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检索条件"机构=Biostatistics and Statistical Programming"
11 条 记 录,以下是1-10 订阅
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POD-BIN: A PROBABILITY OF DECISION BAYESIAN INTERVAL DESIGN FOR TIME-TO-EVENT DOSE-FINDING TRIALS WITH MULTIPLE TOXICITY GRADES
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Annals of Applied Statistics 2025年 第1期19卷 147-168页
作者: Liu, Meizi Lin, Ji Mi, Gu Lorenzato, Christelle Chen, Xun Ji, Yuan Statistical and Quantitative Sciences Takeda Japan Department of Biostatistics and Programming Sanofi France Department of Public Health Sciences University of Chicago United States
We introduce a Bayesian framework centered on the “probability of decision” for designing dose-finding trials. The proposed PoD-BIN design evaluates the posterior predictive probabilities of up-and-down decisions. I... 详细信息
来源: 评论
Dimension reduction with expectation of conditional difference
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statistical Theory and Related Fields 2023年 第3期7卷 188-201页
作者: Wenhui Sheng Qingcong Yuan Department of Mathematical and Statistical Sciences Marquette UniversityMilwaukeeWIUSA Biostatistics and Programming SanofiUSBridgewaterNJUSA
In this article,we introduce a flexible model-free approach to sufficient dimension reduction analysis using the expectation of conditional difference *** any strict conditions,such as linearity condition or constant ... 详细信息
来源: 评论
On some "disadvantages" of the population approach
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AAPS Journal 2005年 第2期7卷 E374-E382页
作者: Nedelman, Jerry R. Biostatistics and Statistical Programming Novartis Pharmaceuticals East Hanover NJ 07936 One Health Plaza United States
In a seminal article on population pharmacokinetic modeling, researchers demonstrated how means and variances of pharmacokinetic parameters for a patient population could be inferred from sparse data collected under c... 详细信息
来源: 评论
On multi-armed bandit designs for dose-finding clinical trials
The Journal of Machine Learning Research
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The Journal of Machine Learning Research 2021年 第1期22卷 686-723页
作者: Maryam Aziz Emilie Kaufmann Marie-Karelle Riviere Spotify NYC Univ. Lille CNRS Inria Centrale Lille UMR 9189 CRIStAL Lille France Statistical Methodology Group Biostatistics and Programming department Sanofi R&D Chilly-Mazarin France
We study the problem of finding the optimal dosage in early stage clinical trials through the multiarmed bandit lens. We advocate the use of the Thompson Sampling principle, a flexible algorithm that can accommodate d... 详细信息
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Bayesian dose-regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics
arXiv
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arXiv 2020年
作者: Gerard, Emma Zohar, Sarah Thai, Hoai-Thu Lorenzato, Christelle Riviere, Marie-Karelle Ursino, Moreno Centre de Recherche des Cordeliers Sorbonne Université Inserm Université de Paris ParisF-75006 France Oncology biostatistics Biostatistics and Programming department Sanofi R&D Vitry-sur-Seine France Statistical Methodology Group Biostatistics and Programming department Sanofi R&D Chilly-Mazarin France Translation Disease Modeling Digital and Data Science Sanofi R&D Chilly-Mazarin France F-CRIN PARTNERS platform AP-HP Université de Paris Paris France
Phase I dose-finding trials in oncology seek to find the maximum tolerated dose (MTD) of a drug under a specific schedule. Evaluating drug-schedules aims at improving treatment safety while maintaining efficacy. Howev... 详细信息
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Ex utero intrapartum therapy in infants with congenital diaphragmatic hernia:a propensity score matching analysis
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World Journal of Pediatric Surgery 2022年 第4期5卷 267-274页
作者: Yunlong Zhao Ying Wang Chao Liu Yulin Jiang Yandong Wei Hua Meng Shan Jian Xiting Zhu Lijian Pei Xiaochen Bai Feng Feng Yan Lv Xiya Zhou Qingwei Qi Jingna Li Lishuang Ma Peking Union Medical College Graduate School BeijingChina Department of Neonatal Surgery Children’s Hospital of Capital Institute of PediatricsCapital Institute of PediatricsBeijingChina Department of Obstetrics Peking Union Medical College HospitalBeijingChina Department of Ultrasound Peking Union Medical College HospitalBeijingChina Department of Pediatrics Peking Union Medical College HospitalBeijingChina Department of Biostatistics and Statistical Programming Everest Clinical Research CorporationBeijingChina Department of Anesthesiology Peking Union Medical College HospitalBeijingChina Department of Pediatrics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina Department of Radiology Peking Union Medical College HospitalBeijingChina
Objective Previous studies have shown that ex utero intrapartum therapy(EXIT)is safe and feasible for newborns with congenital diaphragmatic hernia(CDH).This study reports our experience with EXIT in fetuses with CDH ... 详细信息
来源: 评论
2376. Incidence ofClostridioides difficileInfection Among United States Medicare Advantage Enrollees
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Open Forum Infectious Diseases 2019年 第SUPPLEMENT_2期6卷 S819–S820页
作者: Heinrich, Kirstin Emir, Birol Ivanova, Jasmina Zhou, Jingying Yu, Holly Health Economics and Outcomes Research Pfizer Inc. Collegeville Pennsylvania Biostatistics Pfizer Inc. New York New York Real-World Data and Analytics Pfizer Inc. New York New York Statistical Programming Pfizer Inc. New York New York Outcome Research Heath Economics Pfizer Inc. Collegeville Pennsylvania
BackgroundClostridioides difficileinfection (CDI) may be life-threatening, and individuals aged ≥ 65 years are at increased risk. CDI burden among Medicare fee-for-service enrollees and nursing home residents in the ...
