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IEEE International Conference on Teaching, Assessment and Learning for engineering (TALE)

作者： Edy Sulistiyo Vindy Nizirwan Anwar Diana Teresia Spits Warnars Setya Chendra Wibawa Goenawan Brotosaputro Dedy Prasetya Kristiadi Harco Leslie Hendric Spits Warnars Kiyota Hashimoto Electrical Engineering Department Universitas Negeri Surabaya Jawa Timur Indonesia Game Application & Technology Program School of Computer Science Bina Nusantara University Jakarta Indonesia Faculty of Computer Science Esa Unggul University Jakarta Indonesia Information Systems Department Bina Nusantara University Jakarta Indonesia Informatics Department Universitas Negeri Surabaya Jawa Timur Indonesia Information System Department Universitas Budi Luhur Jakarta Indonesia Computer Science department Raharja University Tangerang Indonesia Computer Science Department BINUS Graduate Program – Doctor of Computer Science Bina Nusantara University Jakarta Indonesia Faculty of Technology and Environment Prince Songkla University Phuket Campus Thailand

ISBN: (数字)9781728126654

ISBN: (纸本)9781728126661

Currently, the growth of information and technology is rapid. It makes a lot of things in various fields including education becoming more effective and efficient. In education, one of its implementation which is a game is proven to be a useful tool to support conventional teaching methods and bring a more natural understanding of learning materials. Moreover, as a product of the popular culture in modern society, video game mirrors the general culture practice in real life and reflects it via its own culture inside the game. This makes a video game can give a contribution to the social construction of reality as it affects the player's view towards learning in real life and vice versa. From there, we see that there is an opportunity for learning about religion to be supported by its utilization to provide an interactive and fun learning experience. In this paper, we discuss how a video game is implemented to support religious learning. The game was developed with the scrum method where we surveyed to gather the user requirements before the design step. The game design was made by using the use case diagram and storyboard, and it was built using Unity version 2017.3.0f3.

关键词： Games Land mobile radio Education computer science Operating systems Information systems Media

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Some Remarks on Robust Gene Regulation in a Biomolecular Integral Controller

Some Remarks on Robust Gene Regulation in a Biomolecular Int...

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IEEE Annual Conference on Decision and Control

作者： Deepak K. Agrawal Ryan Marshall M. Ali Al-Radhawi Vincent Noireaux Eduardo D Sontag Department of Bioengineering and Department of Electrical and Computer Engineering Northeastern University Boston MA USA School of Physics and Astronomy University of Minnesota Minneapolis MN USA Laboratory of Systems Pharmacology Program in Therapeutic Science Harvard Medical School Boston MA USA

ISBN: (数字)9781728113982

ISBN: (纸本)9781728113999

Integral feedback can help achieve robust tracking independently of external disturbances. Motivated by this knowledge, biological engineers have proposed various designs of biomolecular integral feedback controllers to regulate biological processes. In this paper, we theoretically analyze the operation of a particular synthetic biomolecular integral controller, which we have recently proposed and implemented experimentally. Using a combination of methods, ranging from linearized analysis to sum-of-squares (SOS) Lyapunov functions, we demonstrate that, when the controller is operated in closed-loop, it is capable of providing integral corrections to the concentration of an output species in such a manner that the output tracks a reference signal linearly over a large dynamic range. We investigate the output dependency on the reaction parameters through sensitivity analysis, and quantify performance using control theory metrics to characterize response properties, thus providing clear selection guidelines for practical applications. We then demonstrate the stable operation of the closed-loop control system by constructing quartic Lyapunov functions using SOS optimization techniques, and establish global stability for a unique equilibrium. Our analysis suggests that by incorporating effective molecular sequestration, a biomolecular closed-loop integral controller that is capable of robustly regulating gene expression is feasible.

关键词： Steady-state Robustness Mathematical model Proteins Gene expression Kinetic theory Production

