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arXiv 2023年

作者： Zulueta-Coarasa, Teresa Jug, Florian Mathur, Aastha Moore, Josh Muñoz-Barrutia, Arrate Anita, Liviu Babalola, Kola Bankhead, Pete Gilloteaux, Perrine Gogoberidze, Nodar Jones, Martin Kleywegt, Gerard J. Korir, Paul Kreshuk, Anna Yoldaş, Aybüke Küpcü Marconato, Luca Narayan, Kedar Norlin, Nils Oezdemir, Bugra Riesterer, Jessica Rzepka, Norman Sarkans, Ugis Serrano, Beatriz Tischer, Christian Uhlmann, Virginie Ulman, Vladimír Hartley, Matthew European Molecular Biology Laboratory European Bioinformatics Institute Hinxton United Kingdom Human Technopole V.le Rita Levi-Montalcini 1 Milan20017 Italy Heidelberg Meyerhofstraße 1 Heidelberg69117 Germany German BioImaging Gesellschaft für Mikroskopie und Bildanalyse e.V. Konstanz Germany Universidad Carlos III de Madrid Leganés Madrid Spain Instituto de Investigación Sanitaria Gregorio Marañón Madrid Spain Edinburgh Pathology Centre for Genomic and Experimental Medicine CRUK Scotland Centre University of Edinburgh Edinburgh United Kingdom Nantes Université CHU Nantes CNRS Inserm BioCore US16 SFR Bonamy NantesF 44000 France Imaging Platform Broad Institute Cambridge United States Francis Crick Institute London United Kingdom Cell Biology and Biophysics Unit European Molecular Biology Laboratory Heidelberg69117 Germany Genome Biology Unit Heidelberg Germany Heidelberg Germany Collaboration for joint PhD degree between EMBL and Heidelberg University Faculty of Biosciences Germany Center for Molecular Microscopy Center for Cancer Research National Cancer Institute NIH BethesdaMD United States Cancer Research Technology Program Frederick National Laboratory for Cancer Research FrederickMD United States Lund University 221 00 Sweden Knight Cancer Institute Oregon Health & Science University PortlandOR United States Scalable Minds GmbH Potsdam Germany European Molecular Biology Laboratory Heidelberg Germany IT4Innovations VSB – Technical University of Ostrava Ostrava-Poruba Czech Republic

Artificial Intelligence methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new methods, but access to such data is often hindered by the lack of standards for sharing datasets. We brought together community experts in a workshop to develop guidelines to improve the reuse of bioimages and annotations for AI applications. These include standards on data formats, metadata, data presentation and sharing, and incentives to generate new datasets. We are positive that the MIFA (Metadata, Incentives, Formats, and Accessibility) recommendations will accelerate the development of AI tools for bioimage analysis by facilitating access to high quality training data. © 2023, CC BY.

关键词： Metadata

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Time-resolved spectro-polarimetric analysis of extremely bright GRB 230307A: Evidence of evolution from photospheric to synchrotron dominated emission

arXiv

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arXiv 2025年

作者： Gupta, Soumya Gupta, Rahul Chattopadhayay, Tanmoy Sahayanathan, Sunder Frederiks, D. Svinkin, D. Bhattacharya, Dipankar Racusin, Judith Vadawale, Santosh Bhalerao, Varun Lysenko, A. Ridnaia, A. Tsvetkova, A. Ulanov, M. Bhabha Atomic Research Center Maharashtra Mumbai400094 India Homi Bhabha National Institute Maharashtra Mumbai400094 India Astrophysics Science Division NASA Goddard Space Flight Center Mail Code 661 GreenbeltMD20771 United States NASA Postdoctoral Program United States Kavli Institute of Particle Astrophysics and Cosmology Stanford University 452 Lomita Mall StanfordCA94305 United States Ioffe Institute 26 Politekhnicheskaya St. Petersburg194021 Russia Physical Research Laboratory Thaltej Gujarat Ahmedabad380009 India Department of Physics Ashoka University Haryana Sonipat131029 India Indian Institute of Technology Bombay Powai Maharashtra Mumbai400076 India Department of Physics University of Cagliari SP Monserrato-Sestu km 0.7 Monserrato09042 Italy

