylococcus aureus under acidic conditions with a bactericidal rate over 99.99 %. This study presents a promising approach for constructing pH-responsive antimicrobial coatings for biomedical applications. © 2023, The Authors. All rights reserved.

关键词： Oxidation

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Diving into COVID-19: Visualizing SARS-CoV-2 Patient Proteins using Liquid-Electron Microscopy

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 662-664页

作者： Berry, Samantha DiCecco, Liza-Anastasia Gray, Jennifer Boylan, Jack Solares, Maria Kelly, Deborah F. Department of Biomedical Engineering Pennsylvania State University University Park PA United States Department of Materials Science and Engineering McMaster University Hamilton ON Canada Materials Research Institute Pennsylvania State University University Park PA United States Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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