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High-Throughput Screening: One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening (Adv. Sci. 3/2019)

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Advanced science 2019年第3期6卷 1970014-1970014页

作者： Seo Woo Song Su Deok Kim Dong Yoon Oh Yongju Lee Amos Chungwon Lee Yunjin Jeong Hyung Jong Bae Daewon Lee Sumin Lee Jiyun Kim Sunghoon Kwon Department of Electrical and Computer Engineering Seoul National University Seoul 08826 South Korea Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 08826 South Korea Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA Nano Systems Institute Seoul National University Seoul 08826 South Korea Interdisciplinary Program in Bioengineering Seoul National University Seoul 08826 South Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology Ulsan 44919 South Korea

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RATIONALE FOR AN ADA SOFTWARE engineering ENVIRONMENT FOR NAVY MISSION CRITICAL APPLICATIONS

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NAVAL ENGINEERS JOURNAL 1984年第4期96卷 133-145页

作者： PAIGE, KK CONVERSE, RA USN LCdr. Kathleen K. Paige USN:graduated with a BA from the University of New Hampshire in 1970. She received her commission from Officer Candidate School in April 1971 and performed her first tour of duty with VFP-63 NAS Miramar. LCdr. Paige then received her MS from the Naval Post Graduate School in June 1976 and returned to San Diego to serve as Head Support Software Division at the Fleet Combat Direction System Support Activity. In May 1981 she reported to NA VSEA (PMS-408) where she served initially as Chairman of the NAVMAT Software Engineering Environment Working Group. She has been assigned as Deputy AN/UYK-43 Acquisition Manager since October 1981. LCdr. Paige was designated a fully qualified Engineering Duty Officer in December 1983. Robert A. Converse:is presently the Acquisition Manager for the Ada Language System/Navy (ALS/N) for the Naval Sea Systems Command Tactical Embedded Computer Resources Project. As such he is responsible for the definition and development of the ALS/N to be provided as a Navy standard computer programming system for Navy mission critical applications. Mr. Converse received a Bachelor of Science degree in Physics from Wheaton College Wheaton II. He spent fourteen years with the Naval Underwater Systems Center Newport Rhode Island during which time he designed and developed the Fortran compiler for the Navy Standard AN/UYK-7 computer. Also during that period he received a Master of Science degree in Computer Science from the University of Rhode Island. His thesis for that degree was entitled “Optimization Techniques for the NUSC Fortran Cross-Compiler”. Mr. Converse started his involvement with the Ada program in 1975 with the initial “Strawman” requirements review. Subsequently he was named as the Navy Ada Distinguished Reviewer and was intimately involved in the selection and refinement of the Ada language as it evolved to become ANSI/MIL-STD-1815A.

The U.S. Navy introduced the use of digital computers in mission critical applications over a quarter of a century ago. Today, virtually every system in the current and planned Navy inventory makes extensive use of computer technology. computers embedded in mission critical Navy systems are integral to our strategic and tactical defense capabilities. Thus, the military power of the U.S. Navy is inextricably tied to the use of programmable digital computers. The computer program is the essential element that embodies the system “intelligence”. In addition, it provides the flexibility to respond to changing threats and requirements. However, this very flexibility and capability poses a host of difficulties hindering full realization of the advantages. This paper describes the lessons learned about computer program development over the past twenty five years and discusses a software engineering process that addresses these lessons. It then describes how Ada and its related Ada programming Support and Run-Time Environments foster this software engineering process to improve computer program productivity and achieve greater system reliability and adaptibility. Finally, the paper discusses how the use of Ada and its environments can enhance the interoperability and transferability of computer programs among Navy projects and significantly reduce overall life cycle costs for Navy mission critical computer programs.

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Multimodal Whole Slide Foundation Model for Pathology

arXiv

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arXiv 2024年

作者： Ding, Tong Wagner, Sophia J. Song, Andrew H. Chen, Richard J. Lu, Ming Y. Zhang, Andrew Vaidya, Anurag J. Jaume, Guillaume Shaban, Muhammad Kim, Ahrong Williamson, Drew F.K. Chen, Bowen Almagro-Perez, Cristina Doucet, Paul Sahai, Sharifa Chen, Chengkuan Komura, Daisuke Kawabe, Akihiro Ishikawa, Shumpei Gerber, Georg Peng, Tingying Le, Long Phi Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA United States Helmholtz Munich German Research Center for Environment and Health Munich Germany School of Computation Information and Technology Technical University of Munich Munich Germany Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Harvard Data Science Initiative Harvard University CambridgeMA United States Department of Systems Biology Harvard Medical School BostonMA United States Department of Preventive Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Pathology National Cancer Center Exploratory Oncology Research & Clinical Trial Center Chiba Japan

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation. The model is publicly accessible at https://***/mahmoodlab/TITAN © 2024, CC BY-NC-ND.

