Lovász Local Lemma (LLL) is a very powerful tool in combinatorics and probability theory to show the possibility of avoiding all "bad" events under some "weakly dependent" condition. Over the ...
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The Hedgehog (Hh) signaling pathway plays important roles in both embryonic development and adult tissue homeostasis. Such biological functions are mediated by the transcription factor Cubitus interruptus (Ci). Ye...
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The Hedgehog (Hh) signaling pathway plays important roles in both embryonic development and adult tissue homeostasis. Such biological functions are mediated by the transcription factor Cubitus interruptus (Ci). Yet the transcriptional regulation of the effector Ci itself is poorly investigated. Through an RNAi-based genetic screen, we identified that female sterile (1) homeotic (Fsh), a transcription co-activator, directly activates Ci transcription. Biochemistry assays demonstrated physical interactions among Fsh, Sex combs extra (Sce), and Polycomb (Pc). Functional assays further showed that both Pc and Sce are required for Ci expression, which is not likely mediated by the derepression of Engraited (En), a repressor of Ci, in Pc or Sce mutant cells. Finally, we provide evidence showing that Pc/Sce facilitates the binding of Fsh at Ci locus and that the physical interaction between Fsh and Pc is essential for Fsh-mediated Ci transcription. Taken together, we not only uncover that Ci is transcriptionally regulated by Fsh-Pc-Sce complex but also provide evidence for the coordination between Fsh and PcG proteins in transcriptional regulation.
The Area Under the ROC Curve (AUC) is a well-known metric for evaluating instance-level long-tail learning problems. In the past two decades, many AUC optimization methods have been proposed to improve model performan...
With the rapid growth of the number of processors in a multiprocessor system, faulty processors occur in it with a probability that rises quickly. The probability of a subsystem with an appropriate size being fault-fr...
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Aiming at obsolescence and deficiencies of the question bank in the current teaching of computer major courses, we propose a teaching method of student independent proposition, which can not only enrich the question b...
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Nowadays, the network rumor is constantly breeding and spreading. It becomes a big difficulty to trace the source and refute the rumors with high efficiency. For this, we designed and implemented an intelligent rumor ...
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The range query on encrypted databases is usually implemented using the order-preserving encryption (OPE) technique which preserves the order of plaintexts. Since the frequency leakage of plaintexts makes OPE vulnerab...
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Spatial crowdsourcing(SC)is a popular data collection paradigm for numerous *** the increment of tasks and workers in SC,heterogeneity becomes an unavoidable difficulty in task *** researches only focus on the single-...
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Spatial crowdsourcing(SC)is a popular data collection paradigm for numerous *** the increment of tasks and workers in SC,heterogeneity becomes an unavoidable difficulty in task *** researches only focus on the single-heterogeneous task ***,a variety of heterogeneous objects coexist in real-world SC *** dramatically expands the space for searching the optimal task allocation solution,affecting the quality and efficiency of data *** this paper,an aggregation-based dual heterogeneous task allocation algorithm is put *** investigates the impact of dual heterogeneous on the task allocation problem and seeks to maximize the quality of task completion and minimize the average travel *** problem is first proved to be ***,a task aggregation method based on locations and requirements is built to reduce task ***,a time-constrained shortest path planning is also developed to shorten the travel distance in a *** that,two evolutionary task allocation schemes are ***,extensive experiments are conducted based on real-world datasets in various *** with baseline algorithms,our proposed schemes enhance the quality of task completion by up to 25% and utilize 34% less average travel distance.
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