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Conference on Lasers and Electro-Optics Europe

作者： Anastasios D. Koulouklidis Claudia Gollner Valentina Shumakova Vladimir Yu. Fedorov Audrius Pugzlys Andrius Baltuska Stelios Tzortzakis Institute of Electronic Structure and Laser FORTH 70013 Heraklion Crete Greece Science Program Texas A&M University at Qatar P.O. Box 23874 Doha Qatar Photonics Institute TU Wien Gusshausstrasse 27-387 A-1040 Vienna Austria P. N. Lebedev Physical Institute of the Russian Academy of Sciences 53 Leninskiy Prospekt 119991 Moscow Russia Center for Physical Sciences & Technology Savanoriu Ave. 231 LT-02300 Vilnius Lithuania Department of Materials Science and Technology University of Crete 70013 Heraklion Crete Greece

ISBN: (纸本)9781728104690

Despite the rapid development of terahertz (THz) science during the last two decades, the majority of available THz sources remains rather weak, limiting the interactions of THz radiation with matter mostly in the realm of linear optics. Development of powerful THz sources will open the way to many exciting applications spanning from switching and controlling of magnetic domains to THz-enhanced attosecond pulse generation.

关键词： Attosecond pulses Electric fields Laser filaments Pulse generation Terahertz generation Ti:sapphire lasers

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Probing Charm Quark Dynamics via Multiparticle Correlations in Pb-Pb Collisions at sNN=5.02 TeV

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physical Review Letters 2022年第2期129卷 022001-022001页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt J. De Clercq M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen T. T. Tran M. Tytgat W. Verbeke B. Vermassen M. Vit A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn P. Vischia S. Wertz S. Wuyckens G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza D. Matos Figueiredo C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng W. Fang Q. Guo T. Javaid M. Mittal H. Wang L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey USA Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU)

Multiparticle azimuthal correlations of prompt D0 mesons are measured in Pb-Pb collisions at a nucleon-nucleon center-of-mass energy of sNN=5.02 TeV. For the first time, a four-particle cumulant method is used to extract the second Fourier coefficient of the azimuthal distribution (v2) of D0 mesons as a function of event centrality and the D0 transverse momentum. The ratios of the four-particle v2 values to previously measured two-particle cumulant results provide direct experimental access to event-by-event fluctuations of charm quark azimuthal anisotropies. These ratios are also found to be comparable to those of inclusive charged particles in the event. However, hints of deviations are seen in the most central and peripheral collisions. To investigate the origin of flow fluctuations in the charm sector, these measurements are compared to a model implementing fluctuations of charm quark energy loss via collisional or radiative processes in the quark-gluon plasma. These models cannot quantitatively describe the data over the full transverse momentum and centrality ranges, although the calculations with collisional energy loss provide a better description of the data.

关键词： Particle correlations & fluctuations Quark-gluon plasma Relativistic heavy-ion collisions Charm quark

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Search for Resonances Decaying to Three W Bosons in Proton-Proton Collisions at s=13 TeV

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physical Review Letters 2022年第2期129卷 021802-021802页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt J. De Clercq M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza D. Matos Figueiredo C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng Q. Guo T. Javaid M. Mittal H. Wang L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey USA Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou China Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU) F

A search for resonances decaying into a W boson and a radion, where the radion decays into two W bosons, is presented. The data analyzed correspond to an integrated luminosity of 138 fb−1 recorded in proton-proton collisions with the CMS detector at s=13 TeV. One isolated charged lepton is required, together with missing transverse momentum and one or two massive large-radius jets, containing the decay products of either two or one W bosons, respectively. No excess over the background estimation is observed. The results are combined with those from a complementary channel with an all-hadronic final state, described in an accompanying paper. Limits are set on parameters of an extended warped extra-dimensional model. These searches are the first of their kind at the LHC.

关键词： Hypothetical particle physics models W & Z bosons Hadron colliders

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Search for Flavor-Changing Neutral Current Interactions of the Top Quark and Higgs Boson in Final States with Two Photons in Proton-Proton Collisions at s=13 TeV

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physical Review Letters 2022年第3期129卷 032001-032001页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck D. Schwarz S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer L. Wezenbeek T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen M. Tytgat B. Vermassen M. Vit A. Benecke A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza D. Matos Figueiredo C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng T. Javaid M. Mittal L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Kapoor D. Leggat H. Liao Z.-A. Liu V. Mi Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt National Institute of Chemical Physics and Bi

Proton-proton interactions resulting in final states with two photons are studied in a search for the signature of flavor-changing neutral current interactions of top quarks (t) and Higgs bosons (H). The analysis is based on data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb−1. No significant excess above the background prediction is observed. Upper limits on the branching fractions (B) of the top quark decaying to a Higgs boson and an up (u) or charm (c) quark are derived through a binned fit to the diphoton invariant mass spectrum. The observed (expected) 95% confidence level upper limits are found to be 0.019% (0.031%) for B(t→Hu) and 0.073% (0.051%) for B(t→Hc). These are the strictest upper limits yet determined.