关键词： Self-supervised learning

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Retraction: Sylabus and Matrials Design for Vocational Student and Its Dissemination Using Website (J. Phys.: Conf. Ser. 1114 012023)

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Journal of Physics: Conference Series 2018年第1期1114卷

作者： Astro Julida Harahap Erianto Ongko Hotler Manurung Dian Kurnia H Hartono Dahlan Abdullah Cut Ita Erliana Hardianto Djanggih Kundharu Saddhono Dian Rianita Muhammad Ikhsan Setiawan Yuliyanto Budi Setiawan Rosida Tiurma Manurung S Sriadhi Mangasi Sinurat Aisyah Siregar Rapat Piter Soni Hutauruk Nico Benjamain Sibarani 1 Department of Informatics Akademi Teknologi Industri Immanuel Medan Indonesia Department of Computer Systems Universitas Pancabudi Medan Indonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Graduate Program Universitas Sebelas Maret Surakarta Indonesia Department of Administration University of Lancang Kuning Pekanbaru Indonesia Department of Civil Engineering Narotama University Surabaya Indonesia Study Program of Communication Studies Universitas Semarang Indonesia Graduate Program in Scientific Psychology Universitas Kristen Maranatha Indonesia Department of Electrical Engineering Universitas Negeri Medan Indonesia STIE Bina Karya Tebing Tinggi Indonesia

This paper was retracted by IOP Publishing on 12 December 2018. This paper was published due to a technical error and was not intended to be included in this journal. Retraction published: 8 February 2019

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Sylabus and Matrials Design for Vocational Student and Its Dissemination Using Website

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Journal of Physics: Conference Series 2018年第1期1114卷

作者： Astro Julida Harahap Erianto Ongko Hotler Manurung Dian Kurnia H Hartono Dahlan Abdullah Cut Ita Erliana Hardianto Djanggih Kundharu Saddhono Dian Rianita Muhammad Ikhsan Setiawan Yuliyanto Budi Setiawan Rosida Tiurma Manurung S Sriadhi Mangasi Sinurat Aisyah Siregar Rapat Piter Soni Hutauruk Nico Benjamain Sibarani Department of Informatics Akademi Teknologi Industri Immanuel Medan Indonesia Department of Computer Systems Universitas Pancabudi Medan Indonesia Department of Computer Science STMIK IBBI Medan Indonesia Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Industrial Engineering Universitas Malikussaleh Aceh Indonesia Department of Law Universitas Tompotika Luwuk Banggai Indonesia Graduate Program Universitas Sebelas Maret Surakarta Indonesia Department of Administration University of Lancang Kuning Pekanbaru Indonesia Department of Civil Engineering Narotama University Surabaya Indonesia Study Program of Communication Studies Universitas Semarang Indonesia Graduate Program in Scientific Psychology Universitas Kristen Maranatha Indonesia Department of Electrical Engineering Universitas Negeri Medan Indonesia STIE Bina Karya Tebing Tinggi Indonesia

The learners' needs are an important factor in designing syllabus and materials design, this research deals with the syllabus and material design based on the professional's needs. It is expected that the syllabus and materials designes are communicatively applicable to the professional academy. Descriptive method is applied in this research. The sample of this research is 30 students of ATII Immanuel Academy Medan. They were selected by random sampling to get the data, the questioners were administered to students. the questioners consisted of 54 items and the semi structured interview consisted of 5 questions, the finding indicated that learners' needs were focused on reading and speaking skills. With reference appropriately and proportionally derived for students of the Professional Academy. Further on the basis of the syllabus, materials are designed in which the skills of using language become a priority. The results of this research will be disseminated using the website

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Influence of human engineering on manning levels and human performance on ships

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NAVAL ENGINEERS JOURNAL 1997年第5期109卷 67-76页

