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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

Nano research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-Hoon Lee Yong Chui Shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kda enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

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Origin and Improvement of LCd reflectivity

Origin and Improvement of LCD Reflectivity

引用

SId Symposium, Seminar, and Exhibition 2019, display Week 2019

作者： Chen, Lixuan Lin, Xulin Yan, Chunqiu Chen, Hsiao-Hsien Lin, Hsichien Zhang, Xin Zhang, Shengdong Sun, Xiao Wei School of Electronic and Computer Engineering Peking University Shenzhen China Department of Electrical & Electronic Engineering Southern University of Science and Technology Shenzhen China R&D Center She nzhen China Star Optoelectronics Technology Co. Ltd. Guangming New District Shenzhen China

ISBN: (纸本)9781510896161

reflective light from a LCd panel without polarizers is analyzed and simulated. The influence of ITO, PI,BM and Metal are analyzed separately. An interlayer is designed and fabricated to alleviate reflectance at interface between glass substrate and the functional layers. As a result, the total reflectivity of a color Filter on Array LCd with the special polarizers is decreased from 1.5% to 0.8% or even lower for 4K UHd products. Author Keywords © 2019 SId.

关键词： reflection

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Synthesis and properties of modified polyimides containing multiple side methyl and biphenyl structures

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Journal of Macromolecular Science, Part A 2024年第12期61卷

作者： Jingyi Zhu Yan Ma Xiaokun Pan Chenyi Wang a Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials School of Materials Science and Engineering Changzhou University Changzhou Jiangsu China a Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials School of Materials Science and Engineering Changzhou University Changzhou Jiangsu Chinab Heze Key Laboratory of New Generation Information Technology Basic Materials R&D Shandong Xingshun New Materials Co. Ltd Heze Shandong China

With the rapid development of 5 G technology and microelectronics, there is an urgent demand to design and develop modified polyimide films with low dielectric constant as flexible matrix materials. In this work, a diamine containing multiple side methyl and biphenyl groups was synthesized by aromatic nucleophilicsubstitution reaction and oxidation-reduction reaction, respectively. Furthermore, this monomer was used to polymerize with four different commercially available dianhydrides (OdPA, BTdA, BPdA, and PMdA) to produce a class of polyimides (PI 3a∼3d). The structures of the diamine and its PIs are characterized, and the relationship between the structure and properties of the obtained PI films is investigated. These modified PIs are easy to cast into films and have low dielectric constants and water absorption. Their dielectric constants and dielectric losses are in the range of 2.66–2.91 and 0.00579–0.00677 at 1 MHz, respectively. Meanwhile, these PIs also maintains good thermal stability, with glass transition temperatures (Tg) higher than 284 °C and 10% weight loss temperatures in the range of 496–505 °C at *** abstractdisplay full size

关键词： Polyimides dielectric constant thermal stability solubility water absorption

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research on the performance changes of the binder of the wear layer of open-graded asphalt mixture under different aging methods

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IOP conference Series: Materials Science and engineering 2021年第1期1028卷

作者： Jianjun Tian Xiao Shi Hongpo Chen Shuzhen Ji R&D engineer Shanghai municipal engineering design institute (Group) Co. Ltd Shanghai 200092 China Senior engineer Shanghai municipal engineering design institute (Group) Co. Ltd Shanghai 200092 China R&D engineer Shanghai roadphalt asphalt technology co. ltd Shanghai 200092 China