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Effects of a specialized oral nutritional supplement with dietary counseling on nutritional outcomes in community-dwelling older adults at risk of malnutrition: A randomized controlled trial
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Clinical Nutrition ESPEN 2024年 63卷 1318-1318页
作者: Muangpaisan, W. Wichansawakun, S. Huynh, D.T.T. Intalapaporn, S. Chalermsri, C. Thititagul, O. Chupisanyarote, K. Chuansangeam, M. Laiteerapong, A. Yalawar, M. Huang, C. Tey, S.L. Liu, Z. Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Faculty of Medicine Thammasat University Pathum Thani Thailand Abbott Nutrition Research and Development Asia-Pacific Center Singapore Singapore Thammasat University Hospital Pathum Thani Abbott Nutrition Research and Development Bangkok Thailand Biostatistics and Statistical Programming Cognizant Technologies Solution Pvt. Ltd Bangalore India Abbott Nutrition Research and Development Shanghai China
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7 Phase 3 Trial of an Oral CXCR4 Antagonist, Mavorixafor, for Treatment of Patients With WHIM Syndrome: Preliminary Results From Ongoing Open-Label Extension Period of Continuous Mavorixafor Treatment
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Clinical Immunology 2024年 262卷 109949-109949页
作者: Tarrant, Teresa Badolato, Raffaele Donadieu, Jean Dubuc, Susan Hu, Yanping Jiang, Honghua Li, Sunny Steiner, Deborah Yan, Tina Arbet-Engels, Christophe Associate Professor of Medicine Rheumatology and Immunology/Division of Rheumatology and Immunology Department of Medicine Duke University Durham NC USA Full Professor of Pediatrics Chair of Pediatrics ASST Spedali Civili Brescia/Department of Clinical and Experimental Sciences University of Brescia & ASST Spedali Civili Brescia Italy Pediatric Physician/CHU Paris Est - Hôpital d’Enfants Armand-Trousseau Paris France Senior Director Pharmacovigilance & Risk Management/X4 Pharmaceuticals Boston MA USA Director Clinical Research/X4 Pharmaceuticals Boston MA USA Senior Director Biostatistics/X4 Pharmaceuticals Boston MA USA Senior Director Statistical Programming/X4 Pharmaceuticals Boston MA USA Vice President Clinical Development/X4 Pharmaceuticals Boston MA USA Director Statistical Programming/X4 Pharmaceuticals Boston MA USA Chief Medical Officer/X4 Pharmaceuticals Boston MA USA
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POS1050 INCIDENCE RATES OF INTERSTITIAL LUNG DISEASE AMONG PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH ABATACEPT: A POST HOC POOLED ANALYSIS FROM A COMPENDIUM OF CLINICAL TRIALS
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Annals of the Rheumatic Diseases 2023年 82卷 843-843页
作者: P. Dieudé J. Sparks A. Fischer L. Chen K. Lozenski S. Dahan M. Chaballa W. Little Paris Cité University Bichat Hospital APHP Department of Rheumatology Paris France Brigham and Women's Hospital Harvard Medical School Division of Rheumatology Inflammation and Immunity Boston United States of America Bristol Myers Squibb Lung Fibrosis Lawrenceville United States of America Syneos Health Biostatistics and Statistical Programming Richmond Canada Bristol Myers Squibb Rheumatology Pipeline and Early Assets Lawrenceville United States of America Bristol Myers Squibb Worldwide Medical Lawrenceville United States of America Bristol Myers Squibb US Medical Immunology and Fibrosis Lawrenceville United States of America Bristol Myers Squibb Worldwide Rheumatology Lawrenceville United States of America
Background Interstitial lung disease (ILD) is a recognized complication of RA. Prior studies have suggested stabilization or improvement of ILD in patients with RA (RA-ILD) treated with abatacept. [1,2] Few studies ha...
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