关键词： Higgs bosons Top quark Hadron colliders

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First polarisation measurement of coherently photoproduced J/ψ in ultra-peripheral Pb–Pb collisions at s_NN=5.02 TeV

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Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics 2025年 865卷

作者： Acharya, S. Adamová, D. Adler, A. Aglieri Rinella, G. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S.U. Ahuja, I. Akindinov, A. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H.M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altsybeev, I. Alvarado, J.R. Anaam, M.N. Andrei, C. Andronic, A. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Aresti, M. Arnaldi, R. Arneiro, J.G.M.C.A. Arsene, I.C. Arslandok, M. Augustinus, A. Averbeck, R. Azmi, M.D. Badalà, A. Bae, J. Baek, Y.W. Bai, X. Bailhache, R. Bailung, Y. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Banoo, Z. Barbera, R. Barile, F. Barioglio, L. Barlou, M. Barnaföldi, G.G. Barnby, L.S. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J.L. Bearden, I.G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A.D.C. Bellini, F. Bellwied, R. Belokurova, S. Belyaev, V. Bencedi, G. Beole, S. Bercuci, A. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M.G. Betev, L. Bhaduri, P.P. Bhasin, A. Bhat, M.A. Bhattacharjee, B. Bianchi, L. Bianchi, N. Bielčík, J. Bielčíková, J. Biernat, J. Bigot, A.P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J.T. Blau, D. Blidaru, M.B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bogdanov, A. Boi, S. Bok, J. Boldizsár, L. Bombara, M. Bond, P.M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A.G. Bossi, H. Botta, E. Bouziani, Y.E.M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G.E. Buckland, M.D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Buthelezi, Z. Bylinkin, A. Bysiak, S.A. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J.M.M. Camerini, P. Canedo, F.D.M. Cantway, S.L. Carabas, M. Carballo, A.A. Carnesecchi, F. Caron, R. Carvalho, L.A.D. Castillo Castellanos, J. Catalano, F. Ceballos Sanchez, C. Chakaberia, I. Chakraborty, P. Chandra, S. Chapeland, S. Chartier, M. Chattopa A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation Yerevan Armenia AGH University of Krakow Cracow Poland Bogolyubov Institute for Theoretical Physics National Academy of Sciences of Ukraine Kiev Ukraine Bose Institute Department of Physics Centre for Astroparticle Physics and Space Science (CAPSS) Kolkata India California Polytechnic State University San Luis Obispo CA United States Central China Normal University Wuhan China Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN) Havana Cuba Centro de Investigación y de Estudios Avanzados (CINVESTAV) Mexico City and Mérida Mexico Chicago State University Chicago IL United States China Institute of Atomic Energy Beijing China Chungbuk National University Cheongju South Korea Comenius University Bratislava Faculty of Mathematics Physics and Informatics Bratislava Slovakia COMSATS University Islamabad Islamabad Pakistan Creighton University Omaha NE United States Department of Physics Aligarh Muslim University Aligarh India Department of Physics Pusan National University Pusan South Korea Department of Physics Sejong University Seoul South Korea Department of Physics University of California Berkeley CA United States Department of Physics University of Oslo Oslo Norway Department of Physics and Technology University of Bergen Bergen Norway Dipartimento di Fisica Università di Pavia Pavia Italy Dipartimento di Fisica dell'Università Sezione INFN Cagliari Italy Dipartimento di Fisica dell'Università Sezione INFN Trieste Italy Dipartimento di Fisica dell'Università Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Bologna Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Catania Italy Dipartimento di Fisica e Astronomia dell'Università Sezione INFN Padova Italy Dipartimento di Fisica ‘E.R. Caianiello’ dell'Università Gruppo Collegato INFN Salerno Italy Dipartimento DISAT del Politecnico

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at sNN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channe...

