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Combining spitzer parallax and Keck II adaptive optics imaging to measure the mass of a solar-like star orbited by a cold gaseous planet discovered by microlensing

arXiv

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arXiv 2017年

作者： Beaulieu, J.-P. Batista, V. Bennett, D.P. Marquette, J.-B. Blackman, J.W. Cole, A.A. Coutures, C. Danielski, C. Dominis-Prester, D. Donatowicz, J. Fukui, A. Koshimoto, N. Lončaric, C. Morales, J.C. Sumi, T. Suzuki, D. Henderson, C. Shvartzvald, Y. Beichman, C. School of Physical Sciences University of Tasmania Private Bag 37 HobartTAS7001 Australia Sorbonne Universités UPMC Université Paris 6 CNRS UMR 7095 Institut dAstrophysique de Paris 98 bis bd Arago Paris75014 France Laboratory for Exoplanets and Stellar Astrophysics NASA/Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire d’Astrophysique de Bordeaux Univ. Bordeaux CNRS B18N allée Geoffroy Saint-Hilaire Pessac33615 France GEPI Observatoire de Paris Section de Meudon 5 place Jules Janssen Meudon92195 France Department of Physics University of Rijeka Radmile Matejčić 2 Rijeka51000 Croatia Technische Universitt Wien Karlsplatz 13 Wien1040 Austria Okayama Astrophysical Observatory National Astronomical Observatory of Japan Asakuchi Okayama719-0232 Japan Department of Earth and Space Science Graduate School of Science Osaka University 1-1 Machikaneyama Toyonaka Osaka560-0043 Japan Campus UAB Carrer de Can Magrans s/n Cerdanyola del VallsE-08193 Spain Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Drive PasadenaCA91109 United States NASA Exoplanet Science Institute California Institute of Technology Jet Propulsion Laboratory PasadenaCA91125 United States PAC/NExScI Mail Code 100-22 Caltech 1200 East California Boulevard PasadenaCA91125 NASA Postdoctoral Program

To obtain accurate mass measurements for cold planets discovered by microlensing, it is usually necessary to combine light curve modeling with at least two lens mass-distance relations. Often, a constraint on the Einstein ring radius measurement is obtained from the caustic crossing time: This is supplemented by secondary constraints such as precise parallax measurements and/or measures of the lens luminosity using high angular resolution observations. In the discovery paper of the planetary system OGLE-2014-BLG-0124Lb, the OGLE ground-based observations were combined with simultaneous Spitzer observations, providing good measurements of the mass ratio and projeced separation of the planetary system. The parallax was also well-measured, but the photometric data failed to tightly constrain the Einstein ring radius, ΘE. As a consequence, the physical parameters are therefore poorly constrained in the original study. We resolved the source+lens star from subarcsecond blends in H band using adaptive optics (AO) observations with NIRC2 mounted on Keck II telescope. We identify additional flux, coincident with the source to within 160 mas. We estimate the potential contributions to this blended light (chance-aligned star, additional companion to the lens or to the source) and find that 85% of of the NIR flux is due to the lens star at HL = 16.63 ± 0.06 and KL = 16.46 ±0.06. We combined the parallax constraint and the AO constraint to derive the physical parameters of the system. The lensing system is composed of a mid-late type G main sequence star of ML = 0.89 ± 0.05 Mo located at DL = 3.6 ± 0.3 kpc in the Galactic disk. Taking the mass ratio and projected separation from the original study leads to a planet of Mp = 0.64 ± 0.044 MJupiter at 3.48 ± 0.22 AU. Excellent parallax measurement from simultaneous ground-space observations have been obtained on the microlensing event OGLE-2014-BLG-0124, but it is only when they are combined with ∼ 30 min of Keck II AO observations

关键词： Geometrical optics

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04.10 Chronic inflammation regulates the mrna stabilome in rheumatoid arthritis fibroblast-like synoviocytes

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Annals of the Rheumatic Diseases 2017年 76卷 A45-A46页

作者： Konstantinos Loupasakis David Kuo Christopher Sohn Bethany Syracuse Eugenia G Giannopoulou Sung Ho Park Gunnar Rätsch Lionel B Ivashkiv George D Kalliolias 1Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Centre Hospital for Special Surgery New York USA 2Graduate Program in Physiology Biophysics and Systems Biology Weill Cornell Graduate School of Medical Sciences New York USA 3Computational Biology Program Sloan Kettering Institute New York USA 4Biological Sciences Department New York City College of Technology City University of New York Brooklyn New York USA 5Department of Computer Science ETH Zürich 8032 Zürich Switzerland

