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SSRN 2024年

作者： Um, Hyun-Kyung Kim, Songeun Wang, Shan X. Lee, Jung-Rok Department of Mechanical and Biomedical Engineering Ewha Womans University Seoul03760 Korea Republic of Graduate Program in Smart Factory Ewha Womans University Seoul03760 Korea Republic of Department of Materials Science and Engineering Stanford University Stanford CA94305 United States Department of Electrical Engineering Stanford University Stanford CA94305 United States

Rapid, sensitive, multiplexed antibody detection technologies are essential for assessing vaccine efficacy and recipient immunity against viruses. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge, and the fact that novel viruses may pose potential threats in the near future, personalized vaccines can be precisely tailored to an individual’s measured immunity to help mitigate the symptoms of infection and viral spread. Here, we present giant magnetoresistive (GMR) biosensor microarrays for the quantitative multiplexed detection of antibodies against SARS-CoV-2 variants. The multiplexed GMR biosensor microarrays demonstrated high sensitivity, comparable to that of the single-plex enzyme-linked immunosorbent assay, enabling multiplexed measurements using blood obtained from finger pricks. Additionally, the GMR biosensor microarrays demonstrated compatibility with clinical samples and could detect variant-specific antibodies in serum, allowing for the assessment of current immunity status. Notably, an increased concentration of antibodies against the Omicron variant was clearly observed two weeks after receiving an Omicron-based booster vaccination. These results indicate that GMR biosensor microarrays offer a practical point-of-care tool for monitoring humoral immunity and guiding personalized vaccination schedules, thereby supporting immunity management against SARS-CoV-2 and future viral threats. © 2024, The Authors. All rights reserved.

关键词： Giant magnetoresistance

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Segregation effects of doped VN and ZrN on magnetic and microstructural characteristics of FePt-based films

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Thin Solid Films 2024年 798卷

作者： Tsai, Jai-Lin Lin, Jhih-Hong Chen, Tsung-Yi Lin, Yu-Chun Liu, Li-Xiang Hsieh, Ming-Wei Chen, Jyun-you Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Solar Applied Materials Technology Corp. Tainan70955 Taiwan Graduate School of Biomedical Engineering University of New South Wales UNSW SydneyNSW2052 Australia

Segregants are essential materials for forming the complexation or granular microstructure in thin films for magnetic recording media. One such film, FePt-BN, has a metallic L10 FePt main phase as its matrix, in addition to having BN and C segregants at the grain boundaries. Amorphous BN has sufficient mechanical strength to support the columnar growth of FePt grains, however, it has a lower deposition rate resulting in columnar grains with a nonuniform aspect ratio. Moreover, some B diffuses in the interstitial site of FePt lattices. To overcome these limitations, this study added the transition nitride VN and ZrN with equal volume percentages to replace some BN segregants in FePt(BN, Ag, C) films: substantially different segregation behaviors were observed. Microstructural imaging mapping revealed that although VN segregated the FePt grains boundary, ZrN was diffused in the lattice. The FePt-BN-ZrN film thus had more disordered grains contributing to a higher in-plane magnetization and wider hard axis magnetic hysteresis loops than did FePt-BN-VN. The FePt-BN-VN film has the highest perpendicular magnetic anisotropy constant (Ku= 2.17 × 106 J/m3) and coercivity (Hc= 4 T);moreover, parallel remanence magnetization was minimal with a linear in-plane magnetization loop. The FePt-BN-VN film was sputtered directly on MgO(100) but depositing the FePt-BN-ZrN film required a 2-nm-thick FePt nucleation layer. The high atomic number of Zr and high sputter yield ratio (YN/Ymetal) of ZrN may increase the sites occupied by N, potentially affecting ZrN segregation. © 2024 Elsevier B.V.

关键词： Coercive force

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Short-Chain Dense Brush Pegylation on Rigid Nanocarriers Overcomes Anti-Peg Antibody Recognition for Immune-Stealth Drug Delivery