In order to study the effect of asphalt aging of open-graded friction course (OGFC) on the performance of high-viscosity styrene-butadiene-styrene(SBS) modified asphalt during the mixing of the asphalt mixtures and the whole life cycle, Thin Film Oven Test (TFOT), rolling Thin Film Oven Test (rTFOT), and Pressurized Aging Vessel Accelerated Asphalt Aging Test (PAV) were used to conduct aging tests on the high-viscosity SBS modified asphalt. And then the aging of SBS modified asphalt is studied at two levels: microscopic and macroscopic. In the microscopic aspect, first use the fluorescence microscope technology to image the asphalt samples before and after aging. The above images were processed by MATLAB and Image-pro plus software, and the micro-structures of high viscosity SBS modified asphalt before and after aging were obtained. At the same time, use the dSr test to observe the changes in the rheological properties of the SBS modified asphalt before and after aging. On the macro level, the softening point, viscous toughness and pull strength are used to analyse the changes in the mechanical properties of the high-viscosity SBS modified asphalt before and after aging, and the aging conditions of the SBS modified asphalt under the micro and macro indexes are compared. The research shows that after short-term aging (simulation of asphalt aging during the mixing ), rTFOT and TFOT the loss ratio of SBS in modified asphalt are at 78.5% and 68.3%, respectively, the degradation of SBS in modified asphalt is serious, and the SBS modified asphalt aging conditions under the macro and micro indicators are consistent. After long-term aging (simulating the aging of the asphalt during the whole life cycle), the loss ratio of SBS in modified asphalt is 83.4% (rTFOT + PAV) and 84.6% (TFOT + PAV). However, the macroscopic index of SBS modified asphalt shows obvious differences. The aging degree of SBS modified asphalt using rTFOT + PAV aging method is significantly higher than th

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Optimizing wind turbine blade performance: A multi-objective approach for power, load and stall characteristics

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Energy 2025年 331卷

作者： Siyuan Wu Chang Cai Lei Zhang Zhiqiang Hu Xiangyu Sun Xiaohui Zhong Chaoyi Peng Keqilao Meng Jianyu Kou Qing’an Li National Energy Wind Turbine Blade R&D Center Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100190 China The Key Laboratory of Wind Energy Utilization of Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China School of Engineering Newcastle University Newcastle Upon Tyne NE1 7RU UK Goldwind Science&Technology Co. Ltd Beijing 100176 China Zhuzhou Times New Materials Technology Co. Ltd Zhuzhou 412007 China School of Energy and Power Engineering Inner Mongolia University of Technology Hohhot 010051 China Inner Mongolia Energy Group Hohhot 010051 China

Ultra-long flexible wind turbine blades are essential for advancing large-scale and offshore wind energy projects. despite significant progress, optimizing these blades remains a complex challenge due to the need to balance multiple performance objectives simultaneously. In this study, we developed a multi-objective optimization approach for wind turbine blade design that quantitatively addresses power, load, and stall characteristics. To validate the methodology, it was applied to the design of a 2MW wind turbine blade, and the optimized design was compared with a base blade. Sensitivity analysis of the optimization weight parameters was also conducted to enhance the robustness of the approach. The results indicate notable improvements in key performance metrics, including a 1.7% increase in average power generation, a 2.1% reduction in the maximum flap-wise moment at the blade root, and a 1.5°decrease in the running angle of attack. Moreover, the critical tip speed ratio (TSr) decreased by 0.6, aligning with the stall angle and indicating enhanced stall performance. This study not only demonstrates the effectiveness of the multi-objective coupling optimization method but also introduces innovative techniques for stall risk assessment and optimal TSr control, thereby contributing to the advancement of wind turbine blade design.

关键词： Blade design Genetic algorithm Multi-objective optimization Stall assessment Wind turbine

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Oral Administration of Hydrolyzed Egg Yolk Peptides With Low Molecular Weight Increased Bone density by regulating Bone Metabolism and Immune responses

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Journal of food science 2025年第6期90卷 e70255页

作者： Weiying Luan Yemin Hu Wei Sun Jiasheng Bao Bingzhen Pan Haimin Mai Qi Li ruikun He Xuguang Zhang Hong Jiao School of Food Science and Engineering South China University of Technology Guangzhou China. BYHEALTH Institute of Nutrition & Health BYHEALTH Co. Ltd. Guangzhou China. Quality Department Sinolight Inspection & Certification (Guangzhou) Co. Ltd. Guangzhou China. Guangzhou Customs Technology Center Guangzhou Customs District P.R.China Guangzhou China. Department of Orthopedics Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou China. R&D Department Guangzhou BaoLvkang Biotechnology Co. Ltd Guangzhou China. Shanghai Institute of Nutrition and Health The Chinese Academy of Sciences Shanghai China.

