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检索条件"机构=Biostat and Programming"
418 条 记 录,以下是301-310 订阅
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New paradigm for drug developments-From emerging market statistical perspective
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CONTEMPORARY CLINICAL TRIALS 2013年 第2期36卷 697-703页
作者: Quan, Hui Chen, Xun Zhang, Ji Zhao, Peng-Liang Sanofi Biostat & Programming Bridgewater NJ 08807 USA
Paradigm for new drug development has changed dramatically over the last decade. Even though new technology increases efficiency in many aspects, partially due to much more stringent regulatory requirements, it actual... 详细信息
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Fetal growth and cardio-metabolic risk factors in the 20-year-old offspring
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ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2014年 第11期93卷 1150-1159页
作者: Rytter, Dorte Bech, Bodil H. Frydenberg, Morten Henriksen, Tine B. Olsen, Sjurdur F. Aarhus Univ Dept Publ Hlth Epidemiol Sect DK-8000 Aarhus C Denmark Aarhus Univ Dept Publ Hlth Biostat Sect DK-8000 Aarhus C Denmark Aarhus Univ Hosp Dept Pediat DK-8000 Aarhus Denmark Statens Serum Inst Ctr Fetal Programming DK-2300 Copenhagen Denmark
ObjectiveTo investigate the association between prenatal growth patterns as estimated by biparietal diameter and cardio-metabolic risk at 20years. DesignFollow-up study. SettingDenmark 1988-2009. PopulationTwo cohorts... 详细信息
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Aflibercept plus FOLFIRI for 2nd line treatment of metastatic colorectal cancer (mCRC): Long-term safety observation from the global aflibercept safety and quality-of-life (QoL) program (ASQoP)
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ANNALS OF ONCOLOGY 2016年 27卷 vi182-vi182页
作者: Riechelmann, R. Srimuninnimit, V. Kavan, P. Di Bartolomeo, M. Maiello, E. Cicin, I. Kroening, H. Garcia-Alfonso, P. Chau, I. Fernandez-Martos, C. Ter-Ovanesov, M. Peeters, M. Picard, P. Bordonaro, R. Univ Sao Paulo Fac Med Fundacao Fac Med Sao Paulo Brazil Mahidol Univ Siriraj Hosp Dept Med Bangkok Thailand McGill Univ Segal Canc Ctr E715 Montreal PQ Canada Ist Nazl Tumori SC Med Oncol 1 Milan Italy IRCCS Casa Sollievo Sofferenza Oncohematol Dept San Giovanni Rotondo Italy Trakya Univ Dept Med Oncol Edirne Turkey Schwerpunktpraxis Hematol & Onkol Magdeburg Germany Hosp Gen Univ Gregorio Maranon Dept Oncol Madrid Spain Royal Marsden NHS Fdn Trust Dept Med Sutton Surrey England Fdn Inst Valenciano Oncol Gastrointestinal Oncol Unit Valencia Spain Moscow Municipal Oncol Hosp 40 Dept Oncol & Surg Moscow Russia Univ Antwerp Dept Oncol Antwerp Belgium Sanofi R&D Med Affair & Data Min Biostat & Programming Clin Sci & Operat Chilly Mazarin France Azienda Osped ARNAS Garibaldi Oncol Med Catania Italy
552P
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Chemical structure informing statistical hypothesis testing in metabolomics
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BIOINFORMATICS 2014年 第4期30卷 514-522页
作者: Zhu, Hongjie Luo, Man Sanofi Dept Biostat & Programming Bridgewater NJ 08807 USA Duke Univ Dept Psychiat & Behav Sci Durham NC 27710 USA Bristol Myers Squibb Co Exploratory Clin & Translat Res Princeton NJ 08543 USA Hamner Inst Hlth Sci Ctr Human Hlth Assessment Res Triangle Pk NC 27709 USA
Motivation: Metabolomics has been shown as an effective tool to study various biological and biomedical phenotypes, whereas interrogating the inherently noisy metabolite concentration data with limited sample size rem... 详细信息
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Interim treatment selection with a flexible selection margin in clinical trials
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STATISTICS IN MEDICINE 2013年 第15期32卷 2529-2543页
作者: Wu, Yujun Zhao, Peng-Liang Sanofi Aventis US Biostat & Programming Bridgewater NJ 08807 USA