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at s_NN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channel in the forward rapidity interval −4.0−1 ± 5% (syst) is analysed. Hadronic activity is highly suppressed since the interaction is mediated by a photon. The polar and azimuthal angle distributions of the decay muons are measured, and the polarisation parameters λ_θ, λ_φ, λ_θφ are extracted. The analysis is carried out in the helicity frame. The results are found to be consistent with a transversely polarised J/ψ. These values are compared with previous measurements by the H1 and ZEUS experiments. The polarisation parameters of coherent J/ψ photoproduction in Pb–Pb collisions are found to be consistent with the s-channel helicity conservation hypothesis. © 2025 CERN for the benefit of the ALICE Collaboration

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Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera

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Journal of biomedical science 2023年第1期30卷 27页

作者： Yu-Ling Tseng Po-Chao Lu Chi-Chang Lee Ruei-Yu He Yung-An Huang Yin-Chen Tseng Ting-Jen Rachel Cheng Joseph Jen-Tse Huang Jim-Min Fang Department of Chemistry National Taiwan University Taipei 106 Taiwan. Institute of Chemistry Academia Sinica Taipei 115 Taiwan. Chemical Biology and Molecular Biophysics Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan. Department and Graduate Institute of Pharmacology National Taiwan University Taipei 100 Taiwan. The Genomics Research Center Academia Sinica Taipei 115 Taiwan. Institute of Chemistry Academia Sinica Taipei 115 Taiwan. jthuang@gate.sinica.edu.tw. Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan. jthuang@gate.sinica.edu.tw. Department of Applied Chemistry National Chiayi University Chiayi City 600 Taiwan. jthuang@gate.sinica.edu.tw. Neuroscience Program of Academia Sinica Academia Sinica Taipei 115 Taiwan. jthuang@gate.sinica.edu.tw. Department of Chemistry National Taiwan University Taipei 106 Taiwan. jmfang@ntu.edu.tw. The Genomics Research Center Academia Sinica Taipei 115 Taiwan. jmfang@ntu.edu.tw.

BACKGROUND:Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-terminal TDP-43 (C-TDP-43) aggregates and oligomers were neurotoxic and pathologic agents in ALS and frontotemporal lobar degeneration (FTLD). However, misfolding protein has long been considered as an undruggable target by applying conventional inhibitors, agonists, or antagonists. To provide this unmet medical need, we aim to degrade these misfolding proteins by designing a series of proteolysis targeting chimeras (PROTACs) against C-TDP-43. METHODS:By applying filter trap assay, western blotting, and microscopy imaging, the degradation efficiency of C-TDP-43 aggregates was studied in Neuro-2a cells overexpressing eGFP-C-TDP-43 or mCherry-C-TDP-43. The cell viability was characterized by alarmarBlue assay. The beneficial and disaggregating effects of TDP-43 PROTAC were examined with the YFP-C-TDP-43 transgenic C. elegans by motility assay and confocal microscopy. The impact of TDP-43 PROTAC on C-TDP-43 oligomeric intermediates was monitored by fluorescence lifetime imaging microscopy and size exclusion chromatography in the Neuro-2a cells co-expressing eGFP-C-TDP-43 and mCherry-C-TDP-43. RESULTS:Four PROTACs with different linker lengths were synthesized and characterized. Among these chimeras, PROTAC 2 decreased C-TDP-43 aggregates and relieved C-TDP-43-induced cytotoxicity in Neuro-2a cells without affecting endogenous TDP-43. We showed that PROTAC 2 bound to C-TDP-43 aggregates and E3 ligase to initiate ubiquitination and proteolytic degradation. By applying advanced microscopy, it was further shown that PROTAC 2 decreased the compactness and population of C-TDP-43 oligomers. In addition to cellular model, PROTAC 2 also improved the motility of transgenic C. elegans by reducing the C-TDP-43 aggregates in the nervous system. CONCLUSIONS:Our study

关键词： Aggregate and oligomer Amyotrophic lateral sclerosis Neurodegenerative diseases PROTACs Protein degradation TDP-43 cytotoxicity Transgenic C. elegans

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Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at s=13 TeV

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physical Review Letters 2022年第8期129卷 081802-081802页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck D. Schwarz S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen M. Tytgat B. Vermassen L. Wezenbeek A. Benecke A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes P. Rebello Teles W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng T. Javaid M. Mittal L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Kapoor D. Leggat H. Liao Z.-A. Liu V. Milosevic F. Monti R. Sharma J. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Rice University Houston Texas USA Zhejiang University Hangzhou China Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt The University of Kansas Lawrence Kansas USA Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt N