Hydrolyzed egg yolk peptides have been proven to improve bone density in animals of different ages. However, the peptides profile and function of low molecular weight hydrolyzed egg yolk peptides have not been studied, which may have better efficacy, the relationship between these peptides and humoral immunity has not been noticed yet. This study analyzed the amino acid composition and molecular weight distribution of Shinupep, a low-molecular-weight hydrolyzed egg yolk peptides suitable for industrial production. It also investigated its effects and mechanisms in improving osteoporosis in ovariectomized rats. Oral administration 8.33 and 50 mg/d/kg Shinupep significantly increased the levels of the bone formation marker BGP while reducing the levels of bone resorption markers alkaline phosphatase and tartrate-resistant acid phosphatase. It also notably enhanced humoral immunity markers immunoglobulin G and immunoglobulin M and lowered the inflammatory marker receptor activator for nuclear factor-κB ligand. Additionally, Shinupep significantly increased cortical bone thickness, trabecular number, and bone density. The improvements in bone density and microarchitecture observed with the Shinupep were achieved through the regulation of bone metabolism, as well as modulation of both humoral and cellular immunity. Notably, this is the first time to reveal the role of humoral immunity in the hydrolyzed egg yolk peptides' ability to ameliorate osteoporosis.

关键词： Bone metabolism Bone mineral density Femur Humoral immunity Hydrolyzed egg yolk peptides Tibia

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Chelation of cerium (III) with fish skin collagen peptides: Improving the in vitro stability and bioavailability of inorganic cerium

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Food research International 2025年 217卷

作者： Peihan Wu Zongcai Tu Hui Wang Yueming Hu Jie Cheng Hai-bin Liu Pingwei Wen State Key Laboratory of Food Science and Resources Nanchang University Nanchang 330047 China National R&D Center of Freshwater Fish Processing Jiangxi Normal University Nanchang 330022 China Engineering Research Center of Freshwater Fish High-value Utilization of Jiangxi Province Jiangxi Normal University Nanchang 330022 China National Engineering Technology Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co. Ltd. Liaocheng Shandong 252201 China

Purified fish skin collagen peptide (FSCP) was used to chelate Ce 3+ to prepare peptide‑cerium chelate (FSCP-Ce) to improve their in vitro stability and cellular uptake for oral delivery. The study revealed that the primary chelation sites between FSCP and Ce 3+ were located on the side chains of tryptophan, aspartic acid, glutamic acid, lysine and histidine (cerium-chelating capacity 75.32 mg/g). FSCP-Ce showed good in vitro stability, gastrointestinal digestive stability. Furthermore, this study demonstrated that the 1.32 mg/mL FSCP-Ce significantly increase cell viability (FSCP-Ce: 98.77 ± 1.56 % VS CeCl 3 : 64.21 ± 1.92 %) and cerium absorption (FSCP-Ce: 57.59 ± 2.51 % VS CeCl 3 : 27.29 ± 2.02 %) compared to 1 mg/mL CeCl 3 . The endocytosis pathway results indicate that the main cellular transport pathways for FSCP-Ce are giant cytosol drinking and vesicle protein-dependent endocytosis, which adds multiple uptake pathways compared to CeCl 3 . This research establishes a basis for investigating peptide‑cerium chelate as a new type of nutritional supplement, aiming to lower cerium toxicity while enhancing its bioavailability.