Background Chronic synovial inflammation is a hallmark of rheumatoid arthritis (RA). During the long-term course of RA synovitis, chronic exposure of FLS to pro-inflammatory cytokines, such as TNF, induces a constellation of genes, which perpetuate synovial inflammation and provoke joint damage. Inflammation-induced gene expression evolves in a temporal order and involves two integrated processes: transcription and mRNA decay. Although the molecular mechanisms regulating transcription are well characterised, little is known about the impact of mRNA stability on gene expression and the genome-wide impact of chronic inflammation on decay rates of mRNA transcripts in RA FLS. Materials and methods Chronic synovitis was modelled ex vivo by long-term exposure of RA FLS to TNF. RNA-sequencing was performed, gene-transcripts were quantified, and DESeq2 was used for differential testing between TNF treated and control libraries. For pathway analysis, MSigDB and Panther were used. Differentially stable gene transcripts were identified between time points of TNF stimulation by specific statistical analytical tools. Results In our experimental system, long-term exposure of FLS to TNF induces a biphasic gene expression program. Initially, the inducible transcriptome consists primarily of unstable transcripts, but progressively switches and becomes dominated by very stable transcripts. This temporal switch is due to: a) TNF-induced prolonged stabilisation of previously unstable transcripts that enables progressive transcript accumulation over days and b) sustained expression and late induction of very stable transcripts. TNF-induced mRNA stabilisation in RA FLS occurs during the late phase of TNF response, is MAPK-dependent, and involves several genes with pathogenic potential, such as pro-inflammatory cytokines (eg, IL-6), a series of neutrophil-recruiting chemokines (eg, CXCL1, CXCL3, IL-8/CXCL8), CCL2, and PTGS2. Conclusions These results provide the first insights into genome

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Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]

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Redox biology 2018年 14卷 694-696页

作者： J Egea I Fabregat Y M Frapart P Ghezzi A Görlach T Kietzmann K Kubaichuk U G Knaus M G Lopez G Olaso-Gonzalez A Petry R Schulz J Vina P Winyard K Abbas O S Ademowo C B Afonso I Andreadou H Antelmann F Antunes M Aslan M M Bachschmid R M Barbosa V Belousov C Berndt D Bernlohr E Bertrán A Bindoli S P Bottari P M Brito G Carrara A I Casas A Chatzi N Chondrogianni M Conrad M S Cooke J G Costa A Cuadrado P My-Chan Dang B De Smet B Debelec-Butuner I H K Dias J D Dunn A J Edson M El Assar J El-Benna P Ferdinandy A S Fernandes K E Fladmark U Förstermann R Giniatullin Z Giricz A Görbe H Griffiths V Hampl A Hanf J Herget P Hernansanz-Agustín M Hillion J Huang S Ilikay P Jansen-Dürr V Jaquet J A Joles B Kalyanaraman D Kaminskyy M Karbaschi M Kleanthous L O Klotz B Korac K S Korkmaz R Koziel D Kračun K H Krause V Křen T Krieg J Laranjinha A Lazou H Li A Martínez-Ruiz R Matsui G J McBean S P Meredith J Messens V Miguel Y Mikhed I Milisav L Milković A Miranda-Vizuete M Mojović M Monsalve P A Mouthuy J Mulvey T Münzel V Muzykantov I T N Nguyen M Oelze N G Oliveira C M Palmeira N Papaevgeniou A Pavićević B Pedre F Peyrot M Phylactides G G Pircalabioru A R Pitt H E Poulsen I Prieto M P Rigobello N Robledinos-Antón L Rodríguez-Mañas A P Rolo F Rousset T Ruskovska N Saraiva S Sasson K Schröder K Semen T Seredenina A Shakirzyanova G L Smith T Soldati B C Sousa C M Spickett A Stancic M J Stasia H Steinbrenner V Stepanić S Steven K Tokatlidis E Tuncay B Turan F Ursini J Vacek O Vajnerova K Valentová F Van Breusegem L Varisli E A Veal A S Yalçın O Yelisyeyeva N Žarković M Zatloukalová J Zielonka R M Touyz A Papapetropoulos T Grune S Lamas H H H W Schmidt F Di Lisa A Daiber Institute Teofilo Hernando Department of Pharmacology School of Medicine Univerisdad Autonoma de Madrid Spain. Bellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB) L'Hospitalet Barcelona Spain. LCBPT UMR 8601 CNRS - Paris Descartes University Sorbonne Paris Cité Paris France. Brighton & Sussex Medical School Brighton UK. Experimental and Molecular Pediatric Cardiology German Heart Center Munich at the Technical University Munich Munich Germany DZHK (German Centre for Cardiovascular Research) partner site Munich Heart Alliance Munich Germany. Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu University of Oulu Oulu Finland. Conway Institute School of Medicine University College Dublin Dublin Ireland. Department of Physiology University of Valencia Spain. Experimental and Molecular Pediatric Cardiology German Heart Center Munich at the Technical University Munich Munich Germany. Institute of Physiology JLU Giessen Giessen Germany. University of Exeter Medical School St Luke's Campus Exeter EX1 2LU UK. Life & Health Sciences and Aston Research Centre for Healthy Ageing Aston University Aston Triangle Birmingham B4 7ET UK. School of Life & Health Sciences Aston University Aston Triangle Birmingham B47ET UK. Laboratory of Pharmacology Faculty of Pharmacy National and Kapodistrian University of Athens Greece. Institute for Biology-Microbiology Freie Universität Berlin Berlin Germany. Departamento de Química e Bioquímica and Centro de Química e Bioquímica Faculdade de Ciências Portugal. Department of Medical Biochemistry Faculty of Medicine Akdeniz University Antalya Turkey. Vascular Biology Section & Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA USA. Center for Neurosciences and Cell Biology University of Coimbra and Faculty of Pharmacy University of Coimbra Coimbra Portugal. Molecular technologies laboratory Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Miklukho

