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检索条件"机构=Biostat and Programming"
418 条 记 录,以下是81-90 订阅
排序:
Flexibility as a marker of early cognitive decline in humanized apolipoprotein ε 84 (ApoE4) mice
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NEUROBIOLOGY OF AGING 2021年 102卷 129-138页
作者: Schmitt, Julien Paradis, Anne-Lise Boucher, Mathieu Andrieu, Laurent Barneoud, Pascal Rondi-Reig, Laure Sorbonne Univ Inst Biol Paris Seine IBPS Cerebellum Nav & Memory Team CeZaMe INSERMNeurosci Paris Seine NPSCNRS Paris France Sanofi R&D Rare & Neurol Dis Res Neurodegenerat Cluster Chilly Mazarin France IT&M STATS Neuilly Sur Seine France Sanofi R&D Biostat & Programming Dept Nonclin Efficacy & Safety Team Paris France
To test the hypothesis that ApoE4 may be involved in cognitive deficits associated with aging, we investigated the impact of APOE4 status and aging on the flexibility and memory components of spatial learning in mice.... 详细信息
来源: 评论
Improved patient-reported outcomes with iGlarLixi versus premix BIAsp 30 in people with type 2 diabetes in the SoliMix trial
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DIABETES OBESITY & METABOLISM 2022年 第12期24卷 2364-2372页
作者: Polonsky, William H. Giorgino, Francesco Rosenstock, Julio Whitmire, Katherine Lew, Elisheva Coudert, Mathieu Alvarez, Agustina Nicholls, Charlie McCrimmon, Rory J. Behav Diabet Inst 5230 Carroll Canyon Rd San Diego CA 92121 USA Univ Bari Aldo Moro Dept Emergency & Organ Transplantat Sect Internal Med Endocrinol Androl & Metab Dis Bari Italy Dallas Diabet Res Ctr Med City Dallas TX USA Southwest Med Associates Las Vegas NV USA Sanofi Chilly Mazarin France Sanofi Biostat & Programming Dept Chilly Mazarin France Sanofi Buenos Aires DF Argentina Sanofi Reading Berks England Univ Dundee Sch Med Div Syst Med Dundee Scotland
Aim To assess patient-reported outcomes (PROs) in the SoliMix trial, which compared the efficacy and safety of iGlarLixi versus BIAsp 30 in people with type 2 diabetes (T2D). Materials and Methods SoliMix (EudraCT: 20... 详细信息
来源: 评论
Child Abuse Pediatricians Assess a Low Likelihood of Abuse in Half of 2890 Physical Abuse Consults
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CHILD MALTREATMENT 2022年 第2期27卷 202-208页
作者: Johnson, Katie L. Brown, Emily C. B. Feldman, Kenneth W. Qu, Pingping Lindberg, Daniel M. Seattle Childrens Hosp Dept Pediat Safe Child & Adolescent Network SCAN Seattle WA 98105 USA Univ Washington Sch Med Seattle WA USA Seattle Childrens Res Inst Biostat Epidemiol Econometr & Programming BEEP Co Seattle WA USA Univ Colorado Dept Emergency Med Anschutz Med Campus Aurora CO USA Univ Colorado Kempe Ctr Prevent & Treatment Child Abuse & Negle Anschutz Med Campus Aurora CO USA
The aim of this study was to examine the frequency with which child abuse pediatricians (CAPs) assess consultations as low versus high likelihood of abuse. In this retrospective secondary analysis of data from the Exa... 详细信息
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Participant Engagement and Symptom Improvement: Aripiprazole Tablets with Sensor for the Treatment of Schizophrenia
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PATIENT PREFERENCE AND ADHERENCE 2022年 16卷 1805-1817页
作者: Cochran, Jeffrey M. Fang, Hui Le Gallo, Christophe Peters-Strickland, Timothy Lindenmayer, Jean-Pierre Reuteman-Fowler, Corey Otsuka Pharmaceut Dev & Commercializat Inc Med & Real World Data Analyt Princeton NJ USA Otsuka Pharmaceut Dev & Commercializat Inc Biostat Princeton NJ USA Otsuka Pharmaceut Dev & Commercializat Inc Clin Programming Princeton NJ USA PPD Inc Wilmington NC USA New York Univ Grossman Sch Med Dept Psychiat New York NY USA Otsuka Pharmaceut Dev & Commercializat Inc Global Clin Dev Princeton NJ USA Otsuka Pharmaceut Dev & Commercializat Inc Med & Real World Data Analyt 508 Carnegie Ctr Princeton NJ 08540 USA
Purpose: A recent, phase 3b, mirror-image clinical trial of outpatients with schizophrenia found that use of aripiprazole tablets with sensor (AS;Abilify MyCite (R), comprising an ingestible event-marker sensor embedd... 详细信息
来源: 评论
Design and monitoring of survival trials based on restricted mean survival times
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CLINICAL TRIALS 2019年 第6期16卷 616-625页
作者: Luo, Xiaodong Huang, Bo Quan, Hui Sanofi US Dept Biostat & Programming Res & Dev Bridgewater NJ 08807 USA Pfizer Inc New London CT USA