A search for pairs of Higgs bosons produced via gluon and vector boson fusion is presented, focusing on the four b quark final state. The data sample consists of proton-proton collisions at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, and corresponds to an integrated luminosity of 138 fb−1. No deviation from the background-only hypothesis is observed. A 95% confidence level upper limit on the Higgs boson pair production cross section is observed at 3.9 times the standard model prediction for an expected value of 7.8. Constraints are also set on the modifiers of the Higgs field self-coupling, κλ, and of the coupling of two Higgs bosons to two vector bosons, κ2 V. The observed (expected) allowed intervals at the 95% confidence level are −2.3<κλ<9.4 (−5.0<κλ<12.0) and −0.1<κ2 V<2.2 (−0.4<κ2 V<2.5). These are the most stringent observed constraints to date on the HH production cross section and on the κ2 V coupling.

关键词： Bottom quark Higgs bosons Hadron colliders

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MoEDAL-MAPP - an LHC Dedicated Detector Search Facility

arXiv

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arXiv 2022年

作者： Acharya, B. Alexandre, J. Benes, P. Bergmann, B. Bertolucci, S. Bevan, A. Branzas, H. Burian, P. Campbell, M. Cecchini, S. Cho, Y.M. de Montigny, M. De Roeck, A. Ellis, J.R. El Sawy, M. Fairbairn, M. Felea, D. Frank, M. Hays, J. Hirt, A.M. Hung, P.Q. Janecek, J. Kalliokoski, M. Korzenev, A. Lacarrère, D.H. Leroy, C. Levi, G. Lionti, A. Margiotta, A. Maselek, R. Maulik, A. Mauri, N. Mavromatos, N.E. Mieskolainen, M. Millward, L. Mitsou, V.A. Musumeci, E. Orava, R. Ostrovskiy, I. Ouimet, P.-P. Papavassiliou, J. Patrizii, L. Pavalaş, G.E. Pinfold, James L. Popa, L.A. Popa, V. Pozzato, M. Pospisil, S. Rajantie, A. Ruiz de Austri, R. Sahnoun, Z. Sakellariadou, M. Sakurai, K. Santra, A. Sarkar, S. Semenoff, G. Shaa, A. Sirri, G. Sliwa, K. Soluk, R. Spurio, M. Staelens, M. Suk, M. Tenti, M. Togo, V. Tuszynski, J.A. Upreti, A. Vento, V. Vives, O. Theoretical Particle Physics & Cosmology Group Physics Dept. King's College London United Kingdom IEAP Czech Technical University Prague Czech Republic INFN Section of Bologna Bologna Italy School of Physics and Astronomy Queen Mary University of London United Kingdom Institute of Space Science Magurele Bucharest Romania Experimental Physics Department CERN Geneva Switzerland Center for Quantum Spacetime Sogang University Seoul Korea Republic of Physics Department University of Alberta EdmontonAB Canada Theoretical Physics Department CERN Geneva Switzerland Department of Physics Concordia University MontréalQC Canada Department of Earth Sciences Swiss Federal Institute of Technology Zurich Switzerland Department of Physics University of Virginia CharlottesvilleVA United States Helsinki Institute of Physics University of Helsinki Helsinki Finland Département de Physique Nucléaire et Corpusculaire Université de Genève Geneva Switzerland Département de Physique Université de Montréal Québec Canada INFN Section of Bologna Department of Physics & Astronomy University of Bologna Italy Institute of Theoretical Physics University of Warsaw Warsaw Poland Physics Department University of Helsinki Helsinki Finland IFIC Universitat de València - CSIC Valencia Spain Department of Physics and Astronomy University of Alabama TuscaloosaAL United States Physics Department University of Regina ReginaSK Canada Department of Physics Imperial College London United Kingdom Research Centre for Astronomy Astrophysics and Geophysics Algiers Algeria Department of Physics University of British Columbia VancouverBC Canada Department of Physics and Astronomy Tufts University MedfordMA United States INFN CNAF Bologna Italy Int. Centre for Theoretical Physics Trieste Italy National Institute of Chemical Physics & Biophysics Tallinn Estonia Dept. of Physics Faculty of Science Beni-Suef University Egypt Department of Physics School of Applied Mathematica