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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Publisher Correction: A global database of Holocene paleotemperature records

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Scientific data 2020年第1期7卷 183页

作者： Darrell Kaufman Nicholas McKay Cody Routson Michael Erb Basil Davis Oliver Heiri Samuel Jaccard Jessica Tierney Christoph Dätwyler Yarrow Axford Thomas Brussel Olivier Cartapanis Brian Chase Andria Dawson Anne de Vernal Stefan Engels Lukas Jonkers Jeremiah Marsicek Paola Moffa-Sánchez Carrie Morrill Anais Orsi Kira Rehfeld Krystyna Saunders Philipp S Sommer Elizabeth Thomas Marcela Tonello Mónika Tóth Richard Vachula Andrei Andreev Sebastien Bertrand Boris Biskaborn Manuel Bringué Stephen Brooks Magaly Caniupán Manuel Chevalier Les Cwynar Julien Emile-Geay John Fegyveresi Angelica Feurdean Walter Finsinger Marie-Claude Fortin Louise Foster Mathew Fox Konrad Gajewski Martin Grosjean Sonja Hausmann Markus Heinrichs Naomi Holmes Boris Ilyashuk Elena Ilyashuk Steve Juggins Deborah Khider Karin Koinig Peter Langdon Isabelle Larocque-Tobler Jianyong Li André Lotter Tomi Luoto Anson Mackay Eniko Magyari Steven Malevich Bryan Mark Julieta Massaferro Vincent Montade Larisa Nazarova Elena Novenko Petr Pařil Emma Pearson Matthew Peros Reinhard Pienitz Mateusz Płóciennik David Porinchu Aaron Potito Andrew Rees Scott Reinemann Stephen Roberts Nicolas Rolland Sakari Salonen Angela Self Heikki Seppä Shyhrete Shala Jeannine-Marie St-Jacques Barbara Stenni Liudmila Syrykh Pol Tarrats Karen Taylor Valerie van den Bos Gaute Velle Eugene Wahl Ian Walker Janet Wilmshurst Enlou Zhang Snezhana Zhilich Northern Arizona University School of Earth and Sustainability Flagstaff AZ 86011 USA. darrell.kaufman@nau.edu. Northern Arizona University School of Earth and Sustainability Flagstaff AZ 86011 USA. University of Lausanne Institute of Earth Surface Dynamics Lausanne 1015 Switzerland. University of Basel Department of Environmental Sciences Basel 4056 Switzerland. University of Bern Institute of Geological Sciences and Oeschger Center for Climate Change Research Bern CH-3012 Switzerland. University of Arizona Department of Geosciences Tucson AZ 85721 USA. University of Bern Institute of Geography and Oeschger Centre for Climate Change Research Bern 3012 Switzerland. Northwestern University Department of Earth and Planetary Sciences Evanston IL 60208 USA. University of Utah Department of Geography Salt Lake City UT 84112 USA. Université de Montpellier Centre National de la Recherche Scientifique Institut des Sciences de l'Evolution Montpellier 34095 France. Mount Royal University Department of General Education Calgary T3E6K6 Canada. Université du Québec à Montréal Geotop-UQAM Montréal H3C 3P8 Canada. University of London Birkbeck Department of Geography London WC1E 7HX UK. University of Bremen MARUM Center for Marine Environmental Sciences Bremen 28359 Germany. University of Wisconsin-Madison Department of Geoscience Madison WI 53706 USA. Durham University Department of Geography Durham DH1 3LE UK. University of Colorado Cooperative Institute for Research in Environmental Sciences Boulder CO 80309 USA. Laboratoire des Sciences du Climat et de l'Environnement Université Paris-Saclay Gif sur Yvette 91191 France. Heidelberg University Institute of Environmental Physics Heidelberg 69221 Germany. Australian Nuclear Science and Technology Organisation Environment Lucas Heights 2234 Australia. Institute for Coastal Research Helmholtz-Zentrum Geesthacht Germany. University at Buffalo Department of Geology Buffalo NY 14206 USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: A global database of Holocene paleotemperature records

