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design of a sustained-release nanosystem for ultra-efficient absorption of anthocyanins and regulating lung damage through the “lung-gut” axis

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Journal of Advanced research 2025年

作者： Tian, Jin-Long Wang, Nuo Zhao, Qin-Fu Zang, Zhi-Huan Li, Zhi-Ying Wang, Zhen-Yu Zhou, Ying Yang, Bao-ru Makarov, Sergey S. Chudetsky, Anton I. Wang, Liang He, Ying Li, Bin College of Food Science Shenyang Agricultural University National R&D Professional Center for Berry Processing National Engineering and Technology of Research Center for Small Berries Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing Liaoning Province Shenyang 110866 China Department of Pharmaceutics School of Pharmacy Shenyang Pharmaceutical University 103 Wenhua Road Liaoning Province Shenyang 110016 China Food Sciences Department of Life Technologies University of Turku Turku Finland Moscow Timiryazev Agricultural Academy Russian State Agrarian University Moscow 127550 Russian Federation School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin China Zhejiang Lanmei Technology Co. Ltd. Zhejiang Zhuji 311800 China

Introduction: Anthocyanins have various health benefits but are limited by fast elimination and low bioavailability. Many studies have shown that nano delivery systems are effective in improving the intestinal absorption and bioavailability of anthocyanins. However, in the process of selecting anthocyanin nanomaterials, a dilemma is faced: numerous functional nanomaterials lack edible properties, it is difficult to meet the edible and functional requirements of nanomaterials simultaneously. Therefore, it is necessary and inevitable to select nano-anthocyanin carriers that are edible and have certain functional and morphological characteristics. Objectives: The study aim to provide an efficient, sustained-release and easy to industrialize nanosystem method to solve the problem of low bioavailability of anthocyanins. Methods: A succinylated casein-phospholipid-anthocyanin nanosystem (CLS) was designed via computational chemistry-guided one-step self-assembly. Morphological, in vitro/in vivo digestion, pharmacokinetic were conducted. Furthermore, the effects of CLS on intestinal microecology were verified by using enteritis model animals, and the lung-targeting effect of CLS on lung health was verified by using lung injury model animals. results: CLS exhibited 24-hour intestinal sustained release and lung-targeted enrichment. Pharmacokinetic studies showed 25.7-fold higher lung AUC_(0-t) and 13.1-fold higher blood AUC_(0-t) compared to free anthocyanins. CLS significantly alleviated lung injury and colitis in model rats via the gut-lung axis. conclusion: This study significantly improved the bioavailability of anthocyanins and demonstrated the oral lung-targeting function of anthocyanins for the first time, paving the way for utilizing anthocyanins as dietary supplements and precision nutrition. © 2025 The Authors

关键词： Anthocyanins Bioavailability Lung enrichment Nanodelivery Pharmacokinetics

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Position based in-motion alignment method for an auv

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Journal of Institute of control, robotics and Systems 2020年第8期26卷 649-659页

作者： Choo, Jinwoo Lee, Gwonsoo Lee, Phil-Yeob Kim, Ho Sung Lee, Hansol Park, daegil Lee, Jihong Department of Mechatronics Engineering of Chungnam National University Korea Republic of Naval R&D Center Hanwha Systems Co. Ltd Korea Republic of Autonomous System R&D Center Korea Institute of Robot and Technology Convergence Korea Republic of

This paper describes a position based in-motion alignment method for underwater navigation of an AUV(Autonomous Underwater Vehicle). For proper estimation of the position and orientation of the AUV the navigation algorithm requires accurate initial values of its position and attitude. However, it is difficult to obtain exact attitude of the AUV in the marine environment, because of the AUV’s body drift caused by flow of the water. To avoid this, in general, the initial alignment is performed on shore using gravitational acceleration, with further launching of AUV into the water. In this paper, we propose the in-motion alignment algorithm that is able to accurately estimate azimuth in the marine environment. Additionally, the proposed method allows to correct velocity of the AUV. © ICrOS 2020.

