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Optimization of welding parameters for the joint interface of rotary friction welds

AIP conference Proceedings 2022年第1期2648卷

作者： Muralimohan Cheepu S. Venukumar K. Harisivasri Phanindra N. Likhith Mohammad Sameer M. Sai Johith Venkateswarlu devuri Charan Kantumunchu 1Super-TIG Welding Co. Limited Busan 46722 Republic of Korea 2Department of Mechanical Engineering Vardhaman College of Engineering Telangana 501218 India 3Department of Mechanical Engineering Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology Tamilnadu 600062 India 4Department of Mechanical Engineering Marri Laxman Reddy Institute of Technology and Management Telangana 500043 India 5A Division of Methode Electronics Malta Ltd. Hetronic USA Oklahoma USA

dissimilar joining using friction welding is demanding for various applications. Friction welding makes it possible to weld incompatible materials. In the present investigation, carbon steel to high strength steel dissimilar materials was joined using rotary friction welding. The interface characteristics were identified according to the welding conditions. The welding conditions were optimized to observe the intermixing zone width at the weld interface. The major influencing welding parameters of friction pressure, upsetting pressure, and friction time was selected as input factors and intermixing zones as the response factor. The intermixing zone’s width increased with the increase of friction pressure and upsetting pressure along with the friction time. The intermixing zone microstructural analysis revealed the mixed layers of carbon steel and high-strength steel materials in several widths.

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A routing Algorithm for delay Tolerant Networks

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Journal of Physics: conference Series 2020年第1期1684卷

作者： Liu Bin Wang Zhi-lin Zhu ren-jie R&D department Zhongke Jiudu (Beijing) Space Information Technology Co. Ltd Beijing China R&D department Zhongke edge intelligent information technology (Suzhou) Co. Ltd Suzhou China School of Computer science and Engineering Nanjing University of Technology Nanjing China

Based on the limitations of traditional submission ratio of Prophet caused by the performance difference and state difference of nodes in the new service environment, and the idea of utility quantization, a Prophet-BSAS algorithm based on node state was designed. The utility parameters and utility functions of the improved algorithm were analyzed in detail, and the performance of Prophet-BSAS and other classical routing algorithms was simulated and analyzed under the typical mobility model.

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Wear resistance and fracture behavior of thermally sprayed Al-based quasicrystalline composite coatings

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Journal of Physics: conference Series 2021年第1期2044卷

作者： Meng Xiao Zhaoguo Qiu Yaosha Wu dechang Zeng School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China Zhongshan R&D Center for Materials Surface and Thin Films Technology of the South China University of Technology Gent Materials Surface Technology (Guangzhou) Co. Ltd Zhongshan 528437 China Zhongshan Torch Polytechnic Zhongshan 528436 China

Tailoring coating microstructure and the fraction of quasicrystalline phase for enhancing the wear and crack resistance by selecting the appropriate thermal spraying parameters was investigated. To simplify the optimization process, orthogonal test was introduced. According to the statistical analysis and validation experiments, the orders of spraying-parameters that affected the hardness and fraction of quasicrystalline phase were proposed, respectively. The wear resistance and fracture behaviors of coating sprayed with optimal processing parameters were analyzed by pin-on-disk and three-point bending (3PB) tests. The current results indicated that the coating sprayed with optimal parameters exhibit a better wear and crack resistance. The high fraction of quasicrystal phase and dense microstructure contribute to the good wear resistance, meanwhile, the favorable fracture toughness is attributed to the tough phase existing in quasicrystal matrix and a fine-lamellar microstructure which facilitates the stress release during the crack propagation. This study gives insight into the crack propagation behavior in Al-based quasicrystal coating from nano-scale to micro-scale and might provide a viable guideline for the improvement of wear and crack resistance for thermal spraying quasicrystal composite coatings.

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Nanoparticle size distribution measurement scheme using mass-to-charge ratio measurements with Vacuum Ultraviolet irradiation in medium vacuum

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Journal of Aerosol Science 2025年 189卷

作者： Yoon, Jongmin Lee, Seungjae Kim, Taesung Department of Semiconductor and Display Engineering Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi-do Suwon-si16419 Korea Republic of Core Technology R&D Team Samsung Electronics Co. Ltd. 1-1 Samsungjeonja-ro Gyeonggi-do Hwaseong-si18448 Korea Republic of Samsung Institute of Technology 1 Samsung-ro Giheung-gu Gyeonggi-do Yongin-si17113 Korea Republic of School of Mechanical Engineering Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi-do Suwon-si16419 Korea Republic of Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi-do Suwon-si16419 Korea Republic of Department of Semiconductor Convergence Engineering Sungkyunkwan University 2066 Seobu-ro Jangan-gu Gyeonggi-do Suwon-si16419 Korea Republic of

