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Personalized gait trajectory generation based on anthropometric features using Random Forest

Journal of Ambient intelligence and Humanized Computing 2023年第12期14卷 15597-15608页

作者： Ren, Shixin Wang, Weiqun Hou, Zeng-Guang Chen, Badong Liang, Xu Wang, Jiaxing Peng, Liang The State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China The CAS Center for Excellence in Brain Science and Intelligence Technology Beijing100190 China Institute of Artificial Intelligence and Robotics Xi’an Jiaotong University Xi’an710049 China

Using lower limb rehabilitation robots (LLRRs) to help stroke patients recover their walking ability is attracting more and more attention presently. Previous studies have shown that gait rehabilitation training with natural gait pattern can improve the therapeutic outputs. However, how to generate the personalized gait trajectory has not been well researched. In this paper, a personalized gait generation method based anthropometric features is proposed. Firstly, gait trajectories are fitted and simplified into Fourier coefficient vectors, which are used to represent gait trajectories. Secondly, fourteen body features are used to generate the personalized gait trajectories and the feature set is further optimized based on the minimal redundancy maximal relevance criterion for easy application on the LLRR. Then, the relationship between the optimized feature set and gait trajectories is modeled by using the RF algorithm. Finally, the performance of the proposed method is demonstrated by several comparison experiments. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Trajectories

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Comparative Molecular Taxonomics of Neuron in Cingulate Cortex of Rhesus Monkey and Mouse via Single-Nucleus RNA Sequencing

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Neuroscience Bulletin 2024年第11期40卷 1751-1756页

作者： Lei Zhang Yanyong Cheng Zhenyu Xue Shihao Wu Zilong Qiu Hong Jiang Department of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Center for Brain Science and Brain-Inspired Intelligence TechnologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China Kunming Institute of Zoology Chinese Academy of SciencesKunming650223China Shanghai Jiao Tong University School of Medicine Songjiang Institute Shanghai200025China

Dear Editor,The brain has complex molecular and cellular *** knowledge about the molecular taxonomy of the brain is mainly based on rodent *** they share common ancestors,primates and rodents evolved via different routes,diverging more than 75 million years ***,studies of other species do not fully inform the unique cognitive abilities of *** analyses of gene expression profiles across species mainly focus on the hippocampus and prefrontal cortex.

关键词： Neuron Cortex taxonomy

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Decoding effects of psychoactive drugs in a high-dimensional space of eye movements in monkeys

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National science Review 2023年第11期10卷 20-33页

作者： Xu Liu Zhixian Cheng He Lin Jiangxiu Tan Wenyao Chen Yichuan Bao Ying Liu Lei Zhong Yitian Yao Liping Wang Jijun Wang Yong Gu Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine Lingang Laboratory The Third Research Institute of Ministry of Public Security CAS Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of Sciences University of Chinese Academy of Sciences Institute of Psychology and Behavioral Science Shanghai Jiao Tong University

Oculomotor behavior has been shown to be correlated with mental disorders in clinics, making it promising for disease diagnosis. Here we developed a thorough oculomotor test toolkit, involving saccade, smooth pursuit, and fixation, allowing the examination of multiple oculomotor parameters in monkey models induced by psychoactive drugs. Eye movements were recorded after daily injections of phencyclidine(PCP)(3.0 mg/kg), ketamine(0.8 mg/kg) or controlled saline in two macaque monkeys. Both drugs led to robust reduction in accuracy and increment in reaction time during high cognitive-demanding tasks. Saccades,smooth pursuit, and fixation stability were also significantly impaired. During fixation, the involuntary microsaccades exhibited increased amplitudes and were biased toward the lower visual field. Pupillary response was reduced during cognitive tasks. Both drugs also increased sensitivity to auditory cues as reflected in auditory evoked potentials(AEPs). Thus, our animal model induced by psychoactive drugs produced largely similar abnormalities to that in patients with schizophrenia. Importantly, a classifier based on dimension reduction and machine learning could reliably identify altered states induced by different drugs(PCP, ketamine and saline, accuracy = 93%). The high performance of the classifier was reserved even when data from one monkey were used for training and testing the other subject(averaged classification accuracy = 90%). Thus, despite heterogeneity in baseline oculomotor behavior between the two monkeys, our model allows data transferability across individuals, which could be beneficial for future evaluation of pharmaceutical or physical therapy validity.

