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First Search for Exclusive Diphoton Production at High Mass with Tagged Protons in Proton-Proton Collisions at s=13 TeV

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physical Review Letters 2022年第1期129卷 011801-011801页

作者： A. Tumasyan W. Adam T. Bergauer M. Dragicevic J. Erö A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec F. M. Pitters N. Rad J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz M. Zarucki V. Chekhovsky A. Litomin V. Makarenko J. Suarez Gonzalez M. R. Darwish E. A. De Wolf D. Di Croce X. Janssen T. Kello A. Lelek M. Pieters H. Rejeb Sfar H. Van Haevermaet P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols S. S. Chhibra J. D’Hondt J. De Clercq D. Lontkovskyi S. Lowette I. Marchesini S. Moortgat A. Morton Q. Python S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker B. Dorney L. Favart A. Grebenyuk A. K. Kalsi I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur M. Gruchala I. Khvastunov M. Niedziela C. Roskas K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit G. Bruno F. Bury C. Caputo P. David C. Delaere M. Delcourt I. S. Donertas A. Giammanco V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn P. Vischia S. Wertz S. Wuyckens G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior E. Belchior Batista Das Chagas H. Brandao Malbouisson W. Carvalho J. Chinellato E. Coelho E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza J. Martins D. Matos Figueiredo M. Medina Jaime C. Mora Herrera L. Mundim H. Nogima P. Rebello Teles L. J. Sanchez Rosas A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng W. Fang Q. Guo H. Wang L. Yuan M. Ahmad G. Bauer Z. Hu Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen T. Javaid A. Kapoor D. Leggat H. Liao Z.-A. Liu R. Sharma A Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista São Paulo Brazil Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey USA Department of Physics Tsinghua University Tsinghua China University of Virginia Charlottesville Virginia USA Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High E

A search for exclusive two-photon production via photon exchange in proton-proton collisions, pp→pγγp with intact protons, is presented. The data correspond to an integrated luminosity of 9.4 fb−1 collected in 2016 using the CMS and TOTEM detectors at a center-of-mass energy of 13 TeV at the LHC. Events are selected with a diphoton invariant mass above 350 GeV and with both protons intact in the final state, to reduce backgrounds from strong interactions. The events of interest are those where the invariant mass and rapidity calculated from the momentum losses of the forward-moving protons match the mass and rapidity of the central, two-photon system. No events are found that satisfy this condition. Interpreting this result in an effective dimension-8 extension of the standard model, the first limits are set on the two anomalous four-photon coupling parameters. If the other parameter is constrained to its standard model value, the limits at 95% confidence level are |ζ1|<2.9×10−13 GeV−4 and |ζ2|<6.0×10−13 GeV−4.

关键词： Hypothetical scalars Photons Protons Hadron colliders

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Using Z Boson Events to Study Parton-Medium Interactions in Pb-Pb Collisions

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physical Review Letters 2022年第12期128卷 122301-122301页

作者： A. M. Sirunyan A. Tumasyan W. Adam F. Ambrogi T. Bergauer M. Dragicevic J. Erö A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko T. Madlener I. Mikulec F. M. Pitters N. Rad J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz M. Zarucki V. Chekhovsky A. Litomin V. Makarenko J. Suarez Gonzalez M. R. Darwish E. A. De Wolf D. Di Croce X. Janssen T. Kello A. Lelek M. Pieters H. Rejeb Sfar H. Van Haevermaet P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols S. S. Chhibra J. D’Hondt J. De Clercq D. Lontkovskyi S. Lowette I. Marchesini S. Moortgat A. Morton Q. Python S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker B. Dorney L. Favart A. Grebenyuk A. K. Kalsi I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur M. Gruchala I. Khvastunov M. Niedziela C. Roskas K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit G. Bruno F. Bury C. Caputo P. David C. Delaere M. Delcourt I. S. Donertas A. Giammanco V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn P. Vischia S. Wuyckens J. Zobec G. A. Alves G. Correia Silva C. Hensel A. Moraes W. L. Aldá Júnior E. Belchior Batista Das Chagas H. BRANDAO MALBOUISSON W. Carvalho J. Chinellato E. Coelho E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza J. Martins D. Matos Figueiredo M. Medina Jaime M. Melo De Almeida C. Mora Herrera L. Mundim H. Nogima P. Rebello Teles L. J. Sanchez Rosas A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel E. J. Tonelli Manganote F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev I. Atanasov R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov M. Bonchev A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov W. Fang Q. Guo H. Wang L. Yuan M. Ahmad Z. Hu Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Wien Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista São Paulo Brazil Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey USA Department of Physics Tsinghua University Beijing China University of Virginia Charlottesville Virginia USA Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High En

