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Search for long-lived particles that decay into final states containing two electrons or two muons in proton-proton collisions at s=8 TeV

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physical Review D 2015年第5期91卷 052012-052012页

作者： V. Khachatryan A. M. Sirunyan A. Tumasyan W. Adam T. Bergauer M. Dragicevic J. Erö M. Friedl R. Frühwirth V. M. Ghete C. Hartl N. Hörmann J. Hrubec M. Jeitler W. Kiesenhofer V. Knünz M. Krammer I. Krätschmer D. Liko I. Mikulec D. Rabady B. Rahbaran H. Rohringer R. Schöfbeck J. Strauss W. Treberer-Treberspurg W. Waltenberger C.-E. Wulz V. Mossolov N. Shumeiko J. Suarez Gonzalez S. Alderweireldt M. Bansal S. Bansal T. Cornelis E. A. De Wolf X. Janssen A. Knutsson J. Lauwers S. Luyckx S. Ochesanu R. Rougny M. Van De Klundert H. Van Haevermaet P. Van Mechelen N. Van Remortel A. Van Spilbeeck F. Blekman S. Blyweert J. D’Hondt N. Daci N. Heracleous J. Keaveney S. Lowette M. Maes A. Olbrechts Q. Python D. Strom S. Tavernier W. Van Doninck P. Van Mulders G. P. Van Onsem I. Villella C. Caillol B. Clerbaux G. De Lentdecker D. Dobur L. Favart A. P. R. Gay A. Grebenyuk A. Léonard A. Mohammadi L. Perniè A. Randle-conde T. Reis T. Seva L. Thomas C. Vander Velde P. Vanlaer J. Wang F. Zenoni V. Adler K. Beernaert L. Benucci A. Cimmino S. Costantini S. Crucy S. Dildick A. Fagot G. Garcia J. Mccartin A. A. Ocampo Rios D. Ryckbosch S. Salva Diblen M. Sigamani N. Strobbe F. Thyssen M. Tytgat E. Yazgan N. Zaganidis S. Basegmez C. Beluffi G. Bruno R. Castello A. Caudron L. Ceard G. G. Da Silveira C. Delaere T. du Pree D. Favart L. Forthomme A. Giammanco J. Hollar A. Jafari P. Jez M. Komm V. Lemaitre C. Nuttens D. Pagano L. Perrini A. Pin K. Piotrzkowski A. Popov L. Quertenmont M. Selvaggi M. Vidal Marono J. M. Vizan Garcia N. Beliy T. Caebergs E. Daubie G. H. Hammad W. L. Aldá Júnior G. A. Alves L. Brito M. Correa Martins Junior T. Dos Reis Martins C. Mora Herrera M. E. Pol P. Rebello Teles W. Carvalho J. Chinellato A. Custódio E. M. Da Costa D. De Jesus Damiao C. De Oliveira Martins S. Fonseca De Souza H. Malbouisson D. Matos Figueiredo L. Mundim H. Nogima W. L. Prado Da Silva J. Santaolalla A. Santoro A. Sznajder E. J. Tonelli Manganote A. Vilela Pereira C. A. Bernardes S. Dogra T. R. Fernandez Perez Tomei E. M. Gregores P. G. Merca Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik der OeAW Wien Austria National Centre for Particle and High Energy Physics Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Université de Mons Mons Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Federal do ABC São Paulo Brazil Universidade Estadual Paulista São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Sofia Bulgaria University of Sofia Sofia Bulgaria Institute of High Energy Physics Beijing China State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Vanderbilt University Nashville Tennessee 37235 USA Universidad de Los Andes Bogota Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt National Institute of Chemical Physics and Biophysics Tallinn Estonia Department of Physics University of Helsinki Helsinki Finland Helsinki Institute of Physics Helsinki Finland Lappeenranta University of Technology Lappeenranta Finland DSM/IRFU CEA/Saclay Gif-sur-Yvette France Laboratoire Leprince-Ringuet Ecole Polytechnique IN2P3-CNRS Palaiseau France Institut Pluridisciplinaire Hubert Curien Université de Strasbourg Université de Haute Alsace Mulhouse CNRS/IN2P3 Strasbourg France Centre de Calcul de l’Institut National de Physique Nucleaire et de Physique des Particules CNRS/IN2P3 Ville

