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International Conference on Information Technology Based Higher Education and Training, ITHET

作者： Ahmet Albayrak Muammer Albayrak Department of Computer Programming Karadeniz Technical University Trabzon Turkey Department of Biostatistics and Medical Informatics Karadeniz Technical University Trabzon Turkey

ISBN: (纸本)9781509007790

In this study, the effect of practical courses (especially robotics) on students' success is evaluated using fuzzy cognitive maps. This study particularly focuses on how practical courses increase the learning achievements in vocational schools. For this purpose, students and academicians were chosen as stakeholders for this study. Student were selected from departments of machine, electronic and computer. In total views of 30 students were taken and evaluated using fuzzy cognitive maps before the study. Students were studied on three projects within this study. These projects are autonomous cleaning robot, chameleon robot and sumo wrestler robot. Each robot was developed by a group consisting of ten students. Three main outputs determined to be gained by students in the robot development process as sensor calibration, improvement of mechanical systems and software optimization. These outputs are also among the output concepts of the fuzzy cognitive map. Sensor calibration, improvement of the mechanical systems and optimization of the software are the critical tasks respectively for the student groups of electronics, machine and computer. Each student group shared students of their departments homogeneously. Academicians were selected as one from each department. Fuzzy cognitive maps' survey applied to 15 academicians. After the design and development processes of robots, students and academicians views re-evaluated. It was observed clearly from the comparison of the results that, learning achievement, desire to learn, desire to interdisciplinary collaboration, self-confidence, interest in robotic technologies, satisfaction and desire to give priority to practical training in other subjects are increased by %45, %63, %42, %74, %85, %88 and %76 respectively.

关键词： Mathematical model Robot sensing systems Fuzzy cognitive maps Training Stakeholders

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214 Efficacy and safety of switching from adalimumab to sarilumab in an open-label extensionof a phase III monotherapy trial in patients with active rheumatoid arthritis

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Rheumatology 2018年第SUPPL_3期57卷

作者： Burmester, Gerd R Fiore, Stefano Hu, Chih-Chi Fay, Jon Lee, Eun Bong Genovese, Mark C Department of Rheumatology and Clinical Immunology Charité—University Medicine Berlin Berlin GERMANY US Global Medical Affairs Sanofi Genzyme Bridgewater NJ USA Biostatistics and Programming Sanofi Bridgewater NJ USA Medical Affairs Regeneron Pharmaceuticals Inc. Tarrytown NY USA Division of Rheumatology Department of Internal Medicine Seoul National University College of Medicine Seoul KOREA REPUBLIC OF Rheumatology Department Stanford University Medical Center Palo Alto CA USA

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215 Efficacy of sarilumab in combination with csDMARDs in patients with rheumatoid arthritisand inadequate response to TNF inhibitors by baseline levels of diseaseactivity

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Rheumatology 2018年第SUPPL_3期57卷

作者： Fleischmann, Roy van Hoogstraten, Hubert Jayawardena, Shyamalie Mangan, Erin K Ching, Daniel Burmester, Gerd R Metroplex Clinical Research Center University of Texas Southwestern Medical Center Dallas TX USA Global Medical Affairs Sanofi Genzyme Bridgewater NJ USA Biostatistics and Programming Sanofi Bridgewater NJ USA Medical Affairs Regeneron Pharmaceuticals Inc Tarrytown NY USA Timaru Medical Specialists Ltd Altoona Center for Clinical Research Timaru NEW ZEALAND Department of Rheumatology and Clinical Immunology Charité - University Medicine Berlin Berlin GERMANY

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187P Impact of KRAS mutational status and primary tumor location on the efficacy of aflibercept plus FOLFIRI in Japanese patients with metastatic colorectal cancer: An exploratory analysis in a phase II study

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Annals of Oncology 2017年第SUPPL_10期28卷

作者： K Yamazaki T Satoh Y Komatsu T Taguchi Y Sunaga T Yoshino Gastroenterology Surgery Oncology Shizuoka Cancer Center Sunto Gun Japan Graduate School of Medicine Osaka University Suita Japan Cancer Center Hokkaido University Hospital Sapporo Japan Medical Sanofi Japan Tokyo Japan Biostatistics & Programming Sanofi Japan Tokyo Japan Department of Gastroenterology and Gastrointestinal Oncology National Cancer Center Hospital East Kashiwa Japan