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A Robust Ensemble Algorithm for Ischemic Stroke Lesion Segmentation: Generalizability and Clinical Utility Beyond the ISLES Challenge

arXiv

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arXiv 2024年

作者： de la Rosa, Ezequiel Reyes, Mauricio Liew, Sook-Lei Hutton, Alexandre Wiest, Roland Kaesmacher, Johannes Hanning, Uta Hakim, Arsany Zubal, Richard Valenzuela, Waldo Robben, David Sima, Diana M. Anania, Vincenzo Brys, Arne Meakin, James A. Mickan, Anne Broocks, Gabriel Heitkamp, Christian Gao, Shengbo Liang, Kongming Zhang, Ziji Siddiquee, Md Mahfuzur Rahman Myronenko, Andriy Ashtari, Pooya Van Huffel, Sabine Jeong, Hyun-Su Yoon, Chi-Ho Kim, Chulhong Huo, Jiayu Ourselin, Sebastien Sparks, Rachel Clèrigues, Albert Oliver, Arnau Lladó, Xavier Chalcroft, Liam Pappas, Ioannis Bertels, Jeroen Heylen, Ewout Moreau, Juliette Hatami, Nima Frindel, Carole Qayyum, Abdul Mazher, Moona Puig, Domenec Lin, Shao-Chieh Juan, Chun-Jung Hu, Tianxi Boone, Lyndon Goubran, Maged Liu, Yi-Jui Wegener, Susanne Kofler, Florian Ezhov, Ivan Shit, Suprosanna Hernandez Petzsche, Moritz R. Menze, Bjoern Kirschke, Jan S. Wiestler, Benedikt Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Informatics Technical University Munich Germany Icometrix Leuven Belgium ARTORG Center for Biomedical Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Switzerland University of Bern Bern Switzerland Chan Division of Occupational Science and Occupational Therapy University of Southern California Los AngelesCA United States Stevens Neuroimaging and Informatics Institute Department of Neurology Keck School of Medicine University of Southern California United States University Institute of Diagnostic and Interventional Neuroradiology Inselspital Bern Switzerland University Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Bern Switzerland Department of Diagnostic and Interventional neuroradiology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Medical Imaging Radboud University Medical Center Institute for Health Sciences Nijmegen Netherlands Deepwise AI Lab Beijing China Beijing University of Posts and Telecommunications Bejing China School of Computing and Augmented Intelligence Arizona State University TempeAZ United States NVIDIA Santa ClaraCA United States STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Pohang Korea Republic of School of Biomedical Engineering & Imaging Sciences King’s College London United Kingdom Institute of Computer Vision and Robotics University of Girona Spain Wellcome Centre for Human Neuroimaging University College London London United Kingdom Laboratory of Neuro Imaging Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles United States KU Leuven Leuven Belgium CREATIS Université Lyon1 CNRS UMR5220 INSERM U1206 INSA-Lyon Villeurbanne696

Diffusion-weighted MRI (DWI) is essential for stroke diagnosis, treatment decisions, and prognosis. However, image and disease variability hinder the development of generalizable AI algorithms with clinical value. We address this gap by presenting a novel ensemble algorithm derived from the 2022 Ischemic Stroke Lesion Segmentation (ISLES) challenge. ISLES’22 provided 400 patient scans with ischemic stroke from various medical centers, facilitating the development of a wide range of cutting-edge segmentation algorithms by the research community. By assessing them against a hidden test set, we identified strengths, weaknesses, and potential biases. Through collaboration with leading teams, we combined top-performing algorithms into an ensemble model that overcomes the limitations of individual solutions. Our ensemble model combines the individual algorithms’ strengths and achieved superior ischemic lesion detection and segmentation accuracy (median Dice score: 0.82, median lesion-wise F1 score: 0.86) on our internal test set compared to individual algorithms. This accuracy generalized well across diverse image and disease variables. Furthermore, the model excelled in extracting clinical biomarkers like lesion types and affected vascular territories. Notably, in a Turing-like test, neuroradiologists consistently preferred the algorithm’s segmentations over manual expert efforts, highlighting increased comprehensiveness and precision. Validation using a real-world external dataset (N=1686) confirmed the model’s generalizability (median Dice score: 0.82, median lesion-wise F1 score: 0.86). The algorithm’s outputs also demonstrated strong correlations with clinical scores (admission NIHSS and 90-day mRS) on par with or exceeding expert-derived results, underlining its clinical relevance. This study offers two key findings. First, we present an ensemble algorithm that detects and segments ischemic stroke lesions on DWI across diverse scenarios on par with expert (neuro)rad

关键词： Diagnosis

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In-silico structural and functional analysis of nonsynonymous single nucleotide polymorphisms in human FOLH1 gene

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In silico pharmacology 2025年第1期13卷 32页

作者： Abtin Tondar Muhammad Irfan Sergio Sánchez-Herrero Hafsa Athar Aleena Haqqi Asim Kumar Bepari Laura Calvet Liñán David Hervás Marin Department of Computer Science Multimedia and Telecommunication Interuniversity Doctoral Program in Bioinformatics Universitat Oberta de Catalunya Barcelona (UOC) Spain. Stanford Deep Data Research Center Stanford University Stanford USA. Atta-Ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences and Technology (NUST) Islamabad Punjab Pakistan. School of Medical Laboratory Technology Minhaj University Lahore (MUL) Lahore Punjab Pakistan. Department of Pharmaceutical Sciences North South University (NSU) Dhaka Bangladesh. Telecommunications and Systems Engineering Department Universitat Autònoma de Barcelona (UAB) Sabadell Spain. Department of Applied Statistics and Operational Research and Quality Alcoy Universitat Politècnica de València (UPV) Alcoy Spain.

Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual’s vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehensive in-silico analysis to examine the structural and functional implications of nsSNPs within the Folate Hydrolase 1(FOLH1) gene, which encodes the Prostate-Specific Membrane Antigen (PSMA). A total of 504 SNPs were retrieved, and after filtering, 15 pathogenic nsSNPs were identified using five different in-silico tools. Three of these SNPs—R255H (rs375565491), R255C (rs201789325), and G168E (rs267602926)—were consistently predicted to be pathogenic across all in-silico tools. MutPred2 was used to predict the structural and functional consequences of the identified mutations. The analysis revealed multiple alterations in the PSMA protein, including changes in helical conformations, glycosylation patterns, transmembrane properties, and solvent accessibility. Furthermore, I-Mutant 2.0 analysis demonstrated a decrease in protein stability for most nsSNPs, except for rs267602926 (G168E), which was predicted to increase stability. Conservation analysis using ConSurf revealed varying degrees of amino acid conservation, with R255H and R255C identified as highly conserved residues, indicating their potential functional and structural significance. Additionally, post-translational modification (PTM) analysis indicated that while phosphorylation and methylation sites remained unchanged, specific glycosylation sites were lost in two pathogenic mutant variants (R255H and R255C), potentially affecting PSMA function and adversely impacting prostate cancer. Our findings highlight the importance of in silico studies to investigate the structural and functional impacts of FOLH1 nsSNPs on the PSMA protein. Such in silico studies can deepen our understanding of the roles of nsSNPs in prostate cancer onset, progression, and drug resistance.

关键词： FOLH1 In-silico structural and functional analyses PSMA PTM nsSNPs

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Publisher Correction: The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles

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Genome biology 2025年第1期26卷 31页

作者： Jacob Matthew Schreiber Carles A Boix Jin Wook Lee Hongyang Li Yuanfang Guan Chun-Chieh Chang Jen-Chien Chang Alex Hawkins-Hooker Bernhard Schölkopf Gabriele Schweikert Mateo Rojas Carulla Arif Canakoglu Francesco Guzzo Luca Nanni Marco Masseroli Mark James Carman Pietro Pinoli Chenyang Hong Kevin Y Yip Jefrey P Spence Sanjit Singh Batra Yun S Song Shaun Mahony Zheng Zhang Wuwei Tan Yang Shen Yuanfei Sun Minyi Shi Jessika Adrian Richard S Sandstrom Nina P Farrell Jessica M Halow Kristen Lee Lixia Jiang Xinqiong Yang Charles B Epstein J Seth Strattan Bradley E Bernstein Michael P Snyder Manolis Kellis William S Noble Anshul Bharat Kundaje Department of Genetics Stanford University Stanford CA USA. jmschreiber91@***. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge MA USA. Department of Genetics Stanford University Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. Department of Research and Development DeepSeq.AI San Francisco CA USA. RIKEN Center for Integrative Medical Sciences Yokohama Japan. Department of Empirical Inference Max Planck Institute for Intelligent Systems Stuttgart Germany. School of Life Sciences University of Dundee Dundee UK. Department of Electronics Information and Bioengineering Politecnico Di Milano Milan Italy. Department of Computational Biology University of Lausanne Lausanne Switzerland. Department of Computer Science and Engineering The Chinese University of Hong Kong Sha Tin Hong Kong. Sanford Burnham Prebys Medical Discovery Institute San Diego CA USA. Department of Electrical Engineering and Computer Sciences University of California Berkeley Berkeley CA USA. Department of Statistics University of California Berkeley Berkeley CA USA. Department of Biochemistry & Molecular Biology Center for Eukaryotic Gene Regulation Pennsylvania State University University Park PA USA. Department of Statistics Pennsylvania State University University Park PA USA. Department of Electrical and Computer Engineering Texas A&M University College Station TX USA. Altius Institute Seattle WA USA. Epigenomics Program The Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genome Sciences University of Washington Seattle WA USA. Department of Computer Science Stanford University Stanford CA USA.

