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216P Long-term outcomes of a multicenter phase II trial evaluating the efficacy of preoperative lenvatinib therapy for patients with advanced hepatocellular carcinoma

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Annals of Oncology 2024年 35卷 S1487-S1487页

作者： A. Ichida J. Arita M. Tada E. Hatano S. Eguchi A. Saiura H. Nagano J. Shindoh M. Hashimoto N. Takemura K. Taura Y. Sakamoto Y. Takahashi Y. Seyama Y. Sasaki K. Uemura N. Kokudo K. Hasegawa Hepato-Biliary-Pancreatic Surgery Division Department of Surgery The University of Tokyo Graduate School of Medicine Bunkyo-ku Japan Department of Gastroenterological Surgery Akita University Graduate School of Medicine Akita Japan Department of Gastroenterological Surgery Hyogo Medical University Nishinomiya Japan Department of Surgery Kyoto University Graduate School of Medicine Kyoto Japan Department of Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan Department of Hepatobiliary-Pancreatic Surgery Juntendo University School of Medicine Bunkyo-ku Japan Department of Gastroenterological Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube Japan Hepatobiliary-Pancreatic Surgery Division Department of Gastroenterological Surgery Toranomon Hospital Minato-ku Japan Hepato-Biliary-Pancreatic Surgery Division Department of Surgery NCGM - National Center for Global Health and Medicine Shinjuku-ku Japan Department of Hepato-Biliary-Pancreatic Surgery Kyorin University Hospital Mitaka Japan Division of Hepatobiliary and Pancreatic Surgery The Cancer Institute Hospital of JFCR Koto-ku Japan Department of Hepato-Biliary-Pancreatic Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Bunkyo-ku Japan Center for Clinical Sciences Clinical Data Management Section NCGM - Center Hospital of the National Center for Global Health and Medicine Shinjuku-ku Japan Biostatistics and Bioinformatics Course The University of Tokyo Bunkyo-ku Japan

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Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

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Nature genetics 2023年第10期55卷 1778-1779页