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Scientific data 2020年第1期7卷 246页

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)

arXiv

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arXiv 2017年

作者： Abgrall, N. Abramov, A. Abrosimov, N. Abt, I. Agostini, M. Agartioglu, M. Ajjaq, A. Alvis, S.I. Avignone, F.T. Bai, X. Balata, M. Barabanov, I. Barabash, A.S. Barton, P.J. Baudis, L. Bezrukov, L. Bode, T. Bolozdynya, A. Borowicz, D. Boston, A. Boston, H. Boyd, S.T.P. Breier, R. Brudanin, V. Brugnera, R. Busch, M. Buuck, M. Caldwell, A. Caldwell, T.S. Camellato, T. Carpenter, M. Cattadori, C. Cederkäll, J. Chan, Y.-D. Chen, S. Chernogorov, A. Christofferson, C.D. Chu, P.-H. Cooper, R.J. Cuesta, C. Demidova, E.V. Deng, Z. Deniz, M. Detwiler, J.A. Di Marco, N. Domula, A. Du, Q. Efremenko, Yu. Egorov, V. Elliott, S.R. Fields, D. Fischer, F. Galindo-Uribarri, A. Gangapshev, A. Garfagnini, A. Gilliss, T. Giordano, M. Giovanetti, G.K. Gold, M. Golubev, P. Gooch, C. Grabmayr, P. Green, M.P. Gruszko, J. Guinn, I.S. Guiseppe, V.E. Gurentsov, V. Gurov, Y. Gusev, K. Hakenmüeller, J. Harkness-Brennan, L. Harvey, Z.R. Haufe, C.R. Hauertmann, L. Heglund, D. Hehn, L. Heinz, A. Hiller, R. Hinton, J. Hodak, R. Hofmann, W. Howard, S. Howe, M.A. Hult, M. Inzhechik, L.V. Janicskó Csáthy, J. Janssens, R. Ješkovský, M. Jochum, J. Johansson, H.T. Judson, D. Junker, M. Kaizer, J. Kang, K. Kazalov, V. Kermaïdic, Y. Kiessling, F. Kirsch, A. Kish, A. Klimenko, A. Knöpfle, K.T. Kochetov, O. Konovalov, S.I. Kontul, I. Kornoukhov, V.N. Kraetzschmar, T. Kröninger, K. Kumar, A. Kuzminov, V.V. Lang, K. Laubenstein, M. Lazzaro, A. Li, Y.L. Li, Y.-Y. Li, H.B. Lin, S.T. Lindner, M. Lippi, I. Liu, S.K. Liu, X. Liu, J. Loomba, D. Lubashevskiy, A. Lubsandorzhiev, B. Lutter, G. Ma, H. Majorovits, B. Mamedov, F. Martin, R.D. Massarczyk, R. Matthews, J.A.J. McFadden, N. Mei, D.-M. Mei, H. Meijer, S.J. Mengoni, D. Mertens, S. Miller, W. Miloradovic, M. Mingazheva, R. Misiaszek, M. Moseev, P. Myslik, J. Nemchenok, I. Nilsson, T. Nolan, P. O'Shaughnessy, C. Othman, G. Panas, K. Pandola, L. Papp, L. Pelczar, K. Peterson, D. Pettus, W. Poon, A.W.P. Povinec, P.P. Institute for Nuclear and Particle Astrophysics and Nuclear Science Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States National Research Centre "Kurchatov Institute Moscow Leibniz Institute for Crystal Growth Berlin Germany Max-Planck-Institut für Physik München Germany Gran Sasso Science Institute L'Aquila Italy Department of Physics Dokuz Eylül University Buca Izmir Turkey Center for Experimental Nuclear Physics and Astrophysics Department of Physics University of Washington SeattleWA98195 United States Department of Physics and Astronomy University of South Carolina ColumbiaSC29208 United States Oak Ridge National Laboratory Oak RidgeTN37830 United States South Dakota School of Mines and Technology Rapid CitySD57701 United States Italy Institute for Nuclear Research of the Russian Academy of Sciences Moscow Russia Physik-Institut University of Zürich Zürich Switzerland Moscow115409 Russia Joint Institute for Nuclear Research Dubna Russia University of Liverpool Liverpool United Kingdom Department of Physics and Astronomy University of New Mexico AlbuquerqueNM87131 United States Department of Nuclear Physics and Biophysics Comenius University Bratislava Slovakia Dipartimento di Fisica e Astronomia dell'Universita' di Padova Padova Istituto Nazionale di Fisica Nucleare Padova Italy Department of Physics Duke University DurhamNC27708 United States Triangle Universities Nuclear Laboratory DurhamNC27708 United States Department of Physics and Astronomy University of North Carolina Chapel HillNC27514 United States Physik Department Technische Universität München Germany Argonne National Laboratory ArgonneIL60439 United States Istituto Nazionale di Fisica Nucleare Milano Biocca Milano Italy Lund University Lund Sweden Department of Engineering Physics Tsinghua University Beijing China Los Alamos National Laboratory Los AlamosNM87545 United States Technische Universität Dresden Dresden Germany Co