With increasing demand for Virtual Metrology (VM) and Advanced Process control (APC) in semiconductor manufacturing, the importance of in-situ quantitative monitoring of process results has grown beyond in-situ qualitative monitoring. Particle Size distribution (PSd) analysis of nanoparticles ranging from several to hundreds of nanometers (nm) in diameter offers a possible method for the quantitative monitoring of plasma processes. However, conventional Particle Beam Mass Spectrometer (PBMS) systems designed for PSd analysis require pressures greater than hundreds of millitorrs for operation, which limits their applicability to modern semiconductor processes that require a medium vacuum. We propose a new PSd measurement scheme to perform PSd analysis for medium-vacuum processes. The hardware configuration includes a Vacuum Ultraviolet (VUV) irradiation chamber and a mass-to-charge ratio (m/q) measurement device consisting of a stacked-quadrupole-based charged particle funnel and Quadrupole Mass Analyzer (QMA). With this configuration, a PSd measurement algorithm is developed using a direct photoionization model-based Non-negative Least Squares (NNLSQ) method with gradient descent optimization. The PSd is estimated from multiple m/q distributions measured under various VUV irradiation levels. The simulation results demonstrate that the proposed m/q measurement scheme achieves an m/q selection efficiency of 21% and a resolution of ± 3% for singly charged spherical Sodium Chloride (NaCl) nanoparticles at the sizes of 5–50 nm, which follow Maxwellian velocity distributions at 20 °C in the free molecular regime. Furthermore, under ideal photoionization-dominant conditions for NaCl nanoparticles with randomly assigned initial charges, peak-normalized target monodispersed PSds with distribution change slopes ranging from −0.4 to 0.5 nm−1 can be estimated in the size range of 5–50 nm, with mode errors within 5.6% and Geometric Standard deviation (GSd) errors within 2.0%. ©

关键词： Positive ions

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Tribological and corrosion behavior of HVAF-sprayed (Fe-TiB2)/CNT composite coating

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Journal of Physics: conference Series 2021年第1期2044卷

作者： Xiaoqing Liu Yaosha Wu Shiye Zhuo Zhengyi Lu Shunqiang Yao Zhaoguo Qiu dechang Zeng School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China Zhongshan R&D Center for Materials Surface and Thin Films Technology of the South China University of Technology Gent Materials Surface Technology (Guangdong) Co. Ltd Zhongshan 528437 China Zhongshan Torch Polytechnic Zhongshan 528436 China Zhongshan Zhongsheng Metallic Plate and Strip Science and Technology Co. Ltd Zhongshan 528441 China

Fe-based composite coating doped well-dispersed titanium boride (TiB2) and carbon nanotubes (CNTs) was fabricated via combined ball milling, spray drying, plasma spheroidization and high velocity air fuel (HVAF) spraying. The microstructure evolution of composite powders and coating, the tribological and corrosion behavior of Fe-based metallic, Fe-TiB2 cermet and (Fe-TiB2)/CNT composite coatings were investigated. The results show that doping 50 vol. % TiB2, especially further doping 2.5 vol. % CNTs could remarkably render the coating favorable microstructure with low porosity, enhanced hardness and fracture toughness, and superior wear and corrosion resistance. Mild oxidative and slight abrasive wears were the dominant wear mechanism, and the preferential corrosion was occurred at the pores, inter-splats and then the TiB2-Fe interfaces.

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Engineered MAP30Er: A plant toxin-derived platform for EGFr-Targeted delivery of protein and chemotherapeutic payloads

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Biochemical and biophysical research communications 2025年 776卷 152184页

作者： Yuling Li Luping Chen Qi Sun Jian Zhao Fujun Wang Department of Applied Biology East China University of Science and Technology 130 Meilong Road Shanghai 200237 China. School of Biological Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 China. School of Chinese Materia Medica Nanjing University of Chinese Medicine 138 Xianlin Avenue Nanjing Jiangsu 210023 China. Department of Applied Biology East China University of Science and Technology 130 Meilong Road Shanghai 200237 China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 China. Electronic address: zhaojian@***. New Drug R&D Center Zhejiang Fonow Medicine Co. Ltd. 209 West Hulian Road Dongyang Zhejiang 322100 China Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China.

