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OpenKBP-Opt: An international and reproducible evaluation of 76 knowledge-based planning pipelines

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arXiv 2022年

作者： Babier, Aaron Mahmood, Rafid Zhang, Binghao Alves, Victor G.L. Barragán-Montero, Ana Maria Beaudry, Joel Cardenas, Carlos E. Chang, Yankui Chen, Zijie Chun, Jaehee Diaz, Kelly Eraso, Harold David Faustmann, Erik Gaj, Sibaji Gay, Skylar Gronberg, Mary Guo, Bingqi He, Junjun Heilemann, Gerd Hira, Sanchit Huang, Yuliang Ji, Fuxin Jiang, Dashan Giraldo, Jean Carlo Jimenez Lee, Hoyeon Lian, Jun Liu, Shuolin Liu, Keng-Chi Marrugo, José Miki, Kentaro Nakamura, Kunio Netherton, Tucker Nguyen, Dan Nourzadeh, Hamidreza Osman, Alexander F.I. Peng, Zhao Muñoz, José Darío Quinto Ramsl, Christian Rhee, Dong Joo Rodriguez, Juan David Shan, Hongming Siebers, Jeffrey V. Soomro, Mumtaz H. Sun, Kay Hoyos, Andrés Usuga Valderrama, Carlos Verbeek, Rob Wang, Enpei Willems, Siri Wu, Qi Xu, Xuanang Yang, Sen Yuan, Lulin Zhu, Simeng Zimmermann, Lukas Moore, Kevin L. Purdie, Thomas G. McNiven, Andrea L. Chan, Timothy C.Y. Department Of Mechanical And Industrial Engineering University Of Toronto TorontoON Canada Vector Institute TorontoON Canada Department Of Radiation Oncology University Of Virginia Health System CharlottesvilleVA United States Department Of Molecular Imaging Radiation Oncology UCLouvain Louvain-la-Neuve Belgium Department Of Radiation Oncology Memorial Sloan Kettering Cancer Center New YorkNY United States Department Of Radiation Oncology The University Of Alabama At Birmingham BirminghamAL United States Department Of Engineering And Applied Physics University Of Science And Technology Of China Hefei China Shenying Medical Technology Co. Ltd. Guangdong Shenzhen China Department Of Radiation Oncology Yonsei University Seoul Korea Republic of Department Of Physics National University Of Colombia Medellín Colombia Atominstitut Vienna University Of Technology Vienna Austria Department Of Biomedical Engineering Cleveland Clinic ClevelandOH United States Department Of Radiation Physics The University Of Texas MD Anderson Cancer Center HoustonTX United States Department Of Biomedical Engineering Shanghai Jiao Tong University Shanghai China Department Of Radiation Oncology Medical University Of Vienna Vienna Austria Department Of Biomedical Engineering Johns Hopkins University BaltimoreMD United States Department Of Radiation Oncology Peking University Cancer Hospital And Institute Beijing China Department Of Electrical Engineering And Automation Anhui University Hefei China Department Of Radiation Oncology Massachusetts General Hospital BostonMA United States Department Of Radiation Oncology University Of North Carolina At Chapel Hill Chapel HillNC United States Department Of Medical Imaging Taiwan AI Labs Taipei Taiwan Department Of Biomedical And Health Sciences Hiroshima University Hiroshima Japan Laboratory Department Of Radiation Oncology The University Of Texas Southwestern Medical Center DallasTX United States Department Of Radiatio

We establish an open framework for developing plan optimization models for knowledge-based planning (KBP) in radiotherapy. Our framework includes reference plans for 100 patients with head-and-neck cancer and high-quality dose predictions from 19 KBP models that were developed by different research groups during the OpenKBP Grand Challenge. The dose predictions were input to four optimization models to form 76 unique KBP pipelines that generated 7600 plans. The predictions and plans were compared to the reference plans via: dose score, which is the average mean absolute voxel-by-voxel difference in dose a model achieved;the deviation in dosevolume histogram (DVH) criterion;and the frequency of clinical planning criteria satisfaction. We also performed a theoretical investigation to justify our dose mimicking models. The range in rank order correlation of the dose score between predictions and their KBP pipelines was 0.50 to 0.62, which indicates that the quality of the predictions is generally positively correlated with the quality of the plans. Additionally, compared to the input predictions, the KBPgenerated plans performed significantly better (P © 2022, CC BY.

