咨询与建议

限定检索结果

文献类型

  • 417 篇 期刊文献
  • 1 篇 会议

馆藏范围

  • 418 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 343 篇 医学
    • 164 篇 临床医学
    • 136 篇 药学(可授医学、理...
    • 92 篇 基础医学(可授医学...
    • 63 篇 公共卫生与预防医...
    • 17 篇 中西医结合
    • 2 篇 口腔医学
    • 2 篇 特种医学
  • 187 篇 理学
    • 142 篇 统计学(可授理学、...
    • 108 篇 生物学
    • 8 篇 数学
    • 4 篇 化学
    • 1 篇 物理学
    • 1 篇 地球物理学
    • 1 篇 生态学
  • 34 篇 管理学
    • 34 篇 公共管理
  • 27 篇 工学
    • 14 篇 生物工程
    • 12 篇 计算机科学与技术...
    • 2 篇 环境科学与工程(可...
    • 1 篇 光学工程
    • 1 篇 控制科学与工程
    • 1 篇 化学工程与技术
    • 1 篇 生物医学工程(可授...
    • 1 篇 食品科学与工程(可...
  • 24 篇 农学
    • 3 篇 作物学
  • 19 篇 经济学
    • 19 篇 应用经济学
  • 7 篇 教育学
    • 3 篇 心理学(可授教育学...
    • 3 篇 体育学
    • 1 篇 教育学
  • 5 篇 法学
    • 5 篇 社会学

主题

  • 12 篇 power
  • 10 篇 alirocumab
  • 10 篇 pcsk9
  • 9 篇 conditional powe...
  • 9 篇 pharmacokinetics
  • 9 篇 clinical trial
  • 8 篇 adaptive design
  • 7 篇 sample size
  • 7 篇 interim analysis
  • 7 篇 gee
  • 6 篇 pregnancy
  • 5 篇 pharmacodynamics
  • 5 篇 type 2 diabetes
  • 5 篇 cardiovascular d...
  • 5 篇 type 2 diabetes ...
  • 5 篇 nonparametric
  • 5 篇 oncology
  • 4 篇 signal detection
  • 4 篇 safety
  • 4 篇 ldl-c

机构

  • 17 篇 sanofi biostat &...
  • 13 篇 sanofi aventis b...
  • 13 篇 regeneron pharma...
  • 13 篇 sanofi biostat &...
  • 12 篇 sanofi biostat &...
  • 9 篇 sanofi us inc de...
  • 9 篇 sanofi biostat &...
  • 8 篇 statens serum in...
  • 8 篇 sanofi biostat &...
  • 8 篇 sanofi
  • 7 篇 sanofi us inc de...
  • 6 篇 janssen cilag em...
  • 5 篇 van andel inst d...
  • 5 篇 regeneron pharma...
  • 5 篇 ividata stats le...
  • 5 篇 norwegian inst p...
  • 5 篇 univ toronto li ...
  • 5 篇 univ north carol...
  • 5 篇 sanofi kk biosta...
  • 5 篇 univ pisa dept c...

作者

  • 45 篇 quan hui
  • 24 篇 fan chunpeng
  • 19 篇 zhang donghui
  • 17 篇 olsen sjurdur f.
  • 14 篇 luo xiaodong
  • 12 篇 chen xun
  • 11 篇 letierce alexia
  • 9 篇 zhang ji
  • 9 篇 qi li
  • 8 篇 dwyer terence
  • 8 篇 luo junxiang
  • 8 篇 wei lynn
  • 8 篇 tikellis gabriel...
  • 8 篇 wu yujun
  • 8 篇 zhao peng-liang
  • 7 篇 lemeshow stanley
  • 7 篇 strom marin
  • 7 篇 magnus per
  • 7 篇 sun yanqing
  • 7 篇 bujas-bobanovic ...

