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检索条件"机构=Biostatistics and programming"
76 条 记 录,以下是1-10 订阅
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Considerations on trial design and data analysis for multi-regional clinical trials
Considerations on trial design and data analysis for multi-r...
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2017第七届临床评价方法与应用国际研讨会暨生物统计国际研讨会
作者: Hui Quan Biostatistics and Programming Department of Sanofi
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Sample Size Calculation for Thorough QT/QTc Study Considering Various Factors Related to Multiple Time Points
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Journal of Biopharmaceutical Statistics 2010年 第3期20卷 563-577页
作者: Zhaoling Meng zhaoling.meng@*** Kringle, Robert Xun Chen Peng-Liang Zhao Biostatistics and Programming Sanofi-Aventis Bridgewater New Jersey USA
The sample size requirement in a thorough QT/QTc study is discussed under a balanced parallel or crossover study design. First, we explore the impacts of various factors on the study power, including the mean effect p... 详细信息
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Phase specific analysis of herpes zoster associated pain data: a new statistical approach
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STATISTICS IN MEDICINE 2006年 第2期25卷 359-360页
作者: Kay, R PAREXEL WW Head Biostatistics & Programming
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Book Review: Methodology in Robust and Nonparametric Statistics , Seventh Edition, by Jana Jureckova, Pranab Kumar Sen, and Jan Picek
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Journal of Biopharmaceutical Statistics 2014年 第4期24卷 963-964页
作者: Zhang, Donghui Fan, Chunpeng Global Biostatistics and Programming Clinical Science and Operation Sanofi Bridgewater New Jersey
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Bayesian methods for the analysis of early-phase oncology basket trials with information borrowing across cancer types
arXiv
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arXiv 2020年
作者: Jin, Jin Riviere, Marie-Karelle Luo, Xiaodong Dong, Yingwen Department of Biostatistics Johns Hopkins Bloomberg School of Public Health BaltimoreMD United States Department of Biostatistics and Programming Research and Development Sanofi Chilly-Mazarin France Department of Biostatistics and Programming Sanofi BridgewaterNJ United States Department of Biostatistics and Programming Oncology Sanofi CambridgeMA United States
Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, whic... 详细信息
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Vitamin D intake and cardiovascular mortality in the NHANES i epidemiological follow-up study cohort
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Journal of Dietary Supplements 2012年 第2期9卷 79-89页
作者: Fan, Chunpeng Nieto, F. Javier Bautista, Leonelo E. Fine, Jason P. Department of Biostatistics and Programming Sanofi U.S. Inc. Bridgewater NJ 08807 55 Corporate Drive United States Department of Population Health Sciences University of Wisconsin Madison WI United States Department of Biostatistics University of North Carolina Chapel Hill NC United States
The objective of the present study was to determine whether vitamin D intake is associated with CVD mortality in a general population sample. The association between vitamin D intake and CVD mortality (ICD-9 code 4104... 详细信息
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Integration of Efficacy Biomarkers Together with Toxicity Endpoints in Immune-Oncology Dose Finding Studies
arXiv
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arXiv 2023年
作者: Zhang, Yiding Xu, Zhixing Quan, Hui Lin, Ji Biostatistics and Programming Sanofi 450 Water Street CambridgeMA02141 United States Biostatistics and Programming Sanofi 55 Corporate Drive BridgewaterNJ08807 United States
The primary objective of phase I oncology studies is to establish the safety profile of a new treatment and determine the maximum tolerated dose (MTD). This is motivated by the development of cytotoxic agents based on... 详细信息
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Adaptive design and timeline prediction for cardiovascular event trials for a non-inferiority/superiority claim
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Communications in Statistics Case Studies Data Analysis and Applications 2015年 第2期1卷 71-84页
作者: Quan, Hui Mao, Xuezhou Wu, Yujun Cho, Meehyung Zhao, Peng-Liang Zhang, Ji Bauer, Deborah Biostatistics and Programming Sanofi Bridgewater NJ United States
Cardiovascular event trials can be designed to allow adaptation based on interim results. In this article, we first discuss a strategy either to accept noninferiority at an interim analysis or to continue the study to... 详细信息
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Dimension reduction with expectation of conditional difference
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Statistical Theory and Related Fields 2023年 第3期7卷 188-201页
作者: Wenhui Sheng Qingcong Yuan Department of Mathematical and Statistical Sciences Marquette UniversityMilwaukeeWIUSA Biostatistics and Programming SanofiUSBridgewaterNJUSA
In this article,we introduce a flexible model-free approach to sufficient dimension reduction analysis using the expectation of conditional difference *** any strict conditions,such as linearity condition or constant ... 详细信息
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Sequential Monitoring of Conditional Randomization Tests: Generalized Biased Coin Designs
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Sequential Analysis 2008年 第3期27卷 234-253页
作者: Yanqiong Zhang Yanqiong.Zhang@*** Rosenberger, William F. Department of Biostatistics and Programming Sanofi-Aventis Malvern Pennsylvania USA Department of Statistics George Mason University Fairfax Virginia USA
For the generalized biased coin class of randomization procedures, Smythe (1988) proved asymptotic normality of the conditional linear rank test. Clinical trialists often undertake interim analysis to determine whethe... 详细信息
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