The nonspecific toxicity of traditional chemotherapeutic agents and the intracellular delivery barriers of protein-based drugs have limited their clinical applications. Efficient targeted delivery properties of toxin proteins themselves provide important insights into the design of novel drug delivery systems. Inspired by the natural targeting properties of the plant-derived type I ribosome-inactivating protein (rIPs) MAP30, we engineered a detoxified carrier, MAP30Er, through site-directed mutagenesis of key enzymatic residues (E158A/r161A). This variant retained its cell-binding capability while exhibiting significantly reduced cytotoxicity. ELISA and molecular docking identified EGFr as the primary functional receptor of MAP30, and flow cytometry confirmed a 3-fold higher binding affinity of MAP30 to EGFr-high tumor cells (A431) compared to EGFr-low cells (HeLa). To address endosomal entrapment, we screened triterpenoid saponins and found that Saikosaponin A (SSA) enhanced the endosomal escape efficiency of MAP30Er by inducing vesicle membrane disruption. When applied to deliver Apoptin (a apoptosis-inducing protein), the MAP30Er-SSA system elevated tumor cell killing efficacy from 65 % to 90 % upon SSA co-treatment, and Western blot confirmed that it induced apoptosis through activation of caspase-3/9 and cleavage of PArP1. Furthermore, we extended antibody-drug conjugate (AdC) technology to the MAP30Er platform, constructing a MAP30Er-MMAE conjugate that achieved targeted delivery to A431 cells with negligible toxicity to normal cells. This study establishes a novel paradigm for engineering plant-derived rIPs and provides a multifunctional delivery platform with targeting specificity, safety, and versatility, offering innovative solutions to overcome drug delivery challenges in cancer therapy.

关键词： Apoptin EGFr Endosomal escape MMAE ribosome-inactivating protein Targeted delivery

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replacement Scheme of drive Boards For Traction Inverter Module of Beijing dKZ31 Metro Vehicle

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Journal of Physics: conference Series 2021年第1期1754卷

作者： Fan Zhang Lujun Zhang Shuangqing Liang Lu Sun Xiaoteng dai Yunsi branch of Beijing Metro Operation Co. Ltd Beijing 100000 China Metro operation technology R&D center of Beijing Metro Operation Co. Ltd Beijing 100000 China BeiJing He ShengKaiDa Rail Transit Equipment Co Ltd Beijing 100000 China College of Electrical Engineering BeiJing Jiao Tong University Beijing 100000 China

Nowadays, the status of metro in urban traffic is particularly prominent in Beijing. How to ensure the normal operation of metro train is particularly important. At present, the problems of high failure rate, high maintenance cost and long maintenance cycle exist in the drive boards of imported traction system. In view of the above problems, this paper put forward the alternative scheme of drive boards on dKZ31 metro, and carried out the test work. On the basis of ensuring the safety and reliability, the maintenance cost is greatly reduced and the maintenance efficiency is improved. At present, the samples of drive boards have been completed and the relevant functional tests have been carried out. The test results show that the performance of the drive boards is good, which meets the requirements and achieves the predetermined goal.

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Hydraulic damping and Swing Assistance control of A robotic Electrohydraulic Transfemoral Prosthesis: Preliminary results

Hydraulic Damping and Swing Assistance Control of A Robotic ...

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IEEE Workshop on Advanced robotics and its Social Impacts, ArSO

作者： Siyuan Gao Chentao Wang Jinying Zhu Jingeng Mai Qining Wang Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT) Peking University China and also with the Beijing Engineering Research Center of Intelligent Rehabilitation Engineering Beijing China R&D Center of the SpeedSmart Co. Ltd. Beijing China

This paper presents a robotic electrohydraulic transfemoral prosthesis that consists of a controllable bidirectional hydraulic damping and an electrical actuator. The embedded finite-state based controller enables the prosthesis with hydraulic damping adaptation in the stance phase and motorized swing assistance control in the swing phase during level walking. The proposed prosthesis was shorter in length than a fully powered transfemoral prosthesis. Additionally, the prosthesis with swing assistance and bi-directional hydraulic damping control could restore a better gait symmetry on knee angle assessment during level walking, compared with a hydraulic microprocessor controlled transfemoral prosthesis. Preliminary experimental results from a transfemoral amputee demonstrate the potential benefit of the proposed transfemoral prosthesis.