Context. The radiation mechanisms powering Gamma-ray bursts (GRBs) and their physical processes remain one of the unresolved questions in high-energy astrophysics. Spectro-polarimetric observations of exceptionally bright GRBs provide a powerful diagnostic tool to address these challenges. Aims. GRB 230307A, the second-brightest long-duration GRB ever detected, exhibits a rare association with a Kilonova, offering a unique and rare probe into the emission processes of GRBs originating from compact object mergers. Methods. We present a comprehensive time-averaged and time-resolved spectro-polarimetric analysis of GRB 230307A using joint observations from the AstroSat Cadmium Zinc Telluride Imager (CZTI), the Fermi Gamma-ray Burst Monitor (GBM) and Konus-Wind. Results. Spectral analysis reveals a temporal evolution in the low-energy photon index, α, transitioning from a hard to a softer state over the burst duration. Time-averaged polarimetric measurements yield a low polarization fraction ( 49 %) in the later stages of the emission episode. Conclusions. This spectro-polarimetric evolution suggests a transition in the dominant radiative mechanism: the initial phase characterized by thermal-dominated photospheric emission (unpolarized or weakly polarized) gives way to a regime dominated by non-thermal synchrotron emission (highly polarized). This transition provides critical evidence for the evolving influence of magnetic fields in shaping the GRB emission process and jet dynamics. Copyright © 2025, The Authors. All rights reserved.

关键词： Gamma radiography

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Multiplicity-dependent jet modification from di-hadron correlations in pp collisions at = 13 TeV

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Journal of High Energy Physics 2025年第3期2025卷 1-32页

作者： Acharya, S. Agarwal, A. Aglieri Rinella, G. Aglietta, L. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S. U. Ahuja, I. Akindinov, A. Akishina, V. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H. M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altamura, A. R. Altsybeev, I. Alvarado, J. R. Alvarez, C. O. R. Anaam, M. N. Andrei, C. Andreou, N. Andronic, A. Andronov, E. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Arnaldi, R. Arneiro, J. G. M. C. A. Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. Averyanov, D. Azmi, M. D. Baba, H. Badalà, A. Bae, J. Baek, Y. W. Bai, X. Bailhache, R. Bailung, Y. Bala, R. Balbino, A. Baldisseri, A. Balis, B. Banoo, Z. Barbasova, V. Barile, F. Barioglio, L. Barlou, M. Barman, B. Barnaföldi, G. G. Barnby, L. S. Barreau, E. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A. D. C. Bellini, F. Bellwied, R. Belokurova, S. Beltran, L. G. E. Beltran, Y. A. V. Bencedi, G. Bensaoula, A. Beole, S. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M. G. Betev, L. Bhaduri, P. P. Bhasin, A. Bhattacharjee, B. Bianchi, L. Bielčík, J. Bielčíková, J. Bigot, A. P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J. T. Blau, D. Blidaru, M. B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bok, J. Boldizsár, L. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A. G. Botta, E. Bouziani, Y. E. M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G. E. Buchakchiev, V. D. Buckland, M. D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Burmasov, N. Buthelezi, Z. Bylinkin, A. Bysiak, S. A. Cabanillas Noris, J. C. Cabrera, M. F. T. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camerini, P. Canedo, F. D. M. Cantway, S. L. Carabas, M. Carballo, A. A. Car Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento di Fisica dell’Università and Sezione INFN Turin Italy Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Frankfurt Institute for Advanced Studies Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico University of Houston Houston United States Sungkyunkwan University Suwon City Republic of Korea Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany INFN Sezione di Bari Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Universidad Autónoma de Puebla Puebla Mexico Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania University of Derby Derby United Kingdom Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy INFN Sezione di Bologna Bologna Italy Lawrence Berkeley National Laboratory Berkeley United States SUBATECH IMT Atlantique Nantes Université CNRS-IN2P3 Nantes France Laboratoire