关键词： Chelation

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Multi-site, Multi-domain Airway Tree Modeling (ATM’22): A Public Benchmark for Pulmonary Airway Segmentation

arXiv

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arXiv 2023年

作者： Zhang, Minghui Wu, Yangqian Zhang, Hanxiao Qin, Yulei Zheng, Hao Tang, Wen Arnold, corey Pei, Chenhao Yu, Pengxin Nan, Yang Yang, Guang Walsh, Simon Marshall, dominic C. Komorowski, Matthieu Wang, Puyang Guo, dazhou Jin, dakai Wu, Ya'nan Zhao, Shuiqing Chang, runsheng Zhang, Boyu Lv, Xing Qayyum, Abdul Mazher, Moona Su, Qi Wu, Yonghuang Liu, Ying'ao Zhu, Yufei Yang, Jiancheng Pakzad, Ashkan rangelov, Bojidar Estepar, raul San Jose Espinosa, Carlos Cano Sun, Jiayuan Yang, Guang-Zhong Gu, Yun Institute of Medical Robotics Shanghai Jiao Tong University Shanghai200240 China Department of Respiratory and Critical Care Medicine Department of Respiratory Endoscopy Shanghai Chest Hospital Shanghai China InferVision Medical Technology Co. Ltd. Beijing China Imperial College London London United Kingdom Alibaba DAMO Academy 969 West Wen Yi Road Zhejiang Hangzhou China Alibaba DAMO Academy USA 860 Washington Street 8F New York United States College of Medicine and Biological Information Engineering Northeastern University Shenyang China A.I R&D Center Sanmed Biotech Inc. No. 266 Tongchang Road Xiangzhou District Guangdong Zhuhai China A.I R&D Center Sanmed Biotech Inc. T220 Trade st. San DiegoCA United States ENIB UMR CNRS 6285 LabSTICC Brest29238 France Shanghai Jiao Tong University Shanghai China School of Information Science and Technology Fudan University Shanghai China University of Science and Technology of China Anhui Hefei China Dianei Technology Shanghai China EPFL Lausanne Switzerland Department of Surgery and Cancer Imperial College London London United Kingdom University of California Los AngelesCA United States Department of Computer Engineering and Mathematics University Rovira I Virgili Tarragona Spain Brigham and Women’s Hospital Harvard Medical School SomervilleMA02145 United States Medical Physics and Biomedical Engineering Department University College London London United Kingdom Center for Medical Image Computing University College London London United Kingdom

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolution. Since EXACT’09 pulmonary airway segmentation, limited effort has been directed to quantitative comparison of newly emerged algorithms driven by the maturity of deep learning based approaches and clinical drive for resolving finer details of distal airways for early intervention of pulmonary diseases. Thus far, public annotated datasets are extremely limited, hindering the development of data-driven methods and detailed performance evaluation of new algorithms. To provide a benchmark for the medical imaging community, we organized the Multi-site, Multi-domain Airway Tree Modeling (ATM’22), which was held as an official challenge event during the MICCAI 2022 conference. ATM’22 provides large-scale CT scans with detailed pulmonary airway annotation, including 500 CT scans (300 for training, 50 for validation, and 150 for testing). The dataset was collected from different sites and it further included a portion of noisy coVId-19 CTs with ground-glass opacity and consolidation. Twenty-three teams participated in the entire phase of the challenge and the algorithms for the top ten teams are reviewed in this paper. Quantitative and qualitative results revealed that deep learning models embedded with the topological continuity enhancement achieved superior performance in general. ATM’22 challenge holds as an open-call design, the training data and the gold standard evaluation are available upon successful registration via its homepage (https://***/). copyright © 2023, The Authors. All rights reserved.

关键词： computerized tomography

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defining Three distribution System Scenarios for Microgrid Applications

Defining Three Distribution System Scenarios for Microgrid A...

