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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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GWTC-3: Compact Binary Coalescences Observed by LIGO and Virgo during the Second Part of the Third Observing Run

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physical Review X 2023年第4期13卷 041039-041039页

作者： R. Abbott T. D. Abbott F. Acernese K. Ackley C. Adams N. Adhikari R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith S. Akcay T. Akutsu S. Albanesi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koji Arai Koya Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud M. Arogeti S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. M. Aston P. Astone F. Aubin C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi C. P. L. Berry D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare U. Bhardwaj D. Bhattacharjee S. Bhaumik I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. Brandt J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic C. Buy R. L. Byer G. S. Cabourn Davies L. Cadonati G. Cagn LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia LIGO Livingston Observatory Livingston Louisiana 70754 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India University College Dublin Dublin 4 Ireland Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan INFN Sezione di Torino I-10125 Torino Italy Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1 CNRS Institut L

The third Gravitational-Wave Transient Catalog (GWTC-3) describes signals detected with Advanced LIGO and Advanced Virgo up to the end of their third observing run. Updating the previous GWTC-2.1, we present candidate gravitational waves from compact binary coalescences during the second half of the third observing run (O3b) between 1 November 2019, 15∶00 Coordinated Universal Time (UTC) and 27 March 2020, 17∶00 UTC. There are 35 compact binary coalescence candidates identified by at least one of our search algorithms with a probability of astrophysical origin pastro>0.5. Of these, 18 were previously reported as low-latency public alerts, and 17 are reported here for the first time. Based upon estimates for the component masses, our O3b candidates with pastro>0.5 are consistent with gravitational-wave signals from binary black holes or neutron-star–black-hole binaries, and we identify none from binary neutron stars. However, from the gravitational-wave data alone, we are not able to measure matter effects that distinguish whether the binary components are neutron stars or black holes. The range of inferred component masses is similar to that found with previous catalogs, but the O3b candidates include the first confident observations of neutron-star–black-hole binaries. Including the 35 candidates from O3b in addition to those from GWTC-2.1, GWTC-3 contains 90 candidates found by our analysis with pastro>0.5 across the first three observing runs. These observations of compact binary coalescences present an unprecedented view of the properties of black holes and neutron stars.

关键词： Gravitational waves

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A Comparative Study of Th-U233 and Th-Pu Molten-Salt Reactor (MSR) with 2-region core

引用

Journal of Physics: Conference Series 2020年第1期1493卷

作者： M Ifthacharo S Permana G Saputra Master Program of Physics Department Faculty of Mathematics and Natural Science Bandung Institute of Technology Jalan Ganesha 10 Bandung 40132 Indonesia Nuclear Physics and Biophysics Research Division Physics Department Faculty of Mathematics and Natural Science Bandung Institute of Technology Jalan Ganesha 10 Bandung 40132 Indonesia

Sustainable closed fuel cycle and inherent safety are one of the key aspects of Generation IV reactor design. Hence Molten salt reactor (MSR) is chosen as one of the candidates of Generation IV reactor concepts. FUJI-U2 or MSR-2R is a 2-region core MSR design that was proposed as a possible simplification of FUJI-U3 (3-region core). Taking into consideration that uranium−233 doesn't exist naturally, FUJI-U2 utilize both plutonium and uranium−233 as a fissile material. To understand the characteristics further, a comparative study of 2-region core MSR with Th-U233 and Th-Pu as fuel has been carried out. Nuclear analysis code SRAC2006 with the nuclear data library of JENDL4.0 was used, and CITATION was employed to validate the core. The design parameters set for each region are fuel composition, core radius, and fuel fraction. The simulation burn up calculation is set to 2000 days in total, with 21 step each for 100 days cycle. Neutron multiplication factor, fuel elemental, burn up calculation, conversion ratio, and neutron flux in each core will be discussed.

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The Effect of Temperature Variations on Wood's Metal Plate Melting Simulation by Using MPS

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Journal of Physics: Conference Series 2020年第1期1493卷

作者： Anni Nuril Hidayati Abdul Waris Asril Pramutadi Andi Mustari Nur Asiah Apriani Melati Ifthacharo Rindi Wulandari Master Program of Physics Department Faculty of Mathematics and Natural Science Bandung Institute of Technology Jalan Ganesha 10 Bandung 40132 Indonesia Nuclear Physics and Biophysics Research Division Physics Department Faculty of Mathematics and Natural Science Bandung Institute of Technology Jalan Ganesha 10 Bandung 40132 Indonesia