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Oral combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway

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Cancer medicine 2025年第11期14卷 e70987页

作者： Xiaowei Li dengxiong Hua daoyan Wu Wei Hong Yingqian Kang Lei Tang Qin Yang Xinxin Wang Boyan Li renmin Li Zhenghong Chen Guzhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou & Key Laboratory of Medical Molecular Biology of Guizhou Province Guizhou Medical University Guiyang China. Joint Laboratory of Helicobacter Pylori and Intestinal Microecology of Affiliated Hospital of Guizhou Medical University Guiyang China. Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control Guiyang China. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D Guizhou Medical University Guiyang China. School of Public Health Guizhou Medical University Guiyang China. Standard Testing Group Co. Ltd. Qingdao China.

BACKGrOUNd:Breast cancer is the most common malignant tumor among women. recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the tumor microenvironment, and inhibiting cancer progression. METHOdS:We established a 4T1 tumor-bearing mice model and analyzed the proportions of Cd4 T and Cd8 T cells in the spleen using flow cytometry and immunohistochemistry. The expression levels of TNF-α, IL-6, and IL-10 were measured by enzyme-linked immunosorbent assay. Hematoxylin-eosin staining was used to observe the tumor morphology. Selective protein blotting and quantitative real-time PCr were used to analyze the expression of Bax, Bcl-2, and Caspase-3. Cell proliferation was evaluated using the MTT assay, and apoptosis was detected by flow cytometry. rESULTS:The results indicated that oral administration of CB and AKK possesses the capability to inhibit the progression of 4T1 breast cancer; however, the combined treatment with both strains (CB-AKK) exhibited significantly superior effects compared to each individual strain. Further mechanistic analysis revealed that the CB-AKK combination could activate the antitumor immunity in mice and reshape the tumor microenvironment. Additionally, it was found that the live bacteria and their metabolites derived from CB-AKK could inhibit cell proliferation and promote tumor apoptosis by activating the Bcl-2/Bax signaling pathway. coNCLUSION:This study is the first to demonstrate that orally administered live bacteria CB-AKK can inhibit the progression of 4T1 breast cancer, providing a promising new strategy for the development of innovative biotherapies for breast cancer.

关键词： Akkermansia muciniphila Clostridium butyricum Bcl‐2/Bax signaling pathway apoptosis breast cancer probiotics

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Metalized Porphyrin-Based coFs for conductive Porous Layers in Perovskite Solar Cells to Enhance Electron Injection, defect Passivation, and Lead-Protection

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Angewandte Chemie 2025年

作者： Zhengyan He Tianxiang Luan Qilin Wei Liang Wang dan Huang Haibo Chen Ivan Yu dmitriev Peizhou Li Shufang Zhang William W. Yu School of Chemistry and Chemical Engineering Ministry of Education Key Laboratory of Special Functional Aggregated Materials Shandong Key Laboratory of Advanced Organosilicon Materials and Technologies Shandong University Jinan 250100 China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy Conversion Shandong University Qingdao 266237 China School of Integrated Circuits Shandong University Jinan 250101 China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures School of Physical Science and Technology Guangxi University Nanning 530004 China Shandong Muerhls New Material Technology Co. Ltd. Dezhou 251100 China R&D Center of Thin Film Technologies in Energetics Saint Petersburg 194064 Russian Federation School of Physics and Photoelectronic Engineering Ludong University Yantai 264025 China

In perovskite solar cells (PSCs), the introduction of an intermediate layer to bridge the transport and photoactive layers has become a key strategy for enhancing carrier extraction efficiency. However, traditional approaches are often limited by the seesaw effect, making it challenging to achieve an optimal balance between electron transport and defect passivation. In this study, we employed a Cu 2+ -loaded metalized porphyrin-based covalent organic framework (Cu-Por-coF) as a conductive porous layer (CPL) at the perovskite bottom interface. Experimental results showed that a Cu-Por-coF coverage of 19% significantly enhanced electron transport and effectively suppressed long-distance electron diffusion. Moreover, the carefully designed Cu-Por-coF provided abundant active sites, which improved the film-forming quality of the perovskite layer, thereby facilitating the beneficial synergy of electron injection and defect passivation. The n-i-p type devices achieved a power conversion efficiency (PCE) of 25.41% (0.09 cm 2 ) and 21.99% (1.01 cm 2 ). Using Cu-Por-coF to stabilize the perovskite crystal structure, the unencapsulated devices retained over 81% of its initial efficiency after 2000 h. Additionally, Cu-Por-coF effectively chelated lead ions and thus enhanced the environmental sustainability of PSCs.

关键词： covalent organic framework Lead leakage Perovskite solar cell Porous layer

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