作者： Nick Shrine Abril G Izquierdo Jing Chen Richard Packer Robert J Hall Anna L Guyatt Chiara Batini Rebecca J Thompson Chandan Pavuluri Vidhi Malik Brian D Hobbs Matthew Moll Wonji Kim Ruth Tal-Singer Per Bakke Katherine A Fawcett Catherine John Kayesha Coley Noemi Nicole Piga Alfred Pozarickij Kuang Lin Iona Y Millwood Zhengming Chen Liming Li Sara R A Wijnant Lies Lahousse Guy Brusselle Andre G Uitterlinden Ani Manichaikul Elizabeth C Oelsner Stephen S Rich R Graham Barr Shona M Kerr Veronique Vitart Michael R Brown Matthias Wielscher Medea Imboden Ayoung Jeong Traci M Bartz Sina A Gharib Claudia Flexeder Stefan Karrasch Christian Gieger Annette Peters Beate Stubbe Xiaowei Hu Victor E Ortega Deborah A Meyers Eugene R Bleecker Stacey B Gabriel Namrata Gupta Albert Vernon Smith Jian'an Luan Jing-Hua Zhao Ailin F Hansen Arnulf Langhammer Cristen Willer Laxmi Bhatta David Porteous Blair H Smith Archie Campbell Tamar Sofer Jiwon Lee Martha L Daviglus Bing Yu Elise Lim Hanfei Xu George T O'Connor Gaurav Thareja Omar M E Albagha Karsten Suhre Raquel Granell Tariq O Faquih Pieter S Hiemstra Annelies M Slats Benjamin H Mullin Jennie Hui Alan James John Beilby Karina Patasova Pirro Hysi Jukka T Koskela Annah B Wyss Jianping Jin Sinjini Sikdar Mikyeong Lee Sebastian May-Wilson Nicola Pirastu Katherine A Kentistou Peter K Joshi Paul R H J Timmers Alexander T Williams Robert C Free Xueyang Wang John L Morrison Frank D Gilliland Zhanghua Chen Carol A Wang Rachel E Foong Sarah E Harris Adele Taylor Paul Redmond James P Cook Anubha Mahajan Lars Lind Teemu Palviainen Terho Lehtimäki Olli T Raitakari Jaakko Kaprio Taina Rantanen Kirsi H Pietiläinen Simon R Cox Craig E Pennell Graham L Hall W James Gauderman Chris Brightling James F Wilson Tuula Vasankari Tarja Laitinen Veikko Salomaa Dennis O Mook-Kanamori Nicholas J Timpson Eleftheria Zeggini Josée Dupuis Caroline Hayward Ben Brumpton Claudia Langenberg Stefan Weiss Georg Homuth Carsten Oliver Schmidt Nicole Probst-Hensch Marjo-Riitta Jarvelin Alanna C Morrison Ozren Polasek Igor Department of Population Health Sciences University of Leicester Leicester UK. nick.shrine@leicester.ac.uk. Department of Population Health Sciences University of Leicester Leicester UK. Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre University of Nottingham Nottingham UK. Leicester National Institute for Health and Care Research Biomedical Research Centre Glenfield Hospital Leicester UK. Channing Division of Network Medicine Division of Pulmonary and Critical Care Medicine Department of Medicine Brigham and Women's Hospital Boston MA USA. Harvard Medical School Boston MA USA. COPD Foundation Washington DC USA. Department of Clinical Science Unversity of Bergen Bergen Norway. Nuffield Department of Population Health University of Oxford Oxford UK. MRC Population Health Research Unit University of Oxford Oxford UK. Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing China. Department of Respiratory Diseases Ghent Universital Hospital Ghent Belgium. Department of Bioanalysis Faculty of Pharmaceutical Sciences Ghent University Ghent Belgium. Department of Epidemiology Eramus Medical Center Rotterdam The Netherlands. Department of Internal Medicine Eramus Medical Center Rotterdam The Netherlands. Center for Public Health Genomics University of Virginia Charlottesville VA USA. Department of Medicine Columbia University Medical Center New York NY USA. Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK. Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health The University of Texas Health Science Center at Houston Houston TX USA. MRC Centre for Environment and Health Department of Epidemiology and Biostatistics School of Public Health Imperial College London London UK. Department of Epidemiology and Public Health Swiss Tropical

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Author Correction: Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

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Nature communications 2023年第1期14卷 1539页

作者： Harry A Thorpe Elise Tourrette Koji Yahara Filipa F Vale Siqi Liu Mónica Oleastro Teresa Alarcon Tsachi-Tsadok Perets Saeid Latifi-Navid Yoshio Yamaoka Beatriz Martinez-Gonzalez Ioannis Karayiannis Timokratis Karamitros Dionyssios N Sgouras Wael Elamin Ben Pascoe Samuel K Sheppard Jukka Ronkainen Pertti Aro Lars Engstrand Lars Agreus Sebastian Suerbaum Kaisa Thorell Daniel Falush Department of Biostatistics University of Oslo Oslo Norway. CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of Shanghai Chinese Academy of Sciences Shanghai China. Antimicrobial Resistance Research Center National Institute of Infectious Diseases Tokyo Japan. Pathogen Genome Bioinformatics and Computational Biology Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy Universidade de Lisboa Lisbon Portugal. University of Chinese Academy of Sciences Beijing China. National Reference Laboratory for Gastrointestinal Infections Department of Infectious Diseases National Institute of Health Dr Ricardo Jorge Lisbon Portugal. Department of Microbiology Hospital Universitario La Princesa Instituto de Investigación Sanitaria Princesa Madrid Spain. Gastroenterology Laboratory Rabin Medical Center Petah Tikva Israel. Department of Digital Medical Technologies Holon Institute of Technology Holon Israel. Department of Biology Faculty of Sciences University of Mohaghegh Ardabili Ardabil Iran. Department of Environmental and Preventive Medicine Oita University Faculty of Medicine Yufu Oita Japan. Department of Medicine-Gastroenterology Baylor College of Medicine Houston TX USA. Laboratory of Medical Microbiology Hellenic Pasteur Institute Athens Greece. G42 Healthcare Abu Dhabi UAE. Elrazi University Khartoum Sudan. Department of Biology University of Oxford Oxford UK. Ineos Oxford Institute Department of Biology University of Oxford Oxford UK. Center for Life Course Health Research University of Oulu Oulu Finland. Primary Health Care Center Tornio Finland. Arokero Oy Tornio Finland. Center for Translational Microbiome Research Department for Microbiology Tumor and Cell Biology Karolinska Institutet Stockholm Sweden. Division of Family Medicine Karolinska Institutet Stockholm Sweden. Department of Medical Microbiology and Hospital Epidemiology Max von Pettenkofer Institute Faculty of Medicine LMU Munich Munich Ge