Two-dimensional simulation of Wood's Metal Plate (WMP) Melting Process has been conducted by varying the molten temperature. This simulation was performed by using Moving Particle Semi-Implicit (MPS) method which can calculate the Navier-Stokes and heat transfer equation without divining mesh system. As a substitute, particles are selected to represent every part of simulation such as fluid, wall and dummy type. The experiment of WMP melting process has been conducted by Sudha (2018). The molten Wood's Metal was originally set at 573 K. In this simulation, the holes formation in WMP will be investigated as a consequence of molten temperature variation. Furthermore, temperature distribution at top side of WMP and solid-liquid phase change will be analyzed for initial temperature of molten are 523 K, 473 K and 423 K. The results show that the phases change significantly in a short time when the molten temperature is increased. However, until the end of simulation which on 1.5 s just for molten temperature 573 K shows the breaching process to the WMP. This study can be implemented when the reactor nuclear severe accident happened.

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Cosmological perturbations in modified teleparallel gravity models: Boundary term extension

arXiv

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arXiv 2020年

作者： Bahamonde, Sebastian Gakis, Viktor Kiorpelidi, Stella Koivisto, Tomi Said, Jackson Levi Saridakis, Emmanuel N. Laboratory of Theoretical Physics Institute of Physics University of Tartu W. Ostwaldi 1 Tartu50411 Estonia Laboratory for Theoretical Cosmology Tomsk State University of Control Systems and Radioelectronics Tomsk634050 Russia Institute of Space Sciences and Astronomy University of Malta Msida Malta Department of Physics National Technical University of Athens Zografou Campus GR Athens157 73 Greece National Institute of Chemical Physics and Biophysics Rävala pst. 10 Tallinn10143 Estonia Institute of Space Sciences and Astronomy University of Malta Msida Malta Department of Physics University of Malta Msida Malta Department of Astronomy School of Physical Sciences University of Science and Technology of China Hefei230026 China

Teleparallel gravity offers a new avenue in which to construct gravitational models beyond general relativity. While teleparallel gravity can be framed in a way to be dynamically equivalent to general relativity, its modifications are mostly not equivalent to the traditional route to modified gravity. f(T, B) gravity is one such gravitational theory where the second and fourth order contributions to the field equations are decoupled. In this work, we explore the all important cosmological perturbations of this new framework of gravity. We derive the gravitational propagation equation, its vector perturbation stability conditions, and its scalar perturbations. Together with the matter perturbations, we derive the effective gravitational constant in this framework, and find an interesting branching behaviour that depends on the particular gravitational models being probed. We close with a discussion on the relation of these results with other gravitational theories. Copyright © 2020, The Authors. All rights reserved.

关键词： Relativity

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Cover Feature: Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase (ChemSusChem 9/2022)

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ChemSusChem 2022年第9期15卷

作者： Dr. Christian Sonnendecker Dr. Juliane Oeser P. Konstantin Richter Patrick Hille Ziyue Zhao Dr. Cornelius Fischer Dr. Holger Lippold Paula Blázquez-Sánchez Felipe Engelberger Prof. Dr. César A. Ramírez-Sarmiento Thorsten Oeser Yuliia Lihanova Dr. Ronny Frank Dr. Heinz-Georg Jahnke Dr. Susan Billig Prof. Dr. Bernd Abel Prof. Dr. Norbert Sträter Prof. Dr. Jörg Matysik Prof. Dr. Wolfgang Zimmermann Institute of Analytical Chemistry Leipzig University 04103 Leipzig Germany Department of Microbiology and Bioprocess Technology Institute of Biochemistry Leipzig University 04103 Leipzig Germany Institute of Bioanalytical Chemistry Centre for Biotechnology and Biomedicine Leipzig University 04103 Leipzig Germany Helmholtz-Zentrum Dresden-Rossendorf (HZDR) Institut für Ressourcenökologie Abteilung Reaktiver Transport D-04318 Leipzig Germany Institute for Biological and Medical Engineering Schools of Engineering Medicine and Biological Sciences Pontificia Universidad Católica de Chile Santiago 7820436 Chile ANID—Millennium Science Initiative Program Millennium Institute for Integrative Biology (iBio) Santiago 8331150 Chile Centre for Biotechnology and Biomedicine Molecular Biological-Biochemical Processing Technology Leipzig University 04103 Leipzig Germany Leibniz Institute of Surface Engineering (IOM) Wilhelm-Ostwald-Institute of Physical and Theoretical Chemistry 04103 Leipzig Germany

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Exploring Observational Heliophysics Across All Scales: Reflections and Insights From the 2023 NASA Heliophysics Summer School