187P Impact of KRAS mutational status and primary tumor location on the efficacy of aflibercept plus FOLFIRI in Japanese patients with metastatic colorectal cancer: An exploratory analysis in a phase II study K Yamazaki Gastroenterology, Surgery, Oncology, Shizuoka Cancer Center, Sunto Gun, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar K Yamazaki T Satoh Graduate School of Medicine, Osaka University, Suita, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T Satoh Y Komatsu Cancer Center, Hokkaido University Hospital, Sapporo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y Komatsu T Taguchi Medical, Sanofi Japan, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T Taguchi Y Sunaga biostatistics & programming, Sanofi Japan, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y Sunaga T Yoshino department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T Yoshino Annals of Oncology, Volume 28, Issue suppl_10, 1 November 2017, mdx659.044, https://***/10.1093/annonc/mdx659.044 Published: 22 November 2017

关键词： k-ras oncogene kras2 gene

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519P Cabazitaxel plus prednisolone with primary prophylaxis with pegfilgrastim (PEG) in Japanese patients with metastatic castration-resistant prostate cancer: An open label prospective phase 2 study

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Annals of Oncology 2017年第SUPPL_10期28卷

作者： H Uemura T Kosaka M Sumitomo K Harada M Sugimoto N Hayashi K Yoshimura S Fukasawa E B Ecstein-Fraisse Y Sunaga M Oya Department of Urology/Renal Transplantation Yokohama City University Medical Center Yokohama Japan Department of Urology Keio University Hospital Tokyo Japan Department of Urology Aichi Medical University Hospital Aichi Japan Department of Urology Kobe University Hospital Kobe Japan Department of Urology Kagawa University Hospital Kagawa Japan Department of Urology Yokohama City University Hospital Yokohama Japan Department of Urology Kindai University Hospital Osaka Japan Department of Urology/Prostate Cancer Chiba Cancer Center Chiba Japan Medical Sanofi France Paris France Biostatistics & Programming Sanofi Japan Tokyo Japan

519P Cabazitaxel plus prednisolone with primary prophylaxis with pegfilgrastim (PEG) in Japanese patients with metastatic castration-resistant prostate cancer: An open label prospective phase 2 study H Uemura department of Urology/Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar H Uemura T Kosaka department of Urology, Keio University Hospital, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T Kosaka M Sumitomo department of Urology, Aichi Medical University Hospital, Aichi, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M Sumitomo K Harada department of Urology, Kobe University Hospital, Kobe, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar K Harada M Sugimoto department of Urology, Kagawa University Hospital, Kagawa, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M Sugimoto N Hayashi department of Urology, Yokohama City University Hospital, Yokohama, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar N Hayashi K Yoshimura department of Urology, Kindai University Hospital, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar K Yoshimura S Fukasawa department of Urology/Prostate Cancer, Chiba Cancer Center, Chiba, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar S Fukasawa E B Ecstein-Fraisse Medical, Sanofi France, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar E B Ecstein-Fraisse Y Sunaga biostatistics & programming, Sanofi Japan, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y Sunaga ... Show more M Oya department of Urology, Keio University Hospital, Tokyo, Japan Search for other works by this

关键词： prostate cancer, androgen-independent prevention japanese

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Durability of alirocumab effect: Data from an open-label extension to the ODYSSEY program for patients with heterozygous familial hypercholesterolemia

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Annales d'Endocrinologie 2017年第4期78卷 301-301页

作者： M. Farnier G.K. Hovingh G. Langset R. Dufour M. Baccara-Dinet C. Din-Bell G. Manvelian J.R. Guyton Lipid clinic – Point Médical Dijon France Department of Vascular Medicine Academic Medical Center Amsterdam The Netherlands Lipid Clinic Oslo University Hospital Oslo Norway Institut de recherches cliniques de Montréal Université de Montréal Montréal QC Canada Clinical Development R&D Sanofi Montpellier France Biostatistics and Programming Sanofi Chilly-Mazarin France Regeneron Pharmaceuticals Tarrytown NY USA Duke University Medical Center Durham NC USA