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)

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NATURE GENETICS 2021年第5期53卷 762-762页

作者： Surendran, Praveen Feofanova, Elena V. Lahrouchi, Najim Ntalla, Ioanna Karthikeyan, Savita Cook, James Chen, Lingyan Mifsud, Borbala Yao, Chen Kraja, Aldi T. Cartwright, James H. Hellwege, Jacklyn N. Giri, Ayush Tragante, Vinicius Thorleifsson, Gudmar Liu, Dajiang J. Prins, Bram P. Stewart, Isobel D. Cabrera, Claudia P. Eales, James M. Akbarov, Artur Auer, Paul L. Bielak, Lawrence F. Bis, Joshua C. Braithwaite, Vickie S. Brody, Jennifer A. Daw, E. Warwick Warren, Helen R. Drenos, Fotios Nielsen, Sune Fallgaard Faul, Jessica D. Fauman, Eric B. Fava, Cristiano Ferreira, Teresa Foley, Christopher N. Franceschini, Nora Gao, He Giannakopoulou, Olga Giulianini, Franco Gudbjartsson, Daniel F. Guo, Xiuqing Harris, Sarah E. Havulinna, Aki S. Helgadottir, Anna Huffman, Jennifer E. Hwang, Shih-Jen Kanoni, Stavroula Kontto, Jukka Larson, Martin G. Li-Gao, Ruifang Lindstrom, Jaana Lotta, Luca A. Lu, Yingchang Luan, Jian'an Mahajan, Anubha Malerba, Giovanni Masca, Nicholas G. D. Mei, Hao Menni, Cristina Mook-Kanamori, Dennis O. Mosen-Ansorena, David Muller-Nurasyid, Martina Pare, Guillaume Paul, Dirk S. Perola, Markus Poveda, Alaitz Rauramaa, Rainer Richard, Melissa Richardson, Tom G. Sepulveda, Nuno Sim, Xueling Smith, Albert V. Smith, Jennifer A. Staley, James R. Stanakova, Alena Sulem, Patrick Theriault, Sebastien Thorsteinsdottir, Unnur Trompet, Stella Varga, Tibor V. Velez Edwards, Digna R. Veronesi, Giovanni Weiss, Stefan Willems, Sara M. Yao, Jie Young, Robin Yu, Bing Zhang, Weihua Zhao, Jing-Hua Zhao, Wei Zhao, Wei Evangelou, Evangelos Aeschbacher, Stefanie Asllanaj, Eralda Blankenberg, Stefan Bonnycastle, Lori L. Bork-Jensen, Jette Brandslund, Ivan Braund, Peter S. Burgess, Stephen Cho, Kelly Christensen, Cramer Connell, John de Mutsert, Renee Dominiczak, Anna F. Dorr, Marcus Eiriksdottir, Gudny Farmaki, Aliki-Eleni Gaziano, J. Michael Grarup, Niels Grove, Megan L. Hallmans, Goran Hansen, Torben Have, Christian T. Heiss, Gerardo Jorgensen, Marit E. Jousilahti, Pekka Kajantie, Eero Kamat, Mihir Karajamaki, AnneMari Kar British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK British Heart Foundation Centre of Research Excellence University of Cambridge Cambridge UK Health Data Research UK Cambridge Wellcome Genome Campus and University of Cambridge Cambridge UK Rutherford Fund Fellow Department of Public Health and Primary Care University of Cambridge Cambridge UK MRC Biostatistics Unit University of Cambridge Cambridge UK National Institute for Health Research Cambridge Biomedical Research Centre University of Cambridge and Cambridge University Hospitals Cambridge UK MRC Integrative Epidemiology Unit (IEU) Population Health Sciences Bristol Medical School University of Bristol Bristol UK Robertson Centre for Biostatistics University of Glasgow Glasgow UK MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge UK Department of Immunology and Inflammation Imperial College London London UK Centre for Non-communicable Disease Research (CNCR) Dhaka Bangladesh National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge Cambridge UK Department of Human Genetics Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge UK Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Non-Communicable Diseases Karachi Pakistan Department of Genetics Novo Nordisk Research Centre Oxford Oxford UK Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health University of Texas Health Science Center at Houston Houston TX USA Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Cardiovascular Research Center Center for Genomic Medicine