Perspectives of Earth and Space Scientists

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Perspectives of Earth and Space Scientists 2024年第1期5卷

作者： S. R. Shaver A. R. Smith S. S. Babu Y. Baruah M. Bauer V. Chaturmutha H. Chen B. Dalal G. B. Dias da Silva T. Eddy G. González S. Gu E. Gülay A. P. Hoffmann O. R. Idolor R. Khan Y. Liou N. Liu X. Lyu A. Maharana D. K. V. Radhakrishnan O. M. Romeo P. O. C. Silva H. M. Salah C. Thibeault A. Weiss Laboratory for Atmospheric and Space Physics University of Colorado Boulder CO USA Geophysical Institute University of Alaska Fairbanks AK USA Department of Physics University of Alberta Edmonton AB Canada Department of Physical Sciences Indian Institute of Science Education and Research Kolkata Mohanpur West Bengal India Center of Excellence in Space Sciences India Indian Institute of Science Education and Research Kolkata Mohanpur West Bengal India Austrian Space Weather Office GeoSphere Austria Graz Austria Department of Physics & Astronomy Georgia State University Atlanta GA USA Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana IL USA Space and Atmospheric Sciences Physical Research Laboratory Ahmedabad Gujarat India National Institute for Space Research (INPE) São Paulo Brazil Department of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI USA Space Sciences Laboratory University of California Berkeley Berkeley CA USA Department of Physics University of Texas at Dallas Richardson TX USA Istanbul Technical University Istanbul Turkiye Department of Physics Faculty of Science University of Lagos Lagos Nigeria Indian Institute of Astrophysics Bangalore Karnataka India Department of Engineering Physics Embry-Riddle Aeronautical University Daytona Beach FL USA New Jersey Institute of Technology Newark NJ USA West Virginia University Morgantown WV USA Katholieke Universiteit Leuven Leuven Belgium University of Texas at San Antonio San Antonio TX USA Southwest Research Institute San Antonio TX USA Physics Department Faculty of Science Space Weather Monitoring Center Helwan University Cairo Egypt Université de Montréal Montréal QC Canada NASA Postdoctoral Program Fellowship NASA Goddard Space Flight Center Greenbelt MD USA

The field of heliophysics encompasses a diverse range of research areas and rich plasma environments, from the solar dynamo and solar wind turbulence, to the complex terrestrial thermosphere-ionosphere-magnetosphere (TIM) system, to investigations of both induced and intrinsic magnetospheres across the solar system. This perspective paper delves into the experiences and outcomes of a summer school held in person in Boulder, Colorado, USA, from 7–11 August, which offered a platform for interdisciplinary learning and collaboration. The event, supported by NASA's Living with a Star program and hosted by the University Corporation for Atmospheric Research and Cooperative programs for the Advancement of Earth System science, assembled a cohort of 26 graduate students and postdoctoral researchers from around the world, all engaged in heliophysics research. The summer school included a series of lectures, interactive activities, and a culminating capstone project. The participants' diverse backgrounds enriched discussions and encouraged novel approaches to traditional problems. The capstone projects spanned an array of topics, including investigating the origins of solar wind switchbacks, dissecting the sequence of events from solar eruptions and their corresponding terrestrial consequences, investigating the energy transfer from solar coronal mass ejections to Earth's magnetosphere, and advocating for the exploration of Coulomb collisions in understanding large-scale global systems. Through this perspective, we shed light on the value of international and interdisciplinary collaboration in advancing heliophysics research. This perspective paper encapsulates the ethos of the summer school, serving as a testament to the continuing and collective pursuit of unraveling the mysteries of the heliosphere. Cooperative programs for the Advancement of Earth System science/University Corporation for Atmospheric Research held the seventeenth annual NASA Heliophysics Summer School bot

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Assessing the Management of Excessive Daytime Sleepiness by Napping Benefits

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Sleep and Vigilance 2020年第2期4卷 117-123页