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Numerical analysis of general-vibration-based method for structural health monitoring

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AIP Conference Proceedings 2020年第1期2227卷

作者： Fergyanto E. Gunawan Benfano Soewito Nico Surantha Tuga Mauritsius Nobumasa Sekishita 1Industrial Engineering Department BINUS Graduate Program - Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia 11480 2Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 3Information Systems Management Department BINUS Graduate Program - Master of Information Systems Management Bina Nusantara University Jakarta Indonesia 11480 4Department of Mechanical Engineering Toyohashi University of Technology Toyohashi Aichi 441-8580 Japan

For damage detection, this research article discusses an easy-to-compute damage index derived from the governing dynamic of the structure that has potential practical application in Structural Health Monitoring (SHM). The research uses simplified structural models to explore the sensitivity of the index to damages, to compare the index performance with a traditional but popular damage detection method, and to understand the local/global predictive capability of the index. The research uses two simple models, namely, single- and two-degree-of-freedom systems. The results suggest that the damage index is local, that can only monitor damages occurring near the points of measurements, but it is sensitive to damages, unlike the natural frequency, which is global but less sensitive.

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Dynamic laplace: Efficient centrality measure for weighted or unweighted evolving networks

arXiv

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arXiv 2018年

作者： Cordeiro, Mário Sarmento, Rui Portocarrero Brazdil, Pavel Gama, João Doctoral Program in Informatics Engineering Faculty of Engineering University of Porto INESC TEC - Institute for Systems and Computer Engineering Technology and Science

With its origin in sociology, Social Network Analysis (SNA), quickly emerged and spread to other areas of research, including anthropology, biology, information science, organizational studies, political science, and computer science. Being it's objective the investigation of social structures through the use of networks and graph theory, Social Network Analysis is, nowadays, an important research area in several domains. Social Network Analysis cope with different problems namely network metrics, models, visualization and information spreading, each one with several approaches, methods and algorithms. One of the critical areas of Social Network Analysis involves the calculation of different centrality measures (i.e.: the most important vertices within a graph). Today, the challenge is how to do this fast and efficiently, as many increasingly larger datasets are available. Recently, the need to apply such centrality algorithms to non static networks (i.e.: networks that evolve over time) is also a new challenge. Incremental and dynamic versions of centrality measures are starting to emerge (betweenness, closeness, etc). Our contribution is the proposal of two incremental versions of the Laplacian Centrality measure, that can be applied not only to large graphs but also to, weighted or unweighted, dynamically changing networks. The experimental evaluation was performed with several tests in different types of evolving networks, incremental or fully dynamic. Results have shown that our incremental versions of the algorithm can calculate node centralities in large networks, faster and efficiently than the corresponding batch version in both incremental and full dynamic network setups. Copyright © 2018, The Authors. All rights reserved.

关键词： Laplace transforms

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The accuracy of the F statistic for structural health monitoring

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AIP Conference Proceedings 2020年第1期2227卷

作者： Fergyanto E. Gunawan Benfano Soewito Nico Surantha Tuga Mauritsius Nobumasa Sekishita 1Industrial Engineering Department BINUS Graduate Program – Master of Industrial Engineering Bina Nusantara University Jakarta Indonesia 11480 2Computer Science Department BINUS Graduate Program – Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 3Information Systems Management Department BINUS Graduate Program – Master of Information Systems Management Bina Nusantara University Jakarta Indonesia 11480 4Department of Mechanical Engineering Toyohashi University of Technology Toyohashi Aichi 441-8580 Japan

Understanding the reliability of engineering methods is crucial for its adoption and deployment. This research focuses on the reliability of the Power Spectral Density (PSD) method via the use of the F statistic for damage detection. To the author best knowledge, the method is rather classic but its realibility has not been discussed in the context of a large data size. Priory, the research anticipates that the accuracy is a function of the damage level. In this study, we evaluate 3500 cases with five levels of structural integrity, namely, healthy condition and damaged conditions with 1%, 5%, 10%, and 20% damage levels. The dataset is established via a numerical analysis of a seven degree-of-freedom system loaded with a concentrated dynamic force with random magnitude. A spring on the system is reduced in its stiffness to simulate damages. Our significant findings are the following: it is challenging for the PSD-based method to differentiate the healthy condition from the damaged conditions when the damage level is small. However, the reliability is high at 95% probability when the structural integrity has dropped by five percent.

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Work in Progress – Establishing a Master program in Cyber Physical systems: Basic Findings and Future Perspectives

Work in Progress – Establishing a Master Program in Cyber P...

