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作者： Li Yingying CNPC Engineering Technology R&D Company Limited

The special gas wettability phenomenon of reservoir rocks has been recog-nized by more and more *** has a significant effect on efficient development of unconventional ***,based on the preferential gas-covered ability and surface free energy changes,definition and evaluation methods have been ***,a method for altering gas wettability and its mechanisms have been studied,surface oriented phenomena of functional groups with low surface energy are the fundamental reason for gas wettability alteration of ***,the effect of gas wettabil-ity on the surface energy,electrical properties and dilatability are ***,the effects of gas wettability on capillary pressure,oil/gas/water distribution and seepage are investigated with capillary tubes and etched-glass network *** gas wettability theory of reservoir rocks has been initially established,which provides theoretical support for the efficient production of unconventional reservoirs and has great significance.

关键词： gas-wetting fluorocarbon copolymer contact angle capillary pressure surface free energy surface property seepage

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research on Cementing real-Time remote Monitoring System

Research on Cementing Real-Time Remote Monitoring System

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中国石油集团工程技术研究院有限公司首届青年论文报告会

作者： Jiang Le Li Yong Liu Shuoqiong Liu Binhui CNPC Engineering Technology R&D Company Limited

Cementing real-time remotely automatic monitoring system was developed to meet the cementing construction operation requirements and to ensure smooth and high-quality cementing work,aiming at the problems of large amount of construction equipment,large number of personnel,complicated operation procedures,and many un-expected incidents on the site of cementing construction *** construction data can be real-time collected and monitored,in addition,the cementing operation can be remotely automatic controlled by the *** system has been applied for 20 wells in Liaohe Oilfield with a 100% qualification rate of cementing quality,realizing the function of remotely automatic monitoring of cementing *** the test-up phase,the cementing rate is upto 75%.Based on wireless network communication technology,the ability to remotely monitor and control cementing operations is formed for the first time in *** level of cementing automation,scientific and informationization are initially re-alized,which will help improving the cementing quality of complex wells,deep wells and horizontal wells,and improving the overall technical level of the domestic cementing in-dustry.

关键词： real-time monitoring remotely automatic control network communica-tion Wireless broadband networking technology data management

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Using Acoustic Wave as Carrier Signal to Transmit Information from downhole to Surface

Using Acoustic Wave as Carrier Signal to Transmit Informatio...

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中国石油集团工程技术研究院有限公司首届青年论文报告会

作者： Gao Wenkai Jia Hengtian Guan Kang Chen Wenyi CNPC Engineering Technology R&D Company Limited

directional and horizontal wells have become a conventional drilling tech-nique now,which are widely used in various types of hydrocarbon reservoirs and coal mines.A key element of the steering process is the real-time measurement and transmission of the near-bit navigation information from the bottom of the well to *** only com-mercial systems in drilling engineering transmit data to surface by producing pressure pulses within the portion of the drilling mud enclosed in the hollow *** the transmission rates are very low(just 1 ~2 bits per second) in this method,and it can not meet the needs of modern drilling.A most promising method is to use compressional acous-tic wave to transmit data along the *** this technique,telemetry signals are en-coded as acoustic wave pulses that propagate through the drillstring and are subsequently received and converted back to electric signals for data recovery at the surface *** drill string is commonly assembled from segments (9m for oil drilling or 1 m for coal mines drilling in length) of threaded pipe and forms a periodic structure,which is known to behave like band-pass *** the transmission rates can be increased to hundreds of bits per *** on the theoretical analysis and laboratory experiment of the wave propagation properties in the drillstring for both petroleum engineering and coal mine,this paper proves the feasibility of using acoustic wave as carrier signal to transmit information from downhole to surface in drilling engineering.

关键词： acoustic telemetry measurement while drilling transmission characteristic

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Study on Erosive of Weighting Agent in a High density Water-Based drilling Fluid

Study on Erosive of Weighting Agent in a High Density Water-...

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中国石油集团工程技术研究院有限公司首届青年论文报告会

作者： Yan Lili Wang Jianhua Wang Lihui dong Haoan CNPC Engineering Technology R&D Company Limited

Erosive and abrasive wear effect of water-based drilling fluid (WBM) on down-hole tools may reduce the service life of down-hole *** erosive would be worse when a high density WBM densified with a high content weighting agent was *** of the main reasons of the erosive is related to the weighting agent *** re-duce the erosive effect of weighting agent,a micronized barite as a new weighting material was prepared in this paper,and then characterized by scanning electron microscope (SEM) and laser particle size *** our experiments,two conventionally weighting agents,barite and hematite were chosen as the comparing *** erosive effects,lubricity and rheological properties of high density WBM weighting with micronized barite,barite and hematite were evaluated on erosion instrument,an EP lubricity tester and a rotational viscosimeter,*** was found that the high density WBM weighted with micronized barite showed less erosion,better rheological properties,and smaller lubricating coefficient than that weighted with hematite or *** with hematite or barite,the micronized barite could effectively reduce erosive wear on down-hole tools,and control the rheological property of high density WBM,which would significantly contribute to the service life of down-hole tools and the safety of drilling operations.