The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neutrinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 − 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results. Copyright © 2017, The Authors. All rights reserved.

关键词： Germanium

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Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-Activated Potassium Channel with β1 Subunits

Structural Basis for Calcium and Magnesium Regulation of a L...

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第九届亚洲生物物理大会

作者： Haowen Liu Panpan Hou Xiying Guo Zhiwen Zhao Bin Hu Xia Li Luy-ang Wang Jiuping Ding Sheng Wang Key laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology Program in Neurosciences and Mental Health Sick Kids Research Institute & Department of Physiology University of Toronto

Large-conductance Ca2+-and voltage-activated BK channels, composed of poreforming α subunits and auxiliary β subunits, play important roles in diverse physiological activities. The β1 is predominately expressed in smooth muscle cells, where it greatly enhances the Ca2+ sensitivity of BK channels for proper regulation of smooth muscle tone. However, structural basis underlying dynamic interaction between BK m Slo1 α and β1 remains elusive. Using macroscopic ionic current recordings in various Ca2+ and Mg2+ concentrations, we identified two binding sites on the cytosolic N-terminal of β1, namely the electrostatic enhancing(E) site(m Slo1(K392,R393)::β1(E13,T14)), increasing the calcium sensitivity of BK channels, and the hydrophobic(H) site(m Slo1(L906,L908)::β1(L5,V6,M7)), passing the physical force from the Ca2+ bowl onto the E site and S6 C-linker. Dynamic binding of these sites affects the interaction between the cytosolic domain(CTD) and voltage sensing domain(VSD), leading to the reduction of Mg2+ sensitivity. A comprehensive structural model of the BK(m Slo1α/β1) complex was reconstructed based on these functional studies, which provides structural and mechanistic insights for understanding BK gating.

