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arXiv 2023年

作者： Sivarajkumar, Sonish Huang, Yufei Wang, Yanshan Intelligent Systems Program School of Computing and Information University of Pittsburgh PittsburghPA United States Department of Electrical and Computer Engineering University of Pittsburgh PittsburghPA United States Department of Health Information Management University of Pittsburgh PittsburghPA United States Department of Biomedical Informatics University of Pittsburgh PittsburghPA United States Clinical and Translational Science Institute University of Pittsburgh PittsburghPA United States

Objective: To pre-train fair and unbiased patient representations from Electronic Health Records (EHRs) using a novel weighted loss function that reduces bias and improves fairness in deep representation learning models. Methods: We defined a new loss function, called weighted loss function, in the deep representation learning model to balance the importance of different groups of patients and features. We applied the proposed model, called Fair Patient Model (FPM), to a sample of 34,739 patients from the MIMIC-III dataset and learned patient representations for four clinical outcome prediction tasks. Results: FPM outperformed the baseline models in terms of three fairness metrics: demographic parity, equality of opportunity difference, and equalized odds ratio. FPM also achieved comparable predictive performance with the baselines, with an average accuracy of 0.7912. Feature analysis revealed that FPM captured more information from clinical features than the baselines. Conclusion: FPM is a novel method to pre-train fair and unbiased patient representations from EHR data using a weighted loss function. The learned representations can be used for various downstream tasks in healthcare and can be extended to other domains where bias and fairness are important. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep learning

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Chitosan for Biofunctionalization of Microsystems

Chitosan for Biofunctionalization of Microsystems

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IEEE/NLM Life science systems and Applications Workshop

作者： Stephan T. Koev Michael A. Powers Vlad Badilita Hyunmin Yi William E. Bentley Gregory F. Payne Gary W. Rubloff Reza Ghodssi Institute for Systems Research ISR University of Maryland College Park MD USA University System of Maryland Adelphi MD US Department of Materials Science and Engineering University of Maryland College Park MD USA Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland Biotechnology Institute (UMBI) University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742 University of Maryland College Park MD USA University of Maryland Biotechnology Institute College Park MD USA Institute for Systems Research (ISR) University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Institute for Systems Research (ISR) University of Maryland College Park MD 20742

ISBN: (纸本)1424402778

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan 's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different bioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these bioMEMS sensing devices

关键词： DNA Biosensors Molecular biophysics Probes Micromechanical devices Optical sensors Optical surface waves Optical interferometry Assembly Biomedical optical imaging

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Data Storage Media Sanitization Procedures at the U.S. Agency For International Development (USAID)

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EDPACS 2006年第8期29卷 11-19页

作者： James Craft William Cleveland The Information Systems Security Officer at the United States Agency for International Development (USAID) Bureau for Management Information Resources Management (M/IRM) Information Systems Security Team. He has a BS in business management from George Mason University and has 22 years of experience focusing primarily on systems engineering cybersecurity and enterprise operations. He has played a major role in the implementation of the U.S. Government's Model Information Security Policy. The USAID PRIME Security Program Manager Computer Sciences Corporation in Arlington Virginia. He has MS degrees in information and telecommunications systems management and in military science. Cleveland has over 20 years of experience in the planning and management of a wide variety of functions including business process reengineering and IT security.

This article is derived from a Best Security Practice (BSP) developed by the U.S. Agency for International Development (USAID), Bureau for Management, Information Resources Management (M/IRM), Information systems Security Team. The USAID is an independent agency that provides economic, development, and humanitarian assistance around the world in support of the foreign policy goals of the United States. It is located in the Ronald Reagan Building in Washington, D.C.