作者： Anderson, DE Oberman, FR Malone, TB Baker, CC David E. Anderson:has a bachelor of science degree in environmental engineering from Florida Technological University and a master's degree in environmental engineering from the University of Central Florida. He is a graduate of the Naval Sea Systems Command's Engineer-In-Training (EIT) Program. Mr. Anderson was instrumental in introducing the collective protection system (CPS) in the U.S. Navy developing the initial forward-fit package for the USS Gunston Hall and the engineering change proposal (ECP) for the USS Wasp. In 1990 he joined the Human Systems Integration (HSI) Division (SEA 55W5) where he was task leader for auxiliary ships. He is currently the HSI manager for the future technology variant of the SeaLift ship and the future carrier. Association of Scientists and Engineers 33rdAnnual Technical Symposium 26 April 1996. Fred R. Oberman:has B.A. and M.A. degrees from the University of Chicago and Loyola University (experimental psychology) and an M.S. degree in industrial engineering and operations research from Virginia Polytechnic Institute (VPI). He has more than 30 years experience in HSI management planning research analysis design and testing in government and private sector positions. He is currently responsible for NavSea HSI generic research and tool development efforts. He is responsible for Human Engineering Specifications and Standards (Commercial Hypertext) and is the NavSea 03D7 representative on HSI in Performance Specifications and for integration of HSI within Integrated Logistic Support (ILS). He has served as DoD HSI SubTAG chair and member of the Simulation and Modeling Test and Evaluation Display and Control Systems Human Computer Interaction Specifications and Standards and Systems Design Sub Tags as a member of the Society of Naval Architects and Marine Engineers (SNAME) Systems Safety Panel and a member of NATO RSG 14 on man-machine analysis. Thomas B. Malone: CHFEP received a Ph.D. in experimental psychology from Fordham University in 1964. He is president of Carlow

The objectives of Human engineering (HE) are generally viewed as increasing human performance, reducing human error, enhancing personnel and equipment safety, and reducing training and related personnel costs. There are other benefits that are thoroughly consistent with the direction of the Navy of the future, chief among these is reduction of required numbers of personnel to operate and maintain Navy ships. The Naval Research Advisory Committee (NRAC) report on Man-Machine Technology in the Navy estimated that one of the benefits from increased application of man-machine technology to Navy ship design is personnel reduction as well as improving system availability, effectiveness, and safety The objective of this paper is to discuss aspects of the human engineering design of ships and systems that affect manning requirements, and impact human-performance and safety The paper will also discuss how the application of human engineering leads to improved performance, and crew safety, and reduced workload, all of which influence manning levels. Finally, the paper presents a discussion of tools and case studies of good human engineering design practices which reduce manning.

关键词： Human engineering

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Acquisition of the enhanced Maritime Prepositioning Force, MPF(E), Ship

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NAVAL ENGINEERS JOURNAL 1999年第1期111卷 15-26页

作者： Mazumdar, T Sandison, J DuFlocq, R Thpan Mazurndar:is a Deputy Ship Design Manager from Naval Surface Warfare Center Carderock Division. He was the Design Manager for the Engineering and Design Phase ofthe Enhanced Maritime Prepositioning Fme Ship (MPF(E)). Cuwently Mt: M2.zumdar is Deputy Ship Design Manager in NAVSEA 030 for the LHD and LSD classes of ships. Mr. Mazumdar was awarded a BSE in Naval Architecture and Marine Engineering from the University of Michigan in 1981 and an MS in Computer Science fiom Virginia Tech in 1988. He also possesses an International ChiejEngineer License (Motot unlimited). Mr. Mancmdar has been an Associate Member of WAME since 1981. James C. Sandison:is a Senior Ship Design Manager (SDM) for surface ships in the Nawl Sea Systems Command (NAVSEA03D3C). He has a long tem practical background in design construction and testing of surface ships. Starting in NAVSEC as a diving and salvage systems engineer for the Bathyscaph TRIESTE he has been involved with most ofthe Nays Mine Warfare and Auxiliary ships from naval architect to the present Senior Ship Design Manager for the Strategic Sealift Program. Mr: Sandison entered the U.S. Navy in 1956 in the (diesel) Submarine Service. Afterward he “went to sea in sailing ships and completed an apprenticeship as a wooden shipbuildex. In 1971 he graduated from the University of Michigan with a BSE in Naval Architecture and Marine Engineering and was employed by NAVSEC. His latest additional duties have been as engineering coordinator on board the USS CONSTITUTION for her 200th anniversary sail. Mr. Sandison is a member of SNAME ASNE and the U.S. Naval Institute. Rick DuFlocq has over 24 years of combined project management mechanical system and general awangmmt design and design documentation experience the last 14 years urith Advance Marine Enterprises (AME). He has fmjmned this wurk on a wide variety of ships and auxiliary crafl including submarines primarily for the U.S. Navy and the Military Sealift Command (MSC). He has worked for both shiprards and marine eng

The paper will describe the streamlined acquisition process involved in the procurement, and conversion, of the first two of three Enhanced Maritime Prepositioning Force (MPF(E)) ships. This program was one of the first programs undertaken within the Government's new policy of Acquisition Reform, which resulted in the development of "performance based" requirements for these ships. This program is notable in that one prime contractor is responsible for the accomplishment of all phases, and that the contractors participating were not shipyards as is usually the fashion for Government ship acquisition programs. Also of note, was that after the conversion contracts were awarded, responsibility for the conduct of detail design, conversion, and operation and maintenance of the ship was transferred from the NAVSEA Sealift program Office (PMS 385) to the Military Sealift Command (MSC). The first part of the paper will describe the basic mission of the MPF(E) ships, and a description of the origin of the program requirements. The second part of the paper will chronicle in detail the portions of the engineering design and specification development process, which will include descriptions of the unique digital data recording and tracking systems developed by the Government MPF(E) Design Support Team to support the acquisition phases of the procurement. The third and final part of the paper will elaborate on the conversion contract awards and the transition of the program from PMS 385 to MSC.

