咨询与建议

限定检索结果

文献类型

  • 417 篇 期刊文献
  • 1 篇 会议

馆藏范围

  • 418 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 343 篇 医学
    • 164 篇 临床医学
    • 136 篇 药学(可授医学、理...
    • 92 篇 基础医学(可授医学...
    • 63 篇 公共卫生与预防医...
    • 17 篇 中西医结合
    • 2 篇 口腔医学
    • 2 篇 特种医学
  • 187 篇 理学
    • 142 篇 统计学(可授理学、...
    • 108 篇 生物学
    • 8 篇 数学
    • 4 篇 化学
    • 1 篇 物理学
    • 1 篇 地球物理学
    • 1 篇 生态学
  • 34 篇 管理学
    • 34 篇 公共管理
  • 27 篇 工学
    • 14 篇 生物工程
    • 12 篇 计算机科学与技术...
    • 2 篇 环境科学与工程(可...
    • 1 篇 光学工程
    • 1 篇 控制科学与工程
    • 1 篇 化学工程与技术
    • 1 篇 生物医学工程(可授...
    • 1 篇 食品科学与工程(可...
  • 24 篇 农学
    • 3 篇 作物学
  • 19 篇 经济学
    • 19 篇 应用经济学
  • 7 篇 教育学
    • 3 篇 心理学(可授教育学...
    • 3 篇 体育学
    • 1 篇 教育学
  • 5 篇 法学
    • 5 篇 社会学

主题

  • 12 篇 power
  • 10 篇 alirocumab
  • 10 篇 pcsk9
  • 9 篇 conditional powe...
  • 9 篇 pharmacokinetics
  • 9 篇 clinical trial
  • 8 篇 adaptive design
  • 7 篇 sample size
  • 7 篇 interim analysis
  • 7 篇 gee
  • 6 篇 pregnancy
  • 5 篇 pharmacodynamics
  • 5 篇 type 2 diabetes
  • 5 篇 cardiovascular d...
  • 5 篇 type 2 diabetes ...
  • 5 篇 nonparametric
  • 5 篇 oncology
  • 4 篇 signal detection
  • 4 篇 safety
  • 4 篇 ldl-c

机构

  • 17 篇 sanofi biostat &...
  • 13 篇 sanofi aventis b...
  • 13 篇 regeneron pharma...
  • 13 篇 sanofi biostat &...
  • 12 篇 sanofi biostat &...
  • 9 篇 sanofi us inc de...
  • 9 篇 sanofi biostat &...
  • 8 篇 statens serum in...
  • 8 篇 sanofi biostat &...
  • 8 篇 sanofi
  • 7 篇 sanofi us inc de...
  • 6 篇 janssen cilag em...
  • 5 篇 van andel inst d...
  • 5 篇 regeneron pharma...
  • 5 篇 ividata stats le...
  • 5 篇 norwegian inst p...
  • 5 篇 univ toronto li ...
  • 5 篇 univ north carol...
  • 5 篇 sanofi kk biosta...
  • 5 篇 univ pisa dept c...

作者

  • 45 篇 quan hui
  • 24 篇 fan chunpeng
  • 19 篇 zhang donghui
  • 17 篇 olsen sjurdur f.
  • 14 篇 luo xiaodong
  • 12 篇 chen xun
  • 11 篇 letierce alexia
  • 9 篇 zhang ji
  • 9 篇 qi li
  • 8 篇 dwyer terence
  • 8 篇 luo junxiang
  • 8 篇 wei lynn
  • 8 篇 tikellis gabriel...
  • 8 篇 wu yujun
  • 8 篇 zhao peng-liang
  • 7 篇 lemeshow stanley
  • 7 篇 strom marin
  • 7 篇 magnus per
  • 7 篇 sun yanqing
  • 7 篇 bujas-bobanovic ...