关键词： erosive weighting agent micronized barite high density

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Case Study: Effect of Natural Fracture on Stimulation Strategy in Keshen Tight Gas

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IOP Conference Series: Earth and Environmental Science 2020年第6期570卷

作者： Y Zhang Z Chen X Yang Y Qiao Q Teng Y Wang CNPC Engineering Technology R&D Company Limited Beijing 102206 China Research Institute of Petroleum Engineering PetroChina Tarim Oilfield Company Kurla 841000 China

Aimed at problems of poor fracturing effects of fracture-network acid fracturing in three wells in the Keshen 5 block, a fractured and tight gas reservoir in Tarim Oilfield, the mechanical activity of natural fractures was studied. The fractures in this block were divided into three types: fully-filled, semi-filled, and unfilled. The analysis of the correlations showed that the correlation of the number of fully-filled fractures and absolute open flows (AOF) is poor, while the correlation between the number of unfilled and semi-filled fractures and AOF is the best. Core samples with different types of fractures were tested using conventional triaxial compression methods, and the experimental results showed that the friction coefficient of the fully-filled fracture is close to that of semi-filled fracture, while the cohesion of fully-filled natural fractures is close to that of intact rocks, which is much greater than that of semi-filled fractures. The effective stress test results shows that the effective stress coefficient of fully-filled natural fracture rock samples is lower than that of semi-filled fractures. Using Mohr–Coulomb theory to calculate the natural fracture mechanics of high-production wells and low-production wells, the results show that low-production wells are mainly fully-filled fractures, most of which are not activated, so the production is low; while high-production wells are semi-filled and unfilled fractures, most of which can be activated, so the production is high. Based on this, for a well dominated by fully-filled fractures, it is recommended to use conventional gel fracturing to replace the fracture-network acid fracturing process. The stimulation practice of two wells has proven the validity of this strategy. The filling degree of natural fractures affects the increasing production and choice of stimulation process. This may be a relatively new understanding and may provide insights to stimulation strategy decisions for other fractured

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design, Synthesis, Antidiabetic Activity and in Silico Studies of New Hydrazone derivatives derived from Acetohexamide

SSRN

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SSrN 2025年

作者： Kurşun Aktar, Bedriye Seda Sıcak, Yusuf Oruç-Emre, Emine Elçin Kılıç, rabia Sağlam, Ebru Taşdemir, demet Kaya, Süleyman Yılmaz, Gizem Tatar Yaglioglu, Ayse Sahin Department of Hair Care and Beauty Services Yeşilyurt Vocational School Malatya Turgut Özal University Malatya Turkey Department of Medicinal and Aromatic Plants Köyceğiz Vocational School Mugla Sitki Kocman University Köyceğiz Muğla Turkey Department of Chemistry Faculty of Arts and Sciences Gaziantep University Gaziantep Turkey Respiratory Diseases and Respiratory Surgery Research and Practice Center Gaziantep University Gaziantep Turkey Department of Medical Biochemistry Faculty of Medicine Gaziantep University Gaziantep Turkey Department of Biostatistics and Medical Informatics Faculty of Medicine Karadeniz Technical University Trabzon Turkey Karadeniz Technical University Institute of Health Sciences Department of Bioinformatics Trabzon61080 Turkey Yılmaz Bilişim R&D Consulting Software Engineering and Services Trade Limited Company Trabzon61081 Turkey Department of Chemistry and Chemical Process Technology Technical Sciences Vocational School Amasya University Amasya Turkey