SSRN

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SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomedicine, as pre-existing anti-PEG antibodies can compromise therapeutic efficacy through accelerated blood clearance (ABC) and life-threatening hypersensitivity. Here, we address this challenge by engineering the PEG architecture, creating short-chain dense brush PEGylation (PEG500) on rigid mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evades antibodies via three synergistic mechanisms: (1) short-chain PEG500 reduces epitope accessibility, (2) high grafting density (4.43 chains/nm2, according to TGA) forms an dense steric shield, and (3) the rigid silica surface prevents PEG burial. ELISA studies demonstrated that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold reduction in anti-PEG IgG (6.3) binding and a 1000-fold reduction in anti-PEG IgM (AGP3) binding compared to Lipodox (PEG2000), both of which target the PEG backbone. Furthermore, radiolabeled MSN-PEG500 achieved prolonged circulation and 25% tumor accumulation (ID/g) at 24 hours. In strongly immunized mice, doxorubicin-loaded MSN-PEG500 preserved therapeutic efficacy and 100% survival, whereas Lipodox induced fatal hypersensitivity. Mechanistic investigations revealed that complement activation drives PEG2000 immunotoxicity, and pretreatment with the C3 inhibitor compstatin effectively mitigated temperature drops from 10°C to 2°C in immunized hosts. By demonstrating that nanoscale control of polymer conformation dictates immunological fate, this work provides a clinically translatable blueprint for developing immune-evasive nanomedicines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

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Low Intensity Pulsed Ultrasound Activates Excitatory Synaptic Networks in Cultured Hippocampal Neurons

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Ultrasound in Medicine and Biology 2025年

作者： Li, Fenfang Jiang, Hao Lin, Jiawei Qiao, Chaofeng Augustine, George J. Institute of Biomedical Engineering Shenzhen Bay Laboratory Shenzhen China Program in Neuroscience & Mental Health Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore Temasek Life Sciences Laboratory Singapore

Objective: Ultrasound can noninvasively penetrate deep into the brain for neuromodulation, demonstrating good potential for clinical application. However, the underlying mechanisms are unclear. So far most in vitro studies have focused on the activation of individual neurons by ultrasound with calcium imaging. As the focal region of ultrasound is typically millimeter or submillimeter size, it is important to investigate yet so far unclear how the mechanical effects of ultrasound would influence the synaptic circuit activity of neurons. Methods: Low-intensity pulse ultrasound was used to stimulate cultured hippocampal neurons. Postsynaptic currents were recorded in individual cells with the whole-cell patch-clamp technique. We also simultaneously imaged intracellular calcium, along with neuronal electrical signals, to resolve neuronal network dynamics during ultrasound stimulation. Results: Excitatory postsynaptic currents (EPSCs) were evoked by ultrasound in high-density neuronal cultures with increased frequency and amplitude, indicating enhanced glutamatergic synaptic transmission. The probability of evoking responses and the total charge of EPSCs increased with ultrasound intensity. Mechanistic analysis reveals that extracellular calcium influx, action potential firing and synaptic transmission are necessary for the responses to ultrasound in high-density culture. In contrast, EPSCs were not enhanced in low-density culture. Simultaneous calcium imaging of neuronal network activity indicates that recurrent excitatory network activity is recruited during ultrasound stimulation in high-density cultures, which lasts over tens to hundreds of seconds. Conclusion: Our study provides insights into the mechanisms involved in the response of the brain to ultrasound and illuminates the potential to use ultrasound to regulate synaptic function in neurological disorders. © 2025 World Federation for Ultrasound in Medicine & Biology

关键词： Neurons

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In vivo study of conductive 3D printed PCL/MWCNTs scaffolds with electrical stimulation for bone tissue engineering

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Bio-Design and Manufacturing 2021年第2期4卷 190-202页

作者： Edney P.e Silva Boyang Huang Júlia V.Helaehil Paulo R.L.Nalesso Leonardo Bagne Maraiara A.de Oliveira Gabriela C.C.Albiazetti Ali Aldalbahi Mohamed El-Newehy Milton Santamaria-Jr Fernanda A.S.Mendonça Paulo Bártolo Guilherme F.Caetano Postgraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation-FHOArarasSao PauloBrazil Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringUniversity of ManchesterManchester M139PLUK King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Critical bone defects are considered one of the major clinical challenges in reconstructive bone *** combination of 3D printed conductive scaffolds and exogenous electrical stimulation(ES)is a potential favorable approach for bone tissue *** this study,3D conductive scaffolds made with biocompatible and biodegradable polycaprolactone(PCL)and multi-walled carbon nanotubes(MWCNTs)were produced using the extrusion-based additive manufacturing to treat large calvary bone defects in *** results show that the use of PCL/MWCNTs scaffolds and ES contributes to thicker and increased bone tissue formation within the bone *** and mineralization are also significantly promoted using high concentration of MWCNTs(3 wt%)and ***,scaffolds favor the tartrate-resistant acid phosphatase(TRAP)positive cell formation,while the addition of MWCNTs seems to inhibit the osteoclastogenesis but present limited effects on the osteoclast functionalities(receptor activator of nuclear factor κβ ligand(RANKL)and osteoprotegerin(OPG)expressions).The use of ES promotes the osteoclastogenesis and RANKL expressions,showing a dominant effect in the bone remodeling *** results indicate that the combination of 3D printed conductive PCL/MWCNTs scaffold and ES is a promising strategy to treat critical bone defects and provide a cue to establish an optimal protocol to use conductive scaffolds and ES for bone tissue engineering.

