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46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Li, Qingya Zhang, Zhiwei Shi, Mingxia Tao, Xiaoyan Institute of Automation Chinese Academy of Sciences Beijing100190 China Cas Center for Excellence in Brain Science and Intelligence Technology Shanghai200031 China

ISBN: (纸本)9798350371499

Simultaneous recordings of neural activity at massive scope, in the long term, and under bio-safety conditions, could provide crucial information, which helps in better understanding the operation mechanism of the brain and promotes the clinical application evolution for the brain-computer interface. For this purpose, a multi-channel neural signal recording system is presented, which can record up to 2048-channel neural signals by multiple connections of a customized collection system. The system consists of a sensor array module, a central controller module, and an upper computer module. Using the modular design method, the sensor array module can be contrived by changing the number of channels. The single-channel data acquisition module has a sampling resolution of 16 bits, and a sampling rate of 30 KSamples/s. The central controller module can establish a connection between the sensor array module and the upper computer module, and control their operations. The upper computer module can display the data results. The system verifies the performance of the multi-channel data acquisition through the analog neural signal. © 2024 IEEE.

关键词： brain computer interface

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Development and transdifferentiation into inner hair cells require Tbx2

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National science Review 2022年第12期9卷 135-148页

作者： Zhenghong Bi Xiang Li Minhui Ren Yunpeng Gu Tong Zhu Shuting Li Guangqin Wang Suhong Sun Yuwei Sun Zhiyong Liu Institute of Neuroscience State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology

Atohl is essential for the development of both outer hair cells(OHCs) and inner hair cells(IHCs) in the mammalian co *** Ikzf2 is necessary for OHC development,the key gene re quired for IHC development remains *** found that deletion of Tbx2 in neonatal IHCs led to their transdifferentiation into OHCs by repressing 26.7% of IHC genes and inducing 56.3% of OHC genes,including *** importantly,persistent expression of Tbx2 coupled with transient Atohl expression effe ctively reprogrammed non-sensory supporting cells into new IHCs expressing the functional IHC marker *** differentiation status of these new IHCs was considerably more advanced than that previously ***,Tbx2 is essential for IHC development and co-upregulation of Tbx2 with Atohl in supporting cells represents a new approach for treating deafness related to IHC degeneration.

关键词： Tbx2 cochlea inner hair cell supporting cell Ikzf2 outer hair cell

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Genetic Approaches for Neural Circuits Dissection in Non-human Primates

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Neuroscience Bulletin 2023年第10期39卷 1561-1576页

作者： Ling Li Zhen Liu Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyCAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Genetic tools,which can be used for the morphology study of specific neurons,pathway-selective connectome mapping,neuronal activity monitoring,and manipulation with a spatiotemporal resolution,have been widely applied to the understanding of complex neural circuit formation,interactions,and functions in ***,similar genetic approaches have been tried in non-human primates(NHPs)in neuroscience studies for dissecting the neural circuits involved in sophisticated behaviors and clinical brain disorders,although they are still very *** this review,we introduce the progress made in the development and application of genetic tools for brain studies on *** also discuss the advantages and limitations of each approach and provide a perspective for using genetic tools to study the neural circuits of NHPs.

关键词： Genetic tool Neural circuit Non-human primate

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Influence of Recent Trial History on Interval Timing

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Neuroscience Bulletin 2023年第4期39卷 559-575页

作者： Taorong Xie Can Huang Yijie Zhang Jing Liu Haishan Yao Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China

Interval timing is involved in a variety of cognitive behaviors such as associative learning and *** it has been shown that time estimation is adaptive to the temporal context,it remains unclear how interval timing behavior is influenced by recent trial *** we found that,in mice trained to perform a licking-based interval timing task,a decrease of inter-reinforcement interval in the previous trial rapidly shifted the time of anticipatory licking *** inactivation of the anterior lateral motor cortex(ALM),but not the medial prefrontal cortex,for a short time before reward delivery caused a decrease in the peak time of anticipatory licking in the next *** recordings from the ALM showed that the response profiles preceded by short and long inter-reinforcement intervals exhibited task-engagement-dependent temporal ***,interval timing is adaptive to recent experience of the temporal interval,and ALM activity during time estimation reflects recent experience of interval.