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Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight

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Nature genetics 2023年第7期55卷 1250页

作者： Pol Solé-Navais Christopher Flatley Valgerdur Steinthorsdottir Marc Vaudel Julius Juodakis Jing Chen Triin Laisk Abigail L LaBella David Westergaard Jonas Bacelis Ben Brumpton Line Skotte Maria C Borges Øyvind Helgeland Anubha Mahajan Matthias Wielscher Frederick Lin Catherine Briggs Carol A Wang Gunn-Helen Moen Robin N Beaumont Jonathan P Bradfield Abin Abraham Gudmar Thorleifsson Maiken E Gabrielsen Sisse R Ostrowski Dominika Modzelewska Ellen A Nohr Elina Hypponen Amit Srivastava Octavious Talbot Catherine Allard Scott M Williams Ramkumar Menon Beverley M Shields Gardar Sveinbjornsson Huan Xu Mads Melbye William Lowe Luigi Bouchard Emily Oken Ole B Pedersen Daniel F Gudbjartsson Christian Erikstrup Erik Sørensen Rolv T Lie Kari Teramo Mikko Hallman Thorhildur Juliusdottir Hakon Hakonarson Henrik Ullum Andrew T Hattersley Line Sletner Mario Merialdi Sheryl L Rifas-Shiman Thora Steingrimsdottir Denise Scholtens Christine Power Jane West Mette Nyegaard John A Capra Anne H Skogholt Per Magnus Ole A Andreassen Unnur Thorsteinsdottir Struan F A Grant Elisabeth Qvigstad Craig E Pennell Marie-France Hivert Geoffrey M Hayes Marjo-Riitta Jarvelin Mark I McCarthy Deborah A Lawlor Henriette S Nielsen Reedik Mägi Antonis Rokas Kristian Hveem Kari Stefansson Bjarke Feenstra Pål Njolstad Louis J Muglia Rachel M Freathy Stefan Johansson Ge Zhang Bo Jacobsson Department of Obstetrics and Gynaecology Sahlgrenska Academy Institute of Clinical Science University of Gothenburg Gothenburg Sweden. pol.sole.navais@gu.se. Department of Obstetrics and Gynaecology Sahlgrenska Academy Institute of Clinical Science University of Gothenburg Gothenburg Sweden. deCODE genetics/Amgen Reykjavik Iceland. Center for Diabetes Research Department of Clinical Science University of Bergen Bergen Norway. Division of Biomedical Informatics Cincinnati Children's Hospital Medical Center Cincinnati OH USA. Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA. Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia. Department of Biological Sciences Vanderbilt University Nashville TN USA. Novo Nordisk Foundation Center for Protein Research University of Copenhagen Copenhagen Denmark. Department of Obstetrics and Gynaecology Copenhagen University Hospital Hvidovre Hvidovre Denmark. Methods and Analysis Statistics Denmark Copenhagen Denmark. K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing Norwegian University of Science and Technology Trondheim Norway. Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark. MRC Integrative Epidemiology Unit University of Bristol Bristol UK. Population Health Sciences Bristol Medical School University of Bristol Bristol UK. Department of Genetics and Bioinformatics Health Data and Digitalization Norwegian Institute of Public Health Oslo Norway. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Genentech South San Francisco CA USA. Department of Epidemiology and Biostatistics MRC-PHE Centre for Environment and Health School of Public Health Imperial College London London UK. Department of Dermatology Medical University of Vienna Vienna Austria. Northwestern University Feinberg School of Medicine Chicago IL USA. Department of Population Medicine Harvard M