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IEEE conference on Energy Internet and Energy System Integration (EI2)

作者： Chendan Li Olav Bjarte Fosso Marta Molinas Yue Jingpeng Pietro raboni Dep. of Electric Power Engineering Dep. of Engineering Cybernetics Norwegian University of Science and Technology (NTNU) Trondheim Norway Electric Power Research Institute Guangdong Power Grid Co. Ltd Guangzhou China System R&D ENGIE EPS Milano Italy

ISBN: (数字)9781728196060

ISBN: (纸本)9781728196077

Power systems, especially distribution systems, are undergoing the most drastic overhauls with the growing integration of renewable energy and digitalization. One of the most efficient technological solutions to address the challenges the distribution system faces today, is the formation of microgrids. With heterogeneous driving forces from policy, regulation, system operation, infrastructure developer, aggregator, and end-user, how microgrid will evolve and develop in the future distribution system remains an open question and deserve closer scrutiny. In this paper, a brief state of the art of current microgrid design is introduced considering knowledge and experience from both practitioner and academia. Based on a simple foresight method, three foreseeable scenarios for the future distribution system are depicted. Aspects related to its use cases, energy management system features, and market models will be discussed for each possible scenario. This will shed light onthe future research and development of microgrid applications.

关键词： renewable energy sources Systems operation Microgrids System integration regulation Power systems research and development

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Proanthocyanidin Capsules remodel the rOS Microenvironment Via regulating Mapk Signaling for Accelerating diabetic Wound Healing

SSRN

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SSrN 2024年

作者： Wei, Shaoyin Yang, dong Shou, Zeyu Zhang, Yipiao Zheng, Shengwu Zan, Xingjie Li, Lianxin Zhang, Chunwu School of Ophthalmology and Optometry Eye Hospital School of Biomedical Engineering Wenzhou Medical University Wenzhou325035 China Wenzhou Institute University of Chinese Academy of Sciences Zhejiang Wenzhou325001 China Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University Shandong Jinan250100 China The First Affiliated Hospital of Wenzhou Medical University Zhejiang Wenzhou325000 China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology No. 18 Chaowang Road Gongshu District Zhejiang Hangzhou310014 China Zhejiang Provincial Key Laboratory of TCM for Innovative R&D and Digital Intelligent Manufacturing of TCM Great Health Products Huzhou313200 China Wenzhou Celecare Medical Instruments Co. Ltd Wenzhou325000 China Department of Orthopaedics Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong Province Jinan City250021 China Wenzhou Medical University China

The complex nature of the healing deficits associated with diabetic wounds represents a significant clinical challenge. Hyperglycemia-induced excess reactive oxygen species (rOS) activate the MAPK signaling pathway (especially the p38 MAPK), which results in the sustained release of inflammatory factors, leading to cell damage and apoptosis. At present, agents that modulate p38 MAPK are ineffective due to their restricted regulatory capacity and side effects. Plant-derived polyphenols are regarded as highly effective rOS scavengers;however, their low bioavailability (easily degraded in vivo and low efficiency in endocytosis) significantly restricts their application in biomedicine. Herein, we developed a simple and efficient method to prepare proanthocyanidin (PC) capsules, which were constructed through hydrogen bonding and hydrophobic interactions between PC molecules. PC capsules exhibited long-lasting scavenging of multiple free radicals, sustained release of PC molecules, and efficient endocytosis by cells, which dramatically improved the bioavailability of PCs and enabled the healing of traumatic wounds of diabetic mice in just one administration. It was demonstrated that PC capsules markedly diminished the concentration of inflammatory mediators and impeded apoptosis by modulating the p38 MAPK signaling cascade, thereby remodeling the rOS microenvironment of diabetic wounds and accelerating the healing. This study has made an important contribution to the field of polyphenol bioavailability and provided insights into the potential of regulating the MAPK signaling pathway, with implications for the treatment of other inflammatory and oxidative stress-related disorders. © 2024, The Authors. All rights reserved.

关键词： Cell death

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