When several treatment arms are administered along with a control arm in a trial, dropping the non-promising treatments at an early stage helps to save the resources and expedite the trial. In such adaptive designs wi... 详细信息
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Equal improvement in glycaemia with lixisenatide given before breakfast or the main meal of the day
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JOURNAL OF DIABETES AND ITS COMPLICATIONS 2014年 第5期28卷 735-741页
作者: Ahren, Bo Vorokhobina, Natalia Souhami, Elisabeth Demil, Nacima Ye, Jenny Aronson, Ronnie Lund Univ Dept Clin Sci SE-22184 Lund Sweden North Western State Med Univ Dept Endocrinol St Petersburg Russia Sanofi Diabet Div Clin Dev Dept Paris France Sanofi Diabet Med Operat Dept Chilly Mazarin France Sanofi NJ Biostat & Programming Bridgewater NJ USA LMC Diabet & Endocrinol Toronto ON Canada
Aims: The aim of this study is to explore whether administration timing affects glycaemic control by lixisenatide once-daily in type 2 diabetes mellitus (T2DM). Methods: A phase IIIb, open-label, 1:1 randomized, activ... 详细信息
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Velaglucerase alfa (VPRIV) enzyme replacement therapy in patients with Gaucher disease: Long-term data from phase III clinical trials
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AMERICAN JOURNAL OF HEMATOLOGY 2015年 第7期90卷 584-591页
作者: Hughes, Derralynn A. Gonzalez, Derlis E. Lukina, Elena A. Mehta, Atul Kabra, Madhulika Elstein, Deborah Kisinovsky, Isaac Giraldo, Pilar Bavdekar, Ashish Hangartner, Thomas N. Wang, Nan Crombez, Eric Zimran, Ari Royal Free Hosp Dept Haematol London NW3 2QG England UCL Dept Haematol London NW3 2PF England IPHIC Asuncion Paraguay Minist Publ Hlth Russia Hematol Res Ctr Dept Orphan Dis Moscow Russia All India Inst Med Sci Dept Pediat New Delhi India Hebrew Univ Jerusalem Hadassah Med Sch Shaare Zedek Med Ctr Gaucher Clin IL-91010 Jerusalem Israel Your Hlth SA Dept Hematol Buenos Aires DF Argentina CIBERER Med Metab Hereditaria Zaragoza Spain Hosp Univ Miguel Servet Grp Estudio Enfermedades Hematol & Metab Zaragoza Spain King Edward Mem Hosp Res Ctr Dept Pediat Gastroenterol Pune Maharashtra India Wright State Univ Dept Biomed Ind & Human Factors Engn Dayton OH 45435 USA Shire Biostat & Stat Programming Dept Lexington MA USA Shire Rare Dis Unit Lexington MA USA
Type 1 Gaucher disease is an inherited lysosomal enzyme deficiency with variable age of symptom onset. Common presenting signs include thrombocytopenia, anemia, hepatosplenomegaly, bone abnormalities, and, additionall... 详细信息
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Safety and efficacy results of switch from imiglucerase to velaglucerase alfa treatment in patients with type 1 Gaucher disease
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AMERICAN JOURNAL OF HEMATOLOGY 2015年 第7期90卷 592-597页
作者: Elstein, Deborah Mehta, Atul Hughes, Derralynn A. Giraldo, Pilar Charrow, Joel Smith, Laurie Shankar, Suma P. Hangartner, Thomas N. Kunes, Yune Wang, Nan Crombez, Eric Zimran, Ari Hebrew Univ Jerusalem Hadassah Med Sch Shaare Zedek Med Ctr Gaucher Clin IL-91010 Jerusalem Israel Royal Free Hosp Dept Haematol London NW3 2QG England UCL Dept Haematol London England CIBERER Med Metab Hereditaria Zaragoza Spain Hosp Univ Miguel Servet Grp Estudio Enfermedades Hematol & Metab Zaragoza Spain Ann & Robert H Lurie Childrens Hosp Chicago Dept Pediat Chicago IL 60611 USA Childrens Mercy Hosp Ctr Pediat Genom Med Kansas City MO 64108 USA Emory Univ Sch Med Dept Human Genet Atlanta GA USA Emory Univ Sch Med Dept Ophthalmol Atlanta GA 30322 USA Wright State Univ Dept Biomed Ind & Human Factors Engn Dayton OH 45435 USA Shire Bioanalyt & BioMarker Dev Lexington MA USA Shire Biostat & Stat Programming Dept Lexington MA USA Shire Rare Dis Unit Lexington MA USA
Gaucher disease (GD) is a lysosomal storage disorder;symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of...