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Author Correction: Universal DNA methylation age across mammalian tissues

Nature aging

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Nature aging 2023年第11期3卷 1462页

作者： A T Lu Z Fei A Haghani T R Robeck J A Zoller C Z Li R Lowe Q Yan J Zhang H Vu J Ablaeva V A Acosta-Rodriguez D M Adams J Almunia A Aloysius R Ardehali A Arneson C S Baker G Banks K Belov N C Bennett P Black D T Blumstein E K Bors C E Breeze R T Brooke J L Brown G G Carter A Caulton J M Cavin L Chakrabarti I Chatzistamou H Chen K Cheng P Chiavellini O W Choi S M Clarke L N Cooper M L Cossette J Day J DeYoung S DiRocco C Dold E E Ehmke C K Emmons S Emmrich E Erbay C Erlacher-Reid C G Faulkes S H Ferguson C J Finno J E Flower J M Gaillard E Garde L Gerber V N Gladyshev V Gorbunova R G Goya M J Grant C B Green E N Hales M B Hanson D W Hart M Haulena K Herrick A N Hogan C J Hogg T A Hore T Huang J C Izpisua Belmonte A J Jasinska G Jones E Jourdain O Kashpur H Katcher E Katsumata V Kaza H Kiaris M S Kobor P Kordowitzki W R Koski M Krützen S B Kwon B Larison S G Lee M Lehmann J F Lemaitre A J Levine C Li X Li A R Lim D T S Lin D M Lindemann T J Little N Macoretta D Maddox C O Matkin J A Mattison M McClure J Mergl J J Meudt G A Montano K Mozhui J Munshi-South A Naderi M Nagy P Narayan P W Nathanielsz N B Nguyen C Niehrs J K O'Brien P O'Tierney Ginn D T Odom A G Ophir S Osborn E A Ostrander K M Parsons K C Paul M Pellegrini K J Peters A B Pedersen J L Petersen D W Pietersen G M Pinho J Plassais J R Poganik N A Prado P Reddy B Rey B R Ritz J Robbins M Rodriguez J Russell E Rydkina L L Sailer A B Salmon A Sanghavi K M Schachtschneider D Schmitt T Schmitt L Schomacher L B Schook K E Sears A W Seifert A Seluanov A B A Shafer D Shanmuganayagam A V Shindyapina M Simmons K Singh I Sinha J Slone R G Snell E Soltanmaohammadi M L Spangler M C Spriggs L Staggs N Stedman K J Steinman D T Stewart V J Sugrue B Szladovits J S Takahashi M Takasugi E C Teeling M J Thompson B Van Bonn S C Vernes D Villar H V Vinters M C Wallingford N Wang R K Wayne G S Wilkinson C K Williams R W Williams X W Yang M Yao B G Young B Zhang Z Zhang P Zhao Y Zhao W Zhou J Zimmermann J Ernst K Raj S Horvath Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Altos Labs San Diego Institute of Science San Diego CA USA. Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA USA. Department of Statistics University of California Riverside Riverside CA USA. Zoological SeaWorld Parks and Entertainment Orlando FL USA. Altos Labs Cambridge Institute of Science Cambridge UK. Bioinformatics Interdepartmental Program University of California Los Angeles CA USA. Department of Biological Chemistry University of California Los Angeles Los Angeles CA USA. Department of Biology University of Rochester Rochester NY USA. Department of Neuroscience Peter O'Donnell Jr. Brain Institute University of Texas Southwestern Medical Center Dallas TX USA. Department of Biology University of Maryland College Park MD USA. Loro Parque Fundacion Puerto de la Cruz Spain. Department of Biology University of Kentucky Lexington KY USA. Division of Cardiology Department of Internal Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA. Marine Mammal Institute Oregon State University Newport OR USA. School of Science and Technology Clifton Campus Nottingham Trent University Nottingham UK. School of Life and Environmental Sciences the University of Sydney Sydney New South Wales Australia. Department of Zoology and Entomology University of Pretoria Hatfield South Africa. Busch Gardens Tampa Tampa FL USA. Department of Ecology and Evolutionary Biology University of California Los Angeles Los Angeles CA USA. Rocky Mountain Biological Laboratory Crested Butte CO USA. Altius Institute for Biomedical Sciences Seattle WA USA. Epigenetic Clock Development Foundation Los Angeles CA USA. Center for Species Survival Smithsonian Conservation Biology Institute Front Royal VA USA. Department of Evolution Eco

