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检索条件"机构=Biostat and Programming"
418 条 记 录,以下是411-420 订阅
排序:
Bias in the Wagner-Nelson estimate of the fraction of drug absorbed
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PHARMACEUTICAL RESEARCH 2002年 第4期19卷 470-476页
作者: Wang, YB Nedelman, J Novartis Pharmaceut Coporat Biostat & Stat Programming E Hanover NJ 07936 USA
Purpose. To examine and quantify bias in the Wagner-Nelson estimate of the fraction of drug absorbed resulting from the estimation error of the elimination rate constant (k), measurement error of the drug concentratio... 详细信息
来源: 评论
CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
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DRUG METABOLISM AND DISPOSITION 2002年 第7期30卷 795-804页
作者: Luo, G Cunningham, M Kim, S Burn, T Lin, JR Sinz, M Hamilton, G Rizzo, C Jolley, S Gilbert, D Downey, A Mudra, D Graham, R Carroll, K Xie, JD Madan, A Parkinson, A Christ, D Selling, B LeCluyse, E Gan, LS Bristol Myers Squibb Pharma Co Drug Metab & Pharmcokinet Newark DE USA Bristol Myers Squibb Pharma Co Appl Biotechol Wilmington DE USA Bristol Myers Squibb Pharma Co Virol Res Wilmington DE USA Bristol Myers Squibb Co Preclin Candidate Optimizat Metab & Phamacokinet Wallingford CT USA Bristol Myers Squibb Co Biostat & Programming Princeton NJ USA Univ N Carolina Sch Pharm Div Drug Delivery & Disposit Chapel Hill NC USA XenoTech LLC Kansas City KS USA
Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane X receptor (PXR) repo...
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Blinded sample size adjustment
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DRUG INFORMATION JOURNAL 2001年 第4期35卷 1123-1130页
作者: Bristol, DR Shurzinske, L Purdue Pharma LP Biostat & Stat Programming Stamford CT 06901 USA Pfizer Global Res & Dev Biostat Ann Arbor MI USA
The determination of the appropriate sample size is an important aspect of planning a clinical trial. In recent years, procedures for estimation of a nuisance parameter to adjust the sample size if necessary have been... 详细信息
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Advice from prospective employers on training BS statisticians
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AMERICAN STATISTICIAN 2001年 第1期55卷 14-18页
作者: Ritter, MA Starbuck, RR Hogg, RV Wyeth Ayerst Res Global Biostat & Clin Programming Philadelphia PA 19101 USA Univ Iowa Dept Stat & Actuarial Sci Iowa City IA 52242 USA GM Corp Ann Arbor MI 48105 USA
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Approximating power of the unconditional test for correlated binary pairs
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COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION 1998年 第2期27卷 553-564页
作者: Selicato, GR Muller, KE Stat Programming Syst Quintiles Inc Res Triangle Pk NC 27709 USA Univ N Carolina Dept Biostat Chapel Hill NC 27599 USA
We provide a simple and good approximation of power of the unconditional test for two correlated binary variables. Suissa and Shuster (1991) described the exact unconditional test. The most commonly used statistical t... 详细信息
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PLANNING FOR PRECISION IN SURVIVAL STUDIES
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JOURNAL OF CLINICAL EPIDEMIOLOGY 1994年 第11期47卷 1277-1285页
作者: BORENSTEIN, M BIOSTAT PROGRAMMING ASSOCIATES TEANECK NJ USA
If the purpose of a clinical study is not only to test the null hypothesis but also to estimate the magnitude of the treatment effect, the study design should ensure not only that the study will have adequate power bu... 详细信息
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A VISUAL APPROACH TO STATISTICAL POWER ANALYSIS ON THE MICROCOMPUTER
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BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS 1992年 第4期24卷 565-572页
作者: BORENSTEIN, M COHEN, J ROTHSTEIN, HR POLLACK, S KANE, JM BIOSTAT PROGRAMMING ASSOCIATES TEANECKNJ CUNY BERNARD M BARUCH COLL NEW YORKNY 10010 ST JOHNS UNIV JAMAICANY 11439 YESHIVA UNIV ALBERT EINSTEIN COLL MED BRONXNY 10461
Computer programs for statistical power analysis typically require the user to provide a series of values and respond by reporting the corresponding power. These programs provide essentially the same functions as a pu...
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STATISTICAL POWER ANALYSIS FOR ONE-WAY ANALYSIS OF VARIANCE - A COMPUTER-PROGRAM
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BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS 1990年 第3期22卷 271-282页
作者: BORENSTEIN, M COHEN, J ROTHSTEIN, HR POLLACK, S KANE, JM BIOSTAT PROGRAMMING ASSOCIATES TEANECKNJ NYU NEW YORKNY 10003 CUNY BERNARD M BARUCH COLL NEW YORKNY 10010 ST JOHNS UNIV JAMAICANY 11439
To facilitate the computation of statistical power for analysis of variance, Cohen developed the index of effect sizef, defined as theSD between groups divided by theSD within groups. A microcomputer program for stati...
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