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Molecular detection and characterization of a divergent isolate of Plantago asiatica mosaic virus in Plantago asiatica

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VirusDisease 2016年第3期27卷 307-310页

作者： Lim, Seungmo Igori, Davaajargal Zhao, Fumei Do, Yun Su Cho, In-Sook Choi, Gug-Seoun Moon, Jae Sun Molecular Biofarming Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 South Korea Biosystems and Bioengineering Program University of Science and Technology Daejeon 34113 South Korea Apple Research Institute National Institute of Horticultural and Herbal Science Gunwi 39000 South Korea Horticultural and Herbal Crop Environment Division National Institute of Horticultural and Herbal Science RDA Wanju 55365 South Korea

Four samples of Plantago asiatica showing mottle or mottled yellowing symptoms were collected and three of them were confirmed to be infected with Plantago asiatica mosaic virus (PlAMV) by Illumina HiSeq 2500 paired-end RNA sequencing. Consequently, the complete genomic sequence of a Korean isolate of PlAMV (PlAMV isolate Gunwi) from P. asiatica was determined. The nucleotide sequence of PlAMV-Gunwi was most closely related to a Russian isolate of PlAMV (PlAMV-Ru) collected from P. asiatica but highly dissimilar (~23 %) to other isolates of PlAMV from other plant species. Pairwise comparisons revealed that the complete replicase protein and coat protein of PlAMV-Gunwi share 85.15–91.20 and 84.54–90.82 % amino acid sequence identities, respectively, to the corresponding proteins of other PlAMV isolates. To our knowledge, this is the first report of the natural infection of P. asiatica by PlAMV in Korea, and the divergent PlAMV isolate Gunwi expands our understanding of the epidemiology of PlAMV. © 2016, Indian Virological Society.

关键词： Divergent isolate Next-generation sequencing PlAMV Plantago asiatica

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Book reviews

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Annals of Biomedical Engineering 1989年第2期17卷 195-202页

作者： William A. Hyman Richard D. Spence J. G. Llaurado Bioengineering Program Texas A&M University College Station Biosystems Research Group Department of Industrial Engineering Texas A&M University College Station Nuclear Medicine Service Veterans' Hospital and Loma Linda University School of Medicine Loma Linda

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First report of cherry virus A infecting Prunus mume in South Korea

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VirusDisease 2017年第2期28卷 220-221页

作者： Lim, Seungmo Igori, Davaajargal Baek, Dasom Cho, In-Sook Choi, Gug-Seoun Moon, Jae Sun Plant Systems Engineering Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 South Korea Biosystems and Bioengineering Program University of Science and Technology Daejeon 34113 South Korea Horticultural and Herbal Crop Environment Division National Institute of Horticultural and Herbal Science Rural Development Administration Wanju 55365 South Korea Crop Production Technology Research Division National Institute of Crop Science Rural Development Administration Miryang 50424 South Korea

We report the detection of cherry virus A (CVA) in a Prunus mume sample using Illumina HiSeq 2500 paired-end RNA sequencing. CVA isolate OC shared highest sequence identity with CVA isolate J, which was recently identified in P. armeniaca in Japan. To the best of our knowledge, this is the first report of CVA infecting P. mume in Korea and the first complete genome sequence of CVA isolated from P. mume in the world. © 2017, Indian Virological Society.

关键词： Capillovirus CVA Next-generation sequencing Prunus mume

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OPTIMAL PATH PLANNING program FOR AUTONOMOUS SPEED SPRAYER IN ORCHARD USING ORDER-PICKING ALGORITHM

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The Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA2008)

作者： T.S.Park S.J.Park K.Y.Hwang S.I.Cho Department of BioSystems & Biomaterials Science and Engineering Research Institute for Agriculture and Life SciencesSeoul National UniversitySeoul151-921Rep.Korea. Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul151-921Rep.Korea. Department of Biosystems & Biomaterials Science and Engineering Seoul National UniversitySeoul151-921Rep.Korea. Department of Biosystems & Biomaterials Science and Engineering Seoul National University599 GwanangnoGwanak-gu151-921Rep.Korea