During LHC's Run-2 the MoEDAL experiment, the LHC's first dedicated search experiment, took over 6 fb−1 of data at IP8, with p-p and Pb-Pb collisions, operating with 100% efficiency. The LHCC has endorsed the LoI of the MoEDAL Collaboration describing an exciting program to expand the search for highly ionizing particles in proton-proton and heavy-ion collisions to include feebly ionizing and long-lived messengers of new physics at LHC's Run-3 and eventually High Luminosity LHC (HL-LHC). In 2021, as part of Phase-1 of the MoEDAL-MAPP project, the baseline MoEDAL detector was approved by CERN for reinstallation for Run-3 with increased efficiency, lower threshold, a factor of five increase in instantaneous luminosity, and, a higher centre-of-mass energy. MoEDAL will continue the search for highly ionizing particle avatars of new physics with an emphasis on the search for massive, single and multiply electrically charged particles arising from, for example, supersymmetry, neutrino mass models, L-R symmetry, etc. As part of Phase-1 of the MoEDAL-MAPP project, the CERN Research Board also approved, in December 2021, the installation of the MoEDAL Apparatus for Penetrating Particles (MAPP) in the UA83 tunnel some 100 m away from IP8. Installation of MAPP is already underway. The MAPP detector expands the physics reach of MoEDAL to include sensitivity to feebly interacting particles with charge, or effective charge, as low as 10−3e (where e is the electron charge). Additionally, the MAPP detector in conjunction with MoEDAL's trapping detector gives us a unique sensitivity to extremely long-lived charged particles. MAPP also has some sensitivity to long-lived neutral particles. In Phase-2 of the project we will install the MAPP-2 upgrade to the MoEDAL-MAPP experiment for the HL-LHC. We envisage that this detector will be deployed in the UGC1 gallery near to IP8. This phase of the experiment is designed to ensure that MoEDAL-MAPP's sensitivity to very long-lived neutral mes

关键词： Luminance

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Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

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Biophysical Reviews 2018年第5期10卷 1263-1282页

作者： Nussinov, Ruth Zhang, Mingzhen Tsai, Chung-Jung Liao, Tsung-Jen Fushman, David Jang, Hyunbum Cancer and Inflammation Program Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research National Cancer Institute at Frederick 1050 Boyles St. Frederick 21702 MD United States Department of Human Molecular Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel Aviv 69978 Israel Biophysics Program Institute for Physical Science and Technology University of Maryland College Park 20742 MD United States Department of Chemistry and Biochemistry Center for Biomolecular Structure and Organization University of Maryland College Park 20742 MD United States

Autoinhibition is an effective mechanism that guards proteins against spurious activation. Despite its ubiquity, the distinct organizations of the autoinhibited states and their release mechanisms differ. Signaling is most responsive to the cell environment only if a small shift in the equilibrium is required to switch the system from an inactive (occluded) to an active (exposed) state. Ras signaling follows this paradigm. This underscores the challenge in pharmacological intervention to exploit and enhance autoinhibited states. Here, we review autoinhibition and release mechanisms at the membrane focusing on three representative Ras effectors, Raf protein kinase, PI3Kα lipid kinase, and NORE1A (RASSF5) tumor suppressor, and point to the ramifications to drug discovery. We further touch on Ras upstream and downstream signaling, Ras activation, and the Ras superfamily in this light, altogether providing a broad outlook of the principles and complexities of autoinhibition. © 2018, The Author(s).

关键词： Activation Allosteric Drug HRAS Inhibitor K-RAS4A K-RAS4B KRAS NRAS

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Search for heavy resonances decaying to WW, WZ, or WH boson pairs in a final state consisting of a lepton and a large-radius jet in proton-proton collisions at s=13 TeV

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physical Review D 2022年第3期105卷 032008-032008页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf X. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt J. De Clercq M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza D. Matos Figueiredo C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng Q. Guo T. Javaid M. Mittal H. Wang L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista São Paulo Brazil Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey USA Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU)

A search for new heavy resonances decaying to pairs of bosons (WW, WZ, or WH) is presented. The analysis uses data from proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb−1. One of the bosons is required to be a W boson decaying to an electron or muon and a neutrino, while the other boson is required to be reconstructed as a single jet with mass and substructure compatible with a quark pair from a W, Z, or Higgs boson decay. The search is performed in the resonance mass range between 1.0 and 4.5 TeV and includes a specific search for resonances produced via vector boson fusion. The signal is extracted using a two-dimensional maximum likelihood fit to the jet mass and the diboson invariant mass distributions. No significant excess is observed above the estimated background. Model-independent upper limits on the production cross sections of spin-0, spin-1, and spin-2 heavy resonances are derived as functions of the resonance mass and are interpreted in the context of bulk radion, heavy vector triplet, and bulk graviton models. The reported bounds are the most stringent to date.

关键词： Higgs bosons Hypothetical particles W & Z bosons Hadron colliders

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