关键词： Naval vessels

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Interactive tools for signal processing education. The signal processing instructional facility (SPIF lab) at Washington State University

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computer Applications in engineering Education 1993年第6期1卷 517-517页

作者： Bamberger, R.H. Signal Processing Instructional Facility School of Electrical Engineering and Computer Science Washington State University Pullman WA 99164-2752 Dr. Roberto H. Bamberger:was born on January 30 1965 in Buenos Aires Argentina. He received his B.E.E and PhD from the Georgia Institute of Technology in 1986 and 1990 respectively. Currently Dr. Bamberger is an assistant professor in the School of Electrical Engineering and Computer Science at Washington State University. Dr. Bamberger's research program is focused on the design implementation and application of multidimensional multirate filter banks subband image and video compression analysis of nonstationary data and application of digital signal processing techniques in the design of analog and mixed-mode integrated circuits. Dr. Bamberger is the founder and director of the Signal Processing Instructional Facility (SPIF Lab) at Washington State University. The SPIF Lab features interactive multimedia-based tools for teaching concepts related to linear systems theory. Dr. Bamberger is active in developing multimedia-based instructional laboratories for a variety of other topics as well. In addition to his teaching and research programs Dr. Bamberger is an associate editor for theIEEE Transactions on Signal Processingand a member of the editorial board forComputer Applications in Engineering Education. Dr. Bamberger is also advisor to the WSU Student Branch of the IEEE and assistant director of the WSU Cougar Marching Band. Dr. Bamberger is a member of Phi Eta Sigma Eta Kappa Nu Tau Beta Pi and Kappa Kappa Psi.

The Signal Processing Instructional Facility (SPIF Lab) is an experiment in using in interactive multimedia for teaching concepts related to linear systems theory and signal processing. The goals of the SPIF lab are to augment, enhance, and interconnect sophomore, junior, and senior level courses with the common thread of linear systems and transforms by unifying the experimentation medium. In this fashion, physical phenomenon is returned to the forefront of engineering education. The laboratory features powerful Mathematica Notebooks (a form of hypertext) and interactive applications that use dedicated DSP microprocessors.

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Tissue tropisms of avian influenza A viruses affect their spillovers from wild bird to domestic swine

Tissue tropisms of avian influenza A viruses affect their sp...

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作者： Xiaojian Zhang Fred L.Cunningham Lei Li Katie Hanson-Dorr Alicia Olivier Liyuan Liu Brandon S.Schmit Minhui Guan Jacqueline M.Nolting Andrew S.Bowman Mia Kim Torchetti Thomas J.DeLiberto Xiu-Feng Wan Missouri University Center for Research on Influenza Systems Biology (CRISB) University of Missouri Bond Life Sciences Center University of Missouri Department of Molecular Microbiology and Immunology School of Medicine University of Missouri Department of Basic Sciences College of Veterinary Medicine Mississippi State University Mississippi Field Station National Wildlife Research Center Wildlife Services Animal and Plant Health Inspection Service U.S. Department of Agriculture Department of Population and Pathobiology College of Veterinary Medicine Mississippi State University National Wildlife Disease Program Wildlife Services Animal and Plant Health Inspection Service U.S. Department of Agriculture Department of Veterinary Preventive Medicine The Ohio State University National Veterinary Services Laboratories Veterinary Services U.S. Department of Agriculture Department of Electrical Engineering & Computer Science College of Engineering University of Missouri Department of Pathobiology College of Veterinary Medicine University of Missouri MU Informatics Institute University of Missouri

Having both avian-like receptors (?±2,3-linked sialic acid, SA2,3Gal) and human-like receptors (?±2,6-linked sialic acid, SA2,6Gal), swine are proposed as??úmixing vessel??ùfor generating influenza pandemic strains. Laboratory experiments suggested all HA subtypes of influenza A virus (IAV) can infect swine. However, only sporadic cases of avian

关键词： Tissue tropisms of avian influenza A viruses affect their spillovers from wild bird to domestic swine

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