Short-range correlations between charged particles are studied via two-particle angular correlations in pp collisions at $$ \sqrt{s} $$ = 13 TeV. The correlation functions are measured as a function of the relative azimuthal angle ∆φ and the pseudorapidity separation ∆η for pairs of primary charged particles within the pseudorapidity interval |η| < 0.9 and the transverse-momentum range 1 < pT < 8 GeV/c. Near-side (|∆φ| < 1.3) peak widths are extracted from a generalised Gaussian fitted over the correlations in full pseudorapidity separation (|∆η| < 1.8), while the per-trigger associated near-side yields are extracted for the short-range correlations (|∆η| < 1.3). Both are evaluated as a function of charged-particle multiplicity obtained by two different event activity estimators. The width of the near-side peak decreases with increasing multiplicity, and this trend is reproduced qualitatively by the Monte Carlo event generators PYTHIA 8, AMPT, and EPOS. However, the models overestimate the width in the low transverse-momentum region (pT < 3 GeV/c). The per-trigger associated near-side yield increases with increasing multiplicity. Although this trend is also captured qualitatively by the considered event generators, the yield is mostly overestimated by the models in the considered kinematic range. The measurement of the shape and yield of the short-range correlation peak can help us understand the interplay between jet fragmentation and event activity, quantify the narrowing trend of the near-side peak as a function of transverse momentum and multiplicity selections in pp collisions, and search for final-state jet modification in small collision systems.

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Simulation of hybridized nanofluids flowing and heat transfer enhancement via 3-D vertical heated plate using finite element technique

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Scientific reports 2022年第1期12卷 11658页

作者： Muhammad Bilal Hafeez Marek Krawczuk Hasan Shahzad Amjad Ali Pasha Mohammad Adil Faculty of Mechanical Engineering and Ship Technology Institute of Mechanics and Machine Design Gdansk University of Technology Narutowicza 11/12 80-233 Gdańsk Poland. Muhammad.bilal.hafeez@pg.edu.pl. Faculty of Mechanical Engineering and Ship Technology Institute of Mechanics and Machine Design Gdansk University of Technology Narutowicza 11/12 80-233 Gdańsk Poland. Faculty of Materials and Manufacturing College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Beijing China. Aerospace Engineering Department King Abdulaziz University Jeddah 21589 Saudi Arabia. Mechanical Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal 23955-6900 Saudi Arabia. KAUST Clean Combustion Research Center King Abdullah University of Science and Technology Thuwal 23955-6900 Saudi Arabia.

The present study probed the creation of heat energy and concentrating into Newtonian liquids across vertical 3D-heated plates. The role of the Soret and Dufour theories in concentrating and energy formulas is discussed. The role of hybrid nanoparticles is introduced to illustrate particle efficiency in terms of solute and thermal energy. It is removed a viscous dissipation process and a changing magnetic field. The proposed approach is motivated by the need to maximize solute and thermal energy uses in biological and industrial domains. The constructed system of (partial differential equations) PDEs includes concentration, momentum, and thermal energy equations within various thermal characteristics. Transformations are used to formulate the system of (ordinary differential equations) ODEs for solution. To assess various features vs various variables, a Galerkin finite element approach is used. Motion into nanoscale components is shown to be smaller than motion into hybrid nanoparticles. Furthermore, fluctuations in heat energy and solute particle counts are seen in relation to changes in Soret, Eckert, magnetic, and Dufour numbers. The basic finding is that the generation of thermal energy for hybridized nanomaterials is much higher.

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Prospects for neutrino astrophysics with Hyper-Kamiokande

Prospects for neutrino astrophysics with Hyper-Kamiokande

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37th International Cosmic Ray Conference, ICRC 2021

