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Biological Tissue-Inspired Ultrasoft,Ultrathin,and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics

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Nano-Micro Letters 2023年第9期15卷 175-189页

作者： Qiang Gao Fuqin Sun Yue Li Lianhui Li Mengyuan Liu Shuqi Wang Yongfeng Wang Tie Li Lin Liu Simin Feng Xiaowei Wang Seema Agarwal Ting Zhang i-Lab Nano-X Vacuum Interconnected WorkstationKey Laboratory of Multifunction Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123JiangsuPeople’s Republic of China Department of Chemistry Bavarian Center for Battery Technology(BayBatt)Bayreuth Center for Colloids and Interfacesand Bavarian Polymer InstituteMacromolecular Chemistry IIUniversity of BayreuthUniversitätsstrasse 3095440 BayreuthGermany School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of ScienceShanghai 200031People’s Republic of China

Hydrogels offer tissue-like softness,stretchability,fracture toughness,ionic conductivity,and compatibility with biological tissues,which make them promising candidates for fabricating flexible bioelectronics.A soft hydrogel film offers an ideal interface to directly bridge thin-film electronics with the soft ***,it remains difficult to fabricate a soft hydrogel film with an ultrathin configuration and excellent mechanical *** we report a biological tissue-inspired ultrasoft microfiber composite ultrathin(<5μm)hydrogel film,which is currently the thinnest hydrogel film as far as we *** embedded microfibers endow the composite hydrogel with prominent mechanical strength(tensile stress~6 MPa)and anti-tearing ***,our microfiber composite hydrogel offers the capability of tunable mechanical properties in a broad range,allowing for matching the modulus of most biological tissues and *** incorporation of glycerol and salt ions imparts the microfiber composite hydrogel with high ionic conductivity and prominent anti-dehydration *** microfiber composite hydrogels are promising for constructing attaching-type flexible bioelectronics to monitor biosignals.

关键词： Fiber Hydrogel Flexible electronics Thin film Electrospinning

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Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome

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Protein & Cell 2022年第3期13卷 203-219页

作者： Chaojuan Yang Yonglu Tian Feng Su Yangzhen Wang Mengna Liu Hongyi Wang Yaxuan Cui Peijiang Yuan Xiangning Li Anan Li Hui Gong Qingming Luo Desheng Zhu Peng Cao Yunbo Liu Xunli Wang Min-hua Luo Fuqiang Xu Wei Xiong Liecheng Wang Xiang-yao Li Chen Zhang State Key Laboratory of Membrane Biology PKU-IDG/McGovern Institute for Brain ResearchSchool of Life SciencesPeking UniversityBeijing 100871China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Life Sciences Tsinghua UniversityBeijing 100084China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences(CAS)Beijing 100101China Institute of Laboratory Animal Science Peking Union Medical College/Chinese Academy of Medical ScienceBeijing 100021China Laboratory Animal Center Fujian University of Tradition Chinese MedicineFuzhou 350122China State Key Laboratory of Virology CAS Center for Excellence in Brain Science andIntelligence TechnologyWuhan Institute of VirologyCASWuhan 430071China Center for Brain Science Key Laboratory of Magnetic Resonance in Biological Systems and State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Institute of Physics and MathematicsCASCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesWuhan 430071China Department of Physiology Anhui Medical UniversityHefei 230032China Department of Physiology Institute of Neuroscience and Collaborative Innovation Center for Brain ScienceSchool of MedicineZhejiang UniversityHangzhou 310058China

Many people affected by fragile X syndrome(FXS)and autism spectrum disorders have sensory processing deficits,such as hypersensitivity to auditory,tactile,and visual *** FXS in humans,loss of Fmr1 in rodents also cause sensory,behavioral,and cognitive ***,the neural mechanisms underlying sensory impairment,especially vision impairment,remain *** remains elusive whether the visual processing deficits originate from corrupted inputs,impaired perception in the primary sensory cortex,or altered integration in the higher cortex,and there is no effective *** this study,we used a genetic knockout mouse model(Fmr1^(KO)),in vivo imaging,and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex(V1).Specifically,Fmr1^(KO) mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity *** abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 *** effects were ameliorated by the acute application of GABAA receptor activators,which enhanced the activity of inhibitory neurons,or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult ***,V1 plays an important role in the visual abnormalities of Fmr1^(KO) mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients.

关键词： autism spectrum disorder calcium imaging fragile X syndrome primary visual cortex visual hypersensitivity

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brain science and AI technology in the post-COVID era

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National science Review 2021年第3期8卷 6-6页

作者： Mu-ming Poo CAS Center for Excellence in Brain Science and Intelligence Technology NSR

As COVID-19 pandemic is gradually under control through largescale vaccination, the world is moving into the post-COVID era that few societies are well-prepared for. Besides facing persistent threats imposed by SARS-CoV-2-related viruses and their variants, wideranging consequences of this pandemic will affect the mental health and education for large populations around the globe.

