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Astrocytic Gap Junctions Contribute to Aberrant Neuronal Synchronization in a Mouse Model of MeCP2 Duplication Syndrome

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Neuroscience Bulletin 2022年第6期38卷 591-606页

作者： Shengnan Xia Hua-Tai Xu Institute of Neuroscience and State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Seciences Beijing 100049.China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China

Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains *** with wild-type mice,our in vivo two-photon imaging showed that transgenic(Tgl)mice over-expressing human autism risk gene MeCP2 exhibited higher neuronal synchrony in the young but lower synchrony in the adult ***-cell recording of neuronal pairs in brain slices revealed that higher neuronal synchrony in young postnatal Tgl mice was atributed mainly to more prevalent giant slow inward currents(SICs).Both in vivo and slice imaging further demonstrated more dynamic activity and higher synchrony in astrocytes from young Tgl *** astrocytic gap junctions markedly decreased the generation of SICs and overall cell synchrony in the Tgl ***,the expression level of Cx43 protein and the coupling efficiency of astrocyte gap junctions remained unchanged in Tgi ***,astrocytic gap junctions facilitate but do not act as a direct trigger for the abnormal neuronal synchrony in young Tgl mice,revealing the potential role of the astrocyte network in the pathogenesis of MeCP2 duplication syndrome.

关键词： Autism spectrum disorder Astrocyte Gap junction Neuronal synchrony MeCP2-Slow inward current Neuronal development

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Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells

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Neuroscience Bulletin 2023年第12期39卷 1762-1774页

作者： Yi Pan Shuting Li Shunji He Guangqin Wang Chao Li Zhiyong Liu Mingliang Xiang Department of Otolaryngology and Head and Neck Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China

The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic and perinatal IHCs or OHCs are ***,we generated a new knock-in Fgf8^(P2A-3×GFP/+)(Fgf8^(GFP)/+)strain,in which the expression of a series of three GFP fragments is controlled by endogenous Fgf8 cis-regulatory *** confirming that GFP expression accurately reflects the expression of Fgf8,we successfully obtained both embryonic and neonatal IHCs with high purity,highlighting the power of Fgf8^(GFP)/+.Furthermore,our fate-mapping analysis revealed,unexpectedly,that IHCs are also derived from inner ear progenitors expressing Insm1,which is currently regarded as an OHC ***,besides serving as a highly favorable tool for sorting early IHCs,Fgf8^(GFP)/+will facilitate the isolation of pure early OHCs by excluding IHCs from the entire hair cell pool.

关键词： Fgf8 Inner Hair Cell Inner Ear-Cochlea

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Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

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National science Review 2023年第11期10卷 34-44页

作者： Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan J.Stein Zhi-Qi Xiong Zhen Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of Sciences Lingang Laboratory Shanghai Center for Brain Science and Brain-Inspired Technology Translational Neuropsychiatry Unit(TNU) Department of Clinical MedicineAarhus University Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine

Obsessive-compulsive disorder(OCD) is a chronic and debilitating psychiatric disorder that affects ～2%–3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. brain imaging showed that monkeys with SMBs had larger gray matter(GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor(human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.

关键词： obsessive-compulsive disorder (OCD) primate ritualistic behavior model OCD risk genes caudate nucleus fluoxetine

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Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration

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Neuroscience Bulletin 2022年第8期38卷 871-886页

作者： Hairong Peng Shui Yu Yukai Zhang Yanqing Yin Jiawei Zhou Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China School of Future Technology University of Chinese Academy of SciencesBeijing100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China

A wealth of evidence has suggested that gastrointestinal dysfunction is associated with the onset and progression of Parkinson’s disease(PD).However,the mechanisms underlying these links remain to be ***,we investigated the impact of deregulation of intestinal dopamine D2 receptor(DRD2)signaling in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced dopaminergic ***/dopamine signaling in the mouse colon decreased with *** ablation of Drd2,but not Drd4,in the intestinal epithelium,caused a more severe loss of dopaminergic neurons in the substantia nigra following MPTP challenge,and this was accompanied by a reduced abundance of succinate-producing Alleoprevotella in the gut *** of succinate markedly attenuated dopaminergic neuronal loss in MPTP-treated mice by elevating the mitochondrial membrane *** study suggests that intestinal epithelial DRD2 activity and succinate from the gut microbiome contribute to the maintenance of nigral DA neuron *** findings provide a potential strategy targeting neuroinflammation-related neurological disorders such as PD.