This study was conducted to develop a software program which computes optimal path for autonomous navigation in orchard,especially for speed *** of autonomous navigation in orchar

ISBN: (纸本)9781441902085

This study was conducted to develop a software program which computes optimal path for autonomous navigation in orchard,especially for speed *** of autonomous navigation in orchar

关键词： orchards optimal path Digital mapping autonomous navigation trees Trees graphical interface Byways Travel distance Microsoft Office

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SlPMEI, a pollen-specific gene in tomato

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Canadian Journal of Plant Science 2013年第1期94卷 73-83页

作者： Woong Bom Kim Chan Ju Lim Hyun A. Jang So Young Yi Sang-Keun Oh Ha Yeon Lee Hyun A. Kim Youn-Il Park Suk-Yoon Kwon 1Green Bio Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 305-80 2Department of Biology School of Bioscience & Biotechnology Chungnam National University Daejeon 4Plant Genomics and Breeding Institute Seoul National University Seoul 151-921 Korea 3Biosystems and Bioengineering Program University of Science and Technology Daejeon 305-350 Korea

Kim, W. B., Lim, C. J., Jang, H. A., Yi, S. Y., Oh, S.-K., Lee, H. Y., Kim, H. A., Park, Y.-I. and Kwon, S.-Y. 2014. SlPMEI, a pollen-specific gene in tomato. Can. J. Plant Sci. 94: 73-83. Pectin is one of the main components of plant cell walls, and its biosynthesis is controlled by pectin methylesterase (PME). Pectin methylesterase inhibitors (PMEIs) are key regulators of PME. We report here the cloning and characterization of a novel Solanum lycopersicum L. PMEI gene, SlPMEI. RT-PCR studies of leaf, seed, fruit, flower, and flower organs confirmed that SlPMEI is expressed specifically in pollen. Promoter analysis of SlPMEI revealed pollen-specific cis-acting elements (pollen lat52 and g10). In addition, SlPMEI is expressed independently of abiotic stress, pathogen exposure, and growth stage in tomato, and a histochemical analysis of promoter activity revealed pollen-specific expression in both Arabidopsis and tomato. Under the microscope, we observed pollen-specific GUS expression in the stamen of transgenic tomato plant. These results indicate that the promoter of SlPMEI has strong pollen-specific activity, and could therefore be useful for development of industrially and agronomically important transgenic plants.

关键词： Arabidopsis Arabidopsis gène spécifique au pollen PMEI PMEI pollen-specific gene SlPMEI promoter SlPMEI promoteur stress stress tomate tomato

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Bioelectrical Interfaces Beyond Cellular Excitability: Cancer, Aging, and Gene Expression Reprogramming

arXiv

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arXiv 2025年

作者： Cadinu, Paolo Burgess, Matthew Jones, Catarina Franco Luciani, Titouan Iarossi, Marzia Schröter, Manuel Nakatsuka, Nako Djamgoz, Mustafa B.A. Gonçalves, Gil Sanjuán-Alberte, Paola Mendes, Paula M. Rawson, Frankie J. Nair, Malavika Levin, Michael Moreddu, Rosalia Program in Cellular and Molecular Medicine Boston Children’s Hospital BostonMA02115 United States Department of Microbiology Blavatnik Institute Harvard Medical School BostonMA02115 United States Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford United Kingdom Department of Bioengineering Institute for Bioengineering and Biosciences Instituto Superior Técnico University of Lisbon Lisbon Portugal Associate Laboratory i4HB Institute for Health and Bioeconomy Instituto Superior Técnico Universidade de Lisboa Lisbon Portugal Department of Neuroscience Institut Pasteur Paris75015 France Department of Biomedical Engineering Technion Israel Institute of Technology Haifa Israel ETH Zurich Department of Biosystems Science and Engineering Basel Switzerland Laboratory of Chemical Nanotechnology Neuro-X Institute EPFL Genève1202 Switzerland Department of Life Sciences Imperial College London United Kingdom Department of Mechanical Engineering University of Aveiro Aveiro3810-193 Portugal Guimarães4800-058 Portugal School of Chemical Engineering University of Birmingham Birmingham United Kingdom Bioelectronics Laboratory Division of Regenerative Medicine and Cellular Therapies School of Pharmacy Biodiscovery Institute University of Nottingham Nottingham United Kingdom Allen Discovery Centre Tufts University Tufts University MedfordMA United States Wyss Institute for Bioinspired Engineering Harvard University BostonMA United States School of Electronics and Computer Science University of Southampton Southampton United Kingdom Institute for Life Sciences University of Southampton Southampton United Kingdom