作者： Murillo-Rodríguez, Eric Yamamoto, Tetsuya Monteiro, Diogo Budde, Henning Rocha, Nuno Barbosa Cid, Luis Teixeira, Diogo S. Telles-Correia, Diogo Veras, André Barciela Machado, Sérgio Imperatori, Claudio Torterolo, Pablo Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina División Ciencias de la Salud Universidad Anáhuac Mayab Km. 15.5 Carretera Mérida-Progreso Int. Km. 2 Carretera a Chablekal Mérida C.P. 97308 Yucatán Mexico Intercontinental Neuroscience Research Group Mérida Yucatán Mexico Graduate School of Technology Industrial and Social Sciences Tokushima University Tokushima Japan Research Center in Sport Health and Human Development-CIDESD Vila Real Portugal Sport Science School of Rio Maior-Polytechnic Institute of Santarém Rio Maior Portugal Faculty of Human Sciences Medical School of Hamburg Hamburg Germany School of Health Polytechnic Institute of Porto Porto Portugal Interdisciplinary Center for the Study of Human Performance (CIPER) Universidade Lusófona de Humanidades e Tecnologias Lisbon Portugal Faculty of Medicine University of Lisbon Lisbon Portugal Medical School at State University of Mato Grosso do Sul Campo Grande Mato Grosso do Sul Brazil Laboratory of Physical Activity Neuroscience Physical Activity Sciences Postgraduate Program Salgado de Oliveira University Niterói Brazil Cognitive and Clinical Psychology Laboratory Department of Human Science European University of Rome Rome Italy Laboratorio de Neurobiología del Sueño Departamento de Fisiología Facultad de Medicina Universidad de la República Montevideo Uruguay

Purpose: Demanding lifestyle characterized by extended working hours, shift work schedules as well as excessive use of mobile gadgets leads to the disruption of the circadian and homeostatic factors affecting the sleep quality of individuals. As consequence, subjects complain of suffering several sleep disorders some of them characterized by inducing excessive daytime sleepiness (EDS). Currently, the therapeutic approaches for managing EDS include medication, promotion of sleep hygiene, cognitive and behavioral therapy or using of continuous positive airway pressure machine. In this review, we propose the posology of the personalized sleep medicine by the prescription of naps for treating EDS. Methods: This review included the online search in PubMed and manual review of articles (basic and clinical trials) of a range of personalized medicine potentially associated to factors of dosage in areas such as nutrition, sports and sleep. Articles in English were identified and subsequently analyzed for consideration for this review. Results: Current evidence has demonstrated that naps exert positive outcomes for individuals complaining with EDS. The dosage of naps might follow similar procedures as reported for personalized interventions in diets or exercise programs (by taking the right dose, at the proper time, with a recommended frequency) which have demonstrated successfully results. Conclusions: The management of EDS may include the personalized sleep medicine considering the prescription of dosage of naps. © 2020, Springer Nature Singapore Pte Ltd.

关键词： Diets Dose Exercise Food

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Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study

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Journal of critical care 2025年 89卷 155142页

作者： Kirby P Mayer J Pedro Teixeira Felipe González-Seguel Vinh Q Tran Jessica M Gross Arimitsu Horikawa-Strakovsky Chaitanya Anil Pal Zan T Shareef Hayley Puffer Israel Yuan Wen Benjamin R Griffin Javier A Neyra Department of Physical Therapy College of Health Sciences University of Kentucky Lexington KY USA Center for Muscle Biology University of Kentucky Lexington KY USA. Electronic address: kpmaye2@uky.edu. Division of Nephrology University of New Mexico School of Medicine Albuquerque NM USA Division of Pulmonary Critical Care and Sleep Medicine University of New Mexico School of Medicine Albuquerque NM USA. Center for Muscle Biology University of Kentucky Lexington KY USA School of Physical Therapy Faculty of Medicine Clínica Alemana Universidad del Desarrollo Chile. Division of Physical Therapy Department of Orthopaedics University of New Mexico School of Medicine Albuquerque NM USA. Clinical and Translational Science Center University of New Mexico Health Sciences Center Albuquerque NM USA. Math Science and Technology Center Program Paul Laurence Dunbar High School Lexington KY USA Institute for Biomedical Informatics University of Kentucky Lexington KY USA. Division of Nephrology University of New Mexico School of Medicine Albuquerque NM USA. Institute for Biomedical Informatics University of Kentucky Lexington KY USA Department of Physiology College of Medicine University of Kentucky Lexington KY USA. Division of Nephrology University of Iowa Hospitals and Clinics Iowa City IA USA. Department of Internal Medicine Division of Nephrology University of Alabama at Birmingham Birmingham AL USA. Electronic address: jneyra@uabmc.edu.