关键词： Forecasting

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

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science 2025年第6732期387卷 eadn7277页

作者： Harvey, Lloyd D. Alotaibi, Mona Tai, Yi-Yin Tang, Ying Kim, Hee-Jung J. Kelly, Neil J. Sun, Wei Woodcock, Chen-Shan C. Arshad, Sanya Culley, Miranda K. El Khoury, Wadih Xie, Rong Al Aaraj, Yassmin Zhao, Jingsi Hafeez, Neha Rao, Rashmi J. Jiang, Siyi Negi, Vinny Kirillova, Anna Perk, Dror Watson, Annie M. Croix, Claudette M.St. Stolz, Donna B. Lee, Ji Young Cheng, Mary Hongying Zhang, Manling Detmer, Samuel Guzman, Edward Manan, Rajith S. Saggar, Rajan Haley, Kathleen J. Waxman, Aaron B. Okawa, Satoshi Schwantes-An, Tae-Hwi Pauciulo, Michael W. Wang, Bing Webb, Amy Chauvet, Caroline Anderson, Daniel G. Nichols, William C. Desai, Ankit A. Lafyatis, Robert Mehdi Nouraie, S. Wu, Haodi McDonald, Jeffrey G. Cheng, Susan Bahar, Ivet Bertero, Thomas Benza, Raymond L. Jain, Mohit Chan, Stephen Y. Medical Scientist Training Program University of Pittsburgh Pittsburgh PA United States Center for Pulmonary Vascular Biology and Medicine Heart Lung Blood Vascular Medicine Institute University of Pittsburgh Pittsburgh PA United States Division of Cardiology University of Pittsburgh School of Medicine Pittsburgh PA United States Division of Pulmonary and Critical Care Medicine University of California San Diego La Jolla CA United States Department of Medicine University of California La Jolla San Diego CA United States Department of Pharmacology University of California La Jolla San Diego CA United States Division of Cardiology Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA United States Center for Biologic Imaging University of Pittsburgh Pittsburgh PA United States Laufer Center for Physical and Quantitative Biology Stony Brook University Stony Brook NY United States Department of Biochemistry and Cell Biology Stony Brook University Stony Brook NY United States Department of Chemistry Massachusetts Institute of Technology Boston MA United States Institute of Medical Engineering and Science Massachusetts Institute of Technology Boston MA United States School of Engineering and Applied Sciences Harvard University Cambridge MA United States Department of Chemical Engineering Massachusetts Institute of Technology Boston MA United States Department of Medicine David Geffen School of Medicine University of California Los Angeles (UCLA) Los Angeles CA USA Department of Pathology David Geffen School of Medicine UCLA Los Angeles CA United States Division of Pulmonary and Critical Care Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA United States Department of Computational and Systems Biology University of Pittsburgh Pittsburgh PA United States McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh PA United States Department of Medical and Molecular G

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (NCOA7) deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes. This oxysterol signature overlapped with a plasma metabolite signature associated with human PAH mortality. Mice deficient for endothelial Ncoa7 or exposed to an inflammatory bile acid developed worsened PAH. Genetic predisposition to NCOA7 deficiency was driven by single-nucleotide polymorphism rs11154337, which alters endothelial immunoactivation and is associated with human PAH mortality. An NCOA7-activating agent reversed endothelial immunoactivation and rodent PAH. Thus, we established a genetic and metabolic paradigm that links lysosomal biology and oxysterol processes to endothelial inflammation and PAH. © 2025 American Association for the Advancement of science. All rights reserved.

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TOI-2015 b: a sub-Neptune in strong gravitational interaction with an outer non-transiting planet