A search is performed for long-lived particles that decay into final states that include a pair of electrons or a pair of muons. The experimental signature is a distinctive topology consisting of a pair of charged leptons originating from a displaced secondary vertex. Events corresponding to an integrated luminosity of 19.6 (20.5) fb−1 in the electron (muon) channel were collected with the CMS detector at the CERN LHC in proton-proton collisions at s=8 TeV. No significant excess is observed above standard model expectations. Upper limits on the product of the cross section and branching fraction of such a signal are presented as a function of the long-lived particle’s mean proper decay length. The limits are presented in an approximately model-independent way, allowing them to be applied to a wide class of models yielding the above topology. Over much of the investigated parameter space, the limits obtained are the most stringent to date. In the specific case of a model in which a Higgs boson in the mass range 125–1000 GeV/c2 decays into a pair of long-lived neutral bosons in the mass range 20–350 GeV/c2, each of which can then decay to dileptons, the upper limits obtained are typically in the range 0.2–10 fb for mean proper decay lengths of the long-lived particles in the range 0.01–100 cm. In the case of the lowest Higgs mass considered (125 GeV/c2), the limits are in the range 2–50 fb. These limits are sensitive to Higgs boson branching fractions as low as 10−4.

关键词： MUONS PROTON-proton interactions HIGGS bosons ELECTRONS LUMINOSITY

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An Assistive Wheelchair based on a Concept of a Passive Robotics

An Assistive Wheelchair based on a Concept of a Passive Robo...

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Annual Conference of the IEEE Industrial Electronics Society

作者： Daisuke Chugo Tatsuya Higuchi Sho Yokota Yuki Sakaida Hiroshi Hashimoto School of Science and Technology Kwansei Gakuin University Faculty of Science and Engineering Setsunan University RIKEN-TRI Collaboration Center for Human-Interactive Robot Research (RTC) RIKEN (The Institute of Physical and Chemical Research) Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology

ISBN: (纸本)9781479902255

We propose a novel assistive wheelchair based on a concept of a passive robotics. Our proposed wheelchair consists of a frame, casters, wheels and servo brakes. Our wheelchair system estimates the trajectory its user wants to go using the characteristic of the rowing motion and realizes the estimated tracks by controlling a torque of the servo brake. Our system requires no actuators, and its mechanism is simple and low cost. There is no risk by malfunction of servomotors and patients can use it intuitively because they use our wheelchair passively with their own intentional force. Our key ideas are two topics. One is the development of novel passive-type assistive wheelchair which is suitable for a practical use. The other key topic is a novel driving assistance algorithm with estimation of the user's intention. For realizing this estimation, we use the minimum jerk trajectory model, which expresses a typical human movement. Our proposed system compares a beginning part of rowing motion by the user and this trajectory model, and estimates the whole rowing motion which will be performed. Using our proposed system, the user can drive our wheelchair with natural feeling. We test our proposed assistance system by the experiments with our prototype and verify its effectiveness.

关键词： Assistive Wheelchair Passive Robotics Servo Brakes Minimum Jerk Trajectory Model Wheelchair Servo Device Component trajectory Rowing Human locomotion robotics malfunctions Wheels Torque control

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Searching for Dark Matter Annihilation from Milky Way Dwarf Spheroidal Galaxies with Six Years of Fermi Large Area Telescope Data

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physical Review Letters 2015年第23期115卷 231301-231301页