The spectra measurements of charged hadrons produced in the shower of a parton originating in the same hard scattering with a leptonically decaying Z boson are reported in lead-lead nuclei (Pb-Pb) and proton-proton (pp) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. Both Pb-Pb and pp data sets are recorded by the CMS experiment at the LHC and correspond to an integrated luminosity of 1.7 nb−1 and 320 pb−1, respectively. Hadronic collision data with one reconstructed Z boson candidate with the transverse momentum pT>30 GeV/c are analyzed. The Z boson constrains the initial energy and direction of the associated parton. In heavy ion events, azimuthal angular distributions of charged hadrons with respect to the direction of a Z boson are sensitive to modifications of the in-medium parton shower and medium response. compared to reference data from pp interactions, the results for central Pb-Pb collisions indicate a modification of the angular correlations. The measurements of the fragmentation functions and pT spectra of charged particles in Z boson events, which are sensitive to medium modifications of the parton shower longitudinal structure, are also reported. Significant modifications in central Pb-Pb events compared to the pp reference data are also found for these observables.

关键词： Quark-gluon plasma Relativistic heavy-ion collisions W & Z bosons Hadron colliders

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StormSense: A Blueprint for Coastal Flood Forecast Information & Automated Alert Messaging Systems 3

StormSense: A Blueprint for Coastal Flood Forecast Informati...

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3rd International Workshop on science of Smart City Operations and Platforms Engineering, in Partnership with Global City Teams Challenge, SCOPE-GCTC 2018

作者： Loftis, Jon Derek Katragadda, Sridhar Rhee, Sokwoo Nguyen, Cuong Virginia Institute of Marine Science College of William and Mary Gloucester PointVA United States City of Virginia Beach Dept. of Comm. and Info. Technology Virginia BeachVA United States Smart Grid and Cyber-Physical Systems Program Office National Institute of Standards and Technology GaithersburgMD United States

ISBN: (纸本)9781538667460

Increased availability of low-cost water level sensors communicating through the Internet of Things (IoT) has expanded the horizons of publicly-ingestible data streams available to modern smart cities. StormSense is an IoT-enabled inundation forecasting research initiative and an active participant in the Global City Teams Challenge seeking to enhance flood preparedness in the smart cities of Hampton Roads, VA for flooding resulting from storm surge, rain, and tides. In this study, we present the a blueprint and series of applicable protocols through the use of the new StormSense water level sensors to help establish a regional resilience monitoring network. In furtherance of this effort, the Virginia Commonwealth Center for Recurrent Flooding Resiliency's Tidewatch tidal forecast system is being used as a starting point to integrate the extant (NOAA) and new (USGS and StormSense) water level sensors throughout the region, and demonstrate replicability of the solution across the cities of Newport News, Norfolk, and Virginia Beach within Hampton Roads, VA. StormSense's network employs a mix of ultrasonic sonar and radar remote sensing technologies to record water levels and develop autonomous alert messaging systems through the use of three separate cloud environments. One to manage the water level monitoring sensors and alert messaging, one to run the model and interface with the post-processed results, and one to geospatially present the flood results. © 2018 IEEE.

关键词： Internet of things

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Advanced multiphoton polymerization using tunable shaped laser wavepackets

Advanced multiphoton polymerization using tunable shaped las...