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arXiv 2025年

作者： Barkaoui, K. Korth, J. Gaidos, E. Agol, E. Parviainen, H. Pozuelos, F.J. Palle, E. Narita, N. Grimm, S. Brady, M. Bean, J.L. Morello, G. Rackham, B.V. Burgasser, A.J. Van Grootel, V. Rojas-Ayala, B. Seifahrt, A. Marfil, E. Passegger, V.M. Stalport, M. Gillon, M. Collins, K.A. Shporer, A. Giacalone, S. Yalçınkaya, S. Ducrot, E. Timmermans, M. Triaud, A.H.M.J. de Wit, J. Soubkiou, A. Watkins, C.N. Aganze, C. Alonso, R. Amado, P.J. Basant, R. Baştürk, Ö. Benkhaldoun, Z. Burdanov, A. Calatayud-Borras, Y. Chouqar, J. Conti, D.M. Collins, K.I. Davoudi, F. Delrez, L. Dressing, C.D. de Leon, J. Dévora-Pajares, M. Demory, B.O. Dransfield, G. Esparza-Borges, E. Fernández-Rodriguez, G. Fukuda, I. Fukui, A. Gallardo, P.P.M. Garcia, L. Garcia, N.A. Ghachoui, M. Geraldía-González, S. Chew, Y. Gómez Maqueo González-Rodríguez, J. Günther, M.N. Hayashi, Y. Horne, K. Hooton, M.J. Hsu, C.C. Ikuta, K. Isogai, K. Jehin, E. Jenkins, J.M. Kawauchi, K. Kagetani, T. Kawai, Y. Kasper, D. Kielkopf, J.F. Klagyivik, P. Lacedelli, G. Latham, D.W. Libotte, F. Luque, R. Livingston, J.H. Mancini, L. Massey, B. Mori, M. Torres, S. Muñoz Murgas, F. Niraula, P. Orell-Miquel, J. Rapetti, David Rebolo-López, R. Ricker, G. Papini, R. Pedersen, P.P. Peláez-Torres, A. Pérez-Prieto, J.A. Poultourtzidis, E. Rodriguez, P.M. Queloz, D. Savel, A.B. Schanche, N. Sánchez-Benavente, M. Sibbald, L. Sefako, R. Sohy, S. Sota, A. Schwarz, R.P. Seager, S. Sebastian, D. Southworth, J. Stangret, M. Stefánsson, G. Stürmer, J. Srdoc, G. Thompson, S.J. Terada, Y. Vanderspek, R. Wang, G. Watanabe, N. Wilkin, F.P. Winn, J. Wells, R.D. Ziegler, C. Zúñiga-Fernández, S. Astrobiology Research Unit Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Department of Earth Atmospheric and Planetary Science Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Calle Vía Láctea s/n Tenerife La Laguna38200 Spain Lund Observatory Division of Astrophysics Department of Physics Lund University Box 118 Lund22100 Sweden Department of Earth Sciences University of Hawaii at Manoa 1680 East-West Rd HonoluluHI96822 United States Institute for Astrophysics University of Vienna Türkenschanzstrasse 17 ViennaA-1180 Austria Department of Astronomy Astrobiology Program University of Washington Box 351580 SeattleWA98195 United States NExSS Virtual Planetary Laboratory University of Washington Box 351580 SeattleWA98195 United States Tenerife La LagunaE-38206 Spain Glorieta de la Astronomía s/n Granada18008 Spain INAF- Palermo Astronomical Observatory Piazza del Parlamento 1 Palermo90134 Italy Komaba Institute for Science The University of Tokyo 3-8-1 Komaba Meguro Tokyo153-8902 Japan Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Research Institute for Advanced Computer Science Universities Space Research Association WashingtonDC20024 United States Institute for Particle Physics and Astrophysics ETH Zürich OttoStern-Weg 5 Zürich8093 Switzerland Department of Astrophysics University of Zürich Winterthurerstrasse 190 Zürich8057 Switzerland Department of Astronomy & Astrophysics University of Chicago ChicagoIL United States NHFP Sagan Fellow United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Institute Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Instituto de Alta Investigación Universidad de Tarapacá Casilla 7D Arica Chile Gemini Observatory NSF NOIRLab 670 N. A’ohoku Place HiloHI96720 United States Departamento de