语言

  • 395 篇 英文
  • 22 篇 其他
检索条件"机构=Biostat and Programming"
418 条 记 录,以下是71-80 订阅
排序:
Pharmacokinetics and Safety of Single and Multiple Doses of Peficitinib (ASP015K) in Healthy Chinese Subjects
收藏 引用
DRUG DESIGN DEVELOPMENT AND THERAPY 2022年 第0期16卷 1365-1381页
作者: Gao, Xin He, Xuemei Oshima, Hiroyuki Miyatake, Daisuke Otsuka, Yukio Kato, Kota Cai, Chunxiao Wojtkowski, Tomasz Song, Nan Kaneko, Yuichiro Shi, Aixin Chinese Acad Med Sci Clin Trial Ctr Beijing Hosp Natl Ctr Gerontol Beijing 100730 Peoples R China Chinese Acad Med Sci Inst Geriatr Med Beijing 100730 Peoples R China Astellas Pharma Inc Clin Pharmacol & Exploratory Dev Tokyo Japan Astellas Pharma Inc Anal & Pharmacokinet Res Labs Ibaraki Japan Astellas China Investment Co Ltd Dev Med Dept Beijing Peoples R China Astellas Pharma US Inc Data Sci Dev Northbrook IL USA Astellas China Investment Co Ltd Dev Div Biostat & Stat Programming Beijing Peoples R China Astellas Pharma Inc Dev Japan Asia Data Sci Biostat Grp Tokyo Japan
Objective: To investigate the pharmacokinetics and safety of peficitinib (Janus kinase inhibitor for the treatment of rheumatoid arthritis) in healthy Chinese subjects following single and multiple doses. Methods: Thi... 详细信息
来源: 评论
NO SAFETY CONCERNS OBSERVED WHEN THE ADJUVANTED RECOMBINANT ZOSTER VACCINE (RZV) AND THE COVID-19 MRNA-1273 BOOSTER WERE CO-ADMINISTERED IN ≥ 50-YEAR-OLDS
收藏 引用
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2023年 130卷 S55-S56页
作者: Naficy, A. Pirrotta, P. Kuxhausen, A. Miller, J. Leav, B. Mwakingwe-Omari, A. GSK Clin Sci Viral Vaccines Rockville MD USA GSK Vaccine Clin Safety & Pharmacovigilance Global Safety Wavre Belgium GSK Clin Evidence Generat Biostat & Stat Programming Rockville MD USA Moderna Clin Dev Cambridge MA USA
IntroThe US CDC recommends that COVID-19 vaccines may be coadministered with other age-appropriate vaccines. There is limited data assessing outcomes, including reactogenicity, on such co-administration. For the first...
来源: 评论
Reducing Patient Burden in Clinical Trials Through the Use of Historical Controls: Appropriate Selection of Historical Data to Minimize Risk of Bias
收藏 引用
THERAPEUTIC INNOVATION & REGULATORY SCIENCE 2020年 第4期54卷 850-860页
作者: Lim, Jessica Wang, Li Best, Nicky Liu, Jeen Yuan, Jiacheng Yong, Florence Zhang, Lanju Walley, Rosalind Gosselin, Alice Roebling, Robert Viele, Kert GSK Clin Stat 1250 S Collegeville Rd Collegeville PA 19426 USA AbbVie Data & Stat Sci N Chicago IL USA GSK Adv Biostat & Data Analyt Uxbridge Middx England Allergan Stat Sci & Programming Irvine CA USA Pfizer Biostat Worldwide Res & Dev Cambridge MA USA UCB Ctr Excellence Stat Innovat Slough Berks England Sanofi Biostat & Programming Paris France UCB Global Clin Dev & Med Affairs Monheim Germany Berry Consultants Austin TX USA
Historical data have been used to augment or replace control arms in some rare disease and pediatric clinical trials. With greater availability of historical data and new methodology such as dynamic borrowing, the inc... 详细信息
来源: 评论
The Hospital Recovery Scale: A clinically useful endpoint in patients hospitalized with influenza
收藏 引用
CONTEMPORARY CLINICAL TRIALS 2022年 123卷 106952-106952页
作者: van Duijnhoven, Wilbert Van Dromme, Ilse Haesendonckx, Steven Witek, James Leopold, Lorant Janssen Pharmaceut NV Stat & Decis Sci Beerse Belgium Janssen Pharmaceut NV Clin Biostat Beerse Belgium Janssen Pharmaceut NV Stat Programming Beerse Belgium Janssen Res & Dev Med Dept Titusville NJ USA Janssen Pharmaceut NV Biostat Stat & Decis Sci Turnhoutseweg 30 B-2340 Beerse Belgium
Background: Currently, no single best primary endpoint exists for measuring the efficacy of treatments in seriously ill patients with respiratory infections, such as influenza, who require hospitalization. The Hospita... 详细信息
来源: 评论
A Methodology Report for the Life's Snapshot Cohort Study to Investigate the Long-Term Efficacy of a Violence Intervention
收藏 引用
VIOLENCE AGAINST WOMEN 2022年 第1期28卷 316-344页
作者: Coker, Ann L. Bush, Heather M. Brancato, Candace Huang, Zhengyan Clear, Emily R. Follingstad, Diane R. Univ Kentucky Coll Med Dept Obstet & Gynecol Lexington KY 40506 USA Univ Kentucky Coll Publ Hlth Dept Biostat Lexington KY 40506 USA Univ Kentucky Dept Stat DATAQUeST Data Qual & Stat Programming Lexington KY 40506 USA Univ Kentucky Coll Publ Hlth Dept Hlth Management & Policy Lexington KY 40506 USA Univ Kentucky Dept Psychiat Lexington KY 40506 USA