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Frontiers in Optics, FIO 2018

作者： Manousidaki, Maria Fedorov, Vladimir Yu. Papazoglou, Dimitrios G. Farsari, Maria Tzortzakis, Stelios Institute of Electronic Structure and Laser Foundation for Research and Technology Hellas Heraklion71110 Greece Materials Science and Technology Department University of Crete Heraklion71003 Greece Science Program Texas A and M University at Qatar P.O. Box 23874 Doha Qatar P.N. Lebedev Physical Institute of the Russian Academy of Sciences 53 Leninskiy Prospekt Moscow119991 Russia

Tunable abruptly autofocusing ring Airy beams enable advanced multiscale photo - polymerization. Scaling down to the paraxial regime, these beams can approach the wavelength limit while presenting a strong enhancement... 详细信息

ISBN: (纸本)9781943580460

关键词： Photopolymerization

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Initiation Mechanism of Kinesin's Neck Linker Docking Process

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Chinese Physics Letters 2017年第2期34卷 117-121页

作者：耿轶钊张辉吕刚纪青 Institute of Biophysics Hebei University of TechnologyTianjin 300401 School of Science Hebei University of TechnologyTianjin 300401 Mathematical and Physical Science School North-China Electric-Power UniversityBaoding 071003 State Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190

The neck linker （NL） docking to the motor domain is the key force generation process of a kinesin motor. In the initiation step of NL docking the first three residues （LYS325, THR326 and ILE327 in 2KIN） of the NL must form an ＇extra turn＇, thus the other parts of the NL could dock to the motor domain. How the extra turn is formed remains elusive. We investigate the extra turn formation mechanism using structure-based mechanical analysis via molecular dynamics simulation. We find that the motor head rotation induced by ATP binding first drives ILE327 to move towards a hydrophobic pocket on the motor domain. The driving force, together with the hydrophobic interaction of ILE327 with the hydrophobic pocket, then causes a clockwise rotation of THR326, breaks the locking of LYS325, and finally drives the extra turn formation. This extra turn formation mechanism provides a clear pathway from ATP binding to NL docking of kinesin.

关键词： NL THR

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge CB10 1SA UK Korea Advanced Institute of Science and Technology Daejeon 34141 South Korea Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Korea Advanced Institute of Science and Technology Daejeon South Korea Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston MA USA Ludwig Center at Harvard Medical School Boston MA USA Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Broad Institute of MIT and Harvard

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OpenKBP-Opt: An international and reproducible evaluation of 76 knowledge-based planning pipelines