diabetes is a well-known endocrine system disorder whose incidence has increased recently. The has been shown that the synthesis of new more effective antidiabetic drugs is needed because the drugs used in the treatment of diabetes have many side effects and are used in combination. Since hydrazone derivatives are very active compounds with antidiabetic effects, this aim of this study was to synthesize a series of hydrazone derivatives showing potential antidiabetic activity. In the inhibition activity of α-amylase and α-glucosidase, the compounds that showed the best inhibitory effect against both enzymes were determined as compounds 8 (IC50= 30.21±0.16 µM for α-amylase;IC50= 38.06±0.80 µM for α-glucosidase) and 10 (IC50= 34.49±0.37 µM for α-amylase;IC50= 40.44±0.23 µM for α-glucosidase). All of the compounds were evaluated for their cytotoxic effect by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) test on the human embryonic kidney cell line (HEK293). Compounds 7 and 9 have been observed to kill half of the healthy HEK293 cells (IC50: 61.04 µM and IC50: 69.25 µM) respectively. Other compounds and the positive control acarbose showed no cytotoxic effects on healthy cells even at high concentrations. Additionally, the properties of molecules such as H-bond acceptors, H-bond donors, topological polar surface area (TPSA), Lipinski, iLogP, Gastrointestinal (GI) absorption, and Blood-Brain Barrier (BBB) permeability were also investigated with the SwissAdME program used in drug design. Molecular docking simulations of the synthesized hydrazone derivatives, especially compounds 8 and 10, revealed strong interactions with α-glucosidase and α-amylase in their active sites. © 2025, The Authors. All rights reserved.

关键词： Amylases

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Investigation on Erosion resistance of downhole Throttle with Ultra-high Pressure

Investigation on Erosion Resistance of Downhole Throttle wit...

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作者： Huiyun Ma Yuan Jiang Qiang Yin Fangfang Zhang Shaowei Chen Yanxin Lv Guoping Lei Engineering Technology Research Institute PetroChina Southwest Oil & Gas Field Company National Energy R&D Center of High Sulfur Gas Exploitation CNPC Chuanqing Drilling Engineering Company Limited School of Mechatronic Engineering Southwest Petroleum University

The throttling nozzle, the core element of downhole throttling tool, is seriously eroded in the producing-sand gas well. In this paper, the fixed downhole throttle developed by Petro China Southwest Oil and Gasfield company is taken as the research object, and the flow state of gas and the movement of sand particles are expressed by rNG k-ε model and dPM model respectively. Through Fluent numerical simulation, the internal flow field distribution rule of throttle with diameter of 70 mm is discussed, the most serious erosion area of throttle is obtained, and the influence of solid particle velocity, solid particle diameter and solid particle mass flow rate on the erosion of throttle are analyzed. It is meaningful to design and improve throttle according to working parameters of gas well. According to the simulation, it is believed that the fixed downhole throttle will contribute to a better understanding for erosion resistance of downhole throttle with ultra-high pressure.

关键词： downhole throttle fluent erosion gas-solid two-phase

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development of responsive well plugging material in carbonate reservoir

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Journal of Physics: Conference Series 2021年第1期1777卷

作者： T Zhou J T Liu X J Kong F Qian W J Li Z Zhong N Jing J Feng Q Zheng Y X Gu J Y Li Y Y Li X Shi Y d Sun CNPC Engineering Technology R&D Company Limited. Beijing 102206 China China National Oil and Gas Exploration and Development Corporation Beijing 100034 China Drilling Technology Service Company BHDC Tianjin 300280 China Greatwall Drilling Company Drilling Technology Service Company Panjin 124010 China The fourth branch of China Petroleum Pipeline Bureau Engineering Co. Ltd Langfang 065000 China

One of the most critical problems limiting the exploration and development of the Central Asia and Middle East Areas is lost circulation caused by the natural fracture propagating in carbonate reservoir. Traditional plugging materials had limited performance due to poor adaptability to carbonate formation. This paper investigated the mechanism of lost circulation in Central Asia and Middle East Areas, and a new responsive fracture plugging materials was developed. After implementation, the complexities treatment time was shortened and drilling efficiency was increased. The main types of lost circulation mechanism are summarized and analysed by studied the reservoir characteristics of Central Asia and Middle East Areas. A physical model of horizontal V funnel leakage channel in the target block was established to simulate the migration and plugging process of plugging particles in natural fractures. Based on the analysis of the flow and accumulation pattern of the plugging fluid in the leakage channel with different aperture ratio, a statistical model of the particle flow in the plugging material was established. A response controllable solidification plugging material was developed. The application results show that, the responsive solidification controllable well plugging material could rapidly accumulate in the 1mm and 3mm fractures in the upper sealing formation. The mud cake has good toughness with compressive strength of 3.4-9.5MPa, which achieves a rapid and high-strength plugging for the fracture formation. The acid soluble consolidation plugging material, mainly composed of curing agent, retarder, suspending agent, etc., is developed for long open hole section. The dissolution rate could reach up to 91%, the plugging strength of the solidified plug is up to 10MPa and which could be stable for 15d under 150°C. This innovative anti-lost circulation materials for carbonate reservoirs can effectively solve the problem of serious loss of production due to sever l