关键词： Peak-interval timing procedure Temporal context Trial history Secondary motor cortex Temporal scaling

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The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior

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Neuroscience Bulletin 2023年第10期39卷 1544-1560页

作者： Jing Liu Dechen Liu Xiaotian Pu Kexin Zou Taorong Xie Yaping Li Haishan Yao Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China

The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet how M2 modulates signals in the DS to influence perceptual decision-making is *** mice performing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go *** choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the *** measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA *** results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior.

关键词： Secondary motor cortex Striatum Visual perceptual decision Choice signal Direct and indirect pathway striatal neurons

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Generation of chimeric monkeys using embryonic stem cells

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Zoological Research 2023年第6期44卷 1154-1155页

作者： Jing Cao Zhen Liu Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyCAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai 200031China

Embryonic stem cells(ESCs)represent a subtype of pluripotent stem cells(PSCs)derived from the inner cell mass of *** cells exhibit three principal features:the capacity for unlimited self-replication,the ability to differentiate into diverse somatic cell types in vitro,and the potential to contribute to chimera animals in vivo upon reintroduction into the host ***,ESCs are widely used in basic and biomedical research,as well as in applications such as cell replacement therapy and the creation of genetically modified animal models.

关键词： stem creation diverse

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Cortical Mechanisms of Multisensory Linear Self-motion Perception

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Neuroscience Bulletin 2023年第1期39卷 125-137页

作者： Luxin Zhou Yong Gu CAS Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China

Accurate self-motion perception,which is critical for organisms to survive,is a process involving multiple sensory *** two most powerful cues are visual(optic flow)and vestibular(inertial motion).Psychophysical studies have indicated that humans and nonhuman primates integrate the two cues to improve the estimation of self-motion direction,often in a statistically Bayesian-optimal *** the last decade,single-unit recordings in awake,behaving animals have provided valuable neurophysiological data with a high spatial and temporal resolution,giving insight into possible neural mechanisms underlying multisensory self-motion ***,we review these findings,along with new evidence from the most recent studies focusing on the temporal dynamics of signals in different *** show that,in light of new data,conventional thoughts about the cortical mechanisms underlying visuo-vestibular integration for linear self-motion are *** propose that different temporal component signals may mediate different functions,a possibility that requires future studies.

关键词： Multisensory integration Self-motion perception Vestibular Optic flow

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Neural representation of sexual satiety in mice

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Zoological Research 2023年第3期44卷 522-524页

作者： Ming-Juan Li Xiao-Hong Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 200031China

Mating behaviors are controlled by genetically hardwired circuits(Figure 1A),which endow sexually mature animals with the ability to respond appropriately upon encounters with conspecifics of the opposite sex without needing prior training,thereby facilitating propagation of the species(Chen&Hong,2018;Wei et al.,2021;Xiao et al.,2022).When a male mouse meets a female mouse in estrus and wants to initiate mating,he usually shows appetitive investigation by approaching the female and sniffing her genital area;afterward,the male places his forepaws on the back of the female,a behavior called mounting(Figure 1B).

关键词： Figure approaching thereby

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Multimodal Fusion of brain Imaging Data: Methods and Applications

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Machine intelligence Research 2024年第1期21卷 136-152页

作者： Na Luo Weiyang Shi Zhengyi Yang Ming Song Tianzi Jiang Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intelligence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typically include multiple modalities,such as structural or functional magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide multiple views for observing and analyzing the *** lever-age the complementary representations of different modalities,multimodal fusion is consequently needed to dig out both inter-modality and intra-modality *** the exploited rich information,it is becoming popular to combine multiple modality data to ex-plore the structural and functional characteristics of the brain in both health and disease *** this paper,we first review a wide spectrum of advanced machine learning methodologies for fusing multimodal brain imaging data,broadly categorized into unsupervised and supervised learning *** by this,some representative applications are discussed,including how they help to under-stand the brain arealization,how they improve the prediction of behavioral phenotypes and brain aging,and how they accelerate the biomarker exploration of brain ***,we discuss some exciting emerging trends and important future ***,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful applications,along with the chal-lenges imposed by multi-scale and big data,which arises an urgent demand on developing new models and platforms.

关键词： Multimodal fusion supervised learning unsupervised learning brain atlas cognition brain disorders

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Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National science Review 2024年第7期11卷 106-125页

作者： Yan-Nong Dou Yuan Liu Wen-Qun Ding Qing Li Hua Zhou Ling Li Meng-Ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan Zou Anan Li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

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