The ribosome is an ancient and conserved molecular machine responsible for translating mRNA into protein in all known organisms. The eukaryotic ribosome is com- posed of - 80 ribosomal proteins （RPs） and four riboso...
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The ribosome is an ancient and conserved molecular machine responsible for translating mRNA into protein in all known organisms. The eukaryotic ribosome is com- posed of - 80 ribosomal proteins （RPs） and four ribosomal RNAs （rRNAs）. These RNA and protein components are assembled within the nucleolus into the small 40S and large 60S subunits of the ribosome, through a process termed ribosome biogenesis. Ribosome biogenesis is a highly orchestrated and carefully controlled process that requires - 150 associated proteins and 70 small nucleolar RNAs （snoRNAs）, which assist in prerRNA transcription and maturation, ribosome component assembly, and trafficking to the cytosol. Defects in ribosome biogenesis resulting from mutations in biogenesis cofactors, or in ribosomal structural components themselves, cause a collection of human diseases termed ＂ribosomopathies＂.
Splenic lymphoma with villous lymphocytes （SLVL） or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL ...
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Splenic lymphoma with villous lymphocytes （SLVL） or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t（8;14）（q24;q32） translocation has been reported. In this study, we report a case of B- lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis （lymphocytes 〉 200 × 10^9/L）. The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19^＋, CD20^＋, HLA- DR^＋, CD22^＋, CD5^＋, Kappa^＋, CD25^dim, CD71^dim, Lambda, CD7, CD10-, CD23 , CD34, CD33, CD13 , CD14, CDll7, CD64, CD103, and CD11c-. The karyotype showed complex abnormality： 46XX,＋ 3,-10, t（8;14）（q24; q32）lll]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t（8,14） chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t（8;14）（q24;q32） translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
The name of the one of the authors was misspelt. The author's surname is Rodriguez, not Rodriquez as originally published. This has been corrected in both the PDF and HTML versions of the Article.
The name of the one of the authors was misspelt. The author's surname is Rodriguez, not Rodriquez as originally published. This has been corrected in both the PDF and HTML versions of the Article.
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