TOI-2015 is a known exoplanetary system around an M4 dwarf star, consisting of a transiting sub-Neptune planet in a 3.35-day orbital period, TOI-2015 b, accompanied by a non-transiting companion, TOI-2015 c. High-precision radial velocity measurements were taken with the MAROON-X spectrograph, and high-precision photometric data were collected, primarily using the SPECULOOS, MUSCAT, TRAPPIST and LCOGT networks. We collected 63 transit light curves and 49 different transit epochs for TOI-2015 b. We re-characterize the target star by combining optical spectra obtained by the MAROON-X, Shane/KAST and IRTF/SpeX spectrographs, Bayesian Model Averaging (BMA) and Spectral Energy Distribution (SED) analysis. The TOI-2015 host star is a K = 10.3 mag M4-type dwarf with a sub-solar metallicity of [e/H]= −0.31 ± 0.16, and an effective temperature of Teff ≈ 3200 K. Our photodynamical analysis of the system strongly favors the 5:3 mean motion resonance and in this scenario the planet b (TOI-2015 b) has an orbital period of Pb = 3.34 days, a mass of Mp = 9.02+0.32−0.36 M⊗, a radius of Rp = 3.309+0.013−0.11 R⊗, resulting in a density of ρp = 0.25±0.01 ρ⊗ = 1.40±0.06 g cm−3, indicative of a Neptune-like composition. Its transits exhibit large (> 1 hr) timing variations indicative of an outer perturber in the system. We performed a global analysis of the high-resolution radial-velocity measurements, the photometric data, and the TTVs, and inferred that TOI-2015 hosts a second planet, TOI-2015 c, in a non-transiting configuration. Our analysis places it near a 5:3 resonance with an orbital period of Pc = 5.583 days and a mass of Mp = 8.91+0.38−0.40 M⊗. The dynamical configuration of TOI-2015 b and TOI-2015 c can be used to constrain the system’s planetary formation and migration history. Based on the mass-radius composition models, TOI-2015 b is a water-rich or rocky planet with a hydrogen-helium envelope. Moreover, TOI-2015 b has a high transmission spectroscopic metric (TSM= 149), m

关键词： Stars

Reweighted autoencoded variational bayes for enhanced sampling (RAVE)

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arXiv 2018年

作者： Ribeiro, João Marcelo Lamim Collado, Pablo Bravo Wang, Yihang Tiwary, Pratyush Department of Chemistry and Biochemistry Institute for Physical Science and Technology University of Maryland College Park20742 United States Departamento de Fisica Pontificia Universidad Catolica de Chile Santiago7820436 Chile University of Maryland College Park20742 United States Biophysics Program Institute for Physical Science and Technology University of Maryland College Park20742 United States

Here we propose the Reweighted Autoencoded Variational Bayes for Enhanced Sampling (RAVE) method, a new iterative scheme that uses the deep learning framework of variational autoencoders to enhance sampling in molecular simulations. RAVE involves iterations between molecular simulations and deep learning in order to produce an increasingly accurate probability distribution along a low-dimensional latent space that captures the key features of the molecular simulation trajectory. Using the Kullback-Leibler divergence between this latent space distribution and the distribution of various trial reaction coordinates sampled from the molecular simulation, RAVE determines an optimum, yet nonetheless physically interpretable, reaction coordinate and optimum probability distribution. Both then directly serve as the biasing protocol for a new biased simulation, which is once again fed into the deep learning module with appropriate weights accounting for the bias, the procedure continuing until estimates of desirable thermodynamic observables are converged. Unlike recent methods using deep learning for enhanced sampling purposes, RAVE stands out in that (a) it naturally produces a physically interpretable reaction coordinate, (b) is independent of existing enhanced sampling protocols to enhance the fluctuations along the latent space identified via deep learning, and (c) it provides the ability to easily filter out spurious solutions learned by the deep learning procedure. The usefulness and reliability of RAVE is demonstrated by applying it to model potentials of increasing complexity, including computation of the binding free energy profile for a hydrophobic ligand-substrate system in explicit water with dissociation time of more than three minutes, in computer time at least twenty times less than that needed for umbrella sampling or metadynamics. Copyright © 2018, The Authors. All rights reserved.

关键词： Molecular structure

Closed-loop sparse channel estimation for wideband millimeter-wave full-dimensional MIMO systems

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arXiv 2019年

作者： Liao, Anwen Gao, Zhen Wang, Hua Chen, Sheng Alouini, Mohamed-Slim Yin, Hao School of Information and Electronics Beijing Institute of Technology Beijing100081 China School of Electronics and Computer Science University of Southampton SouthamptonSO17 1BJ United Kingdom King Abdulaziz University Jeddah21589 Saudi Arabia Electrical Engineering Program Division of Physical Sciences and Engineering King Abdullah University of Science and Technology Thuwal Makkah Province Saudi Arabia Institute of China Electronic System Engineering Corporation Beijing100141 China