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Effect of disrupted episodic memory on food consumption:no impact of neuronal loss of endophilin A1 on food intake and energy balance

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Journal of Genetics and Genomics 2022年第4期49卷 329-337页

作者： Jacques Togo Yanrui Yang Sumei Hu Jia-Jia Liu John R.Speakman State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Shijingshan DistrictBeijing 100049China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB242TZUK CAS Center of Excellence for Animal Evolution and Genetics KunmingYunnan 650223China

Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic *** from individuals with memory dysfunction suggests that episodic memory may also play a significant *** reasoned that if memory influences food intake,then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy *** performed spatial learning tests on neuronal specific endophilin A1(EENA1)KO mice using the four-arm baited version of the radial arms maze(RAM).Energy regulation has also been *** anticipated neuronal EENA1 KO mice had impaired spatial ***,loss of endophilin A1 did not result in greater food intake,or altered energy absorption efficiency,relative to wild-type(WT)mice,when fed either low or high fat ***,loss of EENA1 did not significantly affect other features of energy balance—physical activity and energy *** statistically significant changes were observed in the expression of hypothalamic neuropeptides related to food intake regulation,or circulating levels of *** conclude that food intake and energy balance are largely governed by homeostatic and hedonic processes,and when these processes are intact memory probably plays a relatively minor role in food intake regulation.

关键词： Memory Food intake Endophilin A1 Obesity Energy expenditure Physical activity

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CFDA-M: Coarse-to-Fine Domain Adaptation for Mitochondria Segmentation via Patch-wise Image Alignment and Online Self-training

CFDA-M: Coarse-to-Fine Domain Adaptation for Mitochondria Se...

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2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

作者： Zhang, Yanchao Liu, Jiazheng Li, Zhenchen Guo, Jinyue Han, Hua Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Beijing China University of Chinese Academy of Sciences School of Future Technology Beijing China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai China

ISBN: (纸本)9781665468190

Accurate and robust segmentation of mitochondria from electron microscopy images plays a critical role in understanding cellular functions. While effective, learning-based approaches require vast quantities of expert annotations. Manual efforts can be alleviated by transferring the knowledge learned from the source domain to unseen target domains, as known as unsupervised domain adaptation. In this work, we propose a two-stage pipeline for cross-dataset mitochondria segmentation, aiming to mitigate domain shift in a coarse-to-fine manner. In the first stage, we integrate the style transfer block and segmentation network into an end-to-end image alignment framework. Specifically, patch-wise contrastive learning is employed to guarantee the semantic fidelity of mitochondria, providing more reliable translated images for the segmentation network. In the second stage, a novel online self-training network updated with target images and co-evolving pseudo labels is proposed to fine-tune the segmentation network trained beforehand. Furthermore, to effectively utilize unlabeled data, consistency regularization is introduced in both stages to enforce stable predictions under various perturbations. Experimental results on public datasets demonstrate that the proposed approach outperforms the existing methods by a large margin in bidirectional adaptation for mitochondria segmentation and achieves comparable results with supervised methods. © 2022 IEEE.

关键词： Large dataset

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Prototype of A Novel Visuotactile Endoscope Probe 13

Prototype of A Novel Visuotactile Endoscope Probe

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13th IEEE International Conference on CYBER technology in automation, Control, and Intelligent Systems, CYBER 2023

作者： Cui, Shaowei Tian, Yuan Hu, Jingyi Wang, Rui Wang, Yu Wang, Shuo Institute of Automation State Key Laboratory of Multimodal Artificial Intelligence Systems Chinese Academy of Sciences Beijing 100190 China Beijing University of Science and Technology Beijing100083 China School of Future Technology University of Chinese Academy of Sciences Beijing100049 China Institute of Automation Chinese Academy of Sciences Beijing100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai200031 China

ISBN: (纸本)9798350315196

Endoscopes incorporating tactile sensing can significantly improve the efficiency of endoscopic diagnosis and treatment. Unfortunately, traditional tactile endoscopes are difficult to guarantee the accuracy of tactile signals and high-quality visual images at the same time. In this paper, a novel visuotactile endoscope probe is proposed to obtain clear external visual images and rich tactile information simultaneously. The probe is composed of two parts: a miniatured camera and a gel module which is made of highly clear silicone with markers painted on its surface. The visual and tactile information can be extracted from the images captured by the vision system. Specifically, a marker detection and tracking algorithm is used to extract tactile features, and an image inpainting method is proposed to obtain clear vision effect. This study is a preliminary exploration of the visuotactile endoscope, which holds promising potential for in vivo palpation and broad applications in the medical field. © 2023 IEEE.