语言

  • 395 篇 英文
  • 22 篇 其他
检索条件"机构=Biostat and Programming"
418 条 记 录,以下是101-110 订阅
排序:
Single-embryo RNA sequencing for continuous and sex- specific gene expression analysis on Drosophila
收藏 引用
STAR PROTOCOLS 2023年 第3期4卷 102535页
作者: Perez-Mojica, J. Eduardo Enders, Lennart Lau, Kin H. Lempradl, Adelheid Van Andel Inst Dept Metab & Nutr Programming Grand Rapids MI 49503 USA Max Planck Inst Immunobiol & Epigenet Dept Epigenet D-79108 Freiburg Germany Van Andel Inst Bioinformat & Biostat Core Grand Rapids MI 49503 USA Austrian Acad Sci CeMM Res Ctr Mol Med A-1090 Vienna Austria
Exploring early embryonic gene expression is challenging due to the rate of development and the limited material available. Here, we present a protocol for ordering Drosophila embryos along a developmental pseudo-time... 详细信息
来源: 评论
Post-hoc analysis from phase III trials of human papillomavirus vaccines: considerations on impact on non-vaccine types
收藏 引用
EXPERT REVIEW OF VACCINES 2019年 第3期18卷 309-322页
作者: Ryser, Martin Berlaimont, Valerie Karkada, Naveen Mihalyi, Attila Rappuoli, Rino van der Most, Robbert GSK Global Med Affairs Wavre Belgium GSK Biostat & Stat Programming Wavre Belgium GSK Res & Dev Siena Italy GSK Translat Sci Rixensart Belgium
Background: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of HPV type in phase III results for bivalent and quadrivalent human papillo... 详细信息
来源: 评论
State of the art in total pulse production in major states of India using ARIMA techniques
收藏 引用
CURRENT RESEARCH IN FOOD SCIENCE 2021年 4卷 800-806页
作者: Mishra, Pradeep Yonar, Aynur Yonar, Harun Kumari, Binita Abotaleb, Mostafa Das, Soumitra Sankar Patil, S. G. Jawaharlal Nehru Krishi Vishwa Vidyalaya Coll Agr Hoshangabad Madhya Pradesh India Selcuk Univ Dept Stat Fac Sci Konya Turkey Selcuk Univ Dept Biostat Fac Vet Med Konya Turkey Rashtriya Kisan PG Coll Dept Agr Econ Shamli India Chaudhary Charan Singh Univ Meerut Uttar Pradesh India South Ural State Univ Dept Syst Programming Chelyabinsk Russia Birsa Agr Univ Ranchi Jharkhand India Tamil Nadu Agr Univ Coimbatore Tamil Nadu India
Pulses are staple protein-rich food for Indian vegetarians, and India is one of the largest producers in the world. The present investigation is an attempt to study the trend in the production of total pulses in India... 详细信息
来源: 评论
Phase I dose-escalation study of the safety, tolerability, and pharmacokinetics of aflibercept in combination with S-1 in Japanese patients with advanced solid malignancies
收藏 引用
INVESTIGATIONAL NEW DRUGS 2020年 第5期38卷 1390-1399页
作者: Doi, Toshihiko Boku, Narikazu Onozawa, Yusuke Takahashi, Keishiro Kawaguchi, Osamu Ohtsu, Atsushi Natl Canc Ctr Hosp East Dept Gastrointestinal Oncol 6-5-1 Kashiwanoha Kashiwa Chiba 2778577 Japan Natl Canc Ctr Dept Gastrointestinal Med Oncol Tokyo Japan Shizuoka Canc Ctr Div Clin Oncol Shizuoka Japan Sanofi KK Res & Dev Tokyo Japan Sanofi KK Biostat & Programming Tokyo Japan
BackgroundAflibercept, a recombinant fusion protein binding VEGF-A, VEGF-B and placental growth factor, inhibits tumor growth by blocking angiogenesis. The aim of this phase I dose-escalation study was to determine th... 详细信息
来源: 评论
Maternal intake of folate during pregnancy and risk of cerebral palsy in the MOBAND-CP cohort
收藏 引用
AMERICAN JOURNAL OF CLINICAL NUTRITION 2022年 第2期115卷 397-406页
作者: Groot, Jonathan Petersen, Tanja G. Suren, Pal Brantsoeter, Anne Lise Uldall, Peter Martinussen, Torben Granstrom, Charlotta Olsen, Sjurdur F. Wilcox, Allen J. Strandberg-Larsen, Katrine Univ Copenhagen Fac Hlth & Med Sci Dept Publ Hlth Sect Epidemiol Copenhagen Denmark Odense Univ Hosp Open Patient Data Explorat Network Odense Denmark Norwegian Inst Publ Hlth Dept Child Hlth & Dev Div Mental & Phys Hlth Oslo Norway Norwegian Inst Publ Hlth Dept Environm Exposure & Epidemiol Div Infect Control & Environm Hlth Oslo Norway Copenhagen Univ Hosp Rigshosp Pediat Dept Copenhagen Denmark Dianalund Epilepsy Ctr Dianalund Denmark Univ Copenhagen Fac Hlth & Med Sci Dept Publ Hlth Sect Biostat Copenhagen Denmark Ctr Fetal Programming Statens Serum Inst Div Epidemiol Copenhagen Denmark Harvard Sch Publ Hlth Dept Nutr Boston MA USA NIEHS Epidemiol Branch Durham NC USA