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International Conference on Promising Electronic Technologies (ICPET)

作者： Isam Ishaq Rashid Jayousi Salaheddin Odeh Ezzaldeen Edwan Asmaa Shaheen Mohamed Elnaggar Ahmed Elagha Samy Salamah Christian Weber Hasan Abu Rasheed Raimund Kirner Martina Doolan Hamidreza Ahmadian Roman Obermaisser Dhiah el Diehn I. Abou-Tair Ala Khalifeh Sahel Alouneh Zaid Alhalhouli Khalid Alemerien Faiez Gargouri Bassem Bouaziz Nadia Aloui Mohammad Saleh Computer Engineering and Science Departments Al-Quds University Jerusalem Palestine Engineering Program and Computer Department Palestine Technical College - Deir El-Balah Deir El-Balah Palestine Institute of Knowledge Based Systems & Knowledge Management University of Siegen Siegen Germany University of Siegen Siegen Germany School of Engineering and Computer Science University of Hertfordshire Hatfield UK Chair of Embedded Systems University of Siegen Siegen Germany German Jordanian University Amman Jordan School of Electrical Engineering and Information Technology German Jordanian University Amman Jordan Computer and Information Technology Department Tafila Technical University Tafila Jordan Higher Institute of Computer Science and Multimedia University of Sfax Sfax Tunisia Higher Institute of Applied Sciences and Technology of Mateur University of Carthage Mateure Tunisia KTH Royal Institute of Technology Stockholm Sweden

This paper reports on the basic findings and future perspectives of a capacity building project funded by the European Union. The International Master of science on Cyber Physical systems (MS@CPS) is a collaborative project that aims to establish a master program in cyber physical systems (CPS). A consortium composed of nine partners proposed the project. Three partners are European and from Germany, UK and Sweden; while the other six partners are from the South Mediterranean region and include: Palestine, Jordan and Tunisia. The consortium is led by the University of Siegen in Germany who also manages the implementation of the work packages. CPS is an emerging engineering subject with significant economic and societal implications, which motivated the consortium to propose the establishment of a master program to offer educational and training opportunities at graduate level in the fields of CPS. In this paper, CPS as a field of study is presented with an emphasis on its importance, especially with regard to meeting local needs. A brief description of the project is presented in conjunction with the methodology for developing the courses and their learning outcomes.

关键词： computer science Internet of Things Industries Knowledge engineering Embedded systems Europe Collaboration

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3D Tortuosity: a Morphological Characterization of the Central Sulcus to Differentiate Patients with Alzheimer's Disease and Controls

3D Tortuosity: a Morphological Characterization of the Centr...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： Maria Julieta Mateos Jorge Márquez Ernesto Bribiesca Universidad Nacional Autónoma de México Graduate Program in Computer Science and Engineering Ciudad Universitaria Coyoacán CDMX México Instituto de Ciencias Aplicadas y Tecnología Universidad Nacional Autónoma de México Circuito Exterior S/N Ciudad Universitaria Mexico City Universidad Nacional Autónoma de México Institute of Research in Applied Mathematics and Systems (IIMAS) Circuito Escolar 3000 Ciudad Universitaria Coyoacán CDMX

Magnetic Resonance Images of the brain provide detailed anatomical information that allows morphological analysis of the different brain structures. The analysis of the cortical folding patterns variation is inspiring great interest, as this relates to cognitive function. The sulci are a depression in the cerebral cortex and represent ≈ 70% of the cortical surface. The sulcal width, depth and cortical thickness are the most frequent morphological descriptors applied to the sulci. In this work, the 3D tortuosity is proposed as new descriptor to capture information about the twist and turns of the sulci. 1 The 3D tortuosity of the central sulcus of both hemispheres was measured using the Minimal Interval Resonance Imaging in the Alzheimer's Disease (MIRIAD) database, for a set of high-resolution MRI of 66 subjects: 43 patients with Alzheimer Disease (AD) and 23 control subjects. As it is known AD causes significant gray matter loss which cause morphological changes in the cortical structure. It is expected for the tortuosity to capture these changes and serve as a biomarker to differentiate between populations. The result of the Wilcoxon tests show that the tortuosity values of the central sulci are significantly larger for the AD patients (p < 0.05) for the left hemisphere, which is consistent with the hypothesis. The evaluation of the proposed tortuosity measurement of the Central Sulcus as a potential biomarker was performed and the results indicate its effectiveness to extract additional anatomical information and discriminate between AD patients and Controls.

关键词： Brain Three-dimensional displays Shape Shape measurement Sociology Surface morphology Skeleton

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