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检索条件"机构=Biostat and Programming"
418 条 记 录,以下是41-50 订阅
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A diverse proteome is present and enzymatically active in metabolite extracts
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NATURE COMMUNICATIONS 2024年 第1期15卷 5796页
作者: House, Rachel (Rae) J. Soper-Hopper, Molly T. Vincent, Michael P. Ellis, Abigail E. Capan, Colt D. Madaj, Zachary B. Wolfrum, Emily Isaguirre, Christine N. Castello, Carlos D. Johnson, Amy B. Escobar Galvis, Martha L. Williams, Kelsey S. Lee, Hyoungjoo Sheldon, Ryan D. Van Andel Inst Dept Cell Biol Grand Rapids MI USA Van Andel Inst Dept Metab & Nutr Programming Grand Rapids MI USA Van Andel Inst Mass Spectrometry Core Grand Rapids MI 49503 USA Van Andel Inst Bioinformat & Biostat Core Grand Rapids MI USA Van Andel Inst Core Technol & Serv Off Cores Grand Rapids MI USA
Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar met...
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A variable selection approach for highly correlated predictors in high-dimensional genomic data
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BIOINFORMATICS 2021年 第16期37卷 2238-2244页
作者: Zhu, Wencan Levy-Leduc, Celine Ternes, Nils Univ Paris Saclay AgroParisTech UMR MIA Paris INRAE F-75005 Paris France Sanofi R&D Biostat & Programming Dept F-91380 Chilly Mazarin France
Motivation: In genomic studies, identifying biomarkers associated with a variable of interest is a major concern in biomedical research. Regularized approaches are classically used to perform variable selection in hig...
来源: 评论
A multi-arm two-stage (MATS) design for proof-of-concept and dose optimization in early-phase oncology trials
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CONTEMPORARY CLINICAL TRIALS 2023年 第1期132卷 107278-107278页
作者: Jiang, Zhenghao Mi, Gu Lin, Ji Lorenzato, Christelle Ji, Yuan Univ Chicago Dept Stat 5747 South Ellis Ave Chicago IL 60637 USA Sanofi Biostat & Programming 450 Water St Cambridge MA 02141 USA Sanofi R&D Biostat & Programming Vitry sur Seine France Univ Chicago Dept Publ Hlth Sci 5841 South Maryland Ave Chicago IL 60637 USA
The Project Optimus initiative by the FDA's Oncology Center of Excellence is widely viewed as a groundbreaking effort to change the status quo of conventional dose-finding strategies in oncology. Unlike in other t... 详细信息
来源: 评论
Seamless phase II/III/IIIb clinical trial designs with different endpoints for different phases
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COMMUNICATIONS IN STATISTICS-THEORY AND METHODS 2020年 第22期49卷 5436-5454页
作者: Quan, Hui Luo, Xiaodong Zhou, Tianyue Zhao, Peng-Liang Sanofi Biostat & Programming 55C-335A55 Corp Dr Bridgewater MA 08807 USA
In a seamless phase II/III/IIIb trial, K (K >= 2) doses versus placebo control are evaluated at phase II. Based on phase II results, one dose will be selected for phases III and IIIb. Pre-specified additional numbe... 详细信息
来源: 评论
Are self-reported and self-monitored adherence good proxies for reaching relevant plasma concentrations?: Experiences from a study of anti-depressants in healthy volunteers
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CLINICAL TRIALS 2021年 第4期18卷 505-510页
作者: Larsen, Klaus Groes Areberg, Johan Astrom, Daniel Oudin H Lundbeck & Co AS Dept Biostat & Programming Copenhagen Denmark H Lundbeck & Co AS Dept PKPD Modelling & Simulat Copenhagen Denmark H Lundbeck & Co AS Dept Value Evidence Analyt Copenhagen Denmark
Background The use of electronic-based devices to measure and to improve adherence of subjects in clinical trials is increasing. AiCure has developed a mobile technology that is claimed to provide visual confirmation ... 详细信息
来源: 评论
A model-based clustering via mixture of hierarchical models with covariate adjustment for detecting differentially expressed genes from paired design
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BMC BIOINFORMATICS 2023年 第1期24卷 423-423页