关键词： oculomotor monkey schizophrenia phencyclidine ketamine auditory evoked potential

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Active shape reconstruction using a novel visuotactile palm sensor

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Biomimetic intelligence & Robotics 2024年第3期4卷 15-22页

作者： Jingyi Hu Shaowei Cui Shuo Wang Rui Wang Yu Wang Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Tactile sensing enables high-precision 3D shape perception when vision is ***,tactilebased shape reconstruction remains a challenging *** this paper,a novel visuotactile sensor,GelStereo Palm 2.0,is proposed to better capture 3D contact *** the dense tactile point cloud captured by GelStereo Palm 2.0,an active shape reconstruction pipeline is presented to achieve accurate and efficient 3D shape reconstruction on irregular *** Palm 2.0 achieves a spatial resolution of 1.5 mm and a reconstruction accuracy of 0.3 *** accuracy of the proposed active shape reconstruction pipeline reaches 2.3 mm within 18 *** proposed method has potential applications in the shape reconstruction of transparent or underwater objects.

关键词： Tactile sensing Visuotactile sensor Active shape reconstruction

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Ultrasensitive proteomics depicted an in-depth landscape for the very early stage of mouse maternal-to-zygotic transition

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Journal of Pharmaceutical Analysis 2023年第8期13卷 942-954页

作者： Lei Gu Xumiao Li Wencheng Zhu Yi Shen Qinqin Wang Wenjun Liu Junfeng Zhang Huiping Zhang Jingquan Li Ziyi Li Zhen Liu Chen Li Hui Wang Center for Single-Cell Omics School of Public HealthShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyCAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai200031China Shanghai Applied Protein Technology Co. Ltd.Shanghai201100China University of Chinese Academy of Sciences Beijing101408China

Single-cell or low-input multi-omics techniques have revolutionized the study of pre-implantation embryo ***,the single-cell or low-input proteomic research in this field is relatively underdeveloped because of the higher threshold of the starting material for mammalian embryo samples and the lack of hypersensitive proteome *** this study,a comprehensive solution of ultrasensitive proteome technology(CS-UPT)was developed for single-cell or low-input mouse oocyte/embryo *** deep coverage and high-throughput routes significantly reduced the starting material and were selected by investigators based on their *** the deep coverage route,we provided the first large-scale snapshot of the very early stage of mouse maternal-to-zygotic transition,including almost 5,500 protein groups from 20 mouse oocytes or zygotes for each ***,significant protein regulatory networks centered on transcription factors and kinases between the MII oocyte and 1-cell embryo provided rich insights into minor zygotic genome activation.

关键词： Single-cell proteomics Low-input proteomics Maternal-to-zygotic transition Oocyte Embryo

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EM-fMRI:A Promising Method for Mapping the brain Functional Connectome

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Neuroscience Bulletin 2023年第4期39卷 707-709页

作者： Xiaoru Zhang Ming Song Jin Li Tianzi Jiang University of the Chinese Academy of Sciences Beijing100049China National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of SciencesBeijing100190China Institute of Automation Chinese Academy of Sciences Brainnetome CenterBeijing100190China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesBeijing100190China School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin541004China Research Center for Augmented Intelligence Zhejiang LabHangzhou311100China

Electrical microstimulation(EM)can be used to locally stimulate the cerebral cortex or subcortical ***,functional magnetic resonance imaging(fMRI)can noninvasively visualize the activity of the whole *** EM is combined with fMRI(EM-fMRI),it is possible to measure the changes of the whole-brain neural activity using fMRI while applying electrical stimulation to a specific brain site,and accordingly infer the causal links between the stimulated site and the activated brain areas.

关键词： Mapping cerebral fMRI

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Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

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Neuroscience Bulletin 2023年第12期39卷 1749-1761页

作者： Liang Shan Liu Yuan Bo Zhang Jian Ma Xiao Xu Fei Gu Yi Jiang Ji Dai CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Chinese Institute for Brain Research Beijing 102206China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen 518055China Key Laboratory of Brain Science Zunyi Medical UniversityZunyi563000China

Integrating multisensory inputs to generate accurate perception and guide behavior is among the most critical functions of the *** regions such as the amygdala are involved in sensory processing including vision and audition,yet their roles in multisensory integration remain *** this study,we systematically investigated the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs using a semi-chronic multi-electrode array and multiple combinations of audiovisual *** a sample of 332 neurons,we showed the diverse response patterns to audiovisual stimuli and the neural characteristics of bimodal over unimodal modulation,which could be classified into four types with differentiated regional *** the hierarchical clustering method,neurons were further clustered into five groups and associated with different integrating functions and ***,regions distinguishing congruent and incongruent bimodal sensory inputs were ***,visual processing dominates audiovisual integration in the amygdala and adjacent *** findings shed new light on the neural mechanisms of multisensory integration in the primate brain.