This paper proposes a closed-loop sparse channel estimation (CE) scheme for wideband millimeter-wave hybrid full-dimensional multiple-input multiple-output and time division duplexing based systems, which exploits the channel sparsity in both angle and delay domains. At the downlink CE stage, random transmit precoding matrix is designed at base station (BS) for channel sounding, and receive combining matrices at user devices (UDs) are designed whereby the hybrid array is visualized as a low-dimensional digital array for facilitating the multi-dimensional unitary ESPRIT (MDU-ESPRIT) algorithm to estimate respective angle-of-arrivals (AoAs). At the uplink CE stage, the estimated downlink AoAs, namely, uplink angle-of-departures (AoDs), are exploited to design multi-beam transmit precoding matrices at UDs to enable BS to estimate the uplink AoAs, i.e., the downlink AoDs, and delays of different UDs, whereby the MDU-ESPRIT algorithm is used based on the designed receive combining matrix at BS. Furthermore, a maximum likelihood approach is proposed to pair the channel parameters acquired at the two stages, and the path gains are then obtained using least squares estimator. According to spectrum estimation theory, our solution can acquire the super-resolution estimations of the AoAs/AoDs and delays of sparse multipath components with low training overhead. Simulation results verify the better CE performance and lower computational complexity of our solution over state-of-the-art approaches. Copyright © 2019, The Authors. All rights reserved.

关键词： Millimeter waves

Correction: Virtual Arm Boot Camp (V-ABC): study protocol for a mixed-methods study to increase upper limb recovery after stroke with an intensive program coupled with a grasp count device

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Trials 2022年第1期23卷 207页

作者： Lisa A Simpson Ruth Barclay Mark T Bayley Sean P Dukelow Bradley J MacIntosh Marilyn MacKay-Lyons Carlo Menon W Ben Mortenson Tzu-Hsuan Peng Courtney L Pollock Sepideh Pooyania Robert Teasell Chieh-Ling Yang Jennifer Yao Janice J Eng Graduate Program in Rehabilitation Sciences Faculty of Medicine University of British Columbia Vancouver Canada. Rehabilitation Research Program GF Strong Rehabilitation Centre Vancouver Coastal Health Vancouver Canada. Department of Physical Therapy College of Rehabilitation Sciences University of Manitoba Winnipeg Canada. Division of Physical Medicine and Rehabilitation University of Toronto and KITE Research Institute University Health Network Toronto Canada. Department of Clinical Neurosciences and Hotchkiss Brain Institute University of Calgary Calgary Canada. Sunnybrook Health Sciences Centre Toronto Canada. School of Physiotherapy Dalhousie University Halifax Canada. Department of Health Sciences and Technology ETH Zurich Switzerland. Department of Occupational Science and Occupational Therapy University of British Columbia Vancouver Canada. International Collaboration on Repair Discoveries Vancouver Canada. Department of Physical Therapy University of British Columbia Vancouver Canada. Division of Physical Medicine and Rehabilitation University of Manitoba Winnipeg Canada. Schulich School of Medicine & Dentistry Western University and Parkwood Institute Research Lawson Health Research Institute London Canada. Department of Occupational Therapy and Graduate Institute of Behavioral Sciences College of Medicine Chang Gung University Taoyuan City Taiwan. Division of Physical Medicine and Rehabilitation University of British Columbia Vancouver Canada. Rehabilitation Research Program GF Strong Rehabilitation Centre Vancouver Coastal Health Vancouver Canada. Janice.eng@ubc.ca. International Collaboration on Repair Discoveries Vancouver Canada. Janice.eng@ubc.ca. Department of Physical Therapy University of British Columbia Vancouver Canada. Janice.eng@ubc.ca. University of British Columbia 212-2177 Wesbrook Mall Vancouver BC V6T 1Z3 Canada. Janice.eng@ubc.ca.