Bioelectrical interfaces represent a significant evolution in the intersection of nanotechnology and biophysics, oRering new strategies for probing and influencing cellular processes. These systems capitalize on the subtle but powerful electric fields within living matter, potentially enabling applications beyond cellular excitability, ranging from targeted cancer therapies to interventions in genetic mechanisms and aging. This perspective article envisions the translation, development and application of next-generation solid-state bioelectrical interfaces and their transformative impact across several critical areas of medical research. © 2025, CC BY.

关键词： Medical nanotechnology

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Mathematical Modeling of Plasticity and Heterogeneity in EMT

arXiv

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arXiv 2019年

作者： Tripathi, Shubham Xing, Jianhua Levine, Herbert Jolly, Mohit Kumar Program in Systems Synthetic and Physical Biology Rice University HoustonTX77005 United States Department of Computational and Systems Biology University of Pittsburgh PittsburghPA15261 United States Department of Physics Department of Bioengineering Northeastern University BostonMA02115 United States Center for Theoretical Biological Physics Rice University HoustonTX77005 United States Centre for BioSystems Science and Engineering Indian Institute of Science Bangalore Karnataka560012 India

Epithelial-mesenchymal transition (EMT) and the corresponding reverse process, mesenchymal-epithelial transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels. A recent surge in identifying the molecular mechanisms underlying EMT / MET has led to the development of various mathematical models that have contributed to our improved understanding of dynamics at single-cell and population levels: a) multistability (how many phenotypes can cells attain en route EMT / MET?), b) reversibility / irreversibility (what time and / or concentration of an EMT inducer marks the 'tipping point' when cells induced to undergo EMT cannot revert?), c) symmetry in EMT / MET (do cells take the same path when reverting as they took during the induction of EMT?), d) non-cell autonomous mechanisms (how does a cell undergoing EMT alter the tendency of its neighbors to undergo EMT)? These dynamical traits may facilitate a heterogenous response within a cell population undergoing EMT / MET. Here, we present a few examples of designing different mathematical models that can contribute to decoding EMT / MET dynamics. Copyright © 2019, The Authors. All rights reserved.

关键词： Cell proliferation

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Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response

arXiv

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arXiv 2019年

作者： Jia, Dongya Li, Xuefei Bocci, Federico Tripathi, Shubham Deng, Youyuan Jolly, Mohit Kumar Onuchic, José N. Levine, Herbert Center for Theoretical Biological Physics Rice University HoustonTX77005 United States Department of Chemistry Rice University HoustonTX77005 United States Program in Systems Synthetic and Physical Biology Rice University HoustonTX77005 United States Program in Applied Physics Rice University HoustonTX77005 United States Centre for BioSystems Science and Engineering Indian Institute of Science Bangalore560012 India Department of Biosciences Rice University HoustonTX77005 United States Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Bioengineering Northeastern University BostonMA02115 United States Department of Physics Northeastern University BostonMA02115 United States

Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer cells play a pivotal role in seeding metastases and their presence in cancer patients indicates an adverse prognostic factor. Moreover, cancer cells in hybrid E/M phenotypes tend to be more associated with stemness which endows them with tumor-initiation ability and therapy resistance. Most recently, cells undergoing EMT have been shown to promote immune suppression for better survival. A systematic understanding of the emergence of hybrid E/M phenotypes and the connection of EMT with stemness and immune suppression would contribute to more effective therapeutic strategies. In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i.e. the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes. Following we discuss non-cell-autonomous regulation of EMT by cell cooperation and extracellular matrix. Afterwards, we discuss various metrics that can be used to quantify EMT spectrum. We further describe possible mechanisms underlying the formation of clusters of circulating tumor cells. Last but not least, we summarize recent systems biology analysis of the role of EMT in the acquisition of stemness and immune suppression. Copyright © 2019, The Authors. All rights reserved.