关键词： Autonomous underwater vehicles

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Enhanced electrochemical capture of bromine ions from aqueous solutions using SrBiO 2 Br@PPy: A synergistic electroactive material

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Chemical engineering Science 2025年 316卷

作者： Wenlei Fan Haojie Ge Jinghui Li Lejian Zhang Jianlu Liu Yafei Guo Haobo Zhang Tianlong deng State Key Laboratory of Bio-based Fiber Materials Key Laboratory of Marine Resource Chemistry and Food Technology (TUST) in Ministry of Education College of Chemical Engineering and Materials Science Tianjin University of Science and Technology Tianjin 300457 P.R. China Technology R&D Centre of Shandong Haihua Group Co. LTD Weifang 262737 P.R. China

conventional techniques for the removal of bromine ions present several challenges, including low efficiency, high operational costs, and the generation of secondary waste. A novel electroactive composite material of SrBiO 2 Br that efficiently captures bromine ions from aqueous solutions has been reported. The composite material combines the photocatalytic properties of SrBiO 2 Br with the conductive nature of polypyrrole (PPy), thereby markedly enhancing the efficiency of bromine ions removal. The integration of SrBiO 2 Br with PPy’s conductive network results in the formation of a composite material that enhances charge separation and transport due to the more compact structure and improved stability of SrBiO 2 Br. The experimental results demonstrate that SrBiO 2 Br@PPy exhibits excellent bromine capture performance under various voltage and pH conditions, along with promising cycling stability. Under neutral conditions (pH = 7), isothermal modeling analyses further confirmed the high adsorption capacity of this material for Br - , with a theoretical maximum adsorption capacity of 190.29 mg/g, and even a maximum adsorption capacity of 260.13 mg/g under acidic conditions. This research contributes to the advancement of water treatment technologies, particularly in the area of bromide ion extraction for the treatment of specific wastewater, such as those from coal processing, and provides new strategies for improving water quality.

关键词： Bromine capture Electroactive material Electrochemistry SrBiO2Br

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design of control Algorithm of Wheeled robot Based on Wi-Fi and Inertial navigation

Design of Control Algorithm of Wheeled Robot Based on Wi-Fi ...

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Annual conference of Industrial Electronics Society

作者： Zhifeng Wang Heng Xie Zeqin Lin Tao Wen Zhiming Zhen Haichu Chen School of mechanical and electrical engineering Foshan University Foshan China Technology R&D Center Foshan designa technology co. LTD Foshan China

ISBN: (数字)9781728154145

ISBN: (纸本)9781728154152

This paper design a path planning smart car system based on STM32. It can use MPU6050 module to adjust the direction of route and the angle of the turning. Moreover, We use infrared modules and obstacle avoidance algorithms to complete the obstacle avoidance function, and the robot can move along a U-shaped trajectory. While the Wi-Fi module is used as communication to transmit data to the App developed on the Android platform, so as to control the moving distance of the car. We build the software system and the hardware system to test the control algorithm and the ability of avoiding obstacle. The robot runs 20 meters at a speed of 0.3m/s, and it is obtained that its yaw offset is about 1.3 degrees, and its trajectory offset is about 5cm. The results show that the robot can avoid obstacles on the ground and has certain stability, which provides a reference for the further development of a more intelligent robot car.

关键词： robot sensing systems Automobiles collision avoidance Mobile robots Trajectory Sockets Process control

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robust force tracking control via backstepping sliding mode control and virtual damping control for hydraulic quadruped robots

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Journal of Central South University 2020年第9期27卷 2673-2686页

作者： SHEN Wei Lü Xiao-bin MA Chen-jun Department of Mechatronics Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310000China Libin Technology R&D Center Shanghai Electric Hydraulic&Pneumatics Co.Ltd.Hangzhou 310000China

In order to improve the force tracking performance of hydraulic quadruped robots in uncertain and unstructured environments,an impedance-based adaptive reference trajectory generation scheme is ***,in order to improve the robustness to environmental changes and reduce the contact force errors caused by trajectory tracking errors,the backstepping sliding mode controller is combined with the adaptive reference trajectory ***,a virtual damping control based on velocity and pressure feedback is proposed to solve the problem of contact force disappearance and stall caused by sudden environmental *** simulation results show that the proposed scheme has higher contact force tracking accuracy when the environment is unchanged;the contact force error can always be guaranteed within an acceptable range when the environment is reasonably changed;when the environment suddenly changes,the drive unit can move slowly until the robot re-contacts the environment.