作者： M. Ackermann A. Albert B. Anderson W. B. Atwood L. Baldini G. Barbiellini D. Bastieri K. Bechtol R. Bellazzini E. Bissaldi R. D. Blandford E. D. Bloom R. Bonino E. Bottacini T. J. Brandt J. Bregeon P. Bruel R. Buehler G. A. Caliandro R. A. Cameron R. Caputo M. Caragiulo P. A. Caraveo C. Cecchi E. Charles A. Chekhtman J. Chiang G. Chiaro S. Ciprini R. Claus J. Cohen-Tanugi J. Conrad A. Cuoco S. Cutini F. D’Ammando A. de Angelis F. de Palma R. Desiante S. W. Digel L. Di Venere P. S. Drell A. Drlica-Wagner R. Essig C. Favuzzi S. J. Fegan E. C. Ferrara W. B. Focke A. Franckowiak Y. Fukazawa S. Funk P. Fusco F. Gargano D. Gasparrini N. Giglietto F. Giordano M. Giroletti T. Glanzman G. Godfrey G. A. Gomez-Vargas I. A. Grenier S. Guiriec M. Gustafsson E. Hays J. W. Hewitt D. Horan T. Jogler G. Jóhannesson M. Kuss S. Larsson L. Latronico J. Li L. Li M. Llena Garde F. Longo F. Loparco P. Lubrano D. Malyshev M. Mayer M. N. Mazziotta J. E. McEnery M. Meyer P. F. Michelson T. Mizuno A. A. Moiseev M. E. Monzani A. Morselli S. Murgia E. Nuss T. Ohsugi M. Orienti E. Orlando J. F. Ormes D. Paneque J. S. Perkins M. Pesce-Rollins F. Piron G. Pivato T. A. Porter S. Rainò R. Rando M. Razzano A. Reimer O. Reimer S. Ritz M. Sánchez-Conde A. Schulz N. Sehgal C. Sgrò E. J. Siskind F. Spada G. Spandre P. Spinelli L. Strigari H. Tajima H. Takahashi J. B. Thayer L. Tibaldo D. F. Torres E. Troja G. Vianello M. Werner B. L. Winer K. S. Wood M. Wood G. Zaharijas S. Zimmer Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford California 94305 USA Department of Physics Stockholm University AlbaNova SE-106 91 Stockholm Sweden The Oskar Klein Centre for Cosmoparticle Physics AlbaNova SE-106 91 Stockholm Sweden Santa Cruz Institute for Particle Physics Department of Physics and Department of Astronomy and Astrophysics University of California at Santa Cruz Santa Cruz California 95064 USA Università di Pisa and Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica e Astronomia “G. Galilei” Università di Padova I-35131 Padova Italy Dept. of Physics and Wisconsin IceCube Particle Astrophysics Center University of Wisconsin Madison Wisconsin 53706 USA Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari I-70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino I-10125 Torino Italy Dipartimento di Fisica Generale “Amadeo Avogadro” Università degli Studi di Torino I-10125 Torino Italy NASA Goddard Space Flight Center Greenbelt Maryland 20771 USA Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 Montpellier France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 Palaiseau France Consorzio Interuniversitario per la Fisica Spaziale (CIFS) I-10133 Torino Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica I-20133 Milano Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia I-06123 Perugia Italy Dipartimento di Fisica Uni

The dwarf spheroidal satellite galaxies (dSphs) of the Milky Way are some of the most dark matter (DM) dominated objects known. We report on γ-ray observations of Milky Way dSphs based on six years of Fermi Large Area Telescope data processed with the new Pass8 event-level analysis. None of the dSphs are significantly detected in γ rays, and we present upper limits on the DM annihilation cross section from a combined analysis of 15 dSphs. These constraints are among the strongest and most robust to date and lie below the canonical thermal relic cross section for DM of mass ≲100 GeV annihilating via quark and τ-lepton channels.

关键词： Gamma ray astronomy Particle dark matter Normal galaxies

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Native gating behavior of ion channels in neurons with null-deviation modeling

Native gating behavior of ion channels in neurons with null-...