关键词： Additive manufacturing Bone regeneration Bone remodeling Carbon nanotube Conductive scaffolds Electrical stimulation

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Analysis of Fatigue-Induced Compensatory Movements in Bicep Curls: Gaining Insights for the Deployment of Wearable Sensors

arXiv

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arXiv 2024年

作者： Chua, Ming Xuan Okubo, Yoshiro Peng, Shuhua Do, Thanh Nho Wang, Chun Hui Wu, Liao Australia The Falls Balance and Injury Research Centre Neuroscience Research Australia Australia The School of Mechanical and Manufacturing Engineering The University of New South Wales Australia The Graduate School of Biomedical Engineering The University of New South Wales Australia

A common challenge in Bicep Curls rehabilitation is muscle compensation, where patients adopt alternative movement patterns when the primary muscle group cannot act due to injury or fatigue, significantly decreasing the effectiveness of rehabilitation efforts. The problem is exacerbated by the growing trend toward transitioning from in-clinic to home-based rehabilitation, where constant monitoring and correction by physiotherapists are limited. Developing wearable sensors capable of detecting muscle compensation becomes crucial to address this challenge. This study aims to gain insights into the optimal deployment of wearable sensors through a comprehensive study of muscle compensation in Bicep Curls. We collect upper limb joint kinematics and surface electromyography signals (sEMG) from eight muscles in 12 healthy subjects during standard and fatigue stages. Two muscle synergies are derived from sEMG signals and are analyzed comprehensively along with joint kinematics. Our findings reveal a shift in the relative contribution of forearm muscles to shoulder muscles, accompanied by a significant increase in activation amplitude for both synergies. Additionally, more pronounced movement was observed at the shoulder joint during fatigue. These results suggest focusing on the shoulder muscle activities and joint motions when deploying wearable sensors to effectively detect compensatory movements. Copyright © 2024, The Authors. All rights reserved.

关键词： Muscle

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Investigating malignancy-dependent mechanical properties of breast cancer cells

Investigating malignancy-dependent mechanical properties of ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Zeina Habli Ahmad Zantout Marwan El-Sabban Massoud L. Khraiche Biomedical Engineering Program Maroun Semaan Faculty of Engineering and Architecture AUB Beirut Lebanon Department of Anatomy Cell Biology and Physiological Sciences Faculty of Medicine AUB Beirut Lebanon

Cancer invasiveness significantly impacts cellular mechanical properties which regulate cell motility and, subsequently, cell metastatic potential. Understanding the adhesion forces and stiffness/rigidity of cancer cells can provide better insights into their mechanical adaptability related to their degree of invasiveness. Here, we used single-cell force spectroscopy in conjunction with quartz crystal microbalance-with dissipation measurements to compare the mechanical properties of mammary epithelial cancer cells with different metastatic potentials, namely MCF-7 (non-invasive) and MDA-MB-231 (aggressive and highly invasive). Our results showed that MCF-7 exhibits larger adhesion forces, stronger intercellular forces, and a considerably stiff/rigid phenotype, contrary to MDA-MB-231. The biomechanical properties obtained are associated with the malignant potential of these cells such that the forces of adhesion and viscoelasticity are inversely proportional to cell invasiveness. This study integrates a new quantitative tool with real-time measurements to provide better insights into the mechanics of cancer cells across metastatic stages.

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Wearable Active Vibration Sensing for Mid-Activity Knee Health Assessment

Wearable Active Vibration Sensing for Mid-Activity Knee Heal...