关键词： hydraulic quadruped robot impedance control backstepping sliding mode control virtual damping control

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Unevenly Modulation of Prime-Numbered Blades and Tonal Noise reduction Based on the cosecant Function

SSRN

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SSrN 2025年

作者： Zhou, Hao Wang, Wei Zhu, Jiajing Wang, Jun School of Energy and Power Engineering Huazhong University of Science and Technology Address One Hubei Wuhan430074 China Guangdong Sunwill Precision Plastic Co. Ltd. Basic research of R&D Center Address Two Guangdong Foshan528305 China Huazhong University of Science and Technology China

Unevenly blade modulation has emerged as a key technique for turbomachinery tonal noise reduction, yet conventional sine/cosine-based modulation methods exhibit limitations when applied to prime-numbered blade configurations and in suppressing higher-order harmonics. To overcome these challenges, our study innovatively redistributes phase angles of two specific blades under static balance constraints, enabling effective unevenly design for prime-numbered blades. And for the first time, a cosecant-based modulation is proposed, leveraging its singularity characteristics to enhance sensitivity and nonlinear effects to suppress higher harmonics. comprehensive tests on forward/backward-curved squirrel-cage fans show that prime-numbered rotors modulated via the improved cosecant method achieve greater tonal noise reduction, more dispersed spectral energy, and significantly attenuated secondary harmonic peaks compared to traditional methods. The methodology's universal applicability is rigorously validated across various impeller configurations, including different blade counts (Z=7,9,13), modulation amplitudes, and modulation periods. detailed noise spectral and flow field analysis further elucidates the underlying aerodynamic performance modifications and noise generation mechanisms associated with the proposed modulation strategy. This study offers practical solutions for enhanced noise control in turbomachinery through innovative unevenly modulation techniques, while providing valuable insights for broader industrial implementation of advanced noise reduction technologies. © 2025, The Authors. All rights reserved.

关键词： Noise abatement

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Effect of specimen configuration and notch root angle on fatigue behavior of novel dissimilar resistance spot welds of AA5754 to HSLA steel

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Procedia Structural Integrity 2022年 37卷 351-358页

作者： Liting Shi Jia Xue Jidong Kang Amberlee S. Haselhuhn Blair E. Carlson School of Materials Science and Engineering Tianjin University 92 Weijin Road Tianjin 300072 China Canmet MATERIALS 183 Longwood Road South Hamilton L8P 0A5 Canada China Automotive Technology and Research Center Co. Ltd. 68 East Xianfeng Road Tianjin 300300 China General Motors Global R&D Center 30470 Harley Earl Blvd Warren MI 48092 U.S.A.

Facing stringent requirements for fuel economy and regulations for greenhouse gas emissions, structural lightweighting using multi-material solutions has become commonplace in the automotive industry. When joining dissimilar materials such as aluminum to steel by resistance spot welding (rSW), a thin layer of brittle intermetallic compound forms at the aluminum-steel interface and dominates mechanical behavior of the joint. In this contribution, rSW of 1.1 mm thick AA5754 sheet to 2.0 mm thick high-strength low-alloy (HSLA) steel sheet was performed using multi-ring domed (Mrd) electrodes and multiple solidification weld schedules to achieve acceptable static joint strength. Load-controlled fatigue tests were conducted and the results show that the fatigue life is longer in the AA5754 to HSLA steel spot welds than that of the 1.1 mm thick AA5754 joined to itself (aluminum-aluminum). Structural stress analysis revealed that all fatigue life data points from both the lap shear and coach peel configurations fall onto a single master curve indicating that the weld nugget diameter is the controlling parameter for fatigue life. Finite element simulation considering material inhomogeneity in the weld further confirms that a large notch root angle at the weld nugget is beneficial to yield longer fatigue life as less maximum principal strain occurs in the aluminum sheet in the AA5754-HSLA steel spot welds.

关键词： Fatigue life resistance spot welding Aluminum-steel dissimilar welding

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development of Micron-Sized Cu–Ag composite Paste for Oxidation-Free Bare Cu Bonding in Air condition and its deterioration Mechanism during Aging and Power Cycling Tests

SSRN

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SSrN 2023年

作者： Chen, Chuantong Kim, dongjin Liu, Yang Sekiguchi, Takuya Su, Yutai Long, Xu Liu, Canyu Liu, Changqing Suganuma, Katsuaki Flexible 3D System Integration Laboratory Osaka University 8-1 Mihogaoka Ibaraki Osaka5670047 Japan Advanced Joining and Additive Manufacturing R&D Department Korea Institute of Industrial Technology 156 Geatbeolro Incheon21999 Korea Republic of Central Research Center TOPPAN FORMS CO. LTD. 1-2-6 Owada-cho Hachioji-shi Tokyo Japan School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University Shaanxi Xi’an710129 China Wolfson School of Mechanical Electrical and Manufacturing Engineering Loughborough University LoughboroughLE11 3TU United Kingdom