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

作者： Wei Wang Jie Luo Panpan Hou Yimei Yang Feng Xiao Ming Yuchi Anlian Qu Luyang Wang Jiuping Ding Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Wuhan China program in Neurosciences and Mental Health SickKids Research Institute & Department of Physiology University of Toronto Toronto Canada Key Laboratory of Image Processing and Intelligent Control Huazhong University of Science and Technology Ministry of Education Department of Biomedical Engineering College of Life Science and Technology Wuhan China

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Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

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BMC genomics 2016年第6期17 Suppl 6卷 487页

作者： Jerry W. Shay Noriko Homma Ruyun Zhou Muhammad Imran Naseer Adeel G. Chaudhary Mohammed Al-Qahtani Nobutaka Hirokawa Maryam Goudarzi Albert J. Fornace Saleh Baeesa Deema Hussain Mohammed Bangash Fahad Alghamdi Hans-Juergen Schulten Angel Carracedo Ishaq Khan Hanadi Qashqari Nawal Madkhali Mohamad Saka Kulvinder S. Saini Awatif Jamal Jaudah Al-Maghrabi Adel Abuzenadah Adeel Chaudhary Mohammed Al Qahtani Ghazi Damanhouri Heba Alkhatabi Anne Goodeve Laura Crookes Nikolas Niksic Nicholas Beauchamp Adel M. Abuzenadah Jim Vaught Bruce Budowle Mourad Assidi Abdelbaset Buhmeida Leena Merdad Sudhir Kumar Sayaka Miura Karen Gomez Mahmood Rasool Ahmed Rebai Sajjad Karim Hend F. Nour Eldin Heba Abusamra Elham M. Alhathli Nada Salem Mohammed H. Al-Qahtani Hossam Faheem Ashok Agarwa Eberhard Nieschlag Joachim Wistuba Oliver S. Damm Mohd A. Beg Taha A. Abdel-Meguid Hisham A. Mosli Osama S. Bajouh Serdar Coskun Muhammad Abu-Elmagd Ashraf Dallol Sahar Hakamy Wejdan Al-Qahtani Asia Al-Harbi Shireen Hussain Burak Ozkosem Rick DuBois Safia S. Messaoudi Maryam T. Dandana Touhami Mahjoub Wassim Y. Almawi S. Abdalla M. Nabil Al-Aama Asmaa Elzawahry Tsuyoshi Takahashi Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Isao Kurosaka Takahiko Nishigaki Hiromi Nakamura Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato Sajid Mehmood Naeem Mahmood Ashraf Awais Asif Muhammad Bilal Malik Siddique Mehmood Aadil Hussain Qazi Mohammad Sajid Jamal Mughees Uddin Siddiqui Mohammad A. Alzohairy Mohammad A. Al Karaawi Taoufik Nedjadi Heba Al-Khattabi Adel Al-Ammari Ahmed Al-Sayyad Hédia Zitouni Nozha Raguema Marwa Ben Ali Wided Malah Raja Lfalah Wassim Almawi Mohammed Elanbari Andrey Ptitsyn Sana Mahjoub Rabeb El Ghali Bechir Achour Nidhal Ben Amor Brahim N’siri Hamid Morjani Esam Azhar Vera Chayeb Maryam Dendena Hedia Zitouni Khedija Zouari-Limayem Bassem Refaat Ahmed M. Ashshi Sarah A. Batwa Hazem Ramadan Amal Awad Ahmed Ateya Adel Galal Ahmed El-Shemi Ahmad Ashshi Mohammed Basalamah Youjin Na Cha University of Texas Southwestern Medical Center Dallas USA Department of Cell Biology and Anatomy Graduate School of Medicine the University of Tokyo Tokyo Japan Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry and Molecular & Cellular Biology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Radiation Medicine Lombardi Comprehensive Cancer Center Georgetown University Washington USA Center of Excellence in Genomic Medicine Research (CEGMR) King Abdulaziz University Jeddah Kingdom of Saudi Arabia King Fahd Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia Centre of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Sheffield Diagnostic Genetic Service Sheffield Children’s NHS Foundation Trust Western Bank Sheffield UK Center of Innovations in Personalized Medicine King Abdulaziz University Jeddah Saudi Arabia President ISBER Editor-in-Chief Biopreservation & Biobanking ᅟ USA Institute of Applied Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Fort Worth USA Department of Dental Public Health Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia Institute for Genomics and Evolutionary Medicine Temple University Philadelphia USA Center of Excellence in Genomic Medicine King Abdulaziz University Jeddah Kingdom of Saudi Arabia Laboratory of Molecular and Cellular Screening Processes (Bioinformatics Group) Centre of Biotechnology of Sfax Sfax Tunisia Fujitsu Technology Solutions International ᅟ ᅟ Case Western Reserve University School of Medicine and Lerner College of Medicine Cleveland Clinic Foundation Cleveland USA American Center for Reproductive Medicine Andrology Center Cleveland USA Center for Reproductive Medicine and