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LBA21_PR Prospective pooled analysis of six phase III trials investigating duration of adjuvant (adjuv) oxaliplatin-based therapy (3 vs 6 months) for patients (pts) with stage III colon cancer (CC): Updated results of IDEA (International Duration Evaluation of Adjuvant chemotherapy)

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Annals of Oncology 2017年第SUPPL_5期28卷

作者： A. Grothey A. Sobrero J.A. Meyerhardt T. Yoshino J. Paul J. Taieb I. Souglakos R. Kerr R. Labianca A.F. Shields F. Bonnetain T. Yamanaka I. Boukovinas Q. Shi J.P. Meyers D. Niedzwiecki V. Torri D.J. Sargent T. André T. Iveson Division of Medical Oncology Mayo Clinic Rochester MN USA Medical Oncology Unit IRCCS San Martino Genoa Italy Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Gastroenterology and Gastrointestinal Oncology National Cancer Center Hospital East Kashiwa Japan Cancer Research UK Clinical Trials Unit Institute of Cancer Sciences University of Glasgow Glasgow UK Gastroenterology and Digestive Oncology Hôpital Européen Georges-Pompidou Sorbonne Paris Cité Université Paris Descartes Paris France Dept of Medical Oncology University Hospital of Heraklion (PAGNI) Heraklion Greece Dept of Oncology Churchill Hospital University of Oxford Oxford UK Dept of Oncology Ospedale Papa Giovanni XXIII Bergamo Italy Dept of Oncology Karmanos Cancer Institute Detroit MI USA Methodological and Quality of Life Unit in Oncology (INSERM UMR 1098) University Hospital Jean Minjoz Besançon France Medical Course Biostatistics Yokohama City University School of Medicine Yokohama Japan Medical Oncology Unit Bioclinic Thessaloniki Thessaloniki Greece Dept of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA Department of Biostatistics and Bioinformatics Duke University Durham NC USA Dept of Oncology IRRCS Mario Negri Institute for Pharmacological Research Milan Italy Medical Oncology Hopital Saint Antoine Paris France Dept of Medical Oncology University Hospital Southampton Southampton UK

LBA21_PR Prospective pooled analysis of six phase III trials investigating duration of adjuvant (adjuv) oxaliplatin-based therapy (3 vs 6 months) for patients (pts) with stage III colon cancer (CC): Updated results of IDEA (International Duration Evaluation of Adjuvant chemotherapy) A. Grothey Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Grothey A. Sobrero Medical Oncology Unit, IRCCS San Martino, Genoa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Sobrero J.A. Meyerhardt Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J.A. Meyerhardt T. Yoshino Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Yoshino J. Paul Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Paul J. Taieb Gastroenterology and Digestive Oncology, Hôpital Européen Georges-Pompidou, Sorbonne Paris Cité Université Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Taieb I. Souglakos Dept of Medical Oncology, University Hospital of Heraklion (PAGNI), Heraklion, Greece Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Souglakos R. Kerr Dept of Oncology, Churchill Hospital University of Oxford, Oxford, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Kerr R. Labianca Dept of Oncology, Ospedale Papa Giovanni XXIII, Bergamo, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Labianca A.F. Shields Dept of Oncology, Karmanos

关键词： adjuvant chemotherapy immunologic adjuvants brachial plexus neuritis individuals with disabilities education act chief complaint

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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