关键词： Intestine DRD2 Parkinson’s disease MPTP Succinate Mitochondria

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MSDAC: A multi-source domain adversarial framework for motion prediction in intracortical brain-computer interfaces 46

MSDAC: A multi-source domain adversarial framework for motio...

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46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Liu, Haozhou Yang, Banghua Guan, Shouliang Rong, Fenqi Guo, Mengao Fang, Ying Liu, Bingyu Gao, Yan Gu, Yong Shanghai University School of Mechatronic Engineering and Automation Research Center of Brain-Computer Engineering Shanghai200444 China Lingang Laboratory Shanghai200031 China National Center for Nanoscience and Technology Beijing100190 China Institute of Neurosciences Cas Center for Excellence in Brain Science and Intelligence Technology Shanghai200031 China

ISBN: (纸本)9798350371499

Intracortical brain-computer interfaces (iBCIs) restore motor function in patients with paralysis by converting neural activity into control signals for external devices. However, the frequent recalibration required by current decoding methods due to turnover and loss of recording neurons poses a challenge for achieving stable online decoding. To address these issues, we propose a multi-source domain adversarial classification (MSDAC) framework for cross-day decoding that utilizes an out-of-distribution (OOD) generalization approach. This framework divides the historical data into source domains by date and employs adversarial networks to minimize the distribution discrepancies among multiple source domains, thereby achieving robust domain-invariant characteristics and superior performance on unseen test data. The MSDAC framework was evaluated using five months of monkey center-out neural activity data and demonstrated exceptional performance. Without relying on test day data for model calibration or parameter updating, the MSDAC achieved an average decoding accuracy of 84.38% (day-5 to day-150, 27968 trials). These results underscore that the MSDAC-based decoding framework can be an ideal choice for establishing stable iBCI systems. © 2024 IEEE.

关键词： brain computer interface

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A Virtual Reality Platform for Context-Dependent Cognitive Research in

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Neuroscience Bulletin 2023年第5期39卷 717-730页

作者： Xue-Tong Qu Jin-Ni Wu Yunqing Wen Long Che Shi-Lei Lv Li Liu Li-Jie Zhan Tian-Yi Liu Hua He Yu Liu Chun Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Automation Chinese Academy of SciencesBeijing 100190China Department of Neurosurgery Third Affiliated Hospital of Navy Military Medical UniversityShanghai 200438China

Animal survival necessitates adaptive behav-iors in volatile environmental *** reality(VR)technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental con-text by simulating the real world with maximized control of contextual *** current VR tools for rodents have limited flexibility and performance(e.g.,frame rate)for context-dependent cognitive ***,we describe a high-performance VR platform with which to study con-textual behaviors immersed in editable virtual *** platform was assembled from modular hardware and custom-written software with flexibility and *** this platform,we trained mice to perform context-dependent cognitive tasks with rules ranging from discrim-ination to delayed-sample-to-match while recording from thousands of hippocampal place *** precise manipula-tions of context elements,we found that the context recogni-tion was intact with partial context elements,but impaired by exchanges of context ***,our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording.

关键词： Virtual reality Spatial context Contextual behavior Hippocampus Place cell-Learning and memory Ca^(2+)imaging

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A Learning-based Acceleration Framework for Transient Hemodynamic Simulations

A Learning-based Acceleration Framework for Transient Hemody...

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International Conference on Biomimetic intelligence and Robotics & Medical Robotics Forum, ICBIR+MRF 2024

作者： Zhang, Qin-Yi Zhou, Xiao-Hu Xie, Xiao-Liang Liu, Shi-Qi Feng, Zhen-Qiu Gui, Mei-Jiang Li, Hao Xiang, Tian-Yu Huang, De-Xing Hou, Zeng-Guang The State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China The School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China The CAS Center for Excellence in Brain Science and Intelligence Technology Beijing100190 China

Numerical simulations of transient hemodynamics have increasingly become an important assessment for vascular disease. However, the procedure often requires cumbersome steps and high computational costs. To tackle above issues, a novel learning-based acceleration framework is proposed to simulate transient hemodynamics of abdominal aortic aneurysms (AAA). This framework innovatively combines static spatial features with dynamic temporal features to accurately simulate blood pressure at each timestep. PointNet++ is employed to extract hierarchical spatial features from the AAA point clouds. Subsequently, these features are integrated with boundary conditions for learning temporal dynamics using Transformer. The proposed framework is trained and evaluated on a hemodynamic dataset comprising 18 patients, achieving a mean absolute error of 80.87 Pa in blood pressure simulations. These promising results indicate the potential of the framework to facilitate AAA diagnosis efficiently. © 2024 The Authors.