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me

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Chapter green nanotechnology: Development of nanomaterials for environmental and energy applications

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ACS Symposium Series 2013年 1124卷 201-229页

作者： Han, Changseok Andersen, Joel Pillai, Suresh C. Fagan, Rachel Falaras, Polycarpos Byrne, J. Anthony Dunlop, Patrick S.M. Choi, Hyeok Jiang, Wenjun O'Shea, Kevin Dionysiou, Dionysios D. Environmental Engineering and Science Program University of Cincinnati Cincinnati OH 45221-0012 United States FOCAS Institute Dublin Institute of Technology Kevin St. Dublin 8 Ireland Division of Physical Chemistry Institute of Advanced Materials Physicochemical Processes Nanotechnology and Microsystems National Center for Scientific Research Demokritos 15310 Aghia Parakevi Attikis Athens Greece Nanotechnology and Integrated BioEngineering Centre School of Engineering University of Ulster Northern-Ireland BT37 0QB United Kingdom Department of Civil Engineering University of Texas at Arlington Arlington TX 76019-0308 United States Department of Chemistry and Biochemistry Florida International University University Park Miami FL 33199 United States Nireas-International Water Research Centre University of Cyprus 20537 Nicosia Cyprus

ISBN: (纸本)9780841227842

This book chapter discusses the syntheses of various nanomaterials, for green nanotechnology applications in detail. Special attention is given to the development of emerging areas, such as environmental as well as energy materials. Various approaches for preparing nanostructured photocatalysts, such as titanium dioxide, zinc oxide, iron oxide, and metal sulfides, different conventional methods and novel methods, including sol-gel methods, hydrothermal methods, microwave-assisted methods and sonochemical methods are introduced. The use of nanomaterials as photocatalysts, supporting materials for solar cells, and disinfectants is reported for environmental remediation and energy applications. Advanced applications of nanomaterials for water detoxification, air purification, and the inactivation of pathogenic microorganisms in water as well as dye-sensitized solar cells is also discussed. The enhancement of selectivity of photocatalysis, especially TiO2 systems, for the destruction of target contaminants in water is comprehensively presented. Finally, the role of reactive oxygen species (ROS), such as hydroxyl radical (•OH), superoxide anion radical (O2•-), singlet oxygen (1O2) and hydrogen peroxide (H2O2), in semiconductor photocatalysis is introduced and various experimental techniques to detect ROS are also discussed. © 2013 American Chemical Society.

关键词： Nanostructured materials

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Computational analysis of spatiotemporal molecular hierarchy in single live cells

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医用生物力学 2013年第S1期28卷 55-55页

作者： Shaoying Lu Jihye Seong Yi Wang Shiou-chi Chang John Paul Eichorst Mingxing Ouyang Yingxiao Wang Department of Bioengineering Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Neuroscience Program Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Chemical Engineering Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Center of Biophysics and Computational Biology Beckman Institute for Advanced Science and TechnologyDepartment of Molecular and Integrative PhysiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal *** enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell *** have developed a general correlative FRET imaging method(CFIM)to quantify the subcellular coupling between an enzymatic activity and a phenotypic response in live cells,*** focal adhesions(FAs).CFIM quantitatively evaluated the cause-effect relation-