作者: Zhang, Yixin Liu, Wei Qiu, Weiliang Univ Sci & Technol China Sch Math Sci Hefei Anhui Peoples R China York Univ Dept Math & Stat Toronto ON Canada Sanofi Dept Biostat & Programming Cambridge MA USA
The causes of many complex human diseases are still largely unknown. Genetics plays an important role in uncovering the molecular mechanisms of complex human diseases. A key step to characterize the genetics of a comp... 详细信息
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Bayesian modeling of a bivariate toxicity outcome for early phase oncology trials evaluating dose regimens
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STATISTICS IN MEDICINE 2021年 第23期40卷 5096-5114页
作者: Gerard, Emma Zohar, Sarah Lorenzato, Christelle Ursino, Moreno Riviere, Marie-Karelle Univ Paris Sorbonne Univ Ctr Rech Cordeliers INSERM 15 Rue Ecole Med F-75006 Paris France INRIA HeKA Paris France Sanofi R&D Oncol Biostat Biostat & Programming Dept Vitry Sur Seine France Sanofi R&D Stat Methodol Grp Biostat & Programming Dept Chilly Mazarin France Univ Paris CHU Robert Debre AP HP Unit Clin EpidemiolINSERMU1123Sorbonne Paris C Paris France CIC EC 1426 Paris France
Most phase I trials in oncology aim to find the maximum tolerated dose (MTD) based on the occurrence of dose limiting toxicities (DLT). Evaluating the schedule of administration in addition to the dose may improve dru... 详细信息
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Efficacy of Vortioxetine on Anhedonia: Results from a Pooled Analysis of Short-Term Studies in Patients with Major Depressive Disorder
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NEUROPSYCHIATRIC DISEASE AND TREATMENT 2021年 17卷 575-585页
作者: McIntyre, Roger S. Loft, Henrik Christensen, Michael Cronquist Univ Toronto Univ Hlth Network Mood Disorders Psychopharmacol Unit Toronto ON Canada H Lundbeck & Co AS Dept Biostat & Programming Valby Denmark H Lundbeck & Co AS Dept Psychiat Prod Valby Denmark
Purpose: Anhedonia is a core symptom of major depressive disorder (MDD), which has important functional consequences for the patient. This post hoc analysis investigated the relationship between anhedonia and function... 详细信息
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Unified approaches to assessing treatment effect of traditional Chinese medicine based on health profiles
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JOURNAL OF BIOPHARMACEUTICAL STATISTICS 2020年 第3期30卷 564-573页
作者: Cheng, Bin Zhang, Bingzhi Chow, Shein-Chung Columbia Univ Dept Biostat New York NY 10032 USA Sanofi Dept Biostat & Programming Bridgewater MA USA Duke Univ Sch Med Dept Biostat & Bioinformat Durham NC USA
Two dissimilarity indices are introduced to measure the disharmony of a human body system by mimicking the population bioequivalence and the individual bioequivalence concepts. Hypotheses for the treatment effect of a... 详细信息
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Effectiveness and Safety of Resilient Hyaluronic Acid (RHA) Dermal Fillers for the Correction of Moderate-to-Severe Nasolabial Folds in People of Color: Post Hoc Subgroup Analyses of US Pivotal Clinical Data
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AESTHETIC SURGERY JOURNAL 2024年 第4期44卷 412-420页
作者: Taylor, Susan Weinkle, Susan Kaufman-Janette, Joely Gallagher, Conor J. Kooken, Kristie Brown, Jessica Univ Penn Perelman Sch Med Philadelphia PA USA Univ S Florida Dermatol Tampa FL USA Skin Associates South Florida Coral Gables FL USA Revance Therapeut Inc Med Affairs & Sci Innovat Nashville TN USA Revance Therapeut Inc Stat Programming Biostat & Data Management Nashville TN USA Revance Therapeut Inc Med Affairs Nashville TN USA 3400 Civ Ctr Blvd South Tower 7-768 Philadelphia PA 19104 USA
Background People of color (POC) are often underrepresented in clinical studies evaluating the safety and effectiveness of aesthetic products, including hyaluronic acid (HA) fillers, for which there is to date limited...
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