Purpose To evaluate the overall durability of the effect of alirocumab in patients with heterozygous familial hypercholesterolemia (HeFH) using data from the ODYSSEY open-label extension (OLE) of four phase 3 trials (FHI, FHII, LONG-TERM, HIGH-FH) assessing long-term efficacy and safety for up to 40 months. Methods Patients received alirocumab 75 mg (FHI, FHII, LONG-TERM) or 150 mg (HIGH-FH) once every 2 weeks. From Week 12, dose adjustment of alirocumab was allowed as per investigator's clinical judgement. Results A total of 985 patients (mean age 54.4 years, 55.8% male) were included in OLE safety population. At OLE enrollment, 978 patients were receiving statins with 627 other lipid-lowering therapy. At the time of analysis, 938 patients had completed ≥ 1 year of treatment; 5.7% had discontinued treatment (2.2% due to adverse events). Of those who started OLE on 75 mg dose, 537/909 (59.1%) were maintained on that dose throughout. At Week 48 of OLE, the mean LDL-C was 79.7 mg/dL, a mean reduction of 46.9% compared with baseline levels of the parent studies. Other lipid changes included reductions at Week 48 in non-high density lipoprotein cholesterol (40.3%), total cholesterol (29.7%), lipoprotein(a) (25.6%), and apolipoprotein B (37.5%). Overall, 762/985 (77.4%) patients reported treatment-emergent adverse events during OLE (up to 73 weeks). Injection site reactions reported by 49 patients (5.0%) were mild and self-limited. Conclusion In this OLE study of patients with HeFH, alirocumab demonstrated a durable and robust treatment effect, yielding a 47% reduction in LDL-C at Week 48 compared with baseline levels.

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Change-Point Analysis of Survival Data with Application in Clinical Trials

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Open Journal of Statistics 2014年第9期4卷 663-677页

作者： Xuan Chen Michael Baron Department of Biostatistics and Programming Sanofi Beijing China Department of Mathematics and Statistics American University Washington DC USA Department of Mathematical Sciences University of Texas at Dallas Richardson USA

Effects of many medical procedures appear after a time lag, when a significant change occurs in subjects’ failure rate. This paper focuses on the detection and estimation of such changes which is important for the evaluation and comparison of treatments and prediction of their effects. Unlike the classical change-point model, measurements may still be identically distributed, and the change point is a parameter of their common survival function. Some of the classical change-point detection techniques can still be used but the results are different. Contrary to the classical model, the maximum likelihood estimator of a change point appears consistent, even in presence of nuisance parameters. However, a more efficient procedure can be derived from Kaplan-Meier estimation of the survival function followed by the least-squares estimation of the change point. Strong consistency of these estimation schemes is proved. The finite-sample properties are examined by a Monte Carlo study. Proposed methods are applied to a recent clinical trial of the treatment program for strong drug dependence.

关键词： Change-Point Problem Failure Rate Kaplan-Meier Estimation Least Squares Estimation Maximum Likelihood Estimation Strong Consistency Survival Function

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OnabotulinumtoxinA improves spasticity related pain in post-stroke patients: Findings from a randomized controlled trial

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Annals of Physical and Rehabilitation Medicine 2014年 57卷 e44-e44页

作者： Wissel, J. Ganapathy, V. Ma, Y. Ward, A. Borg, J. Ertzgaard, P. Fulford-Smith, A. Gillard, P. Neurological Rehabilitation Department of Neurology Vivantes Klinkum Spandau Berlin Germany Global Health Outcomes Strategy and Research Allergan Inc Irvine CA USA Biostatistics & Programming Allergan Inc Bridgewater NJ USA North Staffordshire Rehabilitation Centre Haywood Hospital Stoke on Trent UK Department of Clinical Sciences Karolinska Institutet Rehabilitation Medicine Danderyd Hospital Stockholm Sweden Department of Rehabilitation Medicine Linköping University Linköping Sweden Allergan Ltd Marlow International The Parkway Marlow Buckinghamshire UK

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Vitamin D intake and cardiovascular mortality in the NHANES i epidemiological follow-up study cohort