关键词： visualize quantify FRET biosensors correlative intelligent quantitatively enormous automated tremendous

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Single-Molecule Study of G-Quadruplex Disruption Using Dynamic Force Spectroscopy

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physical Review Letters 2012年第5期109卷 058101-058101页

作者： Michel de Messieres Jen-Chien Chang Barbara Brawn-Cinani Arthur La Porta Department of Physics Institute for Physical Science and Technology Biophysics Program University of Maryland College Park Maryland 20742-0001 USA

Guanine-rich sequences in nucleic acids can fold into G quadruplexes, in which four guanines on a single strand combine to form G-tetrad planes stabilized by metallic ions. Sequence motifs which are predicted to form a G quadruplex are found throughout the genome and are believed to regulate a variety of biological processes. Detailed knowledge of the kinetics of G-quadruplex folding and unfolding would provide critical insight into these processes. To probe its structural stability, we used optical tweezers to disrupt single molecules of a single-stranded DNA G4 quadruplex. Dynamic force spectroscopy was employed, in which the distribution of rupture forces was measured for different loading rates and used to infer the nature of the transition state barrier for unfolding of the structure. The distance and height of the energy barriers were extracted for two observed conformations. The energy barrier was found to be close to the folded conformation, resulting in a high disruption force despite the relatively low energy barrier height.

关键词： SPECTRUM analysis QUADRUPLEX nucleic acids STRUCTURAL stability SINGLE molecules -- Spectra DNA probes CONFORMATIONAL analysis STRUCTURAL dynamics

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Computational analysis of spatiotemporal molecular hierarchy in single live cells

Computational analysis of spatiotemporal molecular hierarchy...

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第五届中美生物医学工程暨海内外生物力学学术研讨会

作者： Shaoying Lu Jihye Seong Yi Wang Shiou-chi Chang John Paul Eichorst Mingxing Ouyang Yingxiao Wang Department of Bioengineering Beckman Institute for Advanced Science and TechnologyDepartment of Molecular and Integrative PhysiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA. Neuroscience Program Beckman Institute for Advanced Science and TechnologyDepartment of Molecular and Integrative PhysiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Chemical Engineering Beckman Institute for Advanced Science and TechnologyDepartment of Molecular and Integrative PhysiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Center of Biophysics and Computational Biology Beckman Institute for Advanced Science and TechnologyDepartment of Molecular and Integrative PhysiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET) have been widely applied to visualize the molecular activity in live cells with high spatiotemporal *** enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell *** have developed a general correlative FRET imaging method(CFIM) to quan-

关键词： Computational analysis of spatiotemporal molecular hierarchy in single live cells

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Upconversion: Simultaneous Realization of Phase/Size Manipulation, Upconversion Luminescence Enhancement, and Blood Vessel Imaging in Multifunctional Nanoprobes Through Transition Metal Mn2+Doping (Adv. Funct. Mater. 26/2014)

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Advanced Functional Materials 2014年第26期24卷

作者： Songjun Zeng Zhigao Yi Wei Lu Chao Qian Haibo Wang Ling Rao Tianmei Zeng Hongrong Liu Huijing Liu Bin Fei Jianhua Hao College of Physics and Information Science and Key Laboratory of Low‐dimensional Quantum Structures and Quantum Control of the Ministry of Education Hunan Normal University Changsha 410081 China Faculty of Materials Optoelectronics and Physics Key Laboratory of Low‐dimensional Materials and Application Technology (Ministry of Education) Xiangtan University Xiangtan 411105 PR China Department of Applied Physics and Materials Research Center The Hong Kong Polytechnic University Hong Kong China CAS Key Laboratory of Brain Function and Disease the Center for Integrative Imaging (CII) of Hefei National Laboratory for Physical Science at the Microscale and Department of Neurobiology and Biophysics School of Life Sciences University of Science and Technology of China Hefei 230027 China Institute of Textiles & Clothing The Hong Kong Polytechnic University Hong Kong China

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