作者： Yano, Takatomi Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Alj Hakim, Y.I. Ameli, F. Anthony, L.H.V. Araya, A. Asaoka, Y. Aushev, V. Ballester, F. Bandac, I. Barbi, M. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Booth, N. Bordoni, S. Borjabad, S. Boschi, T. Bose, D. Boyd, S.B. Bozza, C. Bravar, A. Bronner, C. Brown, L. Bubak, A. Buchowicz, A. Buizza Avanzini, M. Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Carroll, A. Catanesi, M.G. Cebriàn, S. Chakraborty, S. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cuen-Rochin, S. Danilov, M. Díaz López, G. De la Fuente, E. de Perio, P. De Rosa, G. Dealtry, T. Densham, C.J. Dergacheva, A. Deshmukh, N. Devi, M.M. Di Lodovico, F. Di Meo, P. Di Palma, I. Doyle, T.A. Drakopoulou, E. Drapier, O. Dumarchez, J. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Esteve, R. Fedotov, S. Feng, J. Fernandez, P. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Finch, A. Finley, C. Fiorillo, G. Fitton, M. Friend, M. Fujii, Y. Fujisawa, C. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gousy-Leblanc, V. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Hadley, D.R. Harada, M. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hernando-Morata, J.A. Herrero, V. Hiraide, K. Holin, A. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Idrissi Ibnsalih, W. Ieki, K. Ikeda, M. Ioannisian, A. Ishida, T. Ishidoshiro, K. Ishino, H. Ishitsuka, M. Israel, H.T. Ito, H. Itow, Y. Izumi, N. Izumiyama, S. Jakkapu, M. Jamieson, B. Jang, J.S. Jo, H.S. Jonsson, P. Joo, K.K. Kajita, T. Kakuno, H. Kameda, J. Kaneshima, R. Kano, Y. Karlen, D. Kataoka, Y. Kato, A. Katori, T. Kazarian, N. Khabibullin, M. Kamioka Observatory ICRR The University of Tokyo Mozumi Kamioka Hida Gifu456 Japan University of Tokyo Institute for Cosmic Ray Research Kamioka Observatory Kamioka Japan University of Tokyo Institutes for Advanced Study Kashiwa Japan University of Tokyo Next-generation Neutrino Science Organization Kamioka Japan National Centre for Nuclear Research Warsaw Poland University of Tokyo Department of Physics Tokyo Japan TRIUMF VancouverBC Canada P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow Russia Kyoto University Department of Physics Kyoto Japan Imperial College London Department of Physics London United Kingdom INFN Sezione di Roma Università Sapienza Dipartimento di Fisica Roma Italy University of Tokyo Earthquake Research Institute Tokyo Japan Kyiv National University Department of Nuclear Physics Kyiv Ukraine Valencia Spain Laboratorio Subterráneo de Canfranc Estación Canfranc Spain University of Regina Department of Physics ReginaSK Canada Oxford University Department of Physics Oxford United Kingdom H. Niewodniczański Institute of Nuclear Physics PAN Cracow Poland INFN Sezione di Padova Università di Padova Dipartimento di Fisica Padova Italy INFN Sezione di Bari Università e Politecnico di Bari Bari Italy Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France Tokyo Institute of Technology Department of Physics Tokyo Japan York University Department of Physics and Astronomy TorontoON Canada University of California Irvine Department of Physics and Astronomy IrvineCA United States Laboratoire de Physique Nucleaire et de Hautes Energie IN2P3 CNRS Sorbonne Universitè Paris France INFN Sezione di Napoli Napoli Italy IRFU CEA Universitè Paris-Saclay Gif-sur-Yvette France University of Oviedo Applied Mathematical Modeling Group Department of Physics Oviedo Spain University of Victoria Department of Physics and Astronomy VictoriaBC Canada University of Geneva Section

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics. © Copyright owned by the author(s).

关键词： Water tanks

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Molecular resolution imaging by repetitive optical selective exposure (vol 16, pg 1114, 2019)

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NATURE METHODS 2019年第11期16卷 1193-1193页

作者： Gu, Lusheng Li, Yuanyuan Zhang, Shuwen Xue, Yanhong Li, Weixing Li, Dong Xu, Tao Ji, Wei National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China Physical Science Laboratory Huairou National Comprehensive Science Center Beijing China Center for Biological Instrument Development Core Facility for Protein Research Institute of Biophysics Chinese Academy of Sciences Beijing China College of Life Science University of Chinese Academy of Sciences Beijing China School of Future Technology University of Chinese Academy of Sciences Beijing China

We introduce an interferometric single-molecule localization method for super-resolution fluorescence microscopy. Fluorescence molecules are located by the intensities of multiple excitation patterns of an interference fringe, providing around a twofold improvement in the localization precision compared with the conventional imaging with the same photon budget. We demonstrate this technique by resolving nanostructures down to 5 nm in size over a large 25 × 25 μm2field of view.