arXiv

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arXiv 2022年

作者： Babier, Aaron Mahmood, Rafid Zhang, Binghao Alves, Victor G.L. Barragán-Montero, Ana Maria Beaudry, Joel Cardenas, Carlos E. Chang, Yankui Chen, Zijie Chun, Jaehee Diaz, Kelly Eraso, Harold David Faustmann, Erik Gaj, Sibaji Gay, Skylar Gronberg, Mary Guo, Bingqi He, Junjun Heilemann, Gerd Hira, Sanchit Huang, Yuliang Ji, Fuxin Jiang, Dashan Giraldo, Jean Carlo Jimenez Lee, Hoyeon Lian, Jun Liu, Shuolin Liu, Keng-Chi Marrugo, José Miki, Kentaro Nakamura, Kunio Netherton, Tucker Nguyen, Dan Nourzadeh, Hamidreza Osman, Alexander F.I. Peng, Zhao Muñoz, José Darío Quinto Ramsl, Christian Rhee, Dong Joo Rodriguez, Juan David Shan, Hongming Siebers, Jeffrey V. Soomro, Mumtaz H. Sun, Kay Hoyos, Andrés Usuga Valderrama, Carlos Verbeek, Rob Wang, Enpei Willems, Siri Wu, Qi Xu, Xuanang Yang, Sen Yuan, Lulin Zhu, Simeng Zimmermann, Lukas Moore, Kevin L. Purdie, Thomas G. McNiven, Andrea L. Chan, Timothy C.Y. Department Of Mechanical And Industrial Engineering University Of Toronto TorontoON Canada Vector Institute TorontoON Canada Department Of Radiation Oncology University Of Virginia Health System CharlottesvilleVA United States Department Of Molecular Imaging Radiation Oncology UCLouvain Louvain-la-Neuve Belgium Department Of Radiation Oncology Memorial Sloan Kettering Cancer Center New YorkNY United States Department Of Radiation Oncology The University Of Alabama At Birmingham BirminghamAL United States Department Of Engineering And Applied Physics University Of Science And Technology Of China Hefei China Shenying Medical Technology Co. Ltd. Guangdong Shenzhen China Department Of Radiation Oncology Yonsei University Seoul Korea Republic of Department Of Physics National University Of Colombia Medellín Colombia Atominstitut Vienna University Of Technology Vienna Austria Department Of Biomedical Engineering Cleveland Clinic ClevelandOH United States Department Of Radiation Physics The University Of Texas MD Anderson Cancer Center HoustonTX United States Department Of Biomedical Engineering Shanghai Jiao Tong University Shanghai China Department Of Radiation Oncology Medical University Of Vienna Vienna Austria Department Of Biomedical Engineering Johns Hopkins University BaltimoreMD United States Department Of Radiation Oncology Peking University Cancer Hospital And Institute Beijing China Department Of Electrical Engineering And Automation Anhui University Hefei China Department Of Radiation Oncology Massachusetts General Hospital BostonMA United States Department Of Radiation Oncology University Of North Carolina At Chapel Hill Chapel HillNC United States Department Of Medical Imaging Taiwan AI Labs Taipei Taiwan Department Of Biomedical And Health Sciences Hiroshima University Hiroshima Japan Laboratory Department Of Radiation Oncology The University Of Texas Southwestern Medical Center DallasTX United States Department Of Radiatio

We establish an open framework for developing plan optimization models for knowledge-based planning (KBP) in radiotherapy. Our framework includes reference plans for 100 patients with head-and-neck cancer and high-quality dose predictions from 19 KBP models that were developed by different research groups during the OpenKBP Grand Challenge. The dose predictions were input to four optimization models to form 76 unique KBP pipelines that generated 7600 plans. The predictions and plans were compared to the reference plans via: dose score, which is the average mean absolute voxel-by-voxel difference in dose a model achieved;the deviation in dosevolume histogram (DVH) criterion;and the frequency of clinical planning criteria satisfaction. We also performed a theoretical investigation to justify our dose mimicking models. The range in rank order correlation of the dose score between predictions and their KBP pipelines was 0.50 to 0.62, which indicates that the quality of the predictions is generally positively correlated with the quality of the plans. Additionally, compared to the input predictions, the KBPgenerated plans performed significantly better (P © 2022, CC BY.

关键词： Forecasting

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Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration

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Cell Reports 2025年第6期44卷 115750页