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Modelling and reducing fuel flow pulsation of a fuel-metering system during pump mode switching in a turbofan engine

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IOP Conference Series: Earth and Environmental science 2019年第5期240卷

作者： S Masuda F Shimizu M Fuchiwaki K Tanaka Control Systems Engineering Department Research & Engineering Division Aero Engines Space & Defense Business Area IHI Corporation 229 Tonogaya Mizuho-machi Nishitama-gun Tokyo 190-1297 Japan Department of Computer Science and Systems Engineering Doctoral Program Graduate School of Computer Science and Systems Engineering Kyushu Institute of Technology 680-4 kawazu Iizuka-shi Fukuoka 820-8502 Japan Department of Mechanical Information Science and Technology School of Computer Science and Systems Engineering Kyushu Institute of Technology 680-4 kawazu Iizuka-shi Fukuoka 820-8502 Japan

In this research, the transient characteristics of a new type fuel metering system for aircraft turbofan engines using two types of pumps, a gear pump and a centrifugal pump, were studied by modelling and simulation. This new fuel metering system is capable of hydraulically unloading the operating state of each pump by the pump mode switching mechanism within the permissible range of the pump rotation speed and the fuel flow rate and it is possible to reduce the fuel temperature rise due to the pressure loss in the circuit in the operation region of the entire fuel system. In addition to this, by using a small centrifugal pump that can realize high discharge flow rate, it is possible to reduce weight compared to the conventional fuel system. However, when the pump mode is switched, unexpected fluctuation in the fuel flow rate can occur when a large change in the inlet pressure of the system occurs, the pressure control unit cannot follow the change, and the transient phenomenon cannot be suppressed. At this time, the pressure waveform generated at the time of changing the pump mode includes a high frequency component such that the pressure control unit, which plays a role of keeping the metering valve differential pressure constant, cannot follow up. Therefore, in this paper, we focused on the frequency of the pressure change waveform when the pump mode was changed and studied the model of the fuel system inlet pressure in the gear pump mode. Based on that model, we propose a method to reduce the frequency characteristics of the pressure change occurring at the time of pump mode change.

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Real-time embedded system support for the BTeV level 1 muon trigger

Real-time embedded system support for the BTeV level 1 muon ...

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2003 IEEE Nuclear science Symposium Conference Record - Nuclear science Symposium, Medical Imaging Conference

作者： Haney, Michael J. Beauregard, D. Iyer, R. Kalbarczyk, Z. Liu, Q. Wang, L. Haney, M. Selen, M. Mosse, D. Shigiltchoff, O. Chopade, R. Hovey, L. Jung, M. Messie, D. Oh, J. Stone, S. Bapty, T. Neema, S. Nordstrom, S. Shetty, S. Vashishtha, S. Yao, D. Sheldon, P. Vaandering, E. Butler, J. Gottschalk, E. Kowalkowski, J. Votava, M. Appel, J. University of Illinois Urbana IL 61801 United States Des./Validation Reliable N.S.R.G. University of Illinois High Energy Physics Group Department of Physics University of Illinois Department of Computer Science Coll. in High Sch. Educ. Program University of Pittsburgh Department of Electrical Engineering Syracuse University High Energy Physics Group Department of Physics Syracuse University Inst. for Software Intgd. Systems Vanderbilt University Department of Physics BTeV Group Vanderbilt University BTeV Collaboration Particle Physics Division Fermi Natl. Accelerator Laboratory Computing Division Fermi Natl. Accelerator Laboratory Fermilab Education Office Fermi Natl. Accelerator Laboratory

The Level 1 Muon Trigger subsystem for BTeV will be implemented using the same architectural building blocks as the BTeV Level 1 Pixel Trigger: pipelined field programmable gate arrays feeding a farm of dedicated processing elements. The muon trigger algorithm identifies candidate tracks, and is sensitive to the muon charge (sign);candidate dimuon events are identified by complementary charge track-pairs. To insure that the trigger is operating effectively, the trigger development team is actively collaborating in an independent multi-university research program for reliable, self-aware, fault adaptive behavior in real-time embedded systems (RTES). Key elements of the architecture, algorithm, performance, and engineered reliability are presented.

关键词： Embedded systems

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Finding shortest and nearly shortest path nodes in large substantially incomplete networks

arXiv

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arXiv 2022年

作者： Kitsak, Maksim Ganin, Alexander Elmokashfi, Ahmed Cui, Hongzhu Eisenberg, Daniel A. Alderson, David L. Korkin, Dmitry Linkov, Igor Faculty of Electrical Engineering Mathematics and Computer Science Delft University of Technology Delft Netherlands Network Science Institute Northeastern University BostonMA02115 United States Department of Systems and Information Engineering University of Virginia CharlottesvilleVA22904 United States U.S. Army Engineer Research and Development Center Contractor Concord MA01742 United States Simula Metropolitan Center for Digital Engineering Oslo Norway Bioinformatics and Computational Biology Program Worcester Polytechnic Institute WorcesterMA01609 United States Institute for Genomic Medicine Columbia University Medical Center New YorkNY United States Operations Research Department Naval Postgraduate School MontereyCA93943 United States Data Science Program Worcester Polytechnic Institute WorcesterMA01609 United States Computer Science Department Worcester Polytechnic Institute WorcesterMA01609 United States U.S. Army Engineer Research and Development Center Environmental Laboratory Concord MA01742 United States

Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Unfortunately, our maps of most large networks are substantially incomplete due to either the highly dynamic nature of networks, or high cost of network measurements, or both, rendering traditional path finding methods inefficient. We find that shortest paths in large real networks, such as the network of protein-protein interactions (PPI) and the Internet at the autonomous system (AS) level, are not random but are organized according to latent-geometric rules. If nodes of these networks are mapped to points in latent hyperbolic spaces, shortest paths in them align along geodesic curves connecting endpoint nodes. We find that this alignment is sufficiently strong to allow for the identification of shortest path nodes even in the case of substantially incomplete networks. We demonstrate the utility of latent-geometric path finding in problems of cellular pathway reconstruction and communication security. Copyright © 2022, The Authors. All rights reserved.

关键词： Proteins

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Valley-polarized Exitonic Mott Insulator in WS2/WSe2 Moiré Superlattice

arXiv

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arXiv 2023年

作者： Lian, Zhen Meng, Yuze Ma, Lei Maity, Indrajit Yan, Li Wu, Qiran Huang, Xiong Chen, Dongxue Chen, Xiaotong Chen, Xinyue Blei, Mark Taniguchi, Takashi Watanabe, Kenji Tongay, Sefaattin Lischner, Johannes Cui, Yong-Tao Shi, Su-Fei Department of Chemical and Biological Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Departments of Materials The Thomas Young Centre for Theory and Simulation of Materials Imperial College London United Kingdom Department of Physics and Astronomy University of California RiversideCA92521 United States Department of Materials Science and Engineering University of California RiversideCA92521 United States Materials Science and Engineering Program School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85287 United States International Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan Research Center for Functional Materials National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan Department of Electrical Computer & Systems Engineering Rensselaer Polytechnic Institute TroyNY12180 United States

Strongly enhanced electron-electron interaction in semiconducting moiré superlattices formed by transition metal dichalcogenides (TMDCs) heterobilayers has led to a plethora of intriguing fermionic correlated states1–7. Meanwhile, interlayer excitons in a type-II aligned TMDC heterobilayer moiré superlattice, with electrons and holes separated in different layers8,9, inherit this enhanced interaction and strongly interact with each other, promising for realizing tunable correlated bosonic quasiparticles10,11 with valley degree of freedom. We employ photoluminescence spectroscopy to investigate the strong repulsion between interlayer excitons and correlated electrons in a WS2/WSe2 moiré superlattice and combine with theoretical calculations to reveal the spatial extent of interlayer excitons and the band hierarchy of correlated states. We further find that an excitonic Mott insulator state emerges when one interlayer exciton occupies one moiré cell, evidenced by emerging photoluminescence peaks under increased optical excitation power. Double occupancy of excitons in one unit cell requires overcoming the energy cost of exciton-exciton repulsion of about 30-40 meV, depending on the stacking configuration of the WS2/WSe2 heterobilayer. Further, the valley polarization of the excitonic Mott insulator state is enhanced by nearly one order of magnitude. Our study demonstrates the WS2/WSe2 moiré superlattice as a promising platform for engineering and exploring new correlated states of fermion, bosons, and a mixture of both12 © 2023, CC BY.