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Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

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Cell biochemistry and biophysics 2024年第2期82卷 1325-1333页

作者： Chi-Cheng Li Bruce Chi-Kang Tsai Selvaraj Annseles Rajula Chiung-Hung Hsu Ming-Cheng Chen Chia-Hua Kuo Chung-Min Yeh Dennis Jine-Yuan Hsieh Wei-Wen Kuo Chih-Yang Huang Center of Stem Cell and Precision Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. School of Medicine Tzu Chi University Hualien Taiwan. Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Division of Colorectal Surgery Department of Surgery Taichung Veterans General Hospital Taichung Taiwan. Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Department of Sports Sciences University of Taipei Taipei Taiwan. Laboratory of Exercise Biochemistry University of Taipei Tianmu Campus Taipei Taiwan. Department of Kinesiology and Health Science College of William and Mary Williamsburg VA USA. School of Physical Education and Sports Science Soochow University Suzhou China. Department of Pathology Changhua Christian Hospital Changhua Taiwan. Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. Department of Surgical Pathology Changhua Christian Hospital Changhua Taiwan. Department of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan. Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan. Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. School of Pharmacy China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. cyhuang@mail.cmu.edu.tw. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. cyhuang@mail.cmu.edu.tw. Departmen

Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in many plants, has garnered recent attention for its discernible anti-mutagenic attributes. This investigation endeavored to scrutinize the repercussions of TA on grade II bladder cancer, with a concerted focus on unraveling its anti-cancer mechanisms. The cytotoxic effects of TA on grade II bladder cancer cells were investigated using multiple techniques, including MTT assay, flow cytometry, TUNEL assay, and western blot. Our findings revealed that elevated concentrations of TA induced cytotoxic effects in grade II bladder cancer cells. Both flow cytometry and the TUNEL assay substantiated the dose-dependent capacity of TA to prompt apoptosis. Western blot analysis corroborated that TA treatment in bladder cancer cells resulted in the upregulation of cleaved caspase-3 expression and PARP. Furthermore, heightened TA dosage elicited an augmentation in the expression of pro-apoptotic proteins, namely Bax and Bak, alongside a reduction in the expression of the anti-apoptotic protein Bcl-2 within bladder cancer cells. This study confirms TA as a potential anticancer agent, demonstrably diminishing the viability of bladder cancer cells. TA exerts cytotoxicity through the activation of mitochondrial apoptotic pathways. Specifically, TA initiates the cleavage of PARP and caspase-3, concurrently augmenting the expression of pro-apoptotic proteins to facilitate apoptosis. Collectively, the present study indicates that TA effectively impedes the proliferation of bladder cancer cells by instigating apoptosis through the intrinsic mitochondrial pathway.

关键词： Bax Bladder cancer Caspase Mitochondria Tannic acid

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DeePMD-kit v2: A software package for Deep Potential models

arXiv

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arXiv 2023年

作者： Zeng, Jinzhe Zhang, Duo Lu, Denghui Mo, Pinghui Li, Zeyu Chen, Yixiao Rynik, Marián Huang, Li'ang Li, Ziyao Shi, Shaochen Wang, Yingze Ye, Haotian Tuo, Ping Yang, Jiabin Ding, Ye Li, Yifan Tisi, Davide Zeng, Qiyu Bao, Han Xia, Yu Huang, Jiameng Muraoka, Koki Wang, Yibo Chang, Junhan Yuan, Fengbo Bore, Sigbjørn Løland Cai, Chun Lin, Yinnian Wang, Bo Xu, Jiayan Zhu, Jia-Xin Luo, Chenxing Zhang, Yuzhi Goodall, Rhys E.A. Liang, Wenshuo Singh, Anurag Kumar Yao, Sikai Zhang, Jingchao Wentzcovitch, Renata Han, Jiequn Liu, Jie Jia, Weile York, Darrin M. Weinan, E. Car, Roberto Zhang, Linfeng Wang, Han Laboratory for Biomolecular Simulation Research Institute for Quantitative Biomedicine Department of Chemistry and Chemical Biology Rutgers University PiscatawayNJ08854 United States AI for Science Institute Beijing100080 China DP Technology Beijing100080 China Academy for Advanced Interdisciplinary Studies Peking University Beijing100871 China HEDPS CAPT College of Engineering Peking University Beijing100871 China College of Electrical and Information Engineering Hunan University Changsha China Yuanpei College Peking University Beijing100871 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ08540 United States Department of Experimental Physics Comenius University Mlynská Dolina F2 Bratislava842 48 Slovakia Center for Quantum Information Institute for Interdisciplinary Information Sciences Tsinghua University Beijing100084 China Center for Data Science Peking University Beijing100871 China ByteDance Research Zhonghang Plaza No. 43 North 3rd Ring West Road Haidian District Beijing China College of Chemistry and Molecular Engineering Peking University Beijing100871 China Baidu Inc. Beijing China Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Zhejiang Hangzhou China Westlake AI Therapeutics Lab Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Hangzhou China Department of Chemistry Princeton University PrincetonNJ08544 United States SISSA Scuola Internazionale Superiore di Studi Avanzati Trieste34136 Italy Laboratory of Computational Science and Modeling Institute of Materials École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Department of Physics National University of Defense Technology Hunan Changsha410073 China State Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China School of Electronics Engineerin