关键词： Abdominal Aortic Aneurysms Computational Fluid Dynamics Hemodynamics Point Cloud

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Working memory deficits in Parkinson′s disease mouse model

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中国药理学与毒理学杂志 2023年第7期37卷 517-518页

作者： ZHAO Tingting GU Huating ZHAO Miao CHEN Tianzhi AN Yingjie ZHANG Xian HOU Jincan CAO Peng ZENG Linghui LI Chengyu Institute of Neuroscience State Key Laboratory of Neuroscience Chinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Center for Brain Science and Brain-Inspired Technology Hangzhou City University National Institute of Biological Sciences

OBJECTIVE Parkinson′s disease(PD) is a progressive neurodegenerative disease clinically characterized by dyskinesia, tremor, rigidity, abnormal gait,whereas 90% of patients with PD suffer from defects of the sense of smell before the appearance of the motor dysfunctions. However, the mechanism of olfactory disorder is still not clear. METHODS We utilized olfaction based delayed paired association task in head-fixed *** focused on functional role of neural circuit using optogenetic techniques. In addition, we viewed the synaptic transmission by slice physiological recording and counted the cell number of targeted circuits. RESULTS AND CONCLUSION In our experiments, olfactory working memory impairments were found in the PD mice, and the working memory impairment appeared before motor dysfunctions. Furthermore, we also investigated the functional role of neural circuit for olfactory working memory in PD mice. Meanwhile, the excitatory post synaptic currents were decreased as a result of presynaptic release probability suppression in PD mice. However cell loss wasn′t found in working memory related circuit recently. These will provide a new idea of clinic diagnosis for PD.

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Environmental Sensing and Motion Control for Underwater Robots

Environmental Sensing and Motion Control for Underwater Robo...

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2023 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2023

作者： Ding, Feng Wang, Rui Wang, Yu Wang, Shuo University of Chinese Academy of Science School of Artificial Intelligence China Central South University School of Automation China Chinese Academy of Sciences State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation China Cas Center for Excellence in Brain Science and Intelligence Technology China

ISBN: (纸本)9798350327182

Underwater robot is an underwater equipment with autonomous sensing ability, which can replace human in the high-risk underwater environment to complete tasks such as resource exploration, information collection, underwater fishing, etc. In this paper, we first review current research status of underwater sensing technologies from three aspects: tactile sensing, visual sensing and acoustic sensing. Then we provide an overview of motion control techniques for underwater robots in terms of both traditional motion control methods and reinforcement learning-based motion control methods. Finally, the problems in current researches are summarized and the future development directions are proposed. © 2023 IEEE.

关键词： Motion control

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Dynamic alterations in bacterial and fungal microbiome and inflammatory cytokines following SRV-8 infection in cynomolgus monkeys

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Zoological Research 2025年第2期46卷 325-338页

作者： Yun-Peng Yang Li-Bing Xu Yong Lu Jing Wang Yan-Hong Nie Qiang Sun Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhouJiangsu 225009China Institute of Comparative Medicine Yangzhou UniversityYangzhouJiangsu 225009China Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 201602China Institute of Neuroscience CAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Key Laboratory of Genetic Evolution&Animal Models Chinese Academy of SciencesKunmingYunnan 650201China

While viral infections can disturb the host gut microbiome,the dynamic alterations in microbial composition following infection remain poorly *** study identified SRV-8-infected monkeys and classified them into five groups based on infection progression.16S rRNA amplicon sequencing revealed significant alterations in the relative and inferred absolute abundance of bacterial genera UCG-002,Agathobacter,Coprococcus,and Holdemanella during the early stage of SRV-8 infection,coinciding with provirus *** microbial shifts were accompanied by functional modifications in bacterial communities at the same *** contrast,ITS amplicon sequencing indicated no significant differences in fungal composition between healthy wild-type and SRV-8-infected *** correlation analyses demonstrated close interactions between intestinal bacteria and fungi following SRV-8 ***,SRV-8 seropositive groups exhibited significantly elevated mRNA expression levels of pro-inflammatory(TNF-α,IFN-γ,IL-1β,and IL-6)and anti-inflammatory(IL-10)cytokine genes,highlighting close associations between inflammatory cytokines and immune ***,these findings provide a comprehensive characterization of bacterial and fungal microbiota dynamics and inflammatory cytokine responses associated with SRV-8 infection,clarifying the pathobiological mechanisms underlying SRV-8 infection from the perspective of the gut microbiome.

关键词： Cynomolgus monkeys SRV-8 infection Dynamic alterations Bacterial and fungal microbes Inflammatory cytokines

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