关键词： Excitons

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Meeting the Information Assurance Crisis in the U.S. Now

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EDPACS 2006年第6期28卷 1-14页

作者： Corey Schou Deborah Frincke Charles Reynolds James Frost The Associate Dean of Information Systems Programs at Idaho State University (ISU) in Pocatello and the director of the Center for Decision Support. Currently he serves as the Chair of the National Colloquium on Information System Security Education. Schou also directs the ISU National Center of Excellence in Information Assurance Education and the ISU Technology Innovation Center. Contact Corey Schou one of the authors of this article and the Chair of the NCISSE by email at Schou@*** for help in finding additional ways to address the issues raised in this article. A member of the University of Idaho College of Engineering faculty. She graduated from the University of California at Davis. Frincke is the co-director and co-founder of the university's Center for Secure and Dependable Software (CSDS). She was the program chair for the 2nd International Workshop on Recent Advances in Intrusion Detection (RAID). A professor of Computer Science at the College of Integrated Science and Technology at James Madison University in Harrisonburg Virginia. He holds a Ph.D. in computer science from the University of Texas at Austin and a BA in philosophy from the University of Houston. Reynolds is the Director of Information System Security Education at James Madison University. Since 1997 Reynolds has led the development of the first remote Internet-based curriculum that leads to an M.S. degree in computer science with a concentration in information security. Thus far 160 students have completed this program. A professor of computer information systems at Idaho State University and the manager of its Simplot Decision Support Center.

T he only difference etween evolution and revolution is the speed at which each occurs.

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K, T and D-like fuzzy Kripke models

K, T and D-like fuzzy Kripke models

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Conference of the North American Fuzzy Information Processing Society - NAFIPS

作者： Benjamin Bedregal Regivan H. N. Santiago Mario Benevides Petrúcio Viana Group of Logic Language Information Theory and Applications-LoLITA Department of Informatics and Applied Mathematics Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil Program of Engineering of Systems and Computing-PESC Department of Computer Science Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Department of Analysis Fluminense Federal University (UFF) Niteroi Rio de Janeiro Brazil

The idea of a Kripke semantics endowed with possibility/plausibility information is not new; in fact there are different approaches for that; see: [6], [13], [16], [19]. This paper follows the approach found in [6], but whereas [6] provides a fixed interpretation for connectives into [0,1] here we provide a characterization of a fuzzy semantics for connectives in such a way that the resulting fuzzy frames: K, T and D, are described precisely by the set of statements which also describes, respectively, the usual modal systems K, T and D.

关键词： Semantics Fuzzy sets Fuzzy logic Bismuth Electronic mail Uncertainty Reliability

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Structured Downsampling for Fast, Memory-efficient Curation of Online Data Streams

arXiv

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arXiv 2024年

作者： Moreno, Matthew Andres Zaman, Luis Dolson, Emily Department of Ecology and Evolutionary Biology Ann Arbor United States Center for the Study of Complex Systems Ann Arbor United States Michigan Institute for Data and AI in Society Ann Arbor United States University of Michigan Ann Arbor United States Department of Computer Science and Engineering East Lansing United States Program in Ecology Evolution and Behavior East Lansing United States Michigan State University East Lansing United States

Operations over data streams typically hinge on efficient mechanisms to aggregate or summarize history on a rolling basis. For high-volume data steams, it is critical to manage state in a manner that is fast and memory efficient - particularly in resource-constrained or real-time contexts. Here, we address the problem of extracting a fixed-capacity, rolling subsample from a data stream. Specifically, we explore "data stream curation" strategies to fulfill requirements on the composition of sample time points retained. Our "DStream" suite of algorithms targets three temporal coverage criteria: (1) steady coverage, where retained samples should spread evenly across elapsed data stream history;(2) stretched coverage, where early data items should be proportionally favored;and (3) tilted coverage, where recent data items should be proportionally favored. For each algorithm, we prove worst-case bounds on rolling coverage quality. In contrast to previous work by Moreno, Rodriguez Papa, and Dolson (2024), which dynamically scales memory use to guarantee a specified level of coverage quality, here we focus on the more practical, application-driven case of maximizing coverage quality given a fixed memory capacity. As a core simplifying assumption, we restrict algorithm design to a single update operation: writing from the data stream to a calculated buffer site - with data never being read back, no metadata stored (e.g., sample timestamps), and data eviction occurring only implicitly via overwrite. Drawing only on primitive, low-level operations and ensuring full, overhead-free use of available memory, this "DStream" framework ideally suits domains that are resource-constrained (e.g., embedded systems), performance-critical (e.g., real-time), and fine-grained (e.g., individual data items as small as single bits or bytes). In particular, proposed power-of-two-based buffer layout schemes support O(1) data ingestion via concise bit-level operations. To further practical applica

关键词： Data streams

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