作者： Jacques, Macsue Landen, Shanie Sharples, Adam P. Garnham, Andrew Schittenhelm, Ralf Steele, Joel Heikkinen, Aino Sillanpää, Elina Ollikainen, Miina Broatch, James Zarekookandeh, Navabeh Hanson, Ola Ekström, Ola Asplund, Olof Lamon, Séverine Alexander, Sarah E. Smith, Cassandra Bauer, Carlie Woessner, Mary N. Levinger, Itamar Teschendorff, Andrew E. Gillberg, Linn Blom, Ida Helge, Jørn Wulff Harvey, Nicholas R. Haupt, Larisa M. Griffiths, Lyn R. Deshmukh, Atul S. Pietiläinen, Kirsi H. Piirilä, Päivi Seaborne, Robert A.E. Klevjer, Marie Bye, Anja Wisløff, Ulrik Jones-Freeman, Bernadette Eynon, Nir Australian Regenerative Medicine Institute Monash University Clayton VIC Australia Institute for Health and Sport (iHeS) Victoria University Footscray VIC Australia Centre for Endocrinology and Metabolism Hudson Institute of Medical Research Melbourne VIC Australia Institute of Physical Performance Norwegian School of Sport Sciences Oslo Norway Monash Proteomics & Metabolomics Platform Monash Biomedicine Discovery Institute Monash University Melbourne VIC Australia Institute for Molecular Medicine Finland (FIMM) Helsinki University Helsinki Finland Faculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland Wellbeing Services County of Central Finland Jyväskylä Finland Minerva Foundation Institute for Medical Research Helsinki Finland Department of Clinical Sciences Translational Muscle Research Unit Lund University Diabetes Center Lund University Lund Sweden Institute for Physical Activity and Nutrition (IPAN) School of Exercise and Nutrition Sciences Deakin University 221 Burwood Highway Burwood 3125 VIC Australia Cardiometabolic Health and Exercise Physiology Laboratory Baker Heart and Diabetes Institute 75 Commercial Road Melbourne 3004 VIC Australia Nutrition & Health Innovation Research Institute Edith Cowan University Joondalup WA Australia Medical School The University of Western Australia Perth WA Australia Australian Institute for Musculoskeletal Science (AIMSS) Victoria University Melbourne VIC Australia CAS Key Lab of Computational Biology Shanghai Institute of Nutrition and Health Shanghai China Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark Faculty of Health Sciences and Medicine Bond University Gold Coast QLD Australia Genomics Research Centre Centre for Genomics and Personalised Health School of Biomedical Sciences Queensland University of Technology Brisbane QLD Australia ARC Training Centre for Cell and Tissue Engineering Technologies Queensland University of Technology

We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO_2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. Finally, we created a webtool, OMAx, featuring our individual omics and integration analysis. These findings provide a comprehensive multi-omics framework for understanding exercise-induced molecular adaptations, offering insights into muscle health, cardiorespiratory fitness, and their roles in aging and disease prevention. © 2025 The Author(s)

关键词： CP: Metabolism DNA methylation epigenetics exercise gene expression Multi Omics proteomic skeletal muscle transcriptomic VO2 max

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Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

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science (New York, N.Y.) 2025年第6732期387卷 eadn7277页

作者： Harvey, Lloyd D. Alotaibi, Mona Tai, Yi-Yin Tang, Ying Kim, Hee-Jung J Kelly, Neil J. Sun, Wei Woodcock, Chen-Shan C Arshad, Sanya Culley, Miranda K. El Khoury, Wadih Xie, Rong Al Aaraj, Yassmin Zhao, Jingsi Hafeez, Neha Rao, Rashmi J. Jiang, Siyi Negi, Vinny Kirillova, Anna Perk, Dror Watson, Annie M. St Croix, Claudette M. Stolz, Donna B. Lee, Ji Young Cheng, Mary Hongying Zhang, Manling Detmer, Samuel Guzman, Edward Manan, Rajith S. Saggar, Rajan Haley, Kathleen J. Waxman, Aaron B. Okawa, Satoshi Schwantes-An, Tae-Hwi Pauciulo, Michael W. Wang, Bing Webb, Amy Chauvet, Caroline Anderson, Daniel G. Nichols, William C. Desai, Ankit A. Lafyatis, Robert Nouraie, S Mehdi Wu, Haodi McDonald, Jeffrey G. Cheng, Susan Bahar, Ivet Bertero, Thomas Benza, Raymond L. Jain, Mohit Chan, Stephen Y. Medical Scientist Training Program University of Pittsburgh Pittsburgh PA United States Center for Pulmonary Vascular Biology and Medicine Heart Lung Blood Vascular Medicine Institute University of Pittsburgh Pittsburgh PA United States Division of Cardiology University of Pittsburgh School of Medicine Pittsburgh PA United States Division of Pulmonary and Critical Care Medicine University of California San Diego La Jolla CA United States Department of Medicine University of California La Jolla San Diego CA United States Department of Pharmacology University of California La Jolla San Diego CA United States Division of Cardiology Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA United States Center for Biologic Imaging University of Pittsburgh Pittsburgh PA United States Laufer Center for Physical and Quantitative Biology Stony Brook University Stony Brook NY United States Department of Biochemistry and Cell Biology Stony Brook University Stony Brook NY United States Department of Chemistry Massachusetts Institute of Technology Boston MA United States Institute of Medical Engineering and Science Massachusetts Institute of Technology Boston MA United States School of Engineering and Applied Sciences Harvard University Cambridge MA United States Department of Chemical Engineering Massachusetts Institute of Technology Boston MA United States Department of Medicine David Geffen School of Medicine University of California Los Angeles (UCLA) Los Angeles CA USA Department of Pathology David Geffen School of Medicine UCLA Los Angeles CA United States Division of Pulmonary and Critical Care Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA United States Department of Computational and Systems Biology University of Pittsburgh Pittsburgh PA United States McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh PA United States Department of Medical and Molecular G