关键词： Endoscopy

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Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants

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General Psychiatry 2022年第2期35卷 109-118页

作者： Wenjun Su Zhixing Li Lihua Xu Jiahui Zeng Yingying Tang Xiaochen Tang Yanyan Wei Qian Guo Tianhong Zhang Jijun Wang Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Heaith Center Shanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina

Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for *** lines of evidence suggest that fatty acids,especially unsaturated fatty acids(UFAs),might play a crucial role in the WM pathology of early onset ***,evidence linking UFA and WM microstructure in CHR is quite *** We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls(HC).Methods Plasma fatty acids were assessed and diffusion tensor imaging(DTI)data were performed with tract-based spatial statistics(TBSS)analysis for 66 individuals at CHR for psychosis and 70 *** Both the global and regional diffusion measures showed significant between-group differences,with decreased fractional anisotropy(FA)but increased mean diffusivity(MD)and radial diffusivity(RD)found in the CHR group compared with the HC *** top of that,we found that in the HC group,plasma arachidic acid showed obvious trend-level associations with higher global FA,lower global MD and lower global RD,which regionally spread over the corpus callosum,right anterior and superior corona radiata,bilateral anterior and posterior limb of the internal capsule,and bilateral superior longitudinal ***,there were no associations between global WM measures and any UFA in the CHR ***,we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR *** Compared with the HC group,CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA,with a neuroprotective effect found in the HC group but not in the CHR *** discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group,highlighting the role of balanced plasma-membrane fatty

关键词： unsaturated diffusion linking

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Efficient-VQGAN: Towards High-Resolution Image Generation with Efficient Vision Transformers

Efficient-VQGAN: Towards High-Resolution Image Generation wi...

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International Conference on Computer Vision (ICCV)

作者： Shiyue Cao Yueqin Yin Lianghua Huang Yu Liu Xin Zhao Deli Zhao Kaiqi Huang School of Artificial Intelligence University of Chinese Academy of Sciences Chinese Academy of Sciences Institute of Automation China Machine Intelligence Technology Lab Alibaba Group China CAS Center for Excellence in Brain Science and Intelligence Technology China

Vector-quantized image modeling has shown great potential in synthesizing high-quality images. However, generating high-resolution images remains a challenging task due to the quadratic computational overhead of the self-attention process. In this study, we seek to explore a more efficient two-stage framework for high-resolution image generation with improvements in the following three aspects. (1) Based on the observation that the first quantization stage has solid local property, we employ a local attention-based quantization model instead of the global attention mechanism used in previous methods, leading to better efficiency and reconstruction quality. (2) We emphasize the importance of multi-grained feature interaction during image generation and introduce an efficient attention mechanism that combines global attention (long-range semantic consistency within the whole image) and local attention (fined-grained details). This approach results in faster generation speed, higher generation fidelity, and improved resolution. (3) We propose a new generation pipeline incorporating autoencoding training and autoregressive generation strategy, demonstrating a better paradigm for image synthesis. Extensive experiments demonstrate the superiority of our approach in high-quality and high-resolution image reconstruction and generation.

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Application of Digital Medicine in Addiction

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Journal of Shanghai Jiaotong university(science) 2022年第2期27卷 144-152页

作者： Wu Xiaojun Du Jiang Jiang Haifeng Zhao Min Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Key Laboratory of Psychotic Disorders Shanghai201108China CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of SciencesShanghai200031China

Digital medicine plays an important role in disease assessment,psychological intervention,and relapse management in mental *** with substance use disorders can be easily affected by the environment and negative emotions,inducing addiction and ***,due to social discrimination,stigma,or economic issues,they are unwilling to go to the hospital for treatment,making it difficult for health workers to track their health ***,mental health resources in China are *** medicine aims to solve these *** article reviews digital medicine in the field of addiction,hoping to provide a reference for the future exploration of more individualized and effective digital medicine.

关键词： digital medicine addiction assessment intervention prediction

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Efficient-VQGAN: Towards High-Resolution Image Generation with Efficient Vision Transformers

arXiv

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arXiv 2023年

作者： Cao, Shiyue Yin, Yueqin Huang, Lianghua Liu, Yu Zhao, Xin Zhao, Deli Huang, Kaiqi School of Artificial Intelligence University of Chinese Academy of Sciences China Institute of Automation Chinese Academy of Sciences China Machine Intelligence Technology Lab Alibaba Group China CAS Center for Excellence in Brain Science and Intelligence Technology China

关键词： Image enhancement

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