关键词： Macaque Amygdala-Multisensory Audiovisual integration Neural activity Multichannel recording

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Flexible multichannel electrodes for acute recording in nonhuman primates

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Microsystems & Nanoengineering 2023年第4期9卷 69-76页

作者： Yang Wang Qifan Wang Ruichen Zheng Xinxiu Xu Xinze Yang Qiang Gui Xiaowei Yang Yijun Wang He Cui Weihua Pei State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China University of Chinese Academy of Sciences Beijing 101408China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Chinese Institute for Brain Research Beijing 102206China

Flexible electrodes have demonstrated better biocompatibility than rigid electrodes in relieving tissue encapsulation and long-term *** primates are closer to humans in their brains’structural and functional properties,thus making them more suitable than rodents as animal models for potential clinical ***,the application of flexible electrodes on nonhuman primates has rarely been *** the present study,a flexible multichannel electrode array for nonhuman primates was developed and implemented for extracellular recording in behaving *** minimize the window of durotomy for reducing possible risks,a guide-tube-compatible implantation solution was designed to deliver the flexible electrodes through the dura into the *** proposed structure for inserting flexible electrodes was characterized ex vivo and validated in ***,acute recording of multichannel flexible electrodes for the primates was *** results showed that the flexible electrodes and implantation method used in this study meet the needs of extracellular recording in nonhuman ***-related neuronal activities with a high signal-to-noise ratio of spikes demonstrated that our whole device is currently a minimally invasive and clinically viable approach for extracellular recording.

关键词： recording implantation closer

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Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions

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Neuroscience Bulletin 2024年第11期40卷 1713-1731页

作者： Yanwang Huang Shangyi Wang Qingxiu Wang Chaowen Zheng Feng Yang Lei Wei Xintong Zhou Zuoren Wang Institute of Neuroscience State Key Laboratoryof NeuroscienceCAS Center for Excellence in Brain Scienceand Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Future Technology University of ChineseAcademy of SciencesBeijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The functional role of glutamatergic(vGluT2)neurons in the pedunculopontine nucleus(PPN)in modulating motor activity remains ***,we demonstrated that the activity of vGluT2 neurons in the rostral PPN is correlated with locomotion and ipsilateral *** these motor functions,we found that these rostral PPN-vGluT2 neurons remarkably respond to salient ***,we systematically traced the upstream and downstream projections of these neurons and identifed two downstream projections from these neurons to the caudal pontine reticular nucleus/anterior gigantocellular reticular nucleus(PnC/GiA)and the zona incerta(ZI).Our fndings indicate that the projections to the PnC/GiA inhibit movement,consistent with‘pause-and-play’behavior,whereas those to the ZI promote locomotion,and others respond to a new‘pause-switch-play’***,these fndings elucidate the multifaceted infuence of the PPN on motor functions and provide a robust theoretical framework for understanding its physiological and potential therapeutic implications.

关键词： Pedunculopontine nucleus Glutamatergic neuron Pause-and-play Caudal pontine reticular nucleus Anterior gigantocellular reticular nucleus Zona incerta

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Different Regional Patterns in Gray Matter-based Age Prediction

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Neuroscience Bulletin 2023年第6期39卷 984-988页

作者： Nianming Zuo Tianyu Hu Hao Liu Jing Sui Yong Liu Tianzi Jiang Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing100190China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100190China Chinese Institute for Brain Research Beijing102206China CAS Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing100190China Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu625014China Queensland Brain Institute University of QueenslandBrisbaneQLD4072Australia

Dear Editor,The brain experiences ongoing changes across different ages to support brain development and functional *** the span of adulthood,although the brain has matured from a neurobiological perspective,it is sti... 详细信息

关键词： shaped continuously Pattern

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