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Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C)
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PAEDIATRIC AND PERINATAL EPIDEMIOLOGY 2015年 第4期29卷 335-345页
作者: Paltiel, Ora Tikellis, Gabriella Linet, Martha Golding, Jean Lemeshow, Stanley Phillips, Gary Lamb, Karen Stoltenberg, Camilla Haberg, Siri E. Strom, Marin Granstrom, Charlotta Northstone, Kate Klebanoff, Mark Ponsonby, Anne-Louise Milne, Elizabeth Pedersen, Marie Kogevinas, Manolis Ha, Eunhee Dwyer, Terence Hadassah Hebrew Univ Dept Hematol IL-91120 Jerusalem Israel Hadassah Hebrew Univ Braun Sch Publ Hlth IL-91120 Jerusalem Israel Univ Melbourne Royal Childrens Hosp Dept Environm & Genet Epidemiol Murdoch Childrens Res Inst Melbourne Vic 3010 Australia Deakin Univ Ctr Phys Act & Nutr Burwood Vic Australia Univ Tasmania Menzies Res Inst Hobart Tas Australia Univ Western Australia Telethon Kids Inst Perth WA 6009 Australia NCI Radiat Epidemiol Branch Div Canc Epidemiol & Genet NIH Bethesda MD 20892 USA Ohio State Univ Coll Publ Hlth Div Biostat Columbus OH 43210 USA Ohio State Univ Div Biostat Ctr Biostat Columbus OH 43210 USA Ohio State Univ Coll Med Res Inst Nationwide Childrens Hosp Columbus OH 43210 USA Univ Bristol Ctr Child & Adolescent Hlth Sch Social & Community Med Bristol Avon England Univ Bristol Sch Social & Community Med ALSPAC Children 90s Bristol Avon England Norwegian Inst Publ Hlth Oslo Norway Univ Bergen Dept Global Publ Hlth & Community Care Bergen Norway Statenserum Inst Ctr Fetal Programming Dept Epidemiol Res Copenhagen Denmark Ctr Res Environm Epidemiol CREAL Barcelona Spain Univ Pompeu Fabra Barcelona Spain Hosp del Mar Res Inst IMIM Barcelona Spain CIBER Epidemiol & Salud Publ CIBERESP Madrid Spain Natl Inst Hlth & Med Res INSERM Team Environm Epidemiol Appl Reprod & Resp Hlth Albert BonniotU823 Grenoble France Int Agcy Res Canc F-69372 Lyon France Natl Sch Publ Hlth Dept Nutr Athens Greece Ewha Womans Univ Dept Prevent Med Sch Med Ewha Med Res Ctr Seoul South Korea
BackgroundEvidence relating childhood cancer to high birthweight is derived primarily from registry and case-control studies. We aimed to investigate this association, exploring the potential modifying roles of age at... 详细信息
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SAMPLE SIZE DETERMINATION IN TWO-SIDED DISTRIBUTION-FREE TREATMENT VERSUS CONTROL MULTIPLE COMPARISONS
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JOURNAL OF BIOPHARMACEUTICAL STATISTICS 2013年 第6期23卷 1308-1329页
作者: Fan, Chunpeng Zhang, Donghui Sanofi US Inc Dept Biostat & Programming Bridgewater NJ 08807 USA
The problem of power and sample size determination for distribution-free multiple comparison tests of K treatments versus a control group is addressed. We define the power as the probability of correctly rejecting one... 详细信息
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