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International Workshop on Wearable and Implantable Body Sensor Networks (BSN)

作者： Goktug C. Ozmen Christopher J. Nichols Lan Lan Emily Moise Christopher Sugino Alper Erturk Omer T. Inan School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA BioEngineering Graduate Program Georgia Institute of Technology Atlanta GA USA Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA USA George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA USA Coulter Department of Biomedical Engineering School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA

Non-invasive vibration measurements from the knee offer a convenient and affordable alternative to benchtop or biomechanics lab joint health monitoring systems. Recently, joint acoustic emissions (JAEs) measured from the knee were shown to be an indicator of knee health. However, the origin of JAEs is still not fully understood, which limits its acceptance and use by clinical experts. In this proof-of-concept study, rather than relying on the movements of the knee and corresponding frictional rubbing of internal surfaces to produce vibrations, we propose using an active vibration sensing approach with a known vibration source interrogating the knee. We aim to elucidate the linkage between knee vibration characteristics and structural changes in the joint following injuries. We measured tibial vibration responses of two participants using a laser vibrometer system to quantify the frequency band where the most repeatable tibial vibration measurement can be taken. Subsequently, a custom-designed wearable system measured mid-activity tibial vibration characteristics from four participants (five healthy knees and three knees with prior acute injury) during unloaded knee flexion-extensions. An active sensing knee health score was defined as the ratio of the changes in low- to high-frequency response during flexion-extension. Since changes in the boundary of tibia would alter low-frequency response more than high frequency response, we found that increased knee laxity with acute injuries resulted in an increased active sensing knee health score. Our findings demonstrate the potential of active vibration sensing as an interpretable, computationally inexpensive alternative to JAEs for wearable knee health assessment.

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Recent Advances in Quantum Computing for Drug Discovery and Development

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IEEE Nanotechnology Magazine 2023年第2期17卷 26-30页

作者： Wang, Pei-Hua Chen, Jen-Hao Yang, Yu-Yuan Lee, Chien Tseng, Yufeng Jane Chung Yuan Christian University Quantum Information Center Taoyuan City320314 Taiwan National Taiwan University College of Electrical Engineering and Computer Science Graduate Institute of Biomedical Electronics and Bioinformatics Taipei10617 Taiwan Chunghwa Telecom Co. Ltd. Taipei Taiwan National Taiwan University Department of Computer Science and Information Engineering Taipei10617 Taiwan National Center for Theoretical Sciences Physics Division Taipei10617 Taiwan National Taiwan University Center for Quantum Science and Engineering Taipei10617 Taiwan

Drug discovery and development is a time-consuming and cost-intensive process. Computer-aided drug design can speed up the timeline and reduce costs by decreasing the number of necessary biochemical experiments. The number of studies using quantum computing to solve problems in drug development has been increasing in recent years. In this review, we briefly introduce the main steps in drug discovery and development and how computers help to find potential drug candidates. Recent studies of quantum computing in drug development based on the structure of target proteins are listed chronologically. They include protein structure prediction, molecular docking, quantum simulation, and quantitative structure-activity relationship (QSAR) models. Current quantum devices are still susceptible to noise and error but are well suited for hybrid quantum-classical algorithms. The quantum advantage is demonstrated on hybrid systems and quantum-inspired devices such as quantum annealers. We hope to see more applications of quantum computing in the field of drug discovery and development.

关键词： Proteins

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Comparison of interpolation techniques for 3D freehand ultrasound: A phantom experiment

Comparison of interpolation techniques for 3D freehand ultra...

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Medical Information Processing and Analysis (SIPAIM), International Symposium on

作者： Danitza Bermejo Piero G. Latorre-Quevedo Carlos Zegarra Ana Paula Alejos G Stefano E. Romero Benjamin Castaneda Laboratorio de Imágenes Médicas Pontificia Universidad Catolica del Peru Lima Perú Biomedical Engineering Program PUCP-UPCH Pontificia Universidad Catolica del Perú Lima Perú Department of Biomedical Engineering University of Rochester New York USA

Limited access to advanced medical imaging in rural areas of developing countries due to cost and personnel challenges is addressed through teleultrasound imaging. However, systems like Volume Sweep Imaging (VSI) exhibit spatial limitations, encompassing partially focused regions and poor image quality. This study investigates the potential of 3D freehand reconstruction algorithms using rural teleultrasound equipment. We analyze the integration of 3D reconstruction algorithms and batches to optimize the utility of teleultrasound imaging. Overall, we observe a diversity of behaviors across the interpolation techniques. For instance, the positioning system and time calibration in achieving accurate reconstructions. The results show that the Spherical Kernel interpolation is identified as a high-precision method, much more than VNN. We demonstrate the potential for batches to address the challenges posed by limited resources, paving the way for future work on image-guided surgery.

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