Temporal evolution of self-assembled lead halide perovskite nanocrystal superlattices: effects on photoluminescence and energy transfer

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arXiv 2020年

作者： Baranov, Dmitry Fieramosca, Antonio Yang, Ruo Xi Polimeno, Laura Lerario, Giovanni Toso, Stefano Giansante, Carlo de Giorgi, Milena Tan, Liang Z. Sanvitto, Daniele Manna, Liberato Nanochemistry Department Italian Institute of Technology Via Morego 30 Genova16163 Italy CNR Nanotec Institute of Nanotechnology Via Monteroni Lecce73100 Italy Dipartimento di Matematica e Fisica "E. de Giorgi " Università Del Salento Campus Ecotekne via MonteroniLecce73100 Italy Molecular Foundry Lawrence Berkeley National Lab BerkeleyCA94720 United States International Doctoral Program in Science Università Cattolica del Sacro Cuore Brescia25121 Italy Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore

Excitonic/electronic coupling and cooperative interactions in self-assembled lead halide perovskite nanocrystals were reported to give rise to a collective low energy emission peak with accelerated dynamics. Here we report that similar spectroscopic features could appear as a result of the nanocrystal reactivity within the self-assembled superlattices. This is demonstrated by using CsPbBr3 nanocrystal superlattices under room temperature and cryogenic micro-photoluminescence spectroscopy. It is shown that keeping such structures under vacuum, a gradual contraction of the superlattices and subsequent coalescence of the nanocrystals occurs over several days. As a result, a narrow, low energy emission peak is observed at 4 K with a concomitant shortening of the photoluminescence lifetime due to the energy transfer between nanocrystals. When exposed to air, self-assembled CsPbBr3 nanocrystals develop bulk-like CsPbBr3 particles on top of the superlattices. At 4 K, these particles produce a distribution of narrow, low energy emission peaks with short lifetimes and excitation fluence-dependent, oscillatory decays, resembling the features of superfluorescence. Overall, the reactivity of CsPbBr3 nanocrystals dramatically alters the emission of their assemblies, which should not be overlooked when studying collective optoelectronic properties nor confused with superfluorescence effects. Copyright © 2020, The Authors. All rights reserved.

关键词： Nanocrystals

Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data

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physical Review D 2022年第2期105卷 022002-022002页

作者： R. Abbott T. D. Abbott F. Acernese K. Ackley C. Adams N. Adhikari R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain T. Akutsu S. Albanesi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koji Arai Koya Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. M. Aston P. Astone F. Aubin C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare U. Bhardwaj D. Bhattacharjee S. Bhaumik I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic C. Buy R. L. Byer L. Cadonati G. Cagnoli C. Cahillane J. Calderón Bustillo J. D. Callaghan T. A. Callister E. Ca LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia LIGO Livingston Observatory Livingston Louisiana 70754 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan INFN Sezione di Torino I-10125 Torino Italy Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière F-69622 Villeurbanne France Department of Physics The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Un

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the J-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow subbands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per subband and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4−3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed nonastrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, h095%. The strictest constraint is h095%=4.7×10−26 from IGR J17062−6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and r-mode amplitude, the strictest of which are ε95%=3.1×10−7 and α95%=1.8×10−5 respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond x-ray pulsars to date.

关键词： Gravitational waves Binary stars Neutron stars & pulsars

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing ()

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NATURE BIOMEDICAL ENGINEERING 2020年第11期4卷 1119-1119页

作者： Suh, Susie Choi, Elliot H. Leinonen, Henri Foik, Andrzej T. Newby, Gregory A. Yeh, Wei-Hsi Dong, Zhiqian Kiser, Philip D. Lyon, David C. Liu, David R. Palczewski, Krzysztof Gavin Herbert Eye Institute Department of Ophthalmology University of California Irvine Irvine CA USA Department of Pharmacology Case Western Reserve University Cleveland OH USA Department of Physiology and Biophysics University of California Irvine Irvine CA USA Department of Chemistry University of California Irvine Irvine CA USA Department of Anatomy and Neurobiology School of Medicine University of California Irvine Irvine CA USA International Centre for Translational Eye Research Institute of Physical Chemistry Polish Academy of Sciences Warsaw Poland Merkin Institute of Transformative Technologies in Healthcare Broad Institute of Harvard and MIT Cambridge MA USA Department of Chemistry and Chemical Biology Harvard University Cambridge MA USA Howard Hughes Medical Institute Harvard University Cambridge MA USA Program in Speech and Hearing Bioscience and Technology Harvard Medical School Boston MA USA Research Service VA Long Beach Healthcare System Long Beach CA USA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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