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (NCOA7) deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes. This oxysterol signature overlapped with a plasma metabolite signature associated with human PAH mortality. Mice deficient for endothelial Ncoa7 or exposed to an inflammatory bile acid developed worsened PAH. Genetic predisposition to NCOA7 deficiency was driven by single-nucleotide polymorphism rs11154337, which alters endothelial immunoactivation and is associated with human PAH mortality. An NCOA7-activating agent reversed endothelial immunoactivation and rodent PAH. Thus, we established a genetic and metabolic paradigm that links lysosomal biology and oxysterol processes to endothelial inflammation and PAH.

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TOI-2015 b: a sub-Neptune in strong gravitational interaction with an outer non-transiting planet

arXiv

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arXiv 2025年

作者： Barkaoui, K. Korth, J. Gaidos, E. Agol, E. Parviainen, H. Pozuelos, F.J. Palle, E. Narita, N. Grimm, S. Brady, M. Bean, J.L. Morello, G. Rackham, B.V. Burgasser, A.J. Van Grootel, V. Rojas-Ayala, B. Seifahrt, A. Marfil, E. Passegger, V.M. Stalport, M. Gillon, M. Collins, K.A. Shporer, A. Giacalone, S. Yalçınkaya, S. Ducrot, E. Timmermans, M. Triaud, A.H.M.J. de Wit, J. Soubkiou, A. Watkins, C.N. Aganze, C. Alonso, R. Amado, P.J. Basant, R. Baştürk, Ö. Benkhaldoun, Z. Burdanov, A. Calatayud-Borras, Y. Chouqar, J. Conti, D.M. Collins, K.I. Davoudi, F. Delrez, L. Dressing, C.D. de Leon, J. Dévora-Pajares, M. Demory, B.O. Dransfield, G. Esparza-Borges, E. Fernández-Rodriguez, G. Fukuda, I. Fukui, A. Gallardo, P.P.M. Garcia, L. Garcia, N.A. Ghachoui, M. Geraldía-González, S. Chew, Y. Gómez Maqueo González-Rodríguez, J. Günther, M.N. Hayashi, Y. Horne, K. Hooton, M.J. Hsu, C.C. Ikuta, K. Isogai, K. Jehin, E. Jenkins, J.M. Kawauchi, K. Kagetani, T. Kawai, Y. Kasper, D. Kielkopf, J.F. Klagyivik, P. Lacedelli, G. Latham, D.W. Libotte, F. Luque, R. Livingston, J.H. Mancini, L. Massey, B. Mori, M. Torres, S. Muñoz Murgas, F. Niraula, P. Orell-Miquel, J. Rapetti, David Rebolo-López, R. Ricker, G. Papini, R. Pedersen, P.P. Peláez-Torres, A. Pérez-Prieto, J.A. Poultourtzidis, E. Rodriguez, P.M. Queloz, D. Savel, A.B. Schanche, N. Sánchez-Benavente, M. Sibbald, L. Sefako, R. Sohy, S. Sota, A. Schwarz, R.P. Seager, S. Sebastian, D. Southworth, J. Stangret, M. Stefánsson, G. Stürmer, J. Srdoc, G. Thompson, S.J. Terada, Y. Vanderspek, R. Wang, G. Watanabe, N. Wilkin, F.P. Winn, J. Wells, R.D. Ziegler, C. Zúñiga-Fernández, S. Astrobiology Research Unit Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Department of Earth Atmospheric and Planetary Science Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Calle Vía Láctea s/n Tenerife La Laguna38200 Spain Lund Observatory Division of Astrophysics Department of Physics Lund University Box 118 Lund22100 Sweden Department of Earth Sciences University of Hawaii at Manoa 1680 East-West Rd HonoluluHI96822 United States Institute for Astrophysics University of Vienna Türkenschanzstrasse 17 ViennaA-1180 Austria Department of Astronomy Astrobiology Program University of Washington Box 351580 SeattleWA98195 United States NExSS Virtual Planetary Laboratory University of Washington Box 351580 SeattleWA98195 United States Tenerife La LagunaE-38206 Spain Glorieta de la Astronomía s/n Granada18008 Spain INAF- Palermo Astronomical Observatory Piazza del Parlamento 1 Palermo90134 Italy Komaba Institute for Science The University of Tokyo 3-8-1 Komaba Meguro Tokyo153-8902 Japan Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Research Institute for Advanced Computer Science Universities Space Research Association WashingtonDC20024 United States Institute for Particle Physics and Astrophysics ETH Zürich OttoStern-Weg 5 Zürich8093 Switzerland Department of Astrophysics University of Zürich Winterthurerstrasse 190 Zürich8057 Switzerland Department of Astronomy & Astrophysics University of Chicago ChicagoIL United States NHFP Sagan Fellow United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Institute Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Instituto de Alta Investigación Universidad de Tarapacá Casilla 7D Arica Chile Gemini Observatory NSF NOIRLab 670 N. A’ohoku Place HiloHI96720 United States Departamento de