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Undoped Strained Ge Quantum Well with Ultrahigh Mobility Grown by reduce Pressure Chemical Vapor deposition

arXiv

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arXiv 2022年

作者： Kong, Zhenzhen Li, Zonghu Cao, Gang Su, Jiale Zhang, Yiwen Liu, Jinbiao Liu, Jingxiong ren, Yuhui Wei, Laiming Guo, Guoping Wu, Yuanyuan radamson, Henry H. Li, Junfeng Wu, Zhenhua Li, Haiou Yang, Jiecheng Zhao, Chao Wang, Guilei Integrated Circuit Advanced Process R&D Center Institute of Microelectronics Chinese Academy of Sciences Beijing100029 China School of Integrated Circuits University of Chinese Academy of Sciences Beijing100049 China CAS Key Laboratory of Quantum Information University of Science and Technology of China Hefei230026 China Hefei National Laboratory Hefei230088 China School of Advanced Manufacturing Engineering Hefei University Hefei230601 China Origin Quantum Computing Company Limited Hefei230026 China Research and Development Center of Optoelectronic Hybrid IC Guangdong Greater Bay Area Institute of Integrated Circuit and System Guangzhou510535 China Beijing Superstring Academy of Memory Technology 100176 China

We fabricate an undoped Ge quantum well under a 30 nm relaxed Ge0.8Si0.2 shallow barrier. The bottom barrier contains Ge0.8Si0.2 (650 ℃) followed by Ge0.9Si0.1 (800 ℃) such that variation of Ge content forms a sharp interface that can suppress the threading dislocation density (Tdd) penetrating into the undoped Ge quantum well. The Ge0.8Si0.2 barrier introduces enough in-plane parallel strain (Ε strain -0.41%) in the Ge quantum well. The heterostructure field-effect transistors with a shallow buried channel obtain an ultrahigh two-dimensional hole gas (2dHG) mobility over 2×106 cm2/Vs and a very low percolation of 5.625 × 1010cm−2. A tunable fractional quantum Hall effect at high densities and high magnetic fields has also been observed. This approach defines strained germanium as providing the material basis for tuning the spin-orbit coupling strength for fast and coherent quantum *** Codes 81-05, 81V70 © 2022, CC BY-NC-Nd.

关键词： Germanium

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Mineralogy-controlled frictional and stability properties of longmaxi shale: Implications for hydraulic fracturing induced seismicity 5

Mineralogy-controlled frictional and stability properties of...

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5th ISrM Young Scholars' Symposium on rock Mechanics and International Symposium on rock engineering for Innovative Future, YSrM 2019

作者： An, Mengke Zhang, Fengshou Chen, Zhaowei Elsworth, derek Marone, Chris Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji University Shanghai200092 China Department of Geotechnical Engineering Tongji University Shanghai200092 China Department of CNPC Engineering Technology R&D Company Limited Beijing102206 China Department of Energy and Mineral Engineering EMS Energy Institute and G3 Center Pennsylvania State University University ParkPA16802 United States Department of Geosciences Pennsylvania State University University ParkPA16802 United States

ISBN: (纸本)9784907430047

The Silurian Longmaxi shale formation is a widely distributed gas reservoir in the Sichuan Basin of southwest China. The thick clay rich shale has relatively high organic content, is thermally mature and is a major target for China’s shale gas production. In recent years the shale has become the host to an increasing number of induced earthquakes potentially linked to fluid injection related to hydraulic fracturing. These induced or triggered events are linked to the reactivation of faults. This paper explores the frictional and stability properties of Longmaxi shale to provide insights into the causal mechanisms of induced seismicity and their geological and structural controls. rock samples from a geological section spanning ~150 m were powdered for friction experiments at recreated in-situ stresses and temperatures. Experimental results show that fault frictional and stability properties are strongly controlled by mineral composition. Frictional strength increases with a reduction in phyllosilicate content and exerts a significant control on seismicity. Two of the ten samples exhibited velocity weakening behavior under in-situ conditions, potentially identifying compositions that contribute to unstable slip. These findings have important implications in understanding the frequency and occurrence of induced earthquakes triggered as a result of hydraulic fracturing. ©2019 Japanese Society for rock Mechanics,

关键词： Hydraulic fracturing

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