Background/Aims: Restricted mean survival time has become a popular treatment effect measurement because of its nice interpretability. However, study design based on restricted mean survival times often requires exten... 详细信息
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Bias reduction using surrogate endpoints as auxiliary variables
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ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS 2019年 第4期71卷 837-852页
作者: Takagi, Yoshiharu Kano, Yutaka Sanofi KK Biostat & Programming Tokyo 1631488 Japan Osaka Univ Div Math Sci Grad Sch Engn Sci Toyonaka Osaka 5608531 Japan
Recently, it is becoming more active to apply appropriate statistical methods dealing with missing data in clinical trials. Under not missing at random missingness, MLE based on direct-likelihood, or observed likeliho... 详细信息
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Pharmacokinetics, Pharmacodynamics, Efficacy and Safety of a Romiplostim Biosimilar in Chronic Refractory Immune Thrombocytopenic Purpura (ITP) Patients
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INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION 2022年 第1期38卷 111-121页
作者: Singh, Inderjeet Swetha, R. K. Patel, Ronak Dahiya, Meghana Jose, Vinu Intas Pharmaceut Ltd Biopharma Clin Dev & Med Affairs Ahmadabad Gujarat India Lambda Therapeut Res Ltd Biostat & Programming Ahmadabad Gujarat India Unique Hosp Multispecial & Res Inst Surat Gujarat India Paras HMRI Hosp Patna Bihar India HCG Hosp Ahmadabad Gujarat India Artemis Hosp Gurgaon Haryana India St Johns Med Coll & Hosp Bangalore Karnataka India Sahyadri Hosp Ltd Pune Maharashtra India Inst Haematol & Transfus Med Kolkata W Bengal India Christian Med Coll & Hosp Vellore Tamil Nadu India Apollo Hosp Chennai Tamil Nadu India
Romiplostim (Nplate (R), Amgen Inc.) is an orphan drug approved for the treatment of chronic refractory immune thrombolytic purpura (ITP) in adult and pediatric patients. Limited availability of pharmacokinetic (PK) d... 详细信息
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Rejoinder to "on the alternative hypotheses for the win ratio"
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BIOMETRICS 2019年 第1期75卷 352-354页
作者: Luo, Xiaodong Tian, Hong Mohanty, Surya Tsai, Wei Yann Sanofi US Dept Biostat & Programming Res & Dev Bridgewater NJ 08807 USA Janssen Res & Dev Raritan NJ 08869 USA Columbia Univ Dept Biostat New York NY 10032 USA
The article discusses about the potential use of the win ratio, focusing on the null hypothesis, expanding of the corresponding alternative hypothesis and the testing of null hypothesis against alternative hypothesis....
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Design and monitoring of survival trials in complex scenarios
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STATISTICS IN MEDICINE 2019年 第2期38卷 192-209页
作者: Luo, Xiaodong Mao, Xuezhou Chen, Xun Qiu, Junshan Bai, Steven Quan, Hui Sanofi US Dept Biostat & Programming Res & Dev Bridgewater NJ 08807 USA FDA CDER Off Translat Sci Off BiostatDB1 Silver Spring MD USA
This paper proposes an approach to design and monitor survival trials accounting for complex scenarios such as delayed treatment effect, treatment dilution, and treatment crossover. These scenarios often lead to non-p... 详细信息
来源: 评论
Implementing community-based health program in conflict settings: documenting experiences from the Central African Republic and South Sudan
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BMC HEALTH SERVICES RESEARCH 2023年 第1期23卷 738-738页
作者: Rab, Faiza Razavi, Donya Kone, Mariam Sohani, Salim Assefa, Mekdes Tiwana, Muhammad Haaris Rossi, Rodolfo Univ Western Ontario Schulich Sch Med & Dent Dept Epidemiol & Biostat London ON Canada Canadian Red Cross Hlth Emergencies Ottawa ON Canada Canadian Red Cross Hlth Int Long Term Programming London ON Canada McMaster Univ Dept Hlth Aging & Soc Hamilton ON Canada Univ Western Ontario Masters Publ Hlth London ON Canada Int Comm Red Cross Hlth Unit Geneva Switzerland
BackgroundThe delivery of quality healthcare for women and children in conflict-affected settings remains a challenge that cannot be mitigated unless global health policymakers and implementers find an effective modal... 详细信息
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