PURPOSE:Acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT) has been hypothesized to increase the risk of developing intensive care unit-associated weakness (ICU-AW), but prospective data are lacking. MATERIALS AND METHODS:This prospective observational study evaluated critically ill adults with AKI requiring CKRT at two U.S. academic hospitals. Using ultrasonography (US), we quantified changes in rectus femoris (RF) muscle mass and quality in the first week after CKRT initiation. At hospital discharge, we assessed for ICU-AW, physical function, and frailty. RESULTS:Twenty-three patients with median age 56 [IQR 47-60] years, BMI 29 [26-36] kg/m, and Charlson Comorbidity Index 3 [1.5-5] were enrolled. The baseline Sequential Organ Failure Assessment (SOFA) score was 9 [7.5-11.5] and CKRT duration was 4 [1-7] days. Six (26 %) patients died in the ICU and one (4 %) transitioned to comfort measures before study completion. Substantial muscle wasting occurred between Day 1 and Day 7: RF muscle thickness (mT) decreased by 10 % [3 %-20 %]; RF cross-sectional area (CSA) decreased by 19 % [12 %-22 %]; and echo intensity (EI) increased (implying worse muscle quality) by 14 % [5 %-25 %]. A significant effect of time within subjects was observed for all three ultrasound measures (CSA: F = 66.2, p < 0.001; mT: F = 27.1, p < 0.001; EI: F = 22.5, p < 0.001). At hospital discharge, 67 % of survivors (n = 10/15) met criteria for ICU-AW. CONCLUSIONS:Patients with AKI requiring CKRT experienced significant muscle wasting in the first week following CKRT initiation and had high rate of ICU-AW at hospital discharge. TRIAL REGISTRATION:NCT05287204, Registered 20 October 2021.

关键词： Acute kidney injury Continuous kidney replacement therapy Dialysis ICU-acquired weakness Muscle weakness physical frailty physical function

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A large population of strongly lensed faint submillimetre galaxies in future dark energy surveys inferred from JWST imaging

arXiv

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arXiv 2023年

作者： Pearson, James Serjeant, Stephen Wang, Wei-Hao Gao, Zhen-Kai Babul, Arif Chapman, Scott Chen, Chian-Chou Clements, David L. Conselice, Christopher J. Dunlop, James Fan, Lulu Ho, Luis C. Hwang, Ho Seong Koprowski, Maciej Michalowski, Michal Shim, Hyunjin Michalowski, Michal J. School of Physical Sciences The Open University Milton KeynesMK7 6AA United Kingdom No. 1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Department of Physics & Astronomy University of Victoria 3800 Finnerty Road VictoriaBCV8P 5C2 Canada Department of Physics & Astronomy Vancouver Campus University of British Columbia 325 - 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Astrophysics Group Imperial College London Blackett Laboratory Prince Consort Road LondonSW7 2AZ United Kingdom Department of Physics and Astronomy The University of Manchester Alan Turing Building Oxford Road ManchesterM13 9PL United Kingdom Institute for Astronomy Royal Observatory Blackford Hill EdinburghEH9 3HJ United Kingdom Deep Space Exploration Laboratory Department of Astronomy University of Science and Technology of China Hefei230026 China Kavli Institute for Astronomy and Astrophysics Peking University 5 Yi He Yuan Road Haidian District Beijing100871 China Astronomy Program Department of Physics and Astronomy Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University Grudziądzka 5 Toruń87-100 Poland Astronomical Observatory Institute Faculty of Physics Adam Mickiewicz University in Poznań ul. Sloneczna 36 Poznań60-286 Poland Department of Earth Science Education Kyungpook National University 80 Daehak-ro Buk-gu Daegu41566 Korea Republic of

Bright galaxies at sub-millimetre wavelengths from Herschel are now well known to be predominantly strongly gravitationally lensed. The same models that successfully predicted this strongly lensed population also predict about one percent of faint 450 μm -selected galaxies from deep James Clerk Maxwell Telescope (JCMT) surveys will also be strongly lensed. Follow-up ALMA campaigns have so far found one potential lens candidate, but without clear compelling evidence e.g. from lensing arcs. Here we report the discovery of a compelling gravitational lens system confirming the lensing population predictions, with a zs = 3.4 ± 0.4 submm source lensed by a zspec = 0.360 foreground galaxy within the COSMOS field, identified through public JWST imaging of a 450 μm source in the SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES) catalogue. These systems will typically be well within the detectable range of future wide-field surveys such as Euclid and Roman, and since sub-millimetre galaxies are predominantly very red at optical/near-infrared wavelengths, they will tend to appear in near-infrared channels only. Extrapolating to the Euclid-Wide survey, we predict tens of thousands of strongly lensed near-infrared galaxies. This will be transformative for the study of dusty star-forming galaxies at cosmic noon, but will be a contaminant population in searches for strongly lensed ultra-high-redshift galaxies in Euclid and Roman. Copyright © 2023, The Authors. All rights reserved.

关键词： Galaxies

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