Background Folate prevents neural tube defects and may play a role in some neurodevelopmental disorders. Objectives We investigated whether higher intakes of periconceptional or midpregnancy folate, as recommended, we... 详细信息
来源: 评论
Confidence, prediction, and tolerance in linear mixed models
收藏 引用
STATISTICS IN MEDICINE 2019年 第30期38卷 5603-5622页
作者: Francq, Bernard G. Lin, Dan Hoyer, Walter GSK TRD CMC Stat Sci B-1330 Rixensart Belgium GSK Preclin & Res Biostat & Stat Programming Rixensart Belgium GSK TRD CMC Stat Sci Marburg Germany
The literature about Prediction Interval (PI) and Tolerance Interval (TI) in linear mixed models is usually developed for specific designs, which is a main limitation to their use. This paper proposes to reformulate t... 详细信息
来源: 评论
Considerations for pediatric trial designs and analyses
收藏 引用
JOURNAL OF BIOPHARMACEUTICAL STATISTICS 2018年 第3期28卷 413-436页
作者: Cho, Meehyung Qiu, Zhiying Ye, Jenny Quan, Hui Zhao, Peng-Liang Sanofi US Biostat & Programming Bridgewater NJ 08807 USA
There are challenges in designing pediatric trials arising from special ethical issues and the relatively small accessible patient population. The application of conventional phase 3 trial designs to pediatrics is not... 详细信息
来源: 评论
Robust designs in longitudinal studies accounting for parameter and model uncertainties - application to count data
收藏 引用
JOURNAL OF BIOPHARMACEUTICAL STATISTICS 2020年 第1期30卷 31-45页
作者: Loingeville, Florence Thu Thuy Nguyen Riviere, Marie-Karelle Mentre, France INSERM IAME UMR 1137 F-75018 Paris France Univ Paris Diderot Sorbonne Paris Cite F-75018 Paris France Univ Lille Fac Pharm Publ Hlth Epidemiol & Healthcare Qual EA 2694 F-59000 Lille France Sanofi Aventis R&D Stat Methodol Grp Biostat & Programming Dept Chilly Mazarin France
Nonlinear mixed effect models (NLMEMs) are widely used for the analysis of longitudinal data. To design these studies, optimal designs based on the expected Fisher information matrix (FIM) can be used. A method evalua... 详细信息
来源: 评论
Look before you leap: systematic evaluation of tree-based statistical methods in subgroup identification
收藏 引用
JOURNAL OF BIOPHARMACEUTICAL STATISTICS 2019年 第6期29卷 1082-1102页
作者: Liu, Yang Ma, Xiwen Zhang, Donghui Geng, Lijiang Wang, Xiaojing Zheng, Wei Chen, Ming-Hui Univ Connecticut Dept Stat Storrs CT 06269 USA Karyopharm Therapeut Inc Biostat Dept Newton MA USA Sanofi US Global Biostat & Programming Bridgewater NJ USA Kehang Suzhou Informat & Technol Ltd Co Suzhou Jiangsu Peoples R China
Subgroup analysis, as the key component of personalized medicine development, has attracted a lot of interest in recent years. While a number of exploratory subgroup searching approaches have been proposed, informativ... 详细信息
来源: 评论
Burden of Herpes Zoster in the Japanese Population with Immunocompromised/Chronic Disease Conditions: Results from a Cohort Study Claims Database from 2005-2014
收藏 引用
DERMATOLOGY AND THERAPY 2019年 第1期9卷 117-133页
作者: Imafuku, Shinichi Matsuki, Taizo Mizukami, Akiko Goto, Yasushi de Souza, Sabrina Jegou, Celine Bianco, Veronique Rosillon, Dominique Ito, Chie Curran, Desmond Holl, Katsiaryna Fukuoka Univ Dept Dermatol Sch Med Fukuoka Fukuoka Japan GSK Healthoutcomes Dept Tokyo Japan Natl Canc Ctr Dept Thorac Oncol Tokyo Japan GSK Keyrus Biopharma London England GSK Business & Decis Life Sci Wavre Belgium GSK Biostat & Stat Programming Rockville MD USA GSK Biostat & Stat Programming Wavre Belgium JMDC Co Ltd Tokyo Japan GSK Vaccines Hlth Outcomes Dept Wavre Belgium
IntroductionThe aim of this study is to describe the disease burden and costs of herpes zoster (HZ) in the general adult Japanese population or patients with immunocompromised (IC) conditions or chronic *** retrospect... 详细信息
来源: 评论