TOI-2015 is a known exoplanetary system around an M4 dwarf star, consisting of a transiting sub-Neptune planet in a 3.35-day orbital period, TOI-2015 b, accompanied by a non-transiting companion, TOI-2015 c. High-precision radial velocity measurements were taken with the MAROON-X spectrograph, and high-precision photometric data were collected, primarily using the SPECULOOS, MUSCAT, TRAPPIST and LCOGT networks. We collected 63 transit light curves and 49 different transit epochs for TOI-2015 b. We re-characterize the target star by combining optical spectra obtained by the MAROON-X, Shane/KAST and IRTF/SpeX spectrographs, Bayesian Model Averaging (BMA) and Spectral Energy Distribution (SED) analysis. The TOI-2015 host star is a K = 10.3 mag M4-type dwarf with a sub-solar metallicity of [e/H]= −0.31 ± 0.16, and an effective temperature of Teff ≈ 3200 K. Our photodynamical analysis of the system strongly favors the 5:3 mean motion resonance and in this scenario the planet b (TOI-2015 b) has an orbital period of Pb = 3.34 days, a mass of Mp = 9.02+0.32−0.36 M⊗, a radius of Rp = 3.309+0.013−0.11 R⊗, resulting in a density of ρp = 0.25±0.01 ρ⊗ = 1.40±0.06 g cm−3, indicative of a Neptune-like composition. Its transits exhibit large (> 1 hr) timing variations indicative of an outer perturber in the system. We performed a global analysis of the high-resolution radial-velocity measurements, the photometric data, and the TTVs, and inferred that TOI-2015 hosts a second planet, TOI-2015 c, in a non-transiting configuration. Our analysis places it near a 5:3 resonance with an orbital period of Pc = 5.583 days and a mass of Mp = 8.91+0.38−0.40 M⊗. The dynamical configuration of TOI-2015 b and TOI-2015 c can be used to constrain the system’s planetary formation and migration history. Based on the mass-radius composition models, TOI-2015 b is a water-rich or rocky planet with a hydrogen-helium envelope. Moreover, TOI-2015 b has a high transmission spectroscopic metric (TSM= 149), m

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