DeePMD-kit is a powerful open-source software package that facilitates molecular dynamics simulations using machine learning potentials (MLP) known as Deep Potential (DP) models. This package, which was released in 2017, has been widely used in the fields of physics, chemistry, biology, and material science for studying atomistic systems. The current version of DeePMD-kit offers numerous advanced features such as DeepPot-SE, attention-based and hybrid descriptors, the ability to fit tensile properties, type embedding, model deviation, Deep Potential - Range Correction (DPRc), Deep Potential Long Range (DPLR), GPU support for customized operators, model compression, non-von Neumann molecular dynamics (NVNMD), and improved usability, including documentation, compiled binary packages, graphical user interfaces (GUI), and application programming interfaces (API). This article presents an overview of the current major version of the DeePMD-kit package, highlighting its features and technical details. Additionally, the article benchmarks the accuracy and efficiency of different models and discusses ongoing developments. © 2023, CC BY-NC-ND.

关键词： Molecular dynamics

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Cross-calibration and combined analysis of the CTA-LST prototype and the MAGIC telescopes 37

Cross-calibration and combined analysis of the CTA-LST proto...

引用

37th International Cosmic Ray Conference, ICRC 2021

作者： Ohtani, Y. Berti, A. Depaoli, D. Di Pierro, F. Green, D. Heckmann, L. Hütten, M. Inada, T. López-Coto, R. Medina, E. Moralejo, A. Morcuende, D. Pirola, G. Strzys, M. Suda, Y. Vovk, I. Abe, H. Aguasca, A. Agudo, I. Antonelli, L.A. Aramo, C. Armstrong, T. Artero, M. Asano, K. Ashkar, H. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardos, M.I. Biederbeck, N. Bigongiari, C. Blanch, O. Bonnoli, G. Bordas, P. Bose, D. Bulgarelli, A. Burelli, I. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Cassol, F. Cerruti, M. Chai, Y. Cheng, K. Chikawa, M. Chytka, L. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. De Angelis, A. de Bony de Lavergne, M. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsässer, D. Emery, G. Escudero, J. Fiasson, A. Foffano, L. Fonseca, M.V. Freixas Coromina, L. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grespan, P. Gunji, S. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Inome, Y. Iori, M. Ishio, K. Iwamura, Y. Jacquemont, M. Jimenez Martinez, I. Jouvin, L. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Le Flour, T. Longo, F. López-Moya, M. López-Oramas, A. Luque-Escamilla, P.L. Majumdar, P. Makariev, M. Mandat, D. Manganaro, M. Mannheim, K. Mariotti, M. Marquez, P. Marsella, G. Martí, J. Martinez, O. Martínez, G. Martínez, M. Marusevec, P. Mas, A. Maurin, G. Mazin, D. Mestre Guillen, E. Micanovic, S. Miceli, D. Miener, T. Miranda, J.M. Miranda, L.D.M. Mirzoyan, R. Mizuno, T. Molina, E. Montaruli, T. Monteiro, I. Moretti, E. ICRR The University of Tokyo 1-5-1 Kashiwa-no-ha Chiba Kashiwa City Japan Max Planck Institute for Physics Föhringer Ring 6 München80805 Germany INFN Sezione di Torino Via Pietro Giuria 1 Torino10125 Italy INFN Sezione di Padova Via Francesco Marzolo 8 Padova35131 Italy IFAE Edifici Cn Campus Universitat Autònoma de Barcelona Barcelona08193 Spain Universidad Complutense de Madrid Av. Séneca 2 Madrid28040 Spain Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain INFN Sezione di Napoli Italy Aix Marseille Univ CNRS IN2P3 CPPM France IRFU CEA Université Paris-Saclay France LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Italy INFN Sezione di Padova Università degli Studi di Padova Italy Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Department of Physics TU Dortmund University Germany INFN Sezione di Trieste Università degli Studi di Udine Italy INFN Sezione di Catania Italy University of Geneva Département de Physique Nucléaire et Corpusculaire Italy Palacky University Olomouc Faculty of Science Czech Republic Port d'Informació Científica Spain Dipartimento di Fisica Universitá degli Studi di Torino Italy University of Rijeka Department of Physics Croatia Institute for Theoretical Physics and Astrophysics Universität Würzburg Germany Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Japan INFN Sezione di Bari Politecnico di Bari Italy Faculty of Physics and Applied Informatics University of

The Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory, which will consist of three kinds of telescopes of different sizes. Among those, the Large Size Telescope (LST) will be the most sensitive in the low energy range starting from 20 GeV. The prototype LST (LST-1) proposed for CTA was inaugurated in October 2018 in the northern hemisphere site, La Palma (Spain), and is currently in its commissioning phase. MAGIC is a system of two gamma-ray Cherenkov telescopes of the current generation, located approximately 100 m away from LST-1, that have been operating in stereoscopic mode since 2009. Since LST-1 and MAGIC can observe the same air shower events, we can compare the brightness of showers, estimated energies of gamma rays, and other parameters event by event, which can be used to cross-calibrate the telescopes. Ultimately, by performing combined analyses of the events triggering the three telescopes, we can reconstruct the shower geometry more accurately, leading to better energy and angular resolutions, and a better discrimination of the background showers initiated by cosmic rays. For that purpose, as part of the commissioning of LST-1, we performed joint observations of established gamma-ray sources with LST-1 and MAGIC. Also, we have developed Monte Carlo simulations for such joint observations and an analysis pipeline which finds event coincidence in the offline analysis based on their timestamps. In this work, we present the first detection of an astronomical source, the Crab Nebula, with combined observation of LST-1 and MAGIC. Moreover, we show results of the inter-telescope cross-calibration obtained using Crab Nebula data taken during joint observations with LST-1 and MAGIC. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0)

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Multi-wavelength analysis of the galactic PeVatron candidate LHAASO J2108+5157

arXiv

引用

arXiv 2023年

作者： Pirola, G. Juryšek, J. Balbo, M. Eckert, D. Tramacere, A. Walter, R. Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Crespo, N. Alvarez Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Larriva, A. Baquero Baroncelli, L. de Almeida, U. Barres Barrio, J.A. Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernardos, M.I. Medrano, J. Bernete Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Mengual, J. Delgado della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ramazani, V. Fallah Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Coromina, L. Freixas Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. López, R. Garcia Gasbarra, C. Gasparrini, D. Geyer, D. Paiva, J. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Llorente, J. Herrera Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Martinez, I. Jimenez Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany FZU - Institute of Physics the Czech Academy of Sciences Na Slovance 1999/2 182 00 Prague 8 Czech Republic Department of Astronomy University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland Department of Physics Tokai University Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain Port d’Informació Científica Spain University of Rijeka Department of Physics Croatia Institute for Theoretical Physics and Astrophysics Universität Wür

LHAASO J2108+5157 is a recently discovered source, detected in the Ultra-High-Energy band by the LHAASO collaboration. Two molecular clouds were identified in the direction coincident with LHAASO J2108+5157 and, from the spectra reported by LHAASO, there is no sign of an energy cutoff up to 200 TeV. This source makes a promising galactic PeVatron candidate. In 2021, the Large-Sized Telescope prototype (LST-1) of the Cherenkov Telescope Array (CTA) Observatory, collected about 50 hours of quality-selected data on LHAASO J2108+5157. Through these observations, we managed to compute stringent upper limits on the source emission in the multi-TeV band. Together with the analysis of XMM-Newton data and 12 years of Fermi-LAT data, we performed a multi-wavelength study of the source, investigating different possible scenarios of particle acceleration. In this contribution, we will present the results of the analysis, as well as the multi-wavelength modeling, and consequent interpretation of different possible scenarios of emission. © 2023, CC0.

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