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Journal of Dietary Supplements 2012年第2期9卷 79-89页

作者： Fan, Chunpeng Nieto, F. Javier Bautista, Leonelo E. Fine, Jason P. Department of Biostatistics and Programming Sanofi U.S. Inc. Bridgewater NJ 08807 55 Corporate Drive United States Department of Population Health Sciences University of Wisconsin Madison WI United States Department of Biostatistics University of North Carolina Chapel Hill NC United States

The objective of the present study was to determine whether vitamin D intake is associated with CVD mortality in a general population sample. The association between vitamin D intake and CVD mortality (ICD-9 code 410414) rates was investigated using data from the the First National Health and Nutrition Examination Survey (NHANES I) Epidemiological Follow-up Study (NHEFS) 19711992. Overall, higher vitamin D intake was associated with lower CVD mortality. After adjustment for traditional risk factors for CVD, vitamin D intake showed mild but nonstatistically significant protective effects against CVD mortality with a hazard ratio for adequate as compared to low intake (with 95 confidence intervals) of 0.90 (0.74, 1.08). Hazard ratios were 0.95, 0.83, 0.88, and 1.02, in males, females, Whites, and Blacks, respectively (with 95 confidence intervals overlapping 1.0 in all cases). Thus, we did not find a statistically significant association between vitamin D intake and CVD mortality, although our findings are compatible with a mild protective effect, especially among females and Whites. © 2012 Informa Healthcare USA, Inc.

关键词： Dietary supplements ICD-9 Ischemic heart disease NHEFS

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Evaluation of Nutrition Surveys in Flood-affected Areas of Pakistan: Seeing the Unseen!

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IDS BULLETIN-INSTITUTE OF DEVELOPMENT STUDIES 2013年第3期44卷 10-20页

作者： Hossain, S. M. Moazzem Talat, Mah Boyd, Erin Chowdhury, Shamim Rafique Soofi, Sajid Bashir Hussain, Imtiaz Ahmed, Imran Salam, Rehana Abdus Bhutta, Zulfiqar A. Chief of Health and Nutrition in UNICEF Afghanistan having previously worked in UNICEF Pakistan Sri Lanka and the New York Headquarters. Certified Master Trainer with expertise in facilitation skills monitoring and programme management. Emergency Nutrition Specialist at the United Nations Children''s Fund (UNICEF) Headquarters with over ten years of experience in humanitarian response and policy related to emergency nutrition programming and data analysis. Has Been the Director General of the Bureau of Statistics (BOS) Planning and Development Department Government of Punjab Pakistan since 2007. Pediatrician and researcher. He is a Fellow of Pediatrics and has a long affiliation with the Department of Pediatrics and Child Health at the Aga Khan University Karachi where he is currently working as an Assistant Professor and Coordinator. Presently holds the position of Senior Social Scientist at the Aga Khan University Karachi. Working as Data Manager at the Department of Paediatrics Aga Khan University Karachi. Has been a Senior Instructor (Research) at the Aga Khan University Karachi since November 2012 and holds a master''s degree in Epidemiology and Biostatistics from the university. Professor and founding chair of the Division of Maternal and Child Health Aga Khan University Karachi

In 2010 Pakistan experienced the worst floods recorded in its history;millions of people were affected and thousands lost their lives. Nutrition assessment surveys led by UNICEF were conducted in flood-affected areas of Punjab and Sindh provinces to assess the nutrition status of children between 659 months while Aga Khan University (AKU) undertook a parallel assessment including micronutrient status in their project areas within Balochistan, Sindh and Punjab. Standardised Monitoring and Assessment of Relief and Transition (SMART) methodology was used. 881 children from Sindh, 1,143 from Punjab and 817 from AKU project areas were measured for anthropometry and their households were interviewed. The findings indicated that while immediate life-saving interventions were essential, there was also an urgent need to address chronic malnutrition. Through high-level dissemination of the survey results, treatment and prevention of malnutrition has become a priority for the provincial and federal government in Pakistan and for donors.

关键词： FLOODS NUTRITION surveys MALNUTRITION -- Treatment ANTHROPOMETRY PUNJAB (Pakistan) -- Environmental conditions

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