The development of next-generation power electronics requires the semiconductor power devices with higher voltage endurance, higher electrical current density under high-temperature operations above 250°C. Herein, we propose the uses of combined micron-sized Cu particles with Ag–amino composite to achieve a robust direct Cu–Cu bonding under a low sintering pressure and temperature (300°C) in ambient atmosphere. The strong bonding strength of the Cu–Cu joint structure was evaluated as high as 45.3 MPa under 300°C sintering temperature with low pressure (1 MPa). For the high temperature reliability evaluation, the sintered Cu-Ag salt composite Cu-Cu joints were stored at 250 °C in air;the shear strength of the joints remains above 30 MPa after 500 h ageing, suggesting an excellent mechanical stability during high temperature storage. Additionally, a SiC Schottky barrier diode with the sintered Cu–Ag salt composite joint structure was evaluated during a power cycle test at a junction temperature of 200°C for 10,000 cycles. The thermal resistance of the joint structure was almost unaffected, and no large delamination in the bonding layer was observed after the power cycle test, indicating that the Cu–Ag composite joints as a die attach material exhibit remarkable potential in SiC power devices packaging. © 2023, The Authors. All rights reserved.

关键词： Silicon carbide

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Numerical simulation analysis and optimization of modular joint temperature field based on ANSYS

Numerical simulation analysis and optimization of modular jo...

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第33届中国控制与决策会议

作者： Tao Zhang Wenjing Xu Zizhao Huang Zhenqiang Yang Xiyou Chen Bingjie Zhao Hualiang Zhang School of Electrical Engineering Dalian University of Technology Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Key Laboratory of Networked Control Systems Chinese Academy of Sciences CRRC DALIAN R&D CO. LTD. University of Chinese Academy of Sciences

In the low-speed state,temperature change has a significant impact on the working efficiency of a harmonic ***,since modular joints used in collaborative robots arbitrarily arrange nodes and meshes through the Finite Element Method(FEM),a temperature field calculation model of the integrated joints was established in this *** utilizing the ANSYS software,a steady-state temperature field distribution of the modular joint was calculated,and the temperature rise of the harmonic reducer was reduced by changing the thermal *** the results demonstrated that the method was effective,which is very important for the safe operation and performance improvement of modular j oints.

关键词： harmonic reducer modular joint Finite Element Method Temperature Field ANSYS

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Predictive model of frailty onset using Bayesian network

Predictive model of frailty onset using Bayesian network

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IEEE International conference on Big data

作者： Yujiro Kawai Eiichi Sakurai Yuki Sugawara Yukihiko Okada Kai Tanabe Akiko Tsukao Shinya Kuno National Institute of Advanced Industrial Science and Technology Tokyo Japan University of Tsukuba Tsukuba Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and Technology Tokyo Japan Institute of Systems and Information Engineering Center for Artificial Intelligence Research University of Tsukuba Tsukuba Japan R&D Center for Smart Wellness City Policies University of Tsukuba Tsukuba Japan Tsukuba Wellness Research Co. Ltd Chiba Japan

ISBN: (纸本)9781665480468

In this study, we constructed a model for predicting the future frailty status of individuals based on information regarding their current lifestyle habits. In recent years, as the global population ages, the number of people certified for long-term care has increased. In an effort to prevent the need for long-term care, prediction of the onset of frailty, which is positioned as a preliminary stage of the caregiving state, is gaining attention. However, the onset of frailty takes a long time, and the incidence of frailty differs according to one’s health literacy. Therefore, a prediction is extremely difficult to achieve. In this study, we constructed a prediction model using a probabilistic latent semantic analysis and a Bayesian network. First, the probabilistic latent semantic analysis was conducted to classify individuals according to their health literacy. Second, we constructed a future frailty prediction model using a Bayesian network for each health literacy segment. As a result, we clarified the following: It is more appropriate to predict a future frailty by predicting the future lifestyle using information on the current lifestyle. In addition, more accurate prediction models can be constructed when individuals are divided based on their health literacy.

关键词： Analytical models Semantics Buildings Urban areas Predictive models Big data Probabilistic logic

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