关键词： Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-Activated Potassium Channel with Subunits

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Structural Basis for Divalent Regulation of a Large Conductance Calcium-Activated Potassium Channel with β1 Subunits

Structural Basis for Divalent Regulation of a Large Conducta...

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第九届亚洲生物物理大会

作者： Hao-Wen Liu Pan-Pan Hou Xi-Ying Guo Zhi-Wen Zhao Bin Hu Xia Li Lu-Yang Wang Jiu-Ping Ding Sheng Wang Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Program in Neurosciences and Mental Health Sick Kids Research Institute & Department of Physiology University of Toronto

Large-conductance Ca2+-and voltage-activated BK channels, composed of poreforming subunits and auxiliary β subunits, play important roles in diverse physiological activities. The β1 is predominately expressed in smooth muscle cells, where it greatly enhances the Ca2+ sensitivity of BK channels for proper regulation of smooth muscle tone. However, structural basis underlying dynamic interaction between BK m Slo1 and β1 remains elusive. Using macroscopic ionic current recordings in various Ca2+ and Mg2+ concentrations, we identified two binding sites on the cytosolic N-terminal of β1, namely the electrostatic enhancing(E) site(m Slo1(K392,R393)::β1(E13,T14)), increasing the calcium sensitivity of BK channels, and the hydrophobic(H) site(m Slo1(L906,L908)::β1(L5,V6,M7)), passing the physical force from the Ca2+ bowl onto the E site and S6 C-linker. Dynamic binding of these sites affects the interaction between the cytosolic domain(CTD) and voltage sensing domain(VSD), leading to the reduction of Mg2+ sensitivity. A comprehensive structural model of the BK(m Slo1:/β1) complex was reconstructed based on these functional studies, which provides structural and mechanistic insights for understanding BK gating.

关键词： Structural Basis for Divalent Regulation of a Large Conductance Calcium-Activated Potassium Channel with Subunits

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Journeys from quantum optics to quantum technology

arXiv

引用

arXiv 2017年

作者： Barnett, Stephen M. Beige, Almut Ekert, Artur Garraway, Barry M. Keitel, Christoph H. Kendon, Viv Lein, Manfred Milburn, Gerard J. Moya-Cessa, Héctor M. Murao, Mio Pachos, Jiannis K. Palma, G. Massimo Paspalakis, Emmanuel Phoenix, Simon J.D. Piraux, Bernard Plenio, Martin B. Sanders, Barry C. Twamley, Jason Vidiella-Barranco, A. Kim, M.S. School of Physics and Astronomy University of Glasgow GlasgowG12 8QQ United Kingdom School of Physics and Astronomy University of Leeds LeedsLS2 9JT United Kingdom Mathematical Institute University of Oxford Centre for Quantum Technologies National University of Singapore Department of Physics and Astronomy University of Sussex Falmer BrightonBN1 9QH United Kingdom Max-Planck-Institut für Kernphysik Saupfercheckweg 1 Heidelberg69117 Germany Department of Physics Durham University South Road DurhamDH1 3LE United Kingdom Institute for Theoretical Physics Leibniz Universität Hannover Hannover30167 Germany Centre for Engineered Quantum Systems School of Mathematics and Physics University of Queensland 4072 Australia Instituto Nacional de Astrofísica Óptica y Electrónica Calle Luis Enrique Erro No. 1 Sta. Ma. Tonantzintla Pue.CP 72840 Mexico Department of Physics Graduate School of Science University of Tokyo Japan NEST Istituto Nanoscienze CNR Dipartimento di Fisica e Chimica Università degli Studi di Palermo via Archirafi 36 PalermoI-90123 Italy Materials Science Department School of Natural Sciences University of Patras Patras265 04 Greece Department of Applied Mathematics and Sciences Khalifa University P.O. Box: 127788 Abu Dhabi United Arab Emirates Universite Catholique de Louvain Louvain-la-NeuveB-1348 Belgium Universität Ulm Albert-Einstein-Allee 11 Ulm89069 Germany Institute for Quantum Science and Technology University of Calgary ABT2N 1N4 Canada Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Hefei Anhui230026 China Shanghai Branch CAS Center for Excellence Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of China Shanghai201315 China Program in Quantum Information Science Canadian Institute for Advanced Research TorontoONM5G 1Z8 Canada Centre for Engineered Quantum Systems Department of Physics and

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