Engaged bystander interventions are recognized as "promising" programming to reduce sexual violence (SV), yet little is known of the long-term (>12-month) impact of programming on SV and related forms of ... 详细信息
来源: 评论
Neutralizing antibody correlates of sequence specific dengue disease in a tetravalent dengue vaccine efficacy trial in Asia
收藏 引用
VACCINE 2022年 第41期40卷 5912-5923页
作者: Qi, Li Sun, Yanqing Juraska, Michal Moodie, Zoe Magaret, Craig A. Heng, Fei Carpp, Lindsay N. Gilbert, Peter B. Sanofi Biostat & Programming 55 Corp Dr Bridgewater NJ 08807 USA Univ N Carolina Dept Math & Stat 9201 Univ City Blvd Charlotte NC 28223 USA Fred Hutchinson Canc Ctr Vaccine & Infect Dis Div 1100 Fairview Ave North Seattle WA 98109 USA Univ North Florida Dept Math & Stat 1 UNF Dr Jacksonville FL 32224 USA Univ Washington Dept Biostat 3980 15th Ave NE Seattle WA 98109 USA Fred Hutchinson Canc Ctr Vaccine & Infect Dis Div 1100 Fairview Ave NorthM2-C206 Seattle WA 98109 USA Google New York New York NY 10011 USA
In the CYD14 trial of the CYD-TDV dengue vaccine in 2-14 year-olds, neutralizing antibody (nAb) titers to the vaccine-insert dengue strains correlated inversely with symptomatic, virologically-confirmed dengue (VCD). ... 详细信息
来源: 评论
Single-Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC-122) in Subjects With Mild, Moderate, or Severe Renal Impairment
收藏 引用
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT 2020年 第7期9卷 785-796页
作者: Li, Yan MacGorman, Kimberly Liu, Liangang Chen, Jian Hoffmann, Matthew Palmisano, Maria Zhou, Simon Celgene Corp Translat Dev & Clin Pharmacol 86 Morris Ave Summit NJ 07920 USA Celgene Corp Biostat & Stat Programming Summit NJ 07920 USA Celgene Corp Nonclin Dev Summit NJ 07920 USA
CC-122 (Avadomide) is a nonphthalimide analogue of thalidomide that has multiple pharmacological activities including immune modulation of several immune cell subsets, antigrowth activity, antiproliferative activity, ... 详细信息
来源: 评论
Sargramostim (rhu GM-CSF) Improves Survival of Non-Human Primates with Severe Bone Marrow Suppression after Acute, High-Dose, Whole-Body Irradiation
收藏 引用
RADIATION RESEARCH 2021年 第2期195卷 191-199页
作者: Clayton, Nicholas P. Khan-Malek, Richard C. Dangler, Charles A. Zhang, Donghui Ascah, Alexis Gains, Malcolm Gardner, Brent Mockbee, Colleen Keutzer, Joan M. McManus, John Authier, Simon Sanofi Genzyme Global Rare Dis Cambridge MA USA Sanofi Global Biostat & Programming Bridgewater NJ USA Sanofi Preclin Safety Framingham MA USA Liminal Biosci Laval PQ Canada Partner Therapeut Inc Lexington MA USA Charles River Labs 445 Boul Armand Frappier Laval PQ H7V 4B3 Canada
Exposure to acute, high-dose, whole-body ionizing radiation results in bone marrow failure (hematopoietic acute radiation syndrome with resultant infection, bleeding, anemia, and increased risk of death). Sargramostim...
来源: 评论
An innovative phase 2 proof-of-concept trial design to evaluate SAR445088, a monoclonal antibody targeting complement C1s in chronic inflammatory demyelinating polyneuropathy
收藏 引用
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 2023年 第2期28卷 276-285页
作者: Querol, Luis Lewis, Richard A. Hartung, Hans-Peter Van Doorn, Pieter A. Wallstroem, Erik Luo, Xiaodong Alonso-Alonso, Miguel Atassi, Nazem Hughes, Richard A. C. Hosp Santa Creu & Sant Pau Dept Neurol Neuromuscular Dis Unit Barcelona Spain Ctr Invest Biomed Red Enfermedades Raras CIBERER Madrid Spain Cedars Sinai Med Ctr Los Angeles CA USA Heinrich Heine Univ Fac Med Dept Neurol Dusseldorf Germany Univ Sydney Brain & Mind Ctr Sydney NSW Australia Med Univ Vienna Dept Neurol Vienna Austria Palacky Univ Olomouc Dept Neurol Olomouc Czech Republic Univ Med Ctr Erasmus MC Rotterdam Netherlands Sanofi R&D Neurol Dev Cambridge MA USA Sanofi R&D Biostat & Programming Bridgewater NJ USA UCL UCL Queen Sq Inst Neurol London England
Background and AimsChronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nerves, with significant unmet treatment needs. Clinical trials in CIDP are challenging;t... 详细信息
来源: 评论
SPA: Single patient acceleration in oncology dose-escalation trials
收藏 引用
CONTEMPORARY CLINICAL TRIALS 2021年 105卷 106378-106378页
作者: Mi, Gu Bian, Yuanyuan Wang, Xuejing Zhang, Wei Eli Lilly & Co Lilly Corp Ctr Stat Data & Analyt Indianapolis IN 46285 USA Sanofi Biostat & Programming 640 Mem Dr Cambridge MA 02139 USA
Efficient identification of the optimal dose and dosing scheme is one of the most critical and challenging tasks in early-phase oncology trials. The results are far-reaching because advancing a sub-optimal dose to lat... 详细信息
来源: 评论