关键词： Cells

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Cellucalst enzyme-assisted extraction of Sargassum horneri enhances the immunomodulation by regulating TLR4/MyD88/NF-kB pathway in murine splenocytes with or without Concanavalin A

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Biomedicine and Pharmacotherapy 2024年 181卷 117673-117673页

作者： Yang, Jiwon Kim, Hyo Jin Herath, Kalahe Hewage Iresha Nadeeka Madushani Jee, Youngheun Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63243 South Korea Department of Food Bioengineering Jeju National University Jeju 690-756 South Korea Department of Environmental Health Harvard T.H. Chan School of Public Health Harvard University Boston Massachusetts United States Department of Biosystems Engineering Faculty of Agriculture and Plantation Management Wayamba University Gonawila Makandura 60170 Sri Lanka Department of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju 64243 South Korea

Sargassum horneri (S. horneri) is an edible species of large brown algae inhabiting along the coasts of northeastern Asia. The study focuses on the impact of celluclast enzyme extract of S. hoeneri (SHC) on various immune cell populations in splenocytes including granulocytes, macrophages, dendritic cells, and T lymphocytes. SHC alone increased the population of granulocytes and macrophages and the secretion of M1 macrophage-derived cytokines (TNF-α, IL-22), and M2 macrophage-derived cytokines (IL-4, IL-10). Interestingly, however, SHC suppressed the concanavalin A (Con A)-expanded populations of macrophages, dendritic cells, granulocytes, T and B cells, and Con A-promoted secretion of M1-macrophage derived cytokines (IFN-γ, IL-1β, TNF-α, IL-17, IL-22) and M2-macrophage derived cytokines (IL-4, IL-10, IL-13, TGF-β). SHC further restrained the Th1, Th2, and Th17 cell responses through attenuating the expression of respective transcription factors T-bet, Gata3, and Rorγt. The anti-inflammatory property of SHC is highlighted through its influence on cytokine production, particularly in the NF-κB pathway, and the attenuation of Toll-like receptor (TLR) signaling. The results reveal that SHC acts as both an immunostimulator and an inhibitor of hyperimmune reactions, showcasing its potential therapeutic applications in conditions involving dysregulated immune responses such as autoimmune diseases and inflammatory disorders. This positions SHC as a promising candidate for the development of functional ingredients with diverse applications encompassing the realms of food, pharmaceuticals, and cosmetics. © 2024

关键词： Celluclast Concanavalin A S. horneri Splenocytes

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Erratum to: Fermentative production and direct extraction of (-)-α-bisabolol in metabolically engineered Escherichia coli

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Microbial cell factories 2017年第1期16卷 19页

作者： Gui Hwan Han Seong Keun Kim Paul Kyung-Seok Yoon Younghwan Kang Byoung Su Kim Yaoyao Fu Bong Hyun Sung Heung Chae Jung Dae-Hee Lee Seon-Won Kim Seung-Goo Lee Synthetic Biology and Bioengineering Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 Republic of Korea. Biosystems and Bioengineering Program University of Science and Technology (UST) Daejeon 34113 Republic of Korea. Department of Chemical and Biological Engineering Korea University Seoul 02841 Republic of Korea. Department of Biotechnology Chonnam National University Yeosu 550749 Republic of Korea. Bioenergy and Biochemical Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 Republic of Korea. Synthetic Biology and Bioengineering Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 Republic of Korea. dhlee@kribb.re.kr. Biosystems and Bioengineering Program University of Science and Technology (UST) Daejeon 34113 Republic of Korea. dhlee@kribb.re.kr. Division of Applied Life Science (BK21 Plus) PMBBRC Gyeongsang National University Jinju 52828 Republic of Korea. swkim@gnu.ac.kr. Synthetic Biology and Bioengineering Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 Republic of Korea. sglee@kribb.re.kr. Biosystems and Bioengineering Program University of Science and Technology (UST) Daejeon